{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T13:32:10Z","timestamp":1774791130941,"version":"3.50.1"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001530","name":"Canterbury Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008247","name":"University of Otago","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008247","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Aging and Alzheimers Institute"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160521","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T17:37:42Z","timestamp":1471023462000},"page":"e0160521","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Cystathionine-Gamma-Lyase Gene Deletion Protects Mice against Inflammation and Liver Sieve Injury following Polymicrobial Sepsis"],"prefix":"10.1371","volume":"11","author":[{"given":"Ravinder Reddy","family":"Gaddam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Badiei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria C","family":"Cogger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G","family":"Le Couteur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madhav","family":"Bhatia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-319-18144-8_1","article-title":"H<sub>2<\/sub>S Synthesizing Enzymes: Biochemistry and Molecular Aspects","volume":"230","author":"CW Huang","year":"2015","journal-title":"Handb Exp Pharmacol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1089\/ars.2010.3781","article-title":"The quantitative significance of the transsulfuration enzymes for H<sub>2<\/sub>S production in murine tissues","volume":"15","author":"O Kabil","year":"2011","journal-title":"Antioxid Redox Signal"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"L1193","DOI":"10.1152\/ajplung.00489.2005","article-title":"Role of hydrogen sulfide in cecal ligation and puncture-induced sepsis in the mouse","volume":"290","author":"H Zhang","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e32574","DOI":"10.1371\/journal.pone.0032574","article-title":"Effects of S-propargyl-cysteine (SPRC) in caerulein-induced acute pancreatitis in mice","volume":"7","author":"JN Sidhapuriwala","year":"2012","journal-title":"PLoS One"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e0154483","DOI":"10.1371\/journal.pone.0154483","article-title":"Protective Effects of Hydrogen Gas on Experimental Acute Pancreatitis","volume":"11","author":"HX Zhou","year":"2016","journal-title":"PLoS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/sj.bjp.0706367","article-title":"Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia","volume":"146","author":"M Collin","year":"2005","journal-title":"Br J Pharmacol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1096\/fj.04-3583fje","article-title":"Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse","volume":"19","author":"L Li","year":"2005","journal-title":"FASEB J"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2119\/molmed.2010.00027","article-title":"Role of Hydrogen Sulfide in Severe Burn Injury\u2013Induced Inflammation in Mice","volume":"16","author":"J Zhang","year":"2010","journal-title":"Mol Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/sj.bjp.0706186","article-title":"Hydrogen sulphide is a mediator of carrageenan\u2010induced hindpaw oedema in the rat","volume":"145","author":"M Bhatia","year":"2005","journal-title":"Br J Pharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1749-6632.2010.05556.x","article-title":"Detection of hydrogen sulfide in plasma and knee\u2010joint synovial fluid from rheumatoid arthritis patients: relation to clinical and laboratory measures of inflammation","volume":"1203","author":"M Whiteman","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1189\/jlb.0407237","article-title":"Endogenous hydrogen sulfide regulates leukocyte trafficking in cecal ligation and puncture-induced sepsis","volume":"82","author":"H Zhang","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e24535","DOI":"10.1371\/journal.pone.0024535","article-title":"Hydrogen sulfide and neurogenic inflammation in polymicrobial sepsis: involvement of substance P and ERK-NF-\u03baB signaling","volume":"6","author":"SF Ang","year":"2011","journal-title":"PLoS One"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.4049\/jimmunol.181.6.4320","article-title":"Endogenous hydrogen sulfide regulates inflammatory response by activating the ERK pathway in polymicrobial sepsis","volume":"181","author":"H Zhang","year":"2008","journal-title":"J Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.molcel.2011.10.021","article-title":"Hydrogen sulfide-linked sulfhydration of NF-\u03baB mediates its antiapoptotic actions","volume":"45","author":"N Sen","year":"2012","journal-title":"Mol. Cell"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000 N","volume":"348","author":"GS Martin","year":"2003","journal-title":"Engl J Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.2353\/ajpath.2007.060872","article-title":"Pathophysiology of sepsis","volume":"170","author":"DG Remick","year":"2007","journal-title":"Am. J. Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e1001341","DOI":"10.1371\/journal.pmed.1001341","article-title":"New translational research provides insights into liver dysfunction in sepsis","volume":"9","author":"JC Marshall","year":"2012","journal-title":"PLoS Med"},{"key":"ref18","first-page":"661","article-title":"Mediators of inflammation and acute phase response in the liver","volume":"47","author":"K Streetz","year":"2001","journal-title":"Cell Mol. Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1002\/cphy.c140078","article-title":"Liver Sinusoidal Endothelial Cells","volume":"5","author":"KK S\u00f8rensen","year":"2015","journal-title":"Compr Physiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11010-008-9881-7","article-title":"Nitric oxide and MCP-1 regulation in LPS activated rat Kupffer cells","volume":"319","author":"G Kolios","year":"2008","journal-title":"Mol. Cell Biochem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1046\/j.1365-2249.1997.d01-959.x","article-title":"Regulation of endotoxin-induced IL-6 production in liver sinusoidal endothelial cells and Kupffer cells by IL-10","volume":"107","author":"P Knolle","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/hep.510230420","article-title":"Kupffer cell inactivation prevents lipopolysaccharide\u2010induced structural changes in the rat liver sinusoid: An electron\u2010microscopic study","volume":"23","author":"TG