{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T04:03:33Z","timestamp":1648872213496},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Supported in part by: FIS del Instituto de Salud Carlos III (FEDER from E.U.) and Xunta de Galicia, Spain","award":["FIS del Instituto de Salud Carlos III PI10\/00088, PI13\/00322 (FEDER from E.U.) and Xunta de Galicia IN845B-2010\/187, 10CSA916014PR, CN2012\/312, Spain"],"award-info":[{"award-number":["FIS del Instituto de Salud Carlos III PI10\/00088, PI13\/00322 (FEDER from E.U.) and Xunta de Galicia IN845B-2010\/187, 10CSA916014PR, CN2012\/312, Spain"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160364","type":"journal-article","created":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T20:45:03Z","timestamp":1469825103000},"page":"e0160364","update-policy":"http:\/\/dx.doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Circulating Levels of Irisin in Hypopituitary and Normal Subjects"],"prefix":"10.1371","volume":"11","author":[{"given":"Lara","family":"Pena-Bello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"P\u00e9rtega-Diaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Sangiao-Alvarellos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Outeiri\u00f1o-Blanco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Eiras-Leal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00e1rbara","family":"Varela-Rodriguez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Juiz-Vali\u00f1a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"P\u00e9rez-Font\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Cordido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernando","family":"Cordido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,7,29]]},"reference":[{"issue":"7382","key":"ref1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"P Bostrom","year":"2012","journal-title":"Nature"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.1210\/jc.2014-1367","article-title":"Circulating irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with gender, physical activity, diet, and body composition","volume":"99","author":"AD Anastasilakis","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"12","key":"ref3","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/j.metabol.2012.09.002","article-title":"FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise","volume":"61","author":"JY Huh","year":"2012","journal-title":"Metabolism"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"2778","DOI":"10.1210\/jc.2014-1195","article-title":"Implication of circulating irisin levels with brown adipose tissue and sarcopenia in humans","volume":"99","author":"HY Choi","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ajhb.22493","article-title":"Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women","volume":"26","author":"AB Crujeiras","year":"2014","journal-title":"Am J Hum Biol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ajhb.22493","article-title":"Longitudinal variation of circulating irisin after an energy restriction-induced weight loss and following weight regain in obese men and women","volume":"26","author":"AB Crujeiras","year":"2014","journal-title":"Am J Hum Biol"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/oby.21029","article-title":"Irisin levels before and after physical activity among school-age children with different BMI: a direct relation with leptin","volume":"23","author":"B Palacios-Gonzalez","year":"2015","journal-title":"Obesity (Silver Spring)"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1210\/jc.2014-2132","article-title":"Increased Visceral Adiposity and Cortisol to Cortisone Ratio in Adults With Congenital Lifetime Isolated GH Deficiency","volume":"99","author":"E Gomes-Santos","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1530\/EJE-12-1083","article-title":"Fifteen years of GH replacement improves body composition and cardiovascular risk factors","volume":"168","author":"M Elbornsson","year":"2013","journal-title":"Eur J Endocrinol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11102-014-0571-z","article-title":"Effects of low dose versus high dose human growth hormone on body composition and lipids in adults with GH deficiency: a meta-analysis of placebo-controlled randomized trials","volume":"18","author":"CB Newman","year":"2015","journal-title":"Pituitary"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.ghir.2015.12.008","article-title":"FNDC5 relates to skeletal muscle IGF-I and mitochondrial function and gene expression in obese men with reduced growth hormone","volume":"26","author":"S Srinivasa","year":"2016","journal-title":"Growth Horm IGF Res"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1210\/jc.2011-2590","article-title":"Insulin Sensitivity and \u03b2-Cell Function in Adults with Lifetime, Untreated Isolated Growth Hormone Deficiency","volume":"97","author":"CRP Oliveira","year":"2012","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.2337\/dc13-0520","article-title":"Prediction of diabetes based on baseline metabolic characteristics in individuals at high risk","volume":"36","author":"RA Defronzo","year":"2013","journal-title":"Diabetes Care"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"e60563","DOI":"10.1371\/journal.pone.0060563","article-title":"FNDC5\/irisin is not only a myokine but also an adipokine","volume":"8","author":"A Roca-Rivada","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/cen.12627","article-title":"Irisin: 'fat' or artefact","volume":"82","author":"AB