{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T08:55:04Z","timestamp":1771577704521,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T00:00:00Z","timestamp":1470787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004824","name":"Dansk Nefrologisk Selskab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004824","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Region Zealand Health Sciences Research Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160905","type":"journal-article","created":{"date-parts":[[2016,8,10]],"date-time":"2016-08-10T14:14:26Z","timestamp":1470838466000},"page":"e0160905","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["The Effect of High Dose Cholecalciferol on Arterial Stiffness and Peripheral and Central Blood Pressure in Healthy Humans: A Randomized Controlled Trial"],"prefix":"10.1371","volume":"11","author":[{"given":"Iain","family":"Bressendorff","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisbet","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morten","family":"Schou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgitte","family":"Nygaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Erik","family":"Frandsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"\u00d8dum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ove Vyff","family":"\u00d8stergaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,10]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4065\/81.3.353","article-title":"High prevalence of vitamin D inadequacy and implications for health","volume":"81","author":"MF Holick","year":"2006","journal-title":"Mayo Clin Proc"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1161\/CIRCULATIONAHA.107.706127","article-title":"Vitamin D deficiency and risk of cardiovascular disease","volume":"117","author":"TJ Wang","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.atherosclerosis.2008.10.033","article-title":"25-Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey","volume":"205","author":"J Kendrick","year":"2009","journal-title":"Atherosclerosis"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1210\/jc.2011-0385","article-title":"Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline","volume":"96","author":"MF Holick","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref5","article-title":"Dietary Reference Ranges for Calcium and Vitamin D","year":"2010"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jacc.2011.02.051","article-title":"Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans","volume":"58","author":"I Al Mheid","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/jhh.2011.94","article-title":"The association between low 25-hydroxyvitamin D and increased aortic stiffness","volume":"26","author":"O Mayer Jr.","year":"2012","journal-title":"J Hum Hypertens"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jjcc.2013.06.004","article-title":"Serum 25-hydroxyvitamin D is associated with both arterial and ventricular stiffness in healthy subjects","volume":"62","author":"T Seker","year":"2013","journal-title":"J Cardiol"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3109\/10641963.2013.827705","article-title":"25-Hydroxyvitamin D status, arterial stiffness and the renin-angiotensin system in healthy humans","volume":"36","author":"A Abdi-Ali","year":"2014","journal-title":"Clin Exp Hypertens"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.amjhyper.2007.01.017","article-title":"Serum 25-hydroxyvitamin D, ethnicity, and blood pressure in the Third National Health and Nutrition Examination Survey","volume":"20","author":"R Scragg","year":"2007","journal-title":"Am J Hypertens"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"307","DOI":"10.7326\/0003-4819-152-5-201003020-00009","article-title":"Systematic review: Vitamin D and cardiometabolic outcomes","volume":"152","author":"AG Pittas","year":"2010","journal-title":"Ann Intern Med"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10654-013-9790-2","article-title":"Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants","volume":"28","author":"SK Kunutsor","year":"2013","journal-title":"Eur J Epidemiol"},{"key":"ref13","first-page":"13","article-title":"Vitamin D status and hypertension: a review","volume":"8","author":"L Ke","year":"2015","journal-title":"Integr Blood Press Control"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/aje\/kwr274","article-title":"A prospective study of serum 25-hydroxyvitamin D levels, blood pressure, and incident hypertension in postmenopausal women","volume":"175","author":"KL Margolis","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.cyto.2008.12.009","article-title":"1Alpha,25-dihydroxyvitamin D3 inhibits CD40L-induced pro-inflammatory and immunomodulatory activity in human monocytes","volume":"45","author":"C Almerighi","year":"2009","journal-title":"Cytokine"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1172\/JCI0215219","article-title":"1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system","volume":"110","author":"YC Li","year":"2002","journal-title":"J Clin Invest"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"e102965","DOI":"10.1371\/journal.pone.0102965","article-title":"Effects of high doses of cholecalciferol in normal subjects: a randomized double-blinded, placebo-controlled trial","volume":"9","author":"B Nygaard","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1093\/ndt\/gfm470","article-title":"Reproducibility of pulse-wave analysis and pulse-wave velocity determination in chronic kidney disease","volume":"23","author":"M Frimodt-Moller","year":"2008","journal-title":"Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association\u2014European Renal Association"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1097\/HJH.0b013e32832cb04e","article-title":"Noninvasive determination of carotid-femoral pulse wave velocity depends critically on assessment of travel distance: a comparison with invasive measurement","volume":"27","author":"T Weber","year":"2009","journal-title":"J Hypertens"},{"key":"ref20","unstructured":"SphygmoCor Concise Software Guide (2008). In: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.atcormedical.com\" xlink:type=\"simple\">http:\/\/www.atcormedical.com<\/ext-link>, editor. 