{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T15:33:55Z","timestamp":1770564835332,"version":"3.49.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15K11385"],"award-info":[{"award-number":["15K11385"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["15H025789"],"award-info":[{"award-number":["15H025789"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160765","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T17:34:56Z","timestamp":1470850496000},"page":"e0160765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population"],"prefix":"10.1371","volume":"11","author":[{"given":"Jirouta","family":"Kitagaki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shizuka","family":"Miyauchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Asano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikumi","family":"Michikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motozo","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"BL Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1034\/j.1600-0757.2002.290101.x","article-title":"Global epidemiology of periodontal diseases: an overview","volume":"29","author":"JM Albandar","year":"2002","journal-title":"Periodontol 2000"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1902\/jop.2005.76.12.2187","article-title":"Strengthening the prevention of periodontal disease: the WHO approach","volume":"76","author":"PE Petersen","year":"2005","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j..2003.com122.x","article-title":"The World Oral Health Report 2003: continuous improvement of oral health in the 21st century\u2014the approach of the WHO Global Oral Health Programme","volume":"31","author":"PE Petersen","year":"2003","journal-title":"Community Dent Oral Epidemiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1600-0757.2012.00457.x","article-title":"Risk factors for periodontal disease","volume":"62","author":"RJ Genco","year":"2013","journal-title":"Periodontol 2000"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0757.2010.00367.x","article-title":"Genetic study of families affected with aggressive periodontitis","volume":"56","author":"H Meng","year":"2011","journal-title":"Periodontol 2000"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/0022034513501878","article-title":"Tooth loss in aggressive periodontitis: a systematic review","volume":"92","author":"L Nibali","year":"2013","journal-title":"J Dent Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1902\/jop.1991.62.10.608","article-title":"Early onset periodontitis in the United States of America","volume":"62","author":"H L\u00f6e","year":"1991","journal-title":"J Periodontol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/j.1600-0757.2006.00204.x","article-title":"Determinants of host susceptibility in aggressive periodontitis","volume":"43","author":"H Meng","year":"2007","journal-title":"Periodontol 2000"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.2174\/1874210601105010190","article-title":"Toll-like receptor 2 gene polymorphisms associated with aggressive periodontitis in Japanese","volume":"5","author":"M Takahashi","year":"2011","journal-title":"Open Dent J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1902\/jop.1994.65.6.623","article-title":"Evidence for autosomal dominant inheritance and race-specific heterogeneity in early-onset periodontitis","volume":"65","author":"ML Marazita","year":"1994","journal-title":"J Periodontol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1902\/jop.1999.70.4.418","article-title":"Linkage disequilibrium of interleukin-1 genetic polymorphisms with early-onset periodontitis","volume":"70","author":"SR Diehl","year":"1999","journal-title":"J Periodontol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"ML Laine","year":"2012","journal-title":"Periodontol 2000"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1371\/journal.pgen.0030170","article-title":"Power to detect risk alleles using genome-wide tag SNP panels","volume":"3","author":"MA Eberle","year":"2007","journal-title":"PLoS Genet"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ygeno.2008.12.011","article-title":"Is there still a need for candidate gene approaches in the era of genome-wide association studies?","volume":"93","author":"S Wilkening","year":"2009","journal-title":"Genomics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1172\/JCI34772","article-title":"A HapMap harvest of insights into the genetics of common disease","volume":"118","author":"TA Manolio","year":"2008","journal-title":"J Clin Invest"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/nature10405","article-title":"Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk","volume":"478","author":"GB Ehret","year":"2011","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nature05911","article-title":"Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls","volume":"447","year":"2007","journal-title":"Nature"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/hmg\/ddp508","article-title":"A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis","volume":"19","author":"AS Schaefer","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e1000378","DOI":"10.1371\/journal.pgen.1000378","article-title":"Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis","volume":"5","author":"AS Schaefer","year":"2009","journal-title":"PLoS Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1093\/hmg\/ddt299","article-title":"The large non-coding RNA ANRIL, which is associated with atherosclerosis, periodontitis and several forms of cancer, regulates ADIPOR1, VAMP3 and C11ORF10","volume":"22","author":"G