{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T16:22:23Z","timestamp":1778775743108,"version":"3.51.4"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by the Key Program sponsored by the Tianjin Science and Technology Committee, China","award":["12ZCZDSY03500"],"award-info":[{"award-number":["12ZCZDSY03500"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160500","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T17:35:57Z","timestamp":1470677757000},"page":"e0160500","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Efficacy and Safety of Beclomethasone Dipropionate versus 5-Aminosalicylic Acid in the Treatment of Ulcerative Colitis: A Systematic Review and Meta-Analysis"],"prefix":"10.1371","volume":"11","author":[{"given":"Xin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YiMing","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ChunLi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ShengYi","family":"You","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(07)60751-X","article-title":"Inflammatory bowel disease:clinical aspects and established and evolving therapies","volume":"369","author":"DC Baumgart","year":"2007","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MOG.0b013e3281c55eb2","article-title":"Immunopathogenesis of inflammatory boweldisease: current concepts","volume":"23","author":"G Bamias","year":"2007","journal-title":"Curr Opin Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1007\/s10620-014-3350-9","article-title":"Environmental risk factors for inflammatory boweldiseases: a review","volume":"60","author":"AN Ananthakrishnan","year":"2015","journal-title":"Dig Dis Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s10620-012-2371-5","article-title":"Recent trends in the prevalence of Crohn\u2019s disease and ulcerative colitis in a commercially insuredUS population","volume":"58","author":"MD Kappelman","year":"2013","journal-title":"Dig Dis Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/00365520310008386","article-title":"Health-related quality of life in patients with infl ammatory bowel disease five years after the initial diagnosis","volume":"39","author":"T Bernklev","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ajg.2009.727","article-title":"Ulcerative colitis practice guidelines in adults: American College Of Gastroenterology, Practice Parameters Committee","volume":"105","author":"A Kornbluth","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"ref7","first-page":"CD000543","article-title":"Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis","volume":"10","author":"B Feagan","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1084\/jem.20041948","article-title":"Intestinal anti-inflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator-activated receptor-gamma","volume":"201","author":"C Rousseaux","year":"2005","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0025-6196(24)00526-3","article-title":"The effects of the adrenal cortical hormone 17-hydroxy-11-dehydrocorticosterone (Compound E) on the acute phase of rheumatic fever; preliminary report","volume":"24","author":"PS Hench","year":"1949","journal-title":"Mayo Clin Proc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/bmj.2.4884.375","article-title":"Cortisone in ulcerative colitis; preliminary report on a therapeutic trial","volume":"2","author":"SC Truelove","year":"1954","journal-title":"Br Med J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.ejphar.2004.07.011","article-title":"Effects of glucocorticoids on gene transcription","volume":"500","author":"R Hayashi","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1046\/j.1365-2036.2001.01060.x","article-title":"Review article: the limitations of corticosteroid therapy in Crohn\u2019s disease","volume":"15","author":"PJ Rutgeerts","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1007\/BF02556177","article-title":"Treatment of distal ulcerative colitis with beclomethasone enemas: high therapeutic efficacy without endocrine side effects. A prospective, randomized, double-blind trial","volume":"30","author":"G Bansky","year":"1987","journal-title":"Dis Colon Rectum"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMra1102942","article-title":"Ulcerative colitis","volume":"365","author":"S Danese","year":"2011","journal-title":"N Engl J Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(82)91747-0","article-title":"Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushing\u2019s syndrome or hypothalamic pituitary adrenal suppression","volume":"1","author":"CR Kumana","year":"1982","journal-title":"Lancet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1046\/j.1365-2036.2002.01298.x","article-title":"Oral beclometasone dipropionate in the treatment of active ulcerative colitis: a double-blind placebo-controlled study","volume":"16","author":"F Rizzello","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(82)91747-0","article-title":"Beclomethasone dipropionate enemas for treating inflammatory bowel disease without producing Cushing\u2019s syndrome or hypothalamic pituitary adrenal suppression","volume":"1","author":"CR Kumana","year":"1982","journal-title":"Lancet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000073247","article-title":"Standard treatment of ulcerative colitis","volume":"21","author":"P Gionchetti","year":"2003","journal-title":"Dig Dis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-2036.2007.03349.x","article-title":"Meta-analysis: the efficacy of rectal beclomethasone dipropionate vs. 5-aminosalicylic acid in mild to moderate distal ulcerative colitis","volume":"26","author":"F Manguso","year":"2007","journal-title":"Aliment Pharmacol Ther"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/0016-5085(87)90621-4","article-title":"5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis","volume":"92","author":"LR Sutherland","year":"1987","journal-title":"Gastroenterol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1046\/j.1365-2036.2003.01609.x","article-title":"Oral beclometasone dipropionate in the treatment of extensive and left-sided active ulcerative colitis: a multicentre randomised study","volume":"17","author":"M Campieri","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/01.mcg.0000155124.74548.61","article-title":"Topical treatment of distal active ulcerative colitis with beclomethasone dipropionate or mesalamine: a single-blind randomized controlled trial","volume":"39","author":"P Gionchetti","year":"2005","journal-title":"J Clin Gastroenterol"},{"key":"ref23","first-page":"2830","article-title":"Efficacy of mesalazine or beclomethasone dipropionate enema or their combination in patients with distal active ulcerative colitis","volume":"19","author":"P Crispino","year":"2015","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.dld.2007.01.012","article-title":"Beclomethasone dipropionate versus mesalazine in distal ulcerative colitis: A multicenter, randomized, double-blind study","volume":"39","author":"L Biancone","year":"2007","journal-title":"Dig Liver Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/00042737-199606000-00010","article-title":"Beclomethasone dipropionate (3 mg) versus 5-aminosalicylic acid (2 g) versus the combination of both (3 mg\/2 g) as retention enemas in active ulcerative proctitis","volume":"8","author":"CJ Mulder","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref26","first-page":"287","article-title":"Topical treatment of ulcerative colitis. Doubleblind study between beclomethasone dipropionate and mesalazine","volume":"45","author":"A Franz\u00e8","year":"1999","journal-title":"Minerva Gastroenterol Dietol"},{"key":"ref27","first-page":"189","article-title":"Oral beclomethasone dipropionate versus 5-aminosalycilic acid enema in active ulcerative colitis patients: lower efficacy but better compliance","volume":"64","author":"N Pica","journal-title":"Italian. J Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1111\/j.1572-0241.2004.40036.x","article-title":"Ulcerative colitis practice guidelines in adults (update): American College of Gastroenterology, Practice Parameters Committee","volume":"99","author":"A Kornbluth","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/ibd.23024","article-title":"Once daily oral mesalamine compared to conventional dosing for induction and maintenance of remission in ulcerative colitis: A systematic review and meta-analysis","volume":"18","author":"BG Feagan","year":"2012","journal-title":"Inflammatory Bowel Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1097\/MIB.0000000000000379","article-title":"Systematic Review: Rectal Therapies for the Treatment of Distal Forms of Ulcerative Colitis","volume":"21","author":"RD Cohen","year":"2015","journal-title":"Inflamm Bowel Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1007\/s10620-009-0962-6","article-title":"Oral Beclomethasone Dipropionate as an Alternative to Systemic Steroids in Mild to Moderate Ulcerative Colitis Not Responding to Aminosalicylates","volume":"55","author":"C Papi","year":"2010","journal-title":"Digestive Diseases & Sciences"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160500","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T16:12:21Z","timestamp":1749053541000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160500"}},"subtitle":[],"editor":[{"given":"John","family":"Green","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160500","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]}}}