Crujeiras","year":"2015","journal-title":"Clin Endocrinol (Oxf)"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.peptides.2014.03.021","article-title":"Three new players in energy regulation: preptin, adropin and irisin","volume":"56","author":"S Aydin","year":"2014","journal-title":"Peptides"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.2337\/db12-1665","article-title":"Banting Lecture 2012: Regulation of Adipogenesis: Toward New Therapeutics for Metabolic Disease","volume":"62","author":"BM Spiegelman","year":"2013","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1476-511X-14-2","article-title":"Irisin: a new molecular marker and target in metabolic disorder","volume":"14","author":"JQ Chen","year":"2015","journal-title":"Lipids Health Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1038\/nutd.2014.7","article-title":"Higher baseline irisin concentrations are associated with greater reductions in glycemia and insulinemia after weight loss in obese subjects","volume":"4","author":"P Lopez-Legarrea","year":"2014","journal-title":"Nutr Diabetes"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.diabres.2013.01.007","article-title":"Serum irisin levels in new-onset type 2 diabetes","volume":"100","author":"YK Choi","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"key":"ref21","article-title":"Lower irisin level in patients with type 2 diabetes mellitus: A case-control study and meta-analysis","author":"C Zhang","year":"2014","journal-title":"J Diabetes"},{"key":"ref22","article-title":"Serum Irisin Level is Higher and Related with Insulin in Acanthosis Nigricans-related Obesity","author":"JQ Chen","year":"2015","journal-title":"Exp Clin Endocrinol Diabetes"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1210\/jc.2015-1208","article-title":"Irisin and Its Relation to Insulin Resistance and Puberty in Obese Children: A Longitudinal Analysis","volume":"100","author":"T Reinehr","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1210\/jc.2014-2544","article-title":"Elevated circulating levels of irisin and the effect of metformin treatment in women with polycystic ovary syndrome","volume":"100","author":"M Li","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref25","article-title":"High circulating irisin levels are associated with insulin resistance and vascular atherosclerosis in a cohort of nondiabetic adult subjects","author":"G Sesti","year":"2014","journal-title":"Acta Diabetol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.peptides.2012.11.014","article-title":"Circulating levels of irisin in patients with anorexia nervosa and different stages of obesity\u2014Correlation with body mass index","volume":"39","author":"A Stengel","year":"2013","journal-title":"Peptides"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1210\/jc.2013-2373","article-title":"Circulating Irisin in Relation to Insulin Resistance and the Metabolic Syndrome","volume":"98","author":"K Hee Park","year":"2013","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"e0124100","DOI":"10.1371\/journal.pone.0124100","article-title":"Circulating irisin levels are positively associated with metabolic risk factors in sedentary subjects","volume":"10","author":"M Moreno","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"e94235","DOI":"10.1371\/journal.pone.0094235","article-title":"Association of serum irisin with metabolic syndrome in obese chinese adults","volume":"9","author":"B Yan","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1210\/jc.2014-2932","article-title":"Serum irisin levels are regulated by acute strenuous exercise","volume":"100","author":"D Loffler","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref31","article-title":"Leptin administration in physiological or pharmacological doses does not alter circulating irisin levels in humans","author":"A Gavrieli","year":"2016","journal-title":"Int J Obes (Lond)"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"E769","DOI":"10.1210\/jc.2012-2749","article-title":"Irisin Is Expressed and Produced by Human Muscle and Adipose Tissue in Association With Obesity and Insulin Resistance","volume":"98","author":"JM Moreno-Navarrete","year":"2013","journal-title":"Journal of Clinical Endocrinology & Metabolism"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11102-008-0104-8","article-title":"Alterations in body composition in acromegaly","volume":"12","author":"L Katznelson","year":"2009","journal-title":"Pituitary"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"E453","DOI":"10.1210\/jc.2014-2416","article-title":"Irisin in response to exercise in humans with and without metabolic syndrome","volume":"100","author":"JY Huh","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"e0121367","DOI":"10.1371\/journal.pone.0121367","article-title":"Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training","volume":"10","author":"H Nygaard","year":"2015","journal-title":"PLoS One"},{"key":"ref36","article-title":"Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry","author":"MP Jedrychowski","year":"2015","journal-title":"Cell Metab"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:39:46Z","timestamp":1588977586000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160364"}},"subtitle":[],"editor":[{"given":"Raul M.","family":"Luque","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,7,29]]},"references-count":36,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2016,7,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160364","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,29]]}}}