{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:06:09Z","timestamp":1790409969376,"version":"4.1.0"},"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T00:00:00Z","timestamp":1470873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AI093351"],"award-info":[{"award-number":["R01 AI093351"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0160977","type":"journal-article","created":{"date-parts":[[2016,8,11]],"date-time":"2016-08-11T17:54:37Z","timestamp":1470938077000},"page":"e0160977","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["FmvB: A Francisella tularensis Magnesium-Responsive Outer Membrane Protein that Plays a Role in Virulence"],"prefix":"10.1371","volume":"11","author":[{"given":"Xiaojun","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoping","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T.","family":"Gunning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea L.","family":"Kalinoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadik A.","family":"Khuder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason F.","family":"Huntley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,11]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S1369-5274(03)00002-X","article-title":"Virulence determinants and protective antigens of <italic>Francisella tularensis<\/italic>","volume":"6","author":"A Sjostedt","year":"2003","journal-title":"Curr Opin Microbiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fmicb.2010.00138","article-title":"The <italic>Francisella<\/italic> intracellular life cycle: toward molecular mechanisms of intracellular survival and proliferation","volume":"1","author":"A Chong","year":"2010","journal-title":"Front Microbiol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S0966-842X(03)00020-9","article-title":"Will the enigma of <italic>Francisella tularensis<\/italic> virulence soon be solved?","volume":"11","author":"RW Titball","year":"2003","journal-title":"Trends Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archinte.1961.03620050068007","article-title":"Tularemia vaccine study. II. Respiratory challenge","volume":"107","author":"S Saslaw","year":"1961","journal-title":"Arch Intern Med"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/CMR.15.4.631-646.2002","article-title":"Tularemia","volume":"15","author":"J Ellis","year":"2002","journal-title":"Clin Microbiol Rev"},{"issue":"Suppl 4","key":"ref6","doi-asserted-by":"crossref","first-page":"D48","DOI":"10.1016\/j.vaccine.2009.07.090","article-title":"<italic>Francisella tularensis<\/italic> vaccines","volume":"27","author":"PC Oyston","year":"2009","journal-title":"Vaccine"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1128\/IAI.01382-10","article-title":"Phagocytic receptors dictate phagosomal escape and intracellular proliferation of <italic>Francisella tularensis<\/italic>","volume":"79","author":"H Geier","year":"2011","journal-title":"Infect Immun"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.micpath.2008.01.010","article-title":"Interaction of B cells with intracellular pathogen <italic>Francisella tularensis<\/italic>","volume":"45","author":"Z Krocova","year":"2008","journal-title":"Microb Pathog"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.mimet.2013.03.004","article-title":"Examination of in vitro epithelial cell lines as models for <italic>Francisella tularensis<\/italic> non-phagocytic infections","volume":"93","author":"KY Lo","year":"2013","journal-title":"J Microbiol Methods"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/infdis\/jir221","article-title":"Invasion of erythrocytes by <italic>Francisella tularensis<\/italic>","volume":"204","author":"J Horzempa","year":"2011","journal-title":"J Infect Dis"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1078\/1438-4221-00103","article-title":"Iron uptake mechanisms and their regulation in pathogenic bacteria","volume":"291","author":"V Braun","year":"2001","journal-title":"Int J Med Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev-genet-051313-051025","article-title":"Bacterial Mg<sup>2+<\/sup> homeostasis, transport, and virulence","volume":"47","author":"EA Groisman","year":"2013","journal-title":"Annu Rev Genet"},{"key":"ref13","first-page":"2","article-title":"Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis","volume":"4","author":"VE Diaz-Ochoa","year":"2014","journal-title":"Front Cell Infect Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.3389\/fcimb.2013.00080","article-title":"Shared