{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:14:55Z","timestamp":1777065295568,"version":"3.51.4"},"reference-count":105,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160901","type":"journal-article","created":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T17:31:52Z","timestamp":1470677512000},"page":"e0160901","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Genomic Alteration in Head and Neck Squamous Cell Carcinoma (HNSCC) Cell Lines Inferred from Karyotyping, Molecular Cytogenetics, and Array Comparative Genomic Hybridization"],"prefix":"10.1371","volume":"11","author":[{"given":"Worapong","family":"Singchat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekarat","family":"Hitakomate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Budsaba","family":"Rerkarmnuaychoke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aorarat","family":"Suntronpong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beiyuan","family":"Fu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Winai","family":"Bodhisuwan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surin","family":"Peyachoknagul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengtang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sittichai","family":"Koontongkaew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kornsorn","family":"Srikulnath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nrg816","article-title":"The fundamental role of epigenetic events in cancer","volume":"3","author":"PA Jones","year":"2002","journal-title":"Nat Rev Genet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1215","article-title":"Chromosome aberrations in solid tumors","volume":"34","author":"DG Albertson","year":"2003","journal-title":"Nat Genet"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1136\/jcp.2003.007641","article-title":"Molecular biology of squamous cell carcinoma of the head and neck","volume":"59","author":"B Perez-Ordonez","year":"2006","journal-title":"J Clin Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"4550","DOI":"10.1200\/JCO.2013.50.3870","article-title":"Worldwide trends in incidence rates for oral cavity and oropharyngeal cancers","volume":"31","author":"AK Chaturvedi","year":"2013","journal-title":"J Clin Oncol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"885","DOI":"10.7314\/APJCP.2012.13.3.885","article-title":"Survival and prognostic factors of different sites of head and neck cancer: an analysis from Thailand","volume":"13","author":"K Pruegsanusak","year":"2012","journal-title":"Asian Pac J Cancer P"},{"key":"ref6","first-page":"182","article-title":"The burden of head and neck cancers in Thailand","volume":"7","author":"P Vatanasapt","year":"2012","journal-title":"J Med Assoc Thai"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11864-007-0032-2","article-title":"Mechanisms of tumor growth and metastasis in head and neck squamous cell carcinoma","volume":"8","author":"JE Walsh","year":"2007","journal-title":"Curr Treat Options Oncol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.ajpath.2014.01.028","article-title":"Molecular heterogeneity of head and neck squamous cell carcinoma defined by next-generation sequencing","volume":"184","author":"P Zhang","year":"2014","journal-title":"Am J Pathol"},{"key":"ref9","first-page":"244","article-title":"Oral field cancerization: an update on current concepts","volume":"8","author":"M Mohan","journal-title":"Oncol Rev. 2014"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e662","DOI":"10.14694\/EdBook_AM.2015.35.e662","article-title":"Clonal evolution models of tumor heterogeneity","volume":"2015","author":"LI Shlush","year":"2015","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.celrep.2014.06.045","article-title":"Heterogeneous tumor subpopulations cooperate to drive invasion","volume":"8","author":"A Chapman","year":"2014","journal-title":"Cell Rep"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/hed.10042","article-title":"Second primary tumors and field cancerization in oral and oropharyngeal cancer: molecular techniques provide new insights and definitions","volume":"24","author":"BJ Braakhuis","year":"2002","journal-title":"Head Neck"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/hed.10122","article-title":"Molecular cytogenetic analysis of head and neck squamous cell carcinoma: By comparative genomic hybridization, spectral karyotyping, and expression array analysis","volume":"24","author":"JA Squire","year":"2002","journal-title":"Head Neck"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/PDM.0b013e3181804b82","article-title":"Noninvasive molecular detection of head and neck squamous cell carcinoma: an exploratory analysis","volume":"18","author":"S Sethi","year":"2009","journal-title":"Diagn Mol Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.cellbi.2008.10.009","article-title":"Tumor-stroma interactions influence