{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:11:15Z","timestamp":1785208275913,"version":"3.55.0"},"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T00:00:00Z","timestamp":1471824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1 DK083163"],"award-info":[{"award-number":["RO1 DK083163"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["RO1 DK097240"],"award-info":[{"award-number":["RO1 DK097240"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Allergy and Infectious Diseases (NIH AI)","award":["R21AI1094296"],"award-info":[{"award-number":["R21AI1094296"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160755","type":"journal-article","created":{"date-parts":[[2016,8,22]],"date-time":"2016-08-22T13:40:16Z","timestamp":1471873216000},"page":"e0160755","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Cardiomyocyte-Specific Ablation of Med1 Subunit of the Mediator Complex Causes Lethal Dilated Cardiomyopathy in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Yuzhi","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Chun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Schipma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Shete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward B.","family":"Thorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip M.","family":"Barger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Jun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Viswakarma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashpal S.","family":"Kanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Ardehali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bayar","family":"Thimmapaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janardan K.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.tibs.2005.03.011","article-title":"Mediator and the mechanism of transcriptional activation","volume":"30","author":"RD Kornberg","year":"2005","journal-title":"Trends Biochem Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm3951","article-title":"The Mediator complex: a central integrator of transcription","volume":"16","author":"BL Allen","year":"2015","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nrg2901","article-title":"The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation","volume":"11","author":"S Malik","year":"2010","journal-title":"Nat Rev Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.tibs.2013.08.007","article-title":"The multitalented Mediator complex","volume":"38","author":"JO Carlsten","year":"2013","journal-title":"Trends Biochem Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.semcdb.2011.07.024","article-title":"Mediator and human disease","volume":"22","author":"JM Spaeth","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gpb.2013.05.002","article-title":"Mediator complex dependent regulation of cardiac development and disease","volume":"11","author":"CE Grueter","year":"2013","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.tcm.2013.03.002","article-title":"Mediating lipid biosynthesis: implications for cardiovascular disease","volume":"23","author":"Xiaoli","year":"2013","journal-title":"Trends Cardiovasc Med"},{"key":"ref8","first-page":"66","article-title":"Involvement of Mediator complex in malignancy","volume":"1845","author":"C Schiano","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2734","DOI":"10.1002\/ajmg.a.36183","article-title":"MED12 related disorders","volume":"161a","author":"JM Graham Jr.","year":"2013","journal-title":"Am J Med Genet A"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.semcdb.2011.07.026","article-title":"Mediator-dependent nuclear receptor function","volume":"22","author":"W Chen","year":"2011","journal-title":"Semin Cell Dev Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1016\/j.bbagen.2012.02.012","article-title":"The Mediator complex in thyroid hormone receptor action","volume":"1830","author":"JD Fondell","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"4795","DOI":"10.1172\/JCI76737","article-title":"Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy","volume":"124","author":"R Wu","year":"2014","journal-title":"J Clin Invest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(00)80247-6","article-title":"Involvement of the TRAP220 component of the TRAP\/SMCC coactivator complex in embryonic development and thyroid hormone action","volume":"5","author":"M Ito","year":"2000","journal-title":"Mol Cell"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"14779","DOI":"10.1074\/jbc.C000121200","article-title":"Deletion of PBP\/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality","volume":"275","author":"Y Zhu","year":"2000","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1210\/me.2003-0097","article-title":"The thyroid hormone receptor-associated protein TRAP220 is required at distinct embryonic stages in placental, cardiac, and hepatic development","volume":"17","author":"C Landles","year":"2003","journal-title":"Mol Endocrinol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1074\/jbc.M107995200","article-title":"Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors","volume":"277","author":"SE