and distinct mechanisms of iron acquisition by bacterial and fungal pathogens of humans","volume":"3","author":"M Caza","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.1128\/jb.171.9.4742-4751.1989","article-title":"Magnesium transport in <italic>Salmonella typhimurium<\/italic>: genetic characterization and cloning of three magnesium transport loci","volume":"171","author":"SP Hmiel","year":"1989","journal-title":"J Bacteriol"},{"issue":"0","key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.1749-6632.1974.tb43261.x","article-title":"The barrier function of the gram-negative envelope","volume":"235","author":"L Leive","year":"1974","journal-title":"Ann N Y Acad Sci"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nrm1015","article-title":"Acquisition of siderophores in gram-negative bacteria","volume":"4","author":"JD Faraldo-Gomez","year":"2003","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2\u20133","key":"ref18","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0168-6445(03)00055-X","article-title":"Bacterial iron homeostasis","volume":"27","author":"SC Andrews","year":"2003","journal-title":"FEMS Microbiol Rev"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1038\/nrmicro1046","article-title":"Iron and microbial infection","volume":"2","author":"UE Schaible","year":"2004","journal-title":"Nat Rev Microbiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0079-6603(03)75008-9","article-title":"The roles and regulation of potassium in bacteria","volume":"75","author":"W Epstein","year":"2003","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/ng1499","article-title":"The complete genome sequence of <italic>Francisella tularensis<\/italic>, the causative agent of tularemia","volume":"37","author":"P Larsson","year":"2005","journal-title":"Nat Genet"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"8345","DOI":"10.1128\/IAI.73.12.8345-8352.2005","article-title":"A mutant of <italic>Francisella tularensis<\/italic> strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine","volume":"73","author":"S Twine","year":"2005","journal-title":"Infect Immun"},{"issue":"30","key":"ref23","doi-asserted-by":"crossref","first-page":"25191","DOI":"10.1074\/jbc.M112.371856","article-title":"Paralogous outer membrane proteins mediate uptake of different forms of iron and synergistically govern virulence in <italic>Francisella tularensis tularensis<\/italic>","volume":"287","author":"G Ramakrishnan","year":"2012","journal-title":"J Biol Chem"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"4429","DOI":"10.1128\/IAI.00702-09","article-title":"The 58-kilodalton major virulence factor of <italic>Francisella tularensis<\/italic> is required for efficient utilization of iron","volume":"77","author":"H Lindgren","year":"2009","journal-title":"Infect Immun"},{"issue":"15","key":"ref25","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1128\/JB.00181-08","article-title":"<italic>fslE<\/italic> is necessary for siderophore-mediated iron acquisition in <italic>Francisella tularensis<\/italic> Schu S4","volume":"190","author":"G Ramakrishnan","year":"2008","journal-title":"J Bacteriol"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"4276","DOI":"10.1128\/IAI.00503-10","article-title":"The <italic>fslE<\/italic> homolog, FTL_0439 (<italic>fupA\/B<\/italic>), mediates siderophore-dependent iron uptake in <italic>Francisella tularensis<\/italic> LVS","volume":"78","author":"B Sen","year":"2010","journal-title":"Infect Immun"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1128\/IAI.00196-09","article-title":"Reintroduction of two deleted virulence loci restores full virulence to the live vaccine strain of <italic>Francisella tularensis<\/italic>","volume":"77","author":"E Salomonsson","year":"2009","journal-title":"Infect Immun"},{"issue":"Pt 2","key":"ref28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1099\/mic.0.072835-0","article-title":"The FupA\/B protein uniquely facilitates transport of ferrous iron and siderophore-associated ferric iron across the outer membrane of <italic>Francisella tularensis<\/italic> live vaccine strain","volume":"160","author":"G Ramakrishnan","year":"2014","journal-title":"Microbiology"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/mmi.12808","article-title":"Identification of disulfide bond isomerase substrates reveals bacterial virulence factors","volume":"94","author":"G Ren","year":"2014","journal-title":"Mol