cytokine expression and matrix metalloproteinase activities in paired primary and metastatic head and neck cancer cells","volume":"33","author":"S Koontongkaew","year":"2009","journal-title":"Cell Biol Int"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12032-011-9871-6","article-title":"Fibroblasts and extracellular matrix differently modulate MMP activation by primary and metastatic head and neck cancer cells","volume":"29","author":"S Koontongkaew","year":"2012","journal-title":"Med Oncol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/ijc.2910610117","article-title":"Tyrosine phosphorylation as a marker for aberrantly regulated growth-promoting pathways in cell lines derived from head and neck malignancies","volume":"61","author":"M Cardinali","year":"1995","journal-title":"Int J Cancer"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"13981","DOI":"10.4238\/2015.October.29.18","article-title":"Molecular barcoding of venomous snakes and species-specific multiplex PCR assay to identify snake groups for which antivenom is available in Thailand","volume":"14","author":"A Supikamolseni","year":"2015","journal-title":"Genet Mol Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e0134829","DOI":"10.1371\/journal.pone.0134829","article-title":"Karyotype reorganization in the Hokou Gecko (<italic>Gekko hokouensis<\/italic>, Gekkonidae): The process of microchromosome disappearance in Gekkota","volume":"10","author":"K Srikulnath","year":"2015","journal-title":"PLOS ONE"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1083\/jcb.106.3.761","article-title":"Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line","volume":"106","author":"P Boukamp","year":"1988","journal-title":"J Cell Biol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1046\/j.1365-2141.1999.01602.x","article-title":"Phenotypic and molecular analysis of six human cell lines derived from patients with plasma cell dyscrasia","volume":"106","author":"RP Gooding","year":"1999","journal-title":"Br J Haematol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1038\/nprot.2006.160","article-title":"Multiplex-fluorescence <italic>in situ<\/italic> hybridization for chromosome karyotyping","volume":"1","author":"JB Geigl","year":"2006","journal-title":"Nat Protoc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e60482","DOI":"10.1371\/journal.pone.0060482","article-title":"Massively parallel sequencing reveals the complex structure of an irradiated human chromosome on a mouse background in the Tc1 model of down syndrome","volume":"8","author":"SM Gribble","year":"2013","journal-title":"PLOS ONE"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/0014-4827(72)90558-7","article-title":"A simple technique for demonstrating centromeric heterochromatin","volume":"75","author":"AT Sumner","year":"1972","journal-title":"Exp Cell Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/bioinformatics\/bth078","article-title":"Open source clustering software","volume":"20","author":"MJL de Hoon","year":"2004","journal-title":"Bioinformatics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3246","DOI":"10.1093\/bioinformatics\/bth349","article-title":"Java Treeview\u2014extensible visualization of microarray data","volume":"20","author":"AJ Saldanha","year":"2004","journal-title":"Bioinformatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e106952","DOI":"10.1371\/journal.pone.0106952","article-title":"Dual small-molecule targeting of SMAD signaling stimulates human induced pluripotent stem cells toward neural lineages","volume":"9","author":"M Wattanapanitch","year":"2014","journal-title":"PLOS ONE"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2<sup>\u2212\u2206\u2206CT<\/sup> method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nature14129","article-title":"Comprehensive genomic characterization of head and neck squamous cell carcinomas","volume":"517","year":"2015","journal-title":"Nature"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2485\/jhtb.14.251","article-title":"Detecting the (Epidermal Growth Factor Receptor) EGFR gene amplification in oral carcinogenesis","volume":"14","author":"K Kanata","year":"2005","journal-title":"J Hard Tissue Biology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.3324\/haematol.2015.124305","article-title":"Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain\/loss pattern","volume":"100","author":"JF Ferreiro","year":"2015","journal-title":"Haematologica"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13059-015-0583-7","article-title":"Chromosome 7 gain and DNA hypermethylation at the <italic>HOXA10<\/italic> locus are associated with expression of a stem cell related HOX-signature in glioblastoma","volume":"16","author":"S Kurscheid","year":"2015","journal-title":"Genome Biol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.3892\/ol.2014.2719","article-title":"Increased <italic>BRAF<\/italic> copy