Crawford","year":"2002","journal-title":"J Biol Chem"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1172\/JCI62862","article-title":"Genetic mutations and mechanisms in dilated cardiomyopathy","volume":"123","author":"EM McNally","year":"2013","journal-title":"J Clin Invest"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1172\/JCI119509","article-title":"Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo","volume":"100","author":"R Agah","year":"1997","journal-title":"J Clin Invest"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"24427","DOI":"10.1074\/jbc.M402391200","article-title":"Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver","volume":"279","author":"Y Jia","year":"2004","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1161\/hh1301.092687","article-title":"Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein","volume":"89","author":"DS Sohal","year":"2001","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nprot.2012.016","article-title":"Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks","volume":"7","author":"C Trapnell","year":"2012","journal-title":"Nat Protoc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.cell.2012.10.012","article-title":"Revisiting global gene expression analysis","volume":"151","author":"J Loven","year":"2012","journal-title":"Cell"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"H29","DOI":"10.1152\/ajpheart.01125.2007","article-title":"Intergenic transcription and developmental regulation of cardiac myosin heavy chain genes","volume":"294","author":"F Haddad","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"W478","DOI":"10.1093\/nar\/gks402","article-title":"GeneCodis3: a non-redundant and modular enrichment analysis tool for functional genomics","volume":"40","author":"D Tabas-Madrid","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e13823","DOI":"10.1371\/journal.pone.0013823","article-title":"Regulation and cytoprotective role of hexokinase III","volume":"5","author":"E Wyatt","year":"2010","journal-title":"PLoS One"},{"key":"ref26","first-page":"e4205","article-title":"Isolation of cardiomyocyte nuclei from post-mortem tissue","author":"O Bergmann","year":"2012","journal-title":"J Vis Exp"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1161\/CIRCRESAHA.110.223115","article-title":"Reduction in hexokinase II levels results in decreased cardiac function and altered remodeling after ischemia\/reperfusion injury","volume":"108","author":"R Wu","year":"2011","journal-title":"Circ Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1507\/endocrj.K10E-150","article-title":"Regulation and significance of atrial and brain natriuretic peptides as cardiac hormones","volume":"57","author":"K Kuwahara","year":"2010","journal-title":"Endocr J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3727\/105221614X13919976902219","article-title":"Med1 subunit of the mediator complex in nuclear receptor-regulated energy metabolism, liver regeneration, and hepatocarcinogenesis","volume":"16","author":"Y Jia","year":"2014","journal-title":"Gene Expr"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"10196","DOI":"10.1073\/pnas.1005626107","article-title":"A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism","volume":"107","author":"W Chen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1002\/hep.24155","article-title":"Transcription coactivator mediator subunit MED1 is required for the development of fatty liver in the mouse","volume":"53","author":"L Bai","year":"2011","journal-title":"Hepatology"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"19678","DOI":"10.1073\/pnas.1117835108","article-title":"Lethal mitochondrial cardiomyopathy in a hypomorphic Med30 mouse mutant is ameliorated by ketogenic diet","volume":"108","author":"P Krebs","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/S0008-6363(01)00552-1","article-title":"Fatty acid metabolism in cardiac failure: biochemical, genetic and cellular analysis","volume":"54","author":"J Marin-Garcia","year":"2002","journal-title":"Cardiovasc Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/nm1116","article-title":"Cardiomyocyte-restricted peroxisome proliferator-activated receptor-delta deletion perturbs myocardial fatty acid oxidation and leads to cardiomyopathy","volume":"10","author":"L Cheng","year":"2004","journal-title":"Nat Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.celrep.2014.07.027","article-title":"Perturbation of NCOA6 leads to dilated cardiomyopathy","volume":"8","author":"JI Roh","year":"2014","journal-title":"Cell Rep"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1111\/bph.12475","article-title":"Mitochondrial fatty acid oxidation alterations in heart failure, ischaemic heart disease and diabetic cardiomyopathy","volume":"171","author":"N Fillmore","year":"2014","journal-title":"Br J Pharmacol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.metabol.2013.09.014","article-title":"The heart is better protected against myocardial infarction in the fed state compared to the fasted state","volume":"63","author":"E