Microbiol"},{"issue":"8","key":"ref30","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1128\/IAI.00374-08","article-title":"Native outer membrane proteins protect mice against pulmonary challenge with virulent type A <italic>Francisella tularensis<\/italic>","volume":"76","author":"JF Huntley","year":"2008","journal-title":"Infect Immun"},{"issue":"12","key":"ref31","first-page":"e1500","article-title":"Generating Isogenic Deletions (Knockouts) in <italic>Francisella tularensis<\/italic>, a Highly-infectious and Fastidious Gram-negative Bacterium","volume":"5","author":"X Wu","year":"2015","journal-title":"Bio Protoc"},{"issue":"23","key":"ref32","doi-asserted-by":"crossref","first-page":"7830","DOI":"10.1128\/JB.01188-08","article-title":"Genetic dissection of the <italic>Francisella novicida<\/italic> restriction barrier","volume":"190","author":"LA Gallagher","year":"2008","journal-title":"J Bacteriol"},{"issue":"11","key":"ref33","doi-asserted-by":"crossref","first-page":"4026","DOI":"10.1128\/IAI.00595-13","article-title":"IglE is an outer membrane-associated lipoprotein essential for intracellular survival and murine virulence of type A <italic>Francisella tularensis<\/italic>","volume":"81","author":"GT Robertson","year":"2013","journal-title":"Infect Immun"},{"issue":"12","key":"ref34","doi-asserted-by":"crossref","first-page":"7511","DOI":"10.1128\/AEM.70.12.7511-7519.2004","article-title":"Construction and characterization of a highly efficient <italic>Francisella<\/italic> shuttle plasmid","volume":"70","author":"TM Maier","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1128\/AEM.13.2.232-235.1965","article-title":"Evaluation of Live Tularemia Vaccine Prepared in a Chemically Defined Medium","volume":"13","author":"RE Chamberlain","year":"1965","journal-title":"Appl Microbiol"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1128\/JB.01505-06","article-title":"Characterization of <italic>Francisella tularensis<\/italic> outer membrane proteins","volume":"189","author":"JF Huntley","year":"2007","journal-title":"J Bacteriol"},{"key":"ref37","first-page":"430","volume":"xv","author":"CA Price","year":"1982"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/infdis\/162.1.148","article-title":"Fluorescence-activated cell sorter analysis of binding by lipopolysaccharide-specific monoclonal antibodies to gram-negative bacteria","volume":"162","author":"ME Evans","year":"1990","journal-title":"J Infect Dis"},{"key":"ref39","first-page":"150","article-title":"The use of flow cytometry in the analysis of lipopolysaccharide epitope expression in <italic>Escherichia coli<\/italic> O26:B6 variants","volume":"5","author":"ME Evans","year":"1994","journal-title":"Old Herborn University Seminar Monograph 5"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"476534","DOI":"10.1155\/2015\/476534","article-title":"Strategies of Intracellular Pathogens for Obtaining Iron from the Environment","volume":"2015","author":"N Leon-Sicairos","year":"2015","journal-title":"Biomed Res Int"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"4224","DOI":"10.1128\/IAI.01975-05","article-title":"Identification of <italic>Francisella tularensis<\/italic> genes affected by iron limitation","volume":"74","author":"K Deng","year":"2006","journal-title":"Infect Immun"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1046\/j.1365-2958.1999.01411.x","article-title":"Iron acquisition systems in the pathogenic <italic>Neisseria<\/italic>","volume":"32","author":"AB Schryvers","year":"1999","journal-title":"Mol Microbiol"},{"issue":"7387","key":"ref43","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nature10823","article-title":"Structural basis for iron piracy by pathogenic <italic>Neisseria<\/italic>","volume":"483","author":"N Noinaj","year":"2012","journal-title":"Nature"},{"issue":"13","key":"ref44","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/bioinformatics\/btq249","article-title":"PSORTb 3.0: improved protein subcellular localization prediction with refined localization subcategories and predictive capabilities for all prokaryotes","volume":"26","author":"NY Yu","year":"2010","journal-title":"Bioinformatics"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0022-2836(03)00855-6","article-title":"Structural evidence for iron-free citrate and ferric citrate binding to the TonB-dependent outer membrane transporter FecA","volume":"332","author":"WW Yue","year":"2003","journal-title":"J Mol