number in lung adenocarcinoma","volume":"9","author":"H Sasaki","year":"2015","journal-title":"Oncol Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1053\/j.gastro.2014.09.019","article-title":"Genomic instability causes HGF gene activation in colon cancer cells, promoting their resistance to necroptosis","volume":"148","author":"D Seneviratne","year":"2015","journal-title":"Gastroenterology"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10120-014-0449-9","article-title":"Gene copy number gain of <italic>EGFR<\/italic> is a poor prognostic biomarker in gastric cancer: evaluation of 855 patients with bright-field dual in situ hybridization (DISH) method","volume":"19","author":"E Higaki","year":"2016","journal-title":"Gastric Cancer"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1186\/1471-2407-8-168","article-title":"Gene-expression of metastasized versus non-metastasized primary head and neck squamous cell carcinomas: a pathway-based analysis","volume":"8","author":"EF Hensen","year":"2008","journal-title":"BMC Cancer"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"4161","DOI":"10.1007\/s11033-013-2496-4","article-title":"Heterogeneity of 11q13 region rearrangements in laryngeal squamous cell carcinoma analyzed by microarray platforms and fluorescence in situ hybridization","volume":"40","author":"M Jarmuz-Szymczak","year":"2013","journal-title":"Mol Biol Rep"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00428-016-1905-1","article-title":"Copy number gain of <italic>PIK3CA<\/italic> and <italic>MET<\/italic> is associated with poor prognosis in head and neck squamous cell carcinoma","volume":"468","author":"D Brauswetter","year":"2016","journal-title":"Virchows Arch"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/PAI.0000000000000087","article-title":"Specific genomic aberrations predict survival, but low mutation rate in cancer hot spots, in clear cell renal cell carcinoma","volume":"23","author":"L Kohn","year":"2015","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9813","DOI":"10.1007\/s13277-015-3726-2","article-title":"Clinical and prognostic value of <italic>MET<\/italic> gene copy number gain and chromosome 7 polysomy in primary colorectal cancer patients","volume":"36","author":"AN Seo","year":"2015","journal-title":"Tumour Biol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/bjc.1993.51","article-title":"Loss of heterozygosity and amplification on chromosome 11q in human ovarian cancer","volume":"67","author":"WD Foulkes","year":"1993","journal-title":"Br J Cancer"},{"key":"ref42","first-page":"253","article-title":"Isolated trisomy 11 in de novo acute myeloid leukemia","volume":"30","author":"EK Krum","year":"2008","journal-title":"Rev Bras Hematol Hemoter"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s11033-009-9817-7","article-title":"<italic>CD1d<\/italic> gene is a target for a novel amplicon at 1q22\u201323.1 in human hepatocellular carcinoma","volume":"37","author":"SG Zhang","year":"2010","journal-title":"Mol Biol Rep"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1038\/onc.2011.317","article-title":"1q gain and <italic>CDT2<\/italic> overexpression underlie an aggressive and highly proliferative form of Ewing sarcoma","volume":"31","author":"C Mackintosh","year":"2012","journal-title":"Oncogene"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10549-013-2408-2","article-title":"Frequent copy number gains at 1q21 and 1q32 are associated with overexpression of the ETS transcription factors <italic>ETV3<\/italic> and <italic>ELF3<\/italic> in breast cancer irrespective of molecular subtypes","volume":"138","author":"B Mesquita","year":"2013","journal-title":"Breast Cancer Res Treat"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e77553","DOI":"10.1371\/journal.pone.0077553","article-title":"Breast tumors with elevated expression of 1q candidate genes confer poor clinical outcome and sensitivity to Ras\/PI3K inhibition","volume":"8","author":"M Muthuswami","year":"2013","journal-title":"PLOS ONE"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bcmd.2014.05.006","article-title":"Quantitative analysis of <italic>CKS1B<\/italic> mRNA expression and copy number gain in patients with plasma cell disorders","volume":"53","author":"F Stella","year":"2014","journal-title":"Blood Cells Mol Dis"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.molonc.2014.12.005","article-title":"Gene expression profiling of lobular carcinoma <italic>in situ<\/italic> reveals candidate precursor genes for invasion","volume":"9","author":"VP Andrade","year":"2015","journal-title":"Mol Oncol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1089\/thy.2009.0008","article-title":"Copy number and gene expression alterations in radiation-induced papillary thyroid carcinoma from chernobyl pediatric patients","volume":"20","author":"L