{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:22:16Z","timestamp":1790464936024,"version":"4.1.0"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T00:00:00Z","timestamp":1470268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81201472"],"award-info":[{"award-number":["81201472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL093439 and HL113541"],"award-info":[{"award-number":["HL093439 and HL113541"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"the American Diabetes Association","doi-asserted-by":"publisher","award":["1-15-BS-148"],"award-info":[{"award-number":["1-15-BS-148"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160411","type":"journal-article","created":{"date-parts":[[2016,8,4]],"date-time":"2016-08-04T17:38:23Z","timestamp":1470332303000},"page":"e0160411","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["E2F1 Hinders Skin Wound Healing by Repressing Vascular Endothelial Growth Factor (VEGF) Expression, Neovascularization, and Macrophage Recruitment"],"prefix":"10.1371","volume":"11","author":[{"given":"Ningning","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keshav","family":"Parthasarathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samaksh","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangjian","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,4]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1524-475X.2010.00666.x","article-title":"Epidemiology of chronic cutaneous wounds in China","volume":"19","author":"Y Jiang","year":"2011","journal-title":"Wound Repair Regen"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"JM Reinke","year":"2012","journal-title":"Eur Surg Res"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"AJ Singer","year":"1999","journal-title":"The New England journal of medicine"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","article-title":"The role of vascular endothelial growth factor in wound healing","volume":"153","author":"P Bao","year":"2009","journal-title":"The Journal of surgical research"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"e516","DOI":"10.3928\/01477447-20110714-42","article-title":"Wound healing problems in total knee arthroplasty","volume":"34","author":"S Garbedian","year":"2011","journal-title":"Orthopedics"},{"key":"ref6","first-page":"641","article-title":"Study of high-risk factors of surgical wound bad healing after cesarean section","volume":"38","author":"S Chang","year":"2009","journal-title":"Chongqing Medicine"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1084\/jem.20050459","article-title":"Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization","volume":"203","author":"G Qin","year":"2006","journal-title":"The Journal of experimental medicine"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1097\/SAP.0b013e3181828141","article-title":"A review on bevacizumab and surgical wound healing: an important warning to all surgeons","volume":"62","author":"CR Gordon","year":"2009","journal-title":"Ann Plast Surg"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1172\/JCI32169","article-title":"Cellular and molecular basis of wound healing in diabetes","volume":"117","author":"H Brem","year":"2007","journal-title":"The Journal of clinical investigation"},{"issue":"6444","key":"ref10","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/365349a0","article-title":"Expression of transcription factor E2F1 induces quiescent cells to enter S phase","volume":"365","author":"DG Johnson","year":"1993","journal-title":"Nature"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nrc2696","article-title":"Emerging roles of E2Fs in cancer: an exit from cell cycle control","volume":"9","author":"H-Z Chen","year":"2009","journal-title":"Nat Rev Cancer"},{"issue":"29","key":"ref12","doi-asserted-by":"crossref","first-page":"11015","DOI":"10.1073\/pnas.0509533103","article-title":"Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF","volume":"103","author":"G Qin","year":"2006","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/cvr\/cvu222","article-title":"E2F1 suppresses cardiac neovascularization by down-regulating VEGF and PlGF expression","volume":"104","author":"M Wu","year":"2014","journal-title":"Cardiovascular research"},{"issue":"3 Pt 1","key":"ref14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/jid.2011.356","article-title":"CXCR4 antagonist AMD3100 accelerates impaired wound healing in diabetic mice","volume":"132","author":"Y Nishimura","year":"2012","journal-title":"The Journal of investigative dermatology"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1177\/33.8.2410480","article-title":"A simple micromethod for collagen and total protein determination in formalin-fixed paraffin-embedded sections","volume":"33","author":"A Lopez-De Leon","year":"1985","journal-title":"J Histochem Cytochem"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/art.27428","article-title":"Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator\/inducible costimulator ligand pathway","volume":"62","author":"C Tanaka","year":"2010","journal-title":"Arthritis Rheum"},{"issue":"10","key":"ref17","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1161\/CIRCRESAHA.109.197723","article-title":"Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression","volume":"104","author":"YL Tang","year":"2009","journal-title":"Circulation research"},{"key":"ref18","article-title":"Inhibition of Sam68 triggers adipose tissue browning","author":"J Zhou","year":"2015","journal-title":"Journal of Endocrinology"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"S Werner","year":"2003","journal-title":"Physiol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.colsurfb.2015.01.024","article-title":"Chitosan-hyaluronic acid\/VEGF loaded fibrin nanoparticles composite sponges for enhancing angiogenesis in wounds","volume":"127","author":"A Mohandas","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clindermatol.2006.09.011","article-title":"Gene therapy and wound healing","volume":"25","author":"SA Eming","year":"2007","journal-title":"Clin Dermatol"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1161\/ATVBAHA.114.303090","article-title":"Diabetes mellitus and ischemic diseases: molecular mechanisms of vascular repair dysfunction","volume":"34","author":"KY Howangyin","year":"2014","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.yjmcc.2011.09.012","article-title":"The role of E2F-1 and downstream target genes in mediating ischemia\/reperfusion injury in vivo","volume":"51","author":"E Angelis","year":"2011","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.imbio.2011.01.001","article-title":"Macrophages in skin injury and repair","volume":"216","author":"B Mahdavian Delavary","year":"2011","journal-title":"Immunobiology"},{"issue":"7446","key":"ref25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature12034","article-title":"Macrophage biology in development, homeostasis and disease","volume":"496","author":"TA Wynn","year":"2013","journal-title":"Nature"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1634\/stemcells.2004-0340","article-title":"Transplantation of endothelial progenitor cells accelerates dermal wound healing with increased recruitment of monocytes\/macrophages and neovascularization","volume":"23","author":"W Suh","year":"2005","journal-title":"Stem Cells"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1182\/blood.V99.6.2037","article-title":"Gene expression profiling identifies significant differences between the molecular phenotypes of bone marrow-derived and circulating human CD34+ hematopoietic stem cells","volume":"99","author":"U Steidl","year":"2002","journal-title":"Blood"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160411","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T23:47:29Z","timestamp":1656978449000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160411"}},"subtitle":[],"editor":[{"given":"Kishore K","family":"Wary","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,4]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160411","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,4]]}}}