Liepinsh","year":"2014","journal-title":"Metabolism"},{"key":"ref38","article-title":"Cardiac contraction-induced GLUT4 translocation requires dual signaling input","author":"JJ Luiken","year":"2015","journal-title":"Trends Endocrinol Metab"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1161\/01.RES.0000117088.36577.EB","article-title":"Cardiac-specific induction of the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha promotes mitochondrial biogenesis and reversible cardiomyopathy in a developmental stage-dependent manner","volume":"94","author":"LK Russell","year":"2004","journal-title":"Circ Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.bbagrm.2012.03.002","article-title":"Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number","volume":"1819","author":"CT Campbell","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1359-6101(03)00044-3","article-title":"Transforming growth factor beta in cardiovascular development and function","volume":"14","author":"M Azhar","year":"2003","journal-title":"Cytokine Growth Factor Rev"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1042\/CS20120269","article-title":"The ACE2 gene: its potential as a functional candidate for cardiovascular disease","volume":"124","author":"LM Burrell","year":"2013","journal-title":"Clin Sci (Lond)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1161\/01.RES.0000252291.88540.ac","article-title":"Integrin activation in the heart: a link between electrical and contractile dysfunction?","volume":"99","author":"ML Valencik","year":"2006","journal-title":"Circ Res"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/35038011","article-title":"Vasoregulation by the beta1 subunit of the calcium-activated potassium channel","volume":"407","author":"R Brenner","year":"2000","journal-title":"Nature"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1161\/01.RES.72.6.1337","article-title":"Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart","volume":"72","author":"T Collin","year":"1993","journal-title":"Circ Res"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1161\/CIRCRESAHA.114.301275","article-title":"Integrins and integrin-associated proteins in the cardiac myocyte","volume":"114","author":"S Israeli-Rosenberg","year":"2014","journal-title":"Circ Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1161\/CIRCULATIONAHA.111.049072","article-title":"Protection against myocardial infarction and no-reflow through preservation of vascular integrity by angiopoietin-like 4","volume":"125","author":"A Galaup","year":"2012","journal-title":"Circulation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3727\/105221610X12819686555015","article-title":"ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?","volume":"15","author":"T Hai","year":"2010","journal-title":"Gene Expr"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"e68396","DOI":"10.1371\/journal.pone.0068396","article-title":"Adult cardiac expression of the activating transcription factor 3, ATF3, promotes ventricular hypertrophy","volume":"8","author":"L Koren","year":"2013","journal-title":"PLoS One"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e26744","DOI":"10.1371\/journal.pone.0026744","article-title":"Activating transcription factor 3 deficiency promotes cardiac hypertrophy, dysfunction, and fibrosis induced by pressure overload","volume":"6","author":"H Zhou","year":"2011","journal-title":"PLoS One"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/CIRCULATIONAHA.105.598409","article-title":"Deletion of the inducible 70-kDa heat shock protein genes in mice impairs cardiac contractile function and calcium handling associated with hypertrophy","volume":"113","author":"YK Kim","year":"2006","journal-title":"Circulation"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.yjmcc.2015.11.003","article-title":"Connective tissue growth factor regulates cardiac function and tissue remodeling in a mouse model of dilated cardiomyopathy","volume":"89","author":"YE Koshman","year":"2015","journal-title":"J Mol Cell Cardiol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1172\/JCI42028","article-title":"Cardiac fibrosis in mice with hypertrophic cardiomyopathy is mediated by non-myocyte proliferation and requires Tgf-beta","volume":"120","author":"P Teekakirikul","year":"2010","journal-title":"J Clin Invest"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.yjmcc.2010.10.033","article-title":"Transforming growth factor (TGF)-beta signaling in cardiac remodeling","volume":"51","author":"M Dobaczewski","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.diabres.2013.01.008","article-title":"Peroxisome proliferator-activated receptors modulate cardiac dysfunction in diabetic cardiomyopathy","volume":"100","author":"TI Lee","year":"2013","journal-title":"Diabetes Res Clin Pract"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"22293","DOI":"10.1074\/jbc.M000248200","article-title":"Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity","volume":"275","author":"K Watanabe","year":"2000","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4963","DOI":"10.1242\/jcs.113662","article-title":"PGC1alpha and mitochondrial