Stein","year":"2010","journal-title":"Thyroid"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-4658.2010.07919.x","article-title":"Roles of matrix metalloproteinases in cancer progression and their pharmacological targeting","volume":"278","author":"C Gialeli","year":"2011","journal-title":"FEBS J"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/gcc.20054","article-title":"Microcell-mediated chromosome transfer provides evidence that polysomy promotes structural instability in tumor cell chromosomes through asynchronous replication and breakage within late-replicating regions","volume":"40","author":"M Kost-Alimova","year":"2004","journal-title":"Genes Chromosomes Cancer"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1126\/science.1210214","article-title":"Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations","volume":"333","author":"A Janssen","year":"2011","journal-title":"Science"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/nature11935","article-title":"Replication stress links structural and numerical cancer chromosomal instability","volume":"494","author":"RA Burrell","year":"2013","journal-title":"Nature"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3748\/wjg.v8.i5.769","article-title":"Chromosomal aberrations related to metastasis of human solid tumors","volume":"8","author":"Lun-Xiu Qin","year":"2002","journal-title":"World J Gastroenterol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"e54705","DOI":"10.1371\/journal.pone.0054705","article-title":"Genome wide analysis of chromosomal alterations in oral squamous cell carcinomas revealed over expression of <italic>MGAM<\/italic> and <italic>ADAM9<\/italic>","volume":"8","author":"VK Vincent-Chong","year":"2013","journal-title":"PLOS ONE"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.oraloncology.2003.10.006","article-title":"OCGR array: an oral cancer genomic regional array for comparative genomic hybridization analysis","volume":"40","author":"C Garnis","year":"2004","journal-title":"Oral Oncol"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4232","DOI":"10.1038\/sj.onc.1208601","article-title":"Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma","volume":"24","author":"AM Snijders","year":"2005","journal-title":"Oncogene"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/mc.20213","article-title":"Array-comparative genomic hybridization to detect genomewide changes in microdissected primary and metastatic oral squamous cell carcinomas","volume":"45","author":"CJ Liu","year":"2006","journal-title":"Mol Carcinog"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/gcc.20551","article-title":"High-resolution copy number and gene expression microarray analyses of head and neck squamous cell carcinoma cell lines of tongue and larynx","volume":"47","author":"AK J\u00e4rvinen","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/gcc.20714","article-title":"Recurrent copy number gain of transcription factor <italic>SOX2<\/italic> and corresponding high protein expression in oral squamous cell carcinoma","volume":"49","author":"K Freier","year":"2010","journal-title":"Genes Chromosomes Cancer"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"e17250","DOI":"10.1371\/journal.pone.0017250","article-title":"Genomic profiling of advanced-stage oral cancers reveals chromosome 11q alterations as markers of poor clinical outcome","volume":"6","author":"S Ambatipudi","year":"2011","journal-title":"PLOS ONE"},{"key":"ref62","first-page":"5128","article-title":"Frequent abnormalities of <italic>FHIT<\/italic>, a candidate tumor suppressor gene, in head and neck cancer cell lines","volume":"56","author":"L Mao","year":"1996","journal-title":"Cancer Res"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1200\/JCO.1999.17.5.1618","article-title":"Role of <italic>FHIT<\/italic> in human cancer","volume":"17","author":"CM Croce","year":"1999","journal-title":"J Clin Oncol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/(SICI)1097-0347(199812)20:8<745::AID-HED14>3.0.CO;2-Z","article-title":"Focal adhesion kinase and its potential involvement in tumor invasion and metastasis","volume":"20","author":"LJ Kornberg","year":"1998","journal-title":"Head Neck"},{"key":"ref65","first-page":"a014217","article-title":"MYC, metabolism, cell growth, and tumorigenesis","volume":"3","author":"CV Dang","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1002\/mc.20768","article-title":"A novel role for the T-box transcription factor <italic>Tbx1<\/italic> as a negative regulator of tumor cell growth in mice","volume":"50","author":"CS Trempus","year":"2011","journal-title":"Mol Carcinog"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1038\/sj.onc.1204421","article-title":"Mutations in the mitotic check point gene, MAD1L1, in human cancers","volume":"20","author":"K Tsukasaki","year":"2001","journal-title":"Oncogene"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"6848","DOI":"10.1038\/sj.onc.1208815","article-title":"Bone-metastatic