Bochenek","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/0022034509359575","article-title":"COX-2 is associated with periodontitis in Europeans","volume":"89","author":"AS Schaefer","year":"2010","journal-title":"J Dent Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/gene.2009.75","article-title":"A 3&apos; UTR transition within DEFB1 is associated with chronic and aggressive periodontitis","volume":"11","author":"AS Schaefer","year":"2010","journal-title":"Genes Immun"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/jcpe.12092","article-title":"Validation of reported genetic risk factors for periodontitis in a large-scale replication study","volume":"40","author":"AS Schaefer","year":"2013","journal-title":"J Clin Periodontol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"19096","DOI":"10.1073\/pnas.0910672106","article-title":"Genetic diagnosis by whole exome capture and massively parallel DNA sequencing","volume":"106","author":"M Choi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0006-291X(03)00026-3","article-title":"There exist at least 30 human G-protein-coupled receptors with long Ser\/Thr-rich N-termini","volume":"301","author":"R Fredriksson","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1356-9597.2004.00743.x","article-title":"DREG, a developmentally regulated G protein-coupled receptor containing two conserved proteolytic cleavage sites","volume":"9","author":"T Moriguchi","year":"2004","journal-title":"Genes Cells"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1038\/emboj.2012.26","article-title":"A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis","volume":"31","author":"D Ara\u00e7","year":"2012","journal-title":"EMBO J"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"GC Armitage","year":"1999","journal-title":"Ann Periodontol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1902\/jop.1959.30.1.7","article-title":"Alveolar bone loss as related to oral hygiene and age","volume":"30","author":"O Schei","year":"1959","journal-title":"J Periodontol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/j.1600-051X.2008.01249.x","article-title":"Periodontal inflamed surface area: quantifying inflammatory burden","volume":"35","author":"W Nesse","year":"2008","journal-title":"J Clin Periodontol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/ng1285","article-title":"Complete sequencing and characterization of 21,243 full-length human cDNAs","volume":"36","author":"T Ota","year":"2004","journal-title":"Nat Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1093\/dnares\/12.2.117","article-title":"Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries","volume":"12","author":"T Otsuki","year":"2005","journal-title":"DNA Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1101\/gr.4039406","article-title":"Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes","volume":"16","author":"K Kimura","year":"2006","journal-title":"Genome Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.2144\/000112209","article-title":"Constructing ORFeome resources with removable termination codons","volume":"41","author":"M Itoh","year":"2006","journal-title":"Biotechniques"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MCB.7.1.379","article-title":"Analysis of mutation in human cells by using an Epstein-Barr virus shuttle system","volume":"7","author":"RB DuBridge","year":"1987","journal-title":"Mol Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/jre.12202","article-title":"Effects of the proteasome inhibitor, bortezomib, on cytodifferentiation and mineralization of periodontal ligament cells","volume":"50","author":"J Kitagaki","year":"2015","journal-title":"J Periodontal Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e100924","DOI":"10.1371\/journal.pone.0100924","article-title":"Large-scale East-Asian eQTL mapping reveals novel candidate genes for LD mapping and the genomic landscape of transcriptional effects of sequence variants","volume":"9","author":"M Narahara","year":"2014","journal-title":"PLoS One"},{"key":"ref39","article-title":"Human genetic variation database, a reference database of genetic variations in the Japanese population","author":"K Higasa","year":"2016","journal-title":"J Hum Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1242\/dev.062224","article-title":"Gpr126 is essential for peripheral nerve development and myelination in mammals","volume":"138","author":"KR Monk","year":"2011","journal-title":"Development"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1126\/science.1173474","article-title":"A G protein-coupled receptor is essential for Schwann cells to initiate myelination","volume":"325","author":"KR Monk","year":"2009","journal-title":"Science"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1600-0757.1997.tb00094.x","article-title":"The periodontal ligament: a unique, multifunctional connective tissue","volume":"13","author":"W Beertsen","year":"1997","journal-title":"Periodontol 2000"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<327::AID-AR15>3.0.CO;2-R","article-title":"Periodontal ligament cell population: the central role of fibroblasts in creating a unique tissue","volume":"245","author":"P Lekic","year":"1996","journal-title":"Anat Rec"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"BM Seo","year":"2004","journal-title":"Lancet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-1119(01)00683-7","article-title":"Expression profile of active genes in human periodontal ligament and isolation of PLAP-1, a novel SLRP family gene","volume":"275","author":"S Yamada","year":"2001","journal-title":"Gene"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"17976","DOI":"10.1523\/JNEUROSCI.1809-13.2013","article-title":"Gpr126 