metabolism\u2014emerging concepts and relevance in ageing and neurodegenerative disorders","volume":"125","author":"S Austin","year":"2012","journal-title":"J Cell Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1002\/9780470725207.ch5","article-title":"Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators","volume":"287","author":"BM Spiegelman","year":"2007","journal-title":"Novartis Found Symp"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"10848","DOI":"10.1073\/pnas.96.19.10848","article-title":"Amplification and overexpression of peroxisome proliferator-activated receptor binding protein (PBP\/PPARBP) gene in breast cancer","volume":"96","author":"Y Zhu","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1158\/1541-7786.MCR-12-0618","article-title":"ERK and AKT signaling drive MED1 overexpression in prostate cancer in association with elevated proliferation and tumorigenicity","volume":"11","author":"F Jin","year":"2013","journal-title":"Mol Cancer Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1007\/s00134-011-2296-z","article-title":"Increased RNA editing in children with cyanotic congenital heart disease","volume":"37","author":"S Borik","year":"2011","journal-title":"Intensive Care Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ejhg.2013.17","article-title":"Dosage changes of MED13L further delineate its role in congenital heart defects and intellectual disability","volume":"21","author":"R Asadollahi","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"ref63","first-page":"23","article-title":"Clinical manifestations of Deletion 22q11.2 syndrome (DiGeorge\/Velo-Cardio-Facial syndrome)","volume":"7","author":"M Digilio","year":"2005","journal-title":"Images Paediatr Cardiol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/cr.2014.120","article-title":"Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity","volume":"24","author":"Y Chu","year":"2014","journal-title":"Cell Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.biochi.2011.05.015","article-title":"Hallmarks of the channelopathies associated with L-type calcium channels: a focus on the Timothy mutations in Ca(v)1.2 channels","volume":"93","author":"I Bidaud","year":"2011","journal-title":"Biochimie"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1054-3589(10)59001-X","article-title":"The ryanodine receptor in cardiac physiology and disease","volume":"59","author":"A Kushnir","year":"2010","journal-title":"Adv Pharmacol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1038\/ncomms5533","article-title":"Integrin-linked kinase mediates force transduction in cardiomyocytes by modulating SERCA2a\/PLN function","volume":"5","author":"A Traister","year":"2014","journal-title":"Nat Commun"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nrm1151","article-title":"Phospholamban: a crucial regulator of cardiac contractility","volume":"4","author":"DH MacLennan","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1172\/JCI62834","article-title":"Calcium cycling proteins and heart failure: mechanisms and therapeutics","volume":"123","author":"AR Marks","year":"2013","journal-title":"J Clin Invest"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrcardio.2012.93","article-title":"Inherited calcium channelopathies in the pathophysiology of arrhythmias","volume":"9","author":"L Venetucci","year":"2012","journal-title":"Nat Rev Cardiol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e002","DOI":"10.1621\/nrs.08002","article-title":"PPARalpha: energy combustion, hypolipidemia, inflammation and cancer","volume":"8","author":"SR Pyper","year":"2010","journal-title":"Nucl Recept Signal"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1101\/gad.273128.115","article-title":"A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism","volume":"30","author":"L Amoasii","year":"2016","journal-title":"Genes Dev"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1093\/carcin\/bgp306","article-title":"Transcription coactivator PBP\/MED1-deficient hepatocytes are not susceptible to diethylnitrosamine-induced hepatocarcinogenesis in the mouse","volume":"31","author":"K Matsumoto","year":"2010","journal-title":"Carcinogenesis"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"27898","DOI":"10.1074\/jbc.M113.486696","article-title":"The Med1 subunit of the mediator complex induces liver cell proliferation and is phosphorylated by AMP kinase","volume":"288","author":"N Viswakarma","year":"2013","journal-title":"J Biol Chem"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0164316","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2016,9,30]],"date-time":"2016-09-30T00:00:00Z","timestamp":1475193600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:09:32Z","timestamp":1540336172000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160755"}},"subtitle":[],"editor":[{"given":"Alfred S","family":"Lewin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,22]]},"references-count":74,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160755","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0164316","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,22]]}}}