potential of human prostate cancer cells correlates with Akt\/PKB activation by alpha platelet-derived growth factor receptor","volume":"24","author":"NG Dolloff","year":"2005","journal-title":"Oncogene"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1101\/gad.1549407","article-title":"Oncogenic Ras-induced secretion of IL6 is required for tumorigenesis","volume":"21","author":"B Ancrile","year":"2007","journal-title":"Genes Dev"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1111\/j.1349-7006.2007.00434.x","article-title":"ADAMs in cancer cell proliferation and progression","volume":"98","author":"S Mochizuki","year":"2007","journal-title":"Cancer Sci"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1038\/sj.bjc.6605654","article-title":"Scorilas1 A. Quantitative expression analysis and prognostic significance of L-DOPA decarboxylase in colorectal adenocarcinoma","volume":"102","author":"CK Kontos","year":"2010","journal-title":"Br J Cancer"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1089\/omi.2009.0124","article-title":"Gene expression profiling of breast cancer cell lines in response to soy isoflavones using a pangenomic microarray approach","volume":"14","author":"S Satih","year":"2010","journal-title":"OMICS"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1756-0500-4-215","article-title":"<italic>TFRC<\/italic> and <italic>ACTB<\/italic> as the best reference genes to quantify Urokinase Plasminogen Activator in breast cancer","volume":"4","author":"K Majidzadeh-A","year":"2011","journal-title":"BMC Res Notes"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.2147\/OTT.S57346","article-title":"Gli3 silencing enhances cyclopamine suppressive effects on ovarian cancer","volume":"7","author":"HY Liu","year":"2014","journal-title":"Onco Targets Ther"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/bju.12452","article-title":"Inflammation and prostate cancer: the role of interleukin 6 (IL-6)","volume":"113","author":"DP Nguyen","year":"2014","journal-title":"BJU Int"},{"key":"ref76","first-page":"108458","article-title":"Long noncoding RNA KIAA0125 potentiates cell migration and invasion in gallbladder cancer","volume":"2015","author":"W Lv","year":"2015","journal-title":"Biomed Res Int"},{"key":"ref77","first-page":"15127","article-title":"High frequency of the <italic>SDK1<\/italic>: <italic>AMACR<\/italic> fusion transcript in Chinese prostate cancer","volume":"8","author":"Y Zhang","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(00)81078-8","article-title":"The <italic>FHIT<\/italic> gene 3p14.2 is abnormal in lung cancer","volume":"85","author":"G Sozzi","year":"1996","journal-title":"Cell"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1476-4598-7-14","article-title":"Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells","volume":"7","author":"N Vie","year":"2008","journal-title":"Mol Cancer"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1038\/onc.2013.356","article-title":"<italic>TNF-\u03b1<\/italic>\/<italic>TNFR1<\/italic> signaling promotes gastric tumorigenesis through induction of <italic>Noxo1<\/italic> and <italic>Gna14<\/italic> in tumor cells","volume":"33","author":"H Oshima","year":"2014","journal-title":"Oncogene"},{"key":"ref81","first-page":"7","article-title":"Cancer-testis (CT) antigen expression in medulloblastoma","volume":"8","author":"SM Oba-Shinjo","year":"2008","journal-title":"Cancer Immun"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1158\/1078-0432.CCR-03-0096","article-title":"The tumor suppressor gene <italic>WWOX<\/italic> at <italic>FRA16D<\/italic> is involved in pancreatic carcinogenesis","volume":"10","author":"T Kuroki","year":"2004","journal-title":"Clin Cancer Res"},{"key":"ref83","first-page":"1607","article-title":"Polymorphisms in the human progesterone receptor (PGR) gene of two human prostate adenocarcinoma cell lines","volume":"25","author":"DG Engehausen","year":"2005","journal-title":"Anticancer Res"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"e845","DOI":"10.1371\/journal.pone.0000845","article-title":"The H19 non-coding RNA is essential for human tumor growth","volume":"2","author":"IJ Matouk","year":"2007","journal-title":"PLOS ONE"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/1471-2407-8-125","article-title":"Expression of <italic>TRPC6<\/italic> channels in human epithelial breast cancer cells","volume":"8","author":"A Guilbert","year":"2008","journal-title":"BMC Cancer"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1073\/pnas.0900571106","article-title":"The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers","volume":"106","author":"S Veeriah","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref87","first-page":"1413","article-title":"<italic>CRTC1<\/italic>-<italic>MAML2<\/italic> gene fusion in mucoepidermoid carcinoma of the lacrimal gland","volume":"27","author":"SL