Biol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"W186","DOI":"10.1093\/nar\/gkl262","article-title":"PROFtmb: a web server for predicting bacterial transmembrane beta barrel proteins","volume":"34","author":"H Bigelow","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"W394","DOI":"10.1093\/nar\/gkh351","article-title":"BOMP: a program to predict integral beta-barrel outer membrane proteins encoded within genomes of Gram-negative bacteria","volume":"32","author":"FS Berven","year":"2004","journal-title":"Nucleic Acids Res"},{"issue":"19","key":"ref48","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1093\/bioinformatics\/bts478","article-title":"TMBB-DB: a transmembrane beta-barrel proteome database","volume":"28","author":"TC Freeman Jr.","year":"2012","journal-title":"Bioinformatics"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1471-2105-6-56","article-title":"TMB-Hunt: an amino acid composition based method to screen proteomes for beta-barrel transmembrane proteins","volume":"6","author":"AG Garrow","year":"2005","journal-title":"BMC Bioinformatics"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.str.2015.10.009","article-title":"OprG Harnesses the Dynamics of its Extracellular Loops to Transport Small Amino Acids across the Outer Membrane of <italic>Pseudomonas aeruginosa<\/italic>","volume":"23","author":"I Kucharska","year":"2015","journal-title":"Structure"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1128\/CMR.00059-12","article-title":"Antimicrobial resistance and virulence: a successful or deleterious association in the bacterial world?","volume":"26","author":"A Beceiro","year":"2013","journal-title":"Clin Microbiol Rev"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cbpa.2008.01.023","article-title":"Discovery of virulence factors of pathogenic bacteria","volume":"12","author":"HJ Wu","year":"2008","journal-title":"Curr Opin Chem Biol"},{"issue":"7","key":"ref53","doi-asserted-by":"crossref","first-page":"e1002136","DOI":"10.1371\/journal.ppat.1002136","article-title":"Microbial virulence as an emergent property: consequences and opportunities","volume":"7","author":"A Casadevall","year":"2011","journal-title":"PLoS Pathog"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens5010007","article-title":"Measuring <italic>Escherichia coli<\/italic> Gene Expression during Human Urinary Tract Infections","volume":"5","author":"HL Mobley","year":"2016","journal-title":"Pathogens"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"e1004600","DOI":"10.1371\/journal.ppat.1004600","article-title":"Reprogramming of <italic>Yersinia<\/italic> from virulent to persistent mode revealed by complex in vivo RNA-seq analysis","volume":"11","author":"K Avican","year":"2015","journal-title":"PLoS Pathog"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01775-14","article-title":"High-resolution transcriptomic analysis of the adaptive response of <italic>Staphylococcus aureus<\/italic> during acute and chronic phases of osteomyelitis","volume":"5","author":"AK Szafranska","year":"2014","journal-title":"MBio"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3389\/fcimb.2013.00090","article-title":"Iron, copper, zinc, and manganese transport and regulation in pathogenic Enterobacteria: correlations between strains, site of infection and the relative importance of the different metal transport systems for virulence","volume":"3","author":"G Porcheron","year":"2013","journal-title":"Front Cell Infect Microbiol"},{"issue":"8","key":"ref58","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nrmicro2836","article-title":"Nutritional immunity: transition metals at the pathogen-host interface","volume":"10","author":"MI Hood","year":"2012","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/nrmicro2057","article-title":"How do bacterial cells ensure that metalloproteins get the correct metal?","volume":"7","author":"KJ Waldron","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"40","key":"ref60","doi-asserted-by":"crossref","DOI":"10.3791\/2044","article-title":"Method for the isolation of <italic>Francisella tularensis<\/italic> outer membranes","author":"JF Huntley","year":"2010","journal-title":"J Vis Exp"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev.mi.38.100184.001321","article-title":"Alterations in outer membrane permeability","volume":"38","author":"RE Hancock","year":"1984","journal-title":"Annu Rev Microbiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-micro-092412-155751","article-title":"The