Sarphie","year":"1996","journal-title":"Hepatology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e857","DOI":"10.1016\/j.ijid.2010.02.2263","article-title":"Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells","volume":"14","author":"R Cheluvappa","year":"2010","journal-title":"Int J Infect Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0676.1994.tb00080.x","article-title":"Endotoxin\u2010induced defenestration of the hepatic sinusoidal endothelium: a factor in the pathogenesis of cirrhosis?","volume":"14","author":"B Dobbs","year":"1994","journal-title":"Liver"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4153","DOI":"10.4049\/jimmunol.179.6.4153","article-title":"Hydrogen sulfide up-regulates substance P in polymicrobial sepsis-associated lung injury","volume":"179","author":"H Zhang","year":"2007","journal-title":"J Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1097\/CCM.0b013e3181c0df00","article-title":"Hydrogen sulfide promotes transient receptor potential vanilloid 1-mediated neurogenic inflammation in polymicrobial sepsis","volume":"38","author":"SF Ang","year":"2010","journal-title":"Crit Care Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1586\/ecp.10.134","article-title":"Hydrogen sulfide and inflammation: the good, the bad, the ugly and the promising","volume":"4","author":"M Whiteman","year":"2011","journal-title":"Expert Rev Clin Pharmacol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1016\/S0021-9258(19)85725-3","article-title":"Mechanism-based inactivation of pig heart L-alanine transaminase by L-propargylglycine. Half-site reactivity","volume":"255","author":"G Burnett","year":"1980","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3070","DOI":"10.1021\/bi00659a021","article-title":"Vinylglycine and propargylglycine: complementary suicide substrates for L-amino acid oxidase and D-amino acid oxidase","volume":"15","author":"P Marcotte","year":"1976","journal-title":"Biochemistry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"26358","DOI":"10.1074\/jbc.M110.147439","article-title":"Cystathionine \u03b3-lyase-deficient mice require dietary cysteine to protect against acute lethal myopathy and oxidative injury","volume":"285","author":"I Ishii","year":"2010","journal-title":"J Biol Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-4804(80)90037-2","article-title":"Sepsis and septic shock\u2014a review of laboratory models and a proposal","volume":"29","author":"KA Wichterman","year":"1980","journal-title":"J Surg Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0006-291X(03)00256-0","article-title":"The regulatory effect of hydrogen sulfide on hypoxic pulmonary hypertension in rats","volume":"302","author":"Z Chunyu","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref33","first-page":"e52698","article-title":"A standardized method for the analysis of liver sinusoidal endothelial cells and their fenestrations by scanning electron microscopy","volume":"98","author":"V Cogger","year":"2015","journal-title":"J Vis Exp"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"RG Knodell","year":"1981","journal-title":"Hepatology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/hep.510310136","article-title":"Grading and staging the histopathological lesions of chronic hepatitis: the Knodell histology activity index and beyond","volume":"31","author":"EM Brunt","year":"2000","journal-title":"Hepatology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1165\/rcmb.2009-0210ST","article-title":"An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals","volume":"44","author":"G Matute-Bello","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1189\/jlb.1006599","article-title":"Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-\u03baB pathway","volume":"81","author":"L Zhi","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/ndt\/gfq447","article-title":"Inhibition of hydrogen sulphide formation reduces cisplatin-induced renal damage","volume":"26","author":"HDC Francescato","year":"2011","journal-title":"Nephrol Dial Transplant"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s10495-012-0770-x","article-title":"Inhibition of hydrogen sulfide synthesis provides protection for severe acute pancreatitis rats via apoptosis pathway","volume":"18","author":"G Wang","year":"2013","journal-title":"Apoptosis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.4049\/jimmunol.181.6.4287","article-title":"Hydrogen sulfide augments neutrophil migration through enhancement of adhesion molecule expression and prevention of CXCR2 internalization: role of ATP-sensitive potassium channels","volume":"181","author":"D Dal-Secco","year":"2008","journal-title":"J Immunol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1006\/jsre.1997.5162","article-title":"Amelioration of sinusoidal endothelial cell damage by Kupffer cell blockade during cold preservation of rat liver","volume":"72","author":"M Niwano","year":"1997","journal-title":"J Surg Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jhep.2004.04.034","article-title":"The effects of oxidative stress on the liver sieve","volume":"41","author":"VC Cogger","year":"2004","journal-title":"J Hepatol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1549-8719.2009.00004.x","article-title":"Liver Sinusoidal Endothelial Fenestrations in Caveolin\u20101 Knockout Mice","volume":"17","author":"A Warren","year":"2010","journal-title":"Microcirculation"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00024382-199703000-00006","article-title":"Gadolinium chloride pretreatment protects against hepatic injury but predisposes the lungs to alveolitis after lipopolysaccharide administration","volume":"7","author":"AP Brown","year":"1997","journal-title":"Shock"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/000313481207800102","article-title":"Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues","volume":"78","author":"DE Fry","year":"2012","journal-title":"Am Surg"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0183304","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2017,8,10]],"date-time":"2017-08-10T00:00:00Z","timestamp":1502323200000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160521","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T22:13:46Z","timestamp":1657059226000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160521"}},"subtitle":[],"editor":[{"given":"Zolt\u00e1n","family":"Rakonczay","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,12]]},"references-count":45,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160521","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0183304","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,12]]}}}