functions in Schwann cells to control differentiation and myelination via G-protein activation","volume":"33","author":"A Mogha","year":"2013","journal-title":"J Neurosci"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1073\/pnas.0711190105","article-title":"cAMP\/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo","volume":"105","author":"R Siddappa","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/ng.2639","article-title":"Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis","volume":"45","author":"I Kou","year":"2013","journal-title":"Nat Genet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1007\/s00586-008-0757-z","article-title":"Low bone mineral status in adolescent idiopathic scoliosis","volume":"17","author":"XF Li","year":"2008","journal-title":"Eur Spine J"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/01241398-198210000-00006","article-title":"Osteoporosis and acquired back deformities","volume":"2","author":"WL Burner","year":"1982","journal-title":"J Pediatr Orthop"},{"key":"ref51","first-page":"2709","article-title":"Osteopenia: a new prognostic factor of curve progression in adolescent idiopathic scoliosis","volume":"87","author":"VW Hung","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1093\/hmg\/ddv170","article-title":"Gpr126\/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice","volume":"24","author":"CM Karner","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1177\/00220345990780100701","article-title":"Recombinant human bone morphogenetic protein-2 stimulates osteoblastic differentiation in cells isolated from human periodontal ligament","volume":"78","author":"M Kobayashi","year":"1999","journal-title":"J Dent Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"e0125590","DOI":"10.1371\/journal.pone.0125590","article-title":"TGF-Beta Negatively Regulates the BMP2-Dependent Early Commitment of Periodontal Ligament Cells into Hard Tissue Forming Cells","volume":"10","author":"T Kawahara","year":"2015","journal-title":"PLoS One"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1902\/jop.1997.68.12.1186","article-title":"A phase I\/II clinical trial to evaluate a combination of recombinant human platelet-derived growth factor-BB and recombinant human insulin-like growth factor-I in patients with periodontal disease","volume":"68","author":"TH Howell","year":"1997","journal-title":"J Periodontol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/447655a","article-title":"Replicating genotype-phenotype associations","volume":"447","author":"SJ Chanock","year":"2007","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/10454411970080020401","article-title":"Tissue engineering, morphogenesis, and regeneration of the periodontal tissues by bone morphogenetic proteins","volume":"8","author":"U Ripamonti","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"4362","DOI":"10.1242\/dev.098061","article-title":"Semicircular canal morphogenesis in the zebrafish inner ear requires the function of gpr126 (lauscher), an adhesion class G protein-coupled receptor gene","volume":"140","author":"FS Geng","year":"2013","journal-title":"Development"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"819760","DOI":"10.1155\/2015\/819760","article-title":"Retinitis Pigmentosa with EYS Mutations Is the Most Prevalent Inherited Retinal Dystrophy in Japanese Populations","volume":"2015","author":"Y Arai","year":"2015","journal-title":"J Ophthalmol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/sj.gene.6364021","article-title":"FcgammaRIIB gene polymorphisms in Japanese periodontitis patients","volume":"4","author":"K Yasuda","year":"2003","journal-title":"Genes Immun"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/jre.12167","article-title":"Moving into a new era of periodontal genetic studies: relevance of large case-control samples using severe phenotypes for genome-wide association studies","volume":"49","author":"RD Vaithilingam","year":"2014","journal-title":"J Periodontal Res"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1093\/hmg\/ddt065","article-title":"Exploring the genetic basis of chronic periodontitis: a genome-wide association study","volume":"22","author":"K Divaris","year":"2013","journal-title":"Hum Mol Genet"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1534\/g3.113.008755","article-title":"Genome-wide association study of periodontal health measured by probing depth in adults ages 18\u201349 years","volume":"4","author":"JR Shaffer","year":"2014","journal-title":"G3 (Bethesda)"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1177\/0022034514544506","article-title":"Chronic periodontitis genome-wide association studies: gene-centric and gene set enrichment analyses","volume":"93","author":"K Rhodin","year":"2014","journal-title":"J Dent Res"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0022034515570315","article-title":"A genome-wide association study of periodontitis in a Japanese population","volume":"94","author":"S Shimizu","year":"2015","journal-title":"J Dent Res"},{"key":"ref66","article-title":"Genomewide association study on chronic periodontitis in Korean population: results from the Yangpyeong health cohort","author":"KW Hong","year":"2015","journal-title":"J Clin Periodontol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:22:46Z","timestamp":1588969366000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160765"}},"subtitle":[],"editor":[{"given":"Motohiro","family":"Komaki","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,10]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160765","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,10]]}}}