{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:53:40Z","timestamp":1791831220294,"version":"4.3.4"},"reference-count":23,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["Anesthesia Foundation"],"award-info":[{"award-number":["Anesthesia Foundation"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["Cardiac Surgery Foundation"],"award-info":[{"award-number":["Cardiac Surgery Foundation"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["The Richard A. and Susan F. Smith President\u2019s Innovation Award"],"award-info":[{"award-number":["The Richard A. and Susan F. Smith President\u2019s Innovation Award"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["Michael B. Klein and Family"],"award-info":[{"award-number":["Michael B. Klein and Family"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["The Sidman Family Foundation"],"award-info":[{"award-number":["The Sidman Family Foundation"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006823","name":"Boston Children's Hospital","doi-asserted-by":"publisher","award":["Cardiac Conduction Fund"],"award-info":[{"award-number":["Cardiac Conduction Fund"]}],"id":[{"id":"10.13039\/100006823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (US)","doi-asserted-by":"crossref","award":["HL108107"],"award-info":[{"award-number":["HL108107"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (US)","doi-asserted-by":"crossref","award":["HL103642"],"award-info":[{"award-number":["HL103642"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160889","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T13:34:05Z","timestamp":1470663245000},"page":"e0160889","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":224,"title":["Intracoronary Delivery of Mitochondria to the Ischemic Heart for Cardioprotection"],"prefix":"10.1371","volume":"11","author":[{"given":"Douglas B.","family":"Cowan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rouan","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vamsidhar","family":"Akurathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin R.","family":"Snay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerusha K.","family":"Thedsanamoorthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zurakowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Ericsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingeborg","family":"Friehs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaotang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidney","family":"Levitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro J.","family":"del Nido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan B.","family":"Packard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1058-6976","authenticated-orcid":true,"given":"James D.","family":"McCully","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1067\/mtc.2001.111421","article-title":"Diazoxide protects mitochondria from anoxic injury: Implications for myopreservation","volume":"121","author":"C Ozcan","year":"2001","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"H258","DOI":"10.1152\/ajpheart.00348.2003","article-title":"Ischemia, rather than reperfusion, inhibits respiration through cytochrome oxidase in the isolated, perfused rabbit heart: Role of cardiolipin","volume":"287","author":"EJ Lesnefsky","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1016\/j.athoracsur.2006.10.059","article-title":"Age- and gender-related differences in mitochondrial oxygen consumption and calcium with cardioplegia and diazoxide","volume":"83","author":"JD McCully","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S667","DOI":"10.1016\/S0003-4975(02)04689-1","article-title":"The mitochondrial K(ATP) channel and cardioprotection","volume":"75","author":"JD McCully","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1016\/S0003-4975(02)04348-5","article-title":"Diazoxide amelioration of myocardial injury and mitochondrial damage during cardiac surgery","volume":"74","author":"JD McCully","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"H1923","DOI":"10.1152\/ajpheart.00935.2003","article-title":"Differential contribution of necrosis and apoptosis in myocardial ischemia-reperfusion injury","volume":"286","author":"JD McCully","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"H1967","DOI":"10.1152\/ajpheart.00338.2004","article-title":"Opening of mitochondrial KATP channels enhances cardioprotection through the modulation of mitochondrial matrix volume, calcium accumulation, and respiration","volume":"287","author":"AJ Rousou","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1161\/CIRCRESAHA.116.305484","article-title":"The ins and outs of mitochondrial calcium","volume":"116","author":"T Finkel","year":"2015","journal-title":"Circ Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.redox.2015.08.020","article-title":"Reperfusion injury and reactive oxygen species: The evolution of a concept","volume":"6","author":"DN Granger","year":"2015","journal-title":"Redox Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1161\/CIRCRESAHA.116.305432","article-title":"Mitochondrial reactive oxygen species at the heart of the matter: New therapeutic approaches for cardiovascular diseases","volume":"116","author":"OS Kornfeld","year":"2015","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40169-016-0095-4","article-title":"Mitochondrial transplantation for therapeutic use","volume":"5","author":"JD McCully","year":"2016","journal-title":"Clin Transl Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"H94","DOI":"10.1152\/ajpheart.00567.2008","article-title":"Injection of isolated mitochondria during early reperfusion for cardioprotection","volume":"296","author":"JD McCully","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"H966","DOI":"10.1152\/ajpheart.00883.2012","article-title":"Transplantation of autologously derived mitochondria protects the heart from ischemia-reperfusion injury","volume":"304","author":"A Masuzawa","year":"2013","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1242\/bio.201511478","article-title":"Actin-dependent mitochondrial internalization in cardiomyocytes: Evidence for rescue of mitochondrial function","volume":"4","author":"CA Pacak","year":"2015","journal-title":"Biol Open"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.nucmedbio.2015.06.008","article-title":"<sup>18<\/sup>F-labeled rhodamines as potential myocardial perfusion agents: Comparison of pharmacokinetic properties of several rhodamines","volume":"42","author":"MD Bartholom\u00e4","year":"2015","journal-title":"Nucl Med Biol"},{"key":"ref16","first-page":"e51682","article-title":"Rapid isolation and purification of mitochondria for transplantation by tissue dissociation and differential filtration","volume":"2014","author":"JM Preble","year":"2014","journal-title":"J Vis Exp"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e108695","DOI":"10.1371\/journal.pone.0108695","article-title":"Superparamagnetic iron oxide nanoparticles function as a long-term, multi-modal imaging label for non-invasive tracking of implanted progenitor cells","volume":"9","author":"CA Pacak","year":"2014","journal-title":"PLOS One"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.nucmedbio.2013.07.006","article-title":"Biological characterization of <sup>18<\/sup>F-labeled Rhodamine B, a potential positron emission tomography perfusion tracer","volume":"40","author":"MD Bartholom\u00e4","year":"2013","journal-title":"Nucl Med Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.athoracsur.2006.04.061","article-title":"Reduction and redistribution of gap and adherens junction proteins after ischemia and reperfusion","volume":"82","author":"EE Tansey","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2353\/ajpath.2006.051163","article-title":"Cardiac conduction through engineered tissue","volume":"169","author":"YH Choi","year":"2006","journal-title":"Am J Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S1010-7940(01)01156-3","article-title":"Selective opening of mitochondrial ATP-sensitive potassium channels during surgically induced myocardial ischemia decreases necrosis and apoptosis","volume":"21","author":"H Wakiyama","year":"2002","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.cbpa.2014.03.019","article-title":"Super-resolution microscopy of mitochondria","volume":"20","author":"S Jakobs","year":"2014","journal-title":"Curr Opin Chem Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160889","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:09:12Z","timestamp":1589018952000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160889"}},"subtitle":[],"editor":[{"given":"Nanette H","family":"Bishopric","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":23,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160889","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]}}}