{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:56:55Z","timestamp":1789516615683,"version":"build-2803163510"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T00:00:00Z","timestamp":1471219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004012","name":"Jane ja Aatos Erkon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Biocentrum Helsinki"},{"DOI":"10.13039\/501100003125","name":"Suomen Kulttuurirahasto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Suomen Akatemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OD010939"],"award-info":[{"award-number":["OD010939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161005","type":"journal-article","created":{"date-parts":[[2016,8,15]],"date-time":"2016-08-15T13:29:08Z","timestamp":1471267748000},"page":"e0161005","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":54,"title":["Genetic Panel Screening of Nearly 100 Mutations Reveals New Insights into the Breed Distribution of Risk Variants for Canine Hereditary Disorders"],"prefix":"10.1371","volume":"11","author":[{"given":"Jonas","family":"Donner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kaukonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fredrik","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Ky\u00f6stil\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satu","family":"Sankari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjo","family":"Hyt\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Giger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"Lohi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,15]]},"reference":[{"key":"ref1","article-title":"Online Mendelian Inheritance in Animals"},{"key":"ref2","unstructured":"PennGen\u2014Section of Medical Genetics, School of Veterinary Medicine, University of Pennsylvania. Listing of Canine and Feline Hereditary Disease (DNA) Testing Laboratories. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/research.vet.upenn.edu\/penngen\/AvailableTests\/TestsAvailableatLabsWorldwide\/tabid\/7620\/Default.aspx\" xlink:type=\"simple\">http:\/\/research.vet.upenn.edu\/penngen\/AvailableTests\/TestsAvailableatLabsWorldwide\/tabid\/7620\/Default.aspx<\/ext-link>."},{"key":"ref3","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.tvjl.2013.02.021","article-title":"A web resource on DNA tests for canine and feline hereditary diseases","volume":"197","author":"J Slutsky","year":"2013","journal-title":"Vet J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00335-011-9361-3","article-title":"Genetic and phenotypic variations of inherited retinal diseases in dogs: the power of within- and across-breed studies","volume":"23","author":"K Miyadera","year":"2012","journal-title":"Mamm Genome"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1111\/j.1939-1676.2012.00958.x","article-title":"Erythrocytic pyruvate kinase mutations causing hemolytic anemia, osteosclerosis, and seconday hemochromatosis in dogs","volume":"26","author":"GI Gultekin","year":"2012","journal-title":"J Vet Intern Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/jvim.12176","article-title":"SLC3A1 and SLC7A9 mutations in autosomal recessive or dominant canine cystinuria: a new classification system","volume":"27","author":"AK Brons","year":"2013","journal-title":"J Vet Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e64627","DOI":"10.1371\/journal.pone.0064627","article-title":"Missense mutation in CAPN1 is associated with spinocerebellar ataxia in the Parson Russell Terrier dog breed","volume":"8","author":"OP Forman","year":"2013","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/jvim.12355","article-title":"A homozygous KCNJ10 mutation in Jack Russell Terriers and related breeds with spinocerebellar ataxia with myokymia, seizures, or both","volume":"28","author":"D Gilliam","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/jvim.12317","article-title":"Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy","volume":"28","author":"R Zeng","year":"2014","journal-title":"J Vet Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1111\/j.1939-1676.2010.0631.x","article-title":"Estimated frequency of the canine hyperuricosuria mutation in different dog breeds","volume":"24","author":"N Karmi","year":"2010","journal-title":"J Vet Intern Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2616","DOI":"10.1111\/j.1538-7836.2006.02203.x","article-title":"A novel missense mutation responsible for factor VII deficiency in research Beagle colonies","volume":"4","author":"MB Callan","year":"2006","journal-title":"J Thromb Haemost"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1939-1676.2007.tb03052.x","article-title":"Hereditary factor VII deficiency in the Alaskan Klee Kai dog","volume":"21","author":"JA Kaae","year":"2007","journal-title":"J Vet Intern Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/j.1463-5224.2011.00892.x","article-title":"ADAMTS17 mutation associated with primary lens luxation is widespread among breeds","volume":"14","author":"D Gould","year":"2011","journal-title":"Vet Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1101\/gr.6772807","article-title":"Breed relationships facilitate fine-mapping studies: a 7.8-kb deletion cosegregates with Collie eye anomaly across multiple dog breeds","volume":"17","author":"HG Parker","year":"2007","journal-title":"Genome Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1167\/iovs.06-1374","article-title":"Bestrophin gene mutations cause canine multifocal retinopathy: a novel animal model for best disease","volume":"48","author":"KE Guziewicz","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1002759","DOI":"10.1371\/journal.pgen.1002759","article-title":"A SEL1L mutation links a canine progressive early-onset cerebellar ataxia to the endoplasmic reticulum-associated protein degradation (ERAD) machinery","volume":"8","author":"K Kyostila","year":"2012","journal-title":"PLoS Genet"},{"key":"ref17","unstructured":"Genoscoper Laboratories Oy. MyDogDNA Technical Sheet\u2014Design, Technology, and Performance Data. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/mydogdna.com\/sites\/default\/files\/files\/mydogdna_technical_sheet.pdf\" xlink:type=\"simple\">http:\/\/mydogdna.com\/sites\/default\/files\/files\/mydogdna_technical_sheet.pdf<\/ext-link>."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"909","DOI":"10.2460\/ajvr.71.8.909","article-title":"Validation of a urine test and characterization of the putative genetic mutation for hyperuricosuria in Bulldogs and Black Russian Terriers","volume":"71","author":"N Karmi","year":"2010","journal-title":"Am J Vet Res"},{"key":"ref19","unstructured":"GenoPro. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.genopro.com\" xlink:type=\"simple\">http:\/\/www.genopro.com<\/ext-link>."},{"key":"ref20","unstructured":"Suomen Kennelliitto ry. KoiraNet jalostustietoj\u00e4rjestelm\u00e4. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/jalostus.kennelliitto.fi\/\" xlink:type=\"simple\">http:\/\/jalostus.kennelliitto.fi\/<\/ext-link>."},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e1000246","DOI":"10.1371\/journal.pgen.1000246","article-title":"Mutations in the SLC2A9 gene cause hyperuricosuria and hyperuricemia in the dog","volume":"4","author":"D Bannasch","year":"2008","journal-title":"PLoS Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"4716","DOI":"10.1167\/iovs.09-5142","article-title":"An ADAMTS17 splice donor site mutation in dogs with primary lens luxation","volume":"51","author":"FH Farias","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"e75621","DOI":"10.1371\/journal.pone.0075621","article-title":"Canine chondrodysplasia caused by a truncating mutation in collagen-binding integrin alpha subunit 10","volume":"8","author":"K Kyostila","year":"2013","journal-title":"PLoS One"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1111\/j.1939-1676.2007.tb02981.x","article-title":"Genetic cause of autosomal recessive hereditary nephropathy in the English Cocker Spaniel","volume":"21","author":"AG Davidson","year":"2007","journal-title":"J Vet Intern Med"},{"key":"ref25","first-page":"2791","article-title":"Assessment of canine BEST1 variations identifies new mutations and establishes an independent bestrophinopathy model (cmr3)","volume":"16","author":"B Zangerl","year":"2010","journal-title":"Mol Vis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/00008571-200111000-00012","article-title":"Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene","volume":"11","author":"KL Mealey","year":"2001","journal-title":"Pharmacogenetics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1354\/vp.41-3-221","article-title":"A von Willebrand&apos;s factor genomic nucleotide variant and polymerase chain reaction diagnostic test associated with inheritable type-2 von Willebrand&apos;s disease in a line of german shorthaired pointer dogs","volume":"41","author":"JW Kramer","year":"2004","journal-title":"Vet Pathol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"e1006037","DOI":"10.1371\/journal.pgen.1006037","article-title":"Molecular Characterization of Three Canine Models of Human Rare Bone Diseases: Caffey, van den Ende-Gupta, and Raine Syndromes","volume":"12","author":"MK Hytonen","year":"2016","journal-title":"PLoS Genet"},{"key":"ref29","first-page":"1637","article-title":"cGMP phosphodiesterase-alpha mutation causes progressive retinal atrophy in the Cardigan Welsh corgi dog","volume":"40","author":"SM Petersen-Jones","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1939-1676.2007.tb02990.x","article-title":"A novel mutation of the CLCN1 gene associated with myotonia hereditaria in an Australian cattle dog","volume":"21","author":"DF Finnigan","year":"2007","journal-title":"J Vet Intern Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1267\/ahc.15.685","article-title":"Catalase activity of erythrocytes from beagle dog: an appearance of hereditary acatalasemia","volume":"15","author":"K Fukuda","year":"1982","journal-title":"Acta Histochem Cytochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S1357-2725(00)00057-1","article-title":"cDNA cloning of mutant catalase in acatalasemic beagle dog: single nucleotide substitution leading to thermal-instability and enhanced proteolysis of mutant enzyme","volume":"32","author":"K Nakamura","year":"2000","journal-title":"Int J Biochem Cell Biol"},{"key":"ref33","doi-asserted-by":"crossref","DOI":"10.1186\/s40575-015-0014-9","article-title":"The challenges of pedigree dog health: approaches to combating inherited disease","volume":"2","author":"LL Farrell","year":"2015","journal-title":"Canine Genet Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T23:14:00Z","timestamp":1540336440000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161005"}},"subtitle":[],"editor":[{"given":"Claire","family":"Wade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,15]]},"references-count":33,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161005","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,15]]}}}