biology of the PmrA\/PmrB two-component system: the major regulator of lipopolysaccharide modifications","volume":"67","author":"HD Chen","year":"2013","journal-title":"Annu Rev Microbiol"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pathogens1010012","article-title":"Roles for <italic>wbtC<\/italic>, <italic>wbtI<\/italic>, and <italic>kdtA<\/italic> Genes in Lipopolysaccharide Biosynthesis, Protein Glycosylation, Virulence, and Immunogenicity in <italic>Francisella tularensis<\/italic> Strain SCHU S4","volume":"1","author":"SM Twine","year":"2012","journal-title":"Pathogens"},{"issue":"7","key":"ref64","doi-asserted-by":"crossref","first-page":"e11060","DOI":"10.1371\/journal.pone.0011060","article-title":"Identification, characterization and immunogenicity of an O-antigen capsular polysaccharide of <italic>Francisella tularensis<\/italic>","volume":"5","author":"MA Apicella","year":"2010","journal-title":"PLoS One"},{"key":"ref65","first-page":"94","article-title":"From the Outside-In: The <italic>Francisella tularensis<\/italic> Envelope and Virulence","volume":"5","author":"HM Rowe","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"11","key":"ref66","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1021\/pr900570b","article-title":"Proteome analysis of an attenuated <italic>Francisella tularensis dsbA<\/italic> mutant: identification of potential DsbA substrate proteins","volume":"8","author":"A Straskova","year":"2009","journal-title":"J Proteome Res"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1111\/j.1365-2958.1994.tb00287.x","article-title":"Identification and characterization of a chromosomal virulence gene, <italic>vacJ<\/italic>, required for intercellular spreading of <italic>Shigella flexneri<\/italic>","volume":"11","author":"T Suzuki","year":"1994","journal-title":"Mol Microbiol"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vetmic.2015.11.021","article-title":"Outer membrane lipoprotein VacJ is required for the membrane integrity, serum resistance and biofilm formation of <italic>Actinobacillus pleuropneumoniae<\/italic>","volume":"183","author":"F Xie","year":"2016","journal-title":"Vet Microbiol"},{"issue":"6227","key":"ref69","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1126\/science.aaa4268","article-title":"Interleukin-3 amplifies acute inflammation and is a potential therapeutic target in sepsis","volume":"347","author":"GF Weber","year":"2015","journal-title":"Science"},{"issue":"6227","key":"ref70","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1126\/science.aaa8334","article-title":"Immunology. Getting sepsis therapy right","volume":"347","author":"RS Hotchkiss","year":"2015","journal-title":"Science"},{"issue":"2","key":"ref71","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1128\/IAI.05208-11","article-title":"The <italic>Neisseria meningitidis<\/italic> ZnuD zinc receptor contributes to interactions with epithelial cells and supports heme utilization when expressed in <italic>Escherichia coli<\/italic>","volume":"80","author":"P Kumar","year":"2012","journal-title":"Infect Immun"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1128\/jb.168.3.1444-1450.1986","article-title":"Magnesium transport in <italic>Salmonella typhimurium<\/italic>: characterization of magnesium influx and cloning of a transport gene","volume":"168","author":"SP Hmiel","year":"1986","journal-title":"J Bacteriol"},{"issue":"19","key":"ref73","doi-asserted-by":"crossref","first-page":"6201","DOI":"10.1128\/jb.179.19.6201-6204.1997","article-title":"Ferrous iron uptake by a magnesium transport system is toxic for <italic>Escherichia coli<\/italic> and <italic>Salmonella typhimurium<\/italic>","volume":"179","author":"K Hantke","year":"1997","journal-title":"J Bacteriol"},{"issue":"9","key":"ref74","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1128\/jb.171.9.4761-4766.1989","article-title":"Magnesium transport in <italic>Salmonella typhimurium<\/italic>: <sup>28<\/sup>Mg<sup>2+<\/sup> transport by the CorA, MgtA, and MgtB systems","volume":"171","author":"MD Snavely","year":"1989","journal-title":"J Bacteriol"},{"issue":"10","key":"ref75","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.bbamem.2015.06.002","article-title":"The Cryo-EM structure of the CorA channel from <italic>Methanocaldococcus jannaschii<\/italic> in low magnesium conditions","volume":"1848","author":"RM Cleverley","year":"2015","journal-title":"Biochim