Von Holstein","year":"2012","journal-title":"Oncol Rep"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"137509","DOI":"10.1155\/2013\/137509","article-title":"Expression of the H19 oncofetal gene in premalignant lesions of cervical cancer: a potential targeting approach for development of nonsurgical treatment of high-risk lesions","volume":"2013","author":"T Feigenberg","year":"2013","journal-title":"ISRN Obstet Gynecol"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"e71816","DOI":"10.1371\/journal.pone.0071816","article-title":"Down-regulation of SIX3 is associated with clinical outcome in lung adenocarcinoma","volume":"8","author":"ML Mo","year":"2013","journal-title":"PLOS ONE"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1038\/onc.2014.236","article-title":"Regulation of tumor cell migration and invasion by the H19\/let-7 axis is antagonized by metformin-induced DNA methylation","volume":"34","author":"L Yan","year":"2015","journal-title":"Oncogene"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0014-5793(99)00780-2","article-title":"The expression of the H19 gene and its function in human bladder carcinoma cell lines","volume":"454","author":"P Ohana","year":"1999","journal-title":"FEBS Lett"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/ijc.10243","article-title":"Use of H19 regulatory sequences for targeted gene therapy in cancer","volume":"98","author":"P Ohana","year":"2002","journal-title":"Int J Cancer"},{"key":"ref93","first-page":"249","article-title":"The Oncofetal H19 RNA in human cancer, from the bench to the patient","volume":"3","author":"I Matouk","year":"2005","journal-title":"Cancer Therapy"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/j.cell.2004.06.006","article-title":"Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis","volume":"117","author":"J Yang","year":"2004","journal-title":"Cell"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nrc1837","article-title":"Protein-tyrosine phosphatases and cancer","volume":"6","author":"A Ostman","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"ref96","first-page":"737","article-title":"Novel tumor suppressor loci on 6q22\u201323 in primary central nervous system lymphomas","volume":"63","author":"M Nakamura","year":"2003","journal-title":"Cancer Res"},{"key":"ref97","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1476-4598-11-6","article-title":"Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene","volume":"11","author":"M Meehan","year":"2012","journal-title":"Mol Cancer"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"8149","DOI":"10.1073\/pnas.1401952111","article-title":"Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis","volume":"111","author":"B Ortiz","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/1535370214561590","article-title":"<italic>WWOX<\/italic>: a fragile tumor suppressor","volume":"240","author":"MS Schrock","year":"2015","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref100","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5507\/bp.2007.002","article-title":"<italic>WWOX<\/italic>, a new potential tumor suppressor gene","volume":"151","author":"R Hezova","year":"2007","journal-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub"},{"key":"ref101","first-page":"877","article-title":"WWOX tumor suppressor gene","volume":"23","author":"J Yang","year":"2008","journal-title":"Histol Histopathol"},{"key":"ref102","first-page":"188","article-title":"<italic>WWOX<\/italic> at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies","volume":"1846","author":"CM Aldaz","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"e0115353","DOI":"10.1371\/journal.pone.0115353","article-title":"Epigenetic and genetic alterations affect the <italic>WWOX<\/italic> gene in head and neck squamous cell carcinoma","volume":"10","author":"S Ekizoglu","year":"2015","journal-title":"PLOS ONE"},{"key":"ref104","doi-asserted-by":"crossref","first-page":"30728","DOI":"10.1074\/jbc.R115.676346","article-title":"Pleiotropic functions of tumor suppressor <italic>WWOX<\/italic> in normal and cancer cells","volume":"290","author":"M Abu-Remaileh","year":"2015","journal-title":"J Biol Chem"},{"key":"ref105","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.3892\/mmr.2015.3640","article-title":"Effect of the <italic>WWOX<\/italic> gene on the regulation of the cell cycle and apoptosis in human ovarian cancer stem cells","volume":"12","author":"H Yan","year":"2015","journal-title":"Mol Med Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T08:40:49Z","timestamp":1568277649000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160901"}},"subtitle":[],"editor":[{"given":"Javier S","family":"Castresana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,8]]},"references-count":105,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160901","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,8]]}}}