2011."},{"issue":"21","key":"ref21","doi-asserted-by":"crossref","first-page":"2588","DOI":"10.1093\/eurheartj\/ehl254","article-title":"Expert consensus document on arterial stiffness: methodological issues and clinical applications","volume":"27","author":"S Laurent","year":"2006","journal-title":"Eur Heart J"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ajh.2012.111","article-title":"Effect of cholecalciferol supplementation during winter months in patients with hypertension: a randomized, placebo-controlled trial","volume":"25","author":"T Larsen","year":"2012","journal-title":"Am J Hypertens"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/HYPERTENSIONAHA.115.05319","article-title":"Effects of vitamin d on blood pressure and cardiovascular risk factors: a randomized controlled trial","volume":"65","author":"S Pilz","year":"2015","journal-title":"Hypertension"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.atherosclerosis.2012.12.013","article-title":"Randomized controlled trial of vitamin D supplement on endothelial function in patients with type 2 diabetes","volume":"227","author":"YF Yiu","year":"2013","journal-title":"Atherosclerosis"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"620","DOI":"10.3904\/kjim.2014.29.5.620","article-title":"The effect of high-dose vitamin D supplementation on insulin resistance and arterial stiffness in patients with type 2 diabetes","volume":"29","author":"OH Ryu","year":"2014","journal-title":"Korean J Intern Med"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1210\/jc.2010-0606","article-title":"A 16-week randomized clinical trial of 2000 international units daily vitamin D3 supplementation in black youth: 25-hydroxyvitamin D, adiposity, and arterial stiffness","volume":"95","author":"Y Dong","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/jbmr.551","article-title":"Oral supplementation with 25(OH)D3 versus vitamin D3: effects on 25(OH)D levels, lower extremity function, blood pressure, and markers of innate immunity","volume":"27","author":"HA Bischoff-Ferrari","year":"2012","journal-title":"J Bone Miner Res"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1161\/HYPERTENSIONAHA.111.00659","article-title":"Effect of vitamin D supplementation on blood pressure in blacks","volume":"61","author":"JP Forman","year":"2013","journal-title":"Hypertension"},{"issue":"18","key":"ref29","first-page":"1672","article-title":"Cholecalciferol treatment to reduce blood pressure in older patients with isolated systolic hypertension: the VitDISH randomized controlled trial","volume":"173","author":"MD Witham","year":"2013","journal-title":"JAMA Intern Med"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1177\/1470320312471149","article-title":"Cholecalciferol administration blunts the systemic renin-angiotensin system in essential hypertensives with hypovitaminosis D","volume":"15","author":"D Carrara","year":"2014","journal-title":"J Renin Angiotensin Aldosterone Syst"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.numecd.2014.02.015","article-title":"Effects of six months of vitamin D supplementation in patients with heart failure: a randomized double-blind controlled trial","volume":"24","author":"A Dalbeni","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/HYPERTENSIONAHA.114.03466","article-title":"Long-term high-dose vitamin D3 supplementation and blood pressure in healthy adults: a randomized controlled trial","volume":"64","author":"R Scragg","year":"2014","journal-title":"Hypertension"},{"issue":"12","key":"ref33","first-page":"5421","article-title":"A 3-month oral vitamin D supplementation marginally improves diastolic blood pressure in Saudi patients with type 2 diabetes mellitus","volume":"7","author":"MK Al-Zahrani","year":"2014","journal-title":"Int J Clin Exp Med"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1161\/CIRCULATIONAHA.114.011732","article-title":"Vitamin D therapy in individuals with prehypertension or hypertension: the DAYLIGHT trial","volume":"131","author":"P Arora","year":"2015","journal-title":"Circulation"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/MBP.0000000000000091","article-title":"The effect of vitamin D supplementation on blood pressure in patients with elevated blood pressure and vitamin D deficiency: a randomized, double-blind, placebo-controlled trial","volume":"20","author":"H Mozaffari-Khosravi","year":"2015","journal-title":"Blood Press Monit"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/jamainternmed.2015.0237","article-title":"Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data","volume":"175","author":"LA Beveridge","year":"2015","journal-title":"JAMA Intern Med"},{"issue":"41","key":"ref37","doi-asserted-by":"crossref","first-page":"29821","DOI":"10.1074\/jbc.M705495200","article-title":"1,25-dihydroxyvitamin D3 suppresses renin gene transcription by blocking the activity of the cyclic AMP response element in the renin gene promoter","volume":"282","author":"W Yuan","year":"2007","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:45:39Z","timestamp":1588959939000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160905"}},"subtitle":[],"editor":[{"given":"Yiqing","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,10]]},"references-count":37,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160905","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,10]]}}}