Biophys Acta"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1007\/s00429-014-0779-8","article-title":"Dietary magnesium restriction reduces amygdala-hypothalamic GluN1 receptor complex levels in mice","volume":"220","author":"M Ghafari","year":"2015","journal-title":"Brain Struct Funct"},{"issue":"1","key":"ref77","first-page":"49","article-title":"Fluorescence measurements of free [Mg<sup>2+<\/sup>] by use of mag-fura 2 in <italic>Salmonella enterica<\/italic>","volume":"237","author":"EM Froschauer","year":"2004","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0003-9861(92)90086-C","article-title":"Regulation of cell magnesium","volume":"298","author":"A Romani","year":"1992","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"ref79","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1023\/A:1016078832697","article-title":"Structure, properties and regulation of magnesium transport proteins","volume":"15","author":"DG Kehres","year":"2002","journal-title":"Biometals"},{"issue":"3","key":"ref80","doi-asserted-by":"crossref","first-page":"e0119143","DOI":"10.1371\/journal.pone.0119143","article-title":"Mechanisms of heme utilization by <italic>Francisella tularensis<\/italic>","volume":"10","author":"H Lindgren","year":"2015","journal-title":"PLoS One"},{"issue":"7","key":"ref81","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.1462-5822.2009.01316.x","article-title":"Intracellular biology and virulence determinants of <italic>Francisella tularensis<\/italic> revealed by transcriptional profiling inside macrophages","volume":"11","author":"TD Wehrly","year":"2009","journal-title":"Cell Microbiol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3389\/fmicb.2015.00338","article-title":"Characterization of <italic>Francisella tularensis<\/italic> Schu S4 mutants identified from a transposon library screened for O-antigen and capsule deficiencies","volume":"6","author":"JA Rasmussen","year":"2015","journal-title":"Front Microbiol"},{"issue":"10","key":"ref83","doi-asserted-by":"crossref","first-page":"4136","DOI":"10.1073\/pnas.0611606104","article-title":"Attenuated virulence of a <italic>Francisella<\/italic> mutant lacking the lipid A 4&apos;-phosphatase","volume":"104","author":"X Wang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref84","doi-asserted-by":"crossref","first-page":"e19003","DOI":"10.1371\/journal.pone.0019003","article-title":"Isolation and mutagenesis of a capsule-like complex (CLC) from <italic>Francisella tularensis<\/italic>, and contribution of the CLC to <italic>F<\/italic>. <italic>tularensis<\/italic> virulence in mice","volume":"6","author":"AB Bandara","year":"2011","journal-title":"PLoS One"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1146\/annurev.micro.091208.073413","article-title":"Biological functions and biogenesis of secreted bacterial outer membrane vesicles","volume":"64","author":"A Kulp","year":"2010","journal-title":"Annu Rev Microbiol"},{"issue":"6","key":"ref86","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1128\/JB.02007-12","article-title":"Production of outer membrane vesicles and outer membrane tubes by <italic>Francisella novicida<\/italic>","volume":"195","author":"WD McCaig","year":"2013","journal-title":"J Bacteriol"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1196\/annals.1409.014","article-title":"Innate and adaptive immunity to <italic>Francisella<\/italic>","volume":"1105","author":"KL Elkins","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"ref88","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1189\/jlb.1205755","article-title":"Critical role for serum opsonins and complement receptors CR3 (CD11b\/CD18) and CR4 (CD11c\/CD18) in phagocytosis of <italic>Francisella tularensis<\/italic> by human dendritic cells (DC): uptake of <italic>Francisella<\/italic> leads to activation of immature DC and intracellular survival of the bacteria","volume":"80","author":"A Ben Nasr","year":"2006","journal-title":"J Leukoc Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0160977","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T03:15:30Z","timestamp":1601003730000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0160977"}},"subtitle":[],"editor":[{"given":"Ashlesh K","family":"Murthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,11]]},"references-count":88,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0160977","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,11]]}}}