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Inatsu","year":"2009","journal-title":"Hepatology"},{"issue":"47","key":"ref54","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1074\/jbc.R400025200","article-title":"C-reactive protein","volume":"279","author":"S Black","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"ref55","author":"CA Janeway","year":"2005"},{"key":"ref56","author":"B Alberts","year":"2002"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S0036-46652011000200009","article-title":"Tnf-a production and apoptosis in hepatocytes after listeria monocytogenes and salmonella typhimurium invasion","volume":"53","author":"SAD Santos","year":"2011","journal-title":"Revista do Instituto de Medicina Tropical de S\u00e3o Paulo"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/hep.26976","article-title":"Hepatocyte specific HMGB1 deletion worsens the injury in liver ischemia\/reperfusion: a role for 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Kindt","year":"2006"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1046\/j.1440-1711.2002.01062.x","article-title":"Recruitment of lymphocytes to the human liver","volume":"80","author":"PF Lalor","year":"2002","journal-title":"Immunology and Cell Biology"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1172\/JCI44490","article-title":"An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice","volume":"121","author":"A Sindrilaru","year":"2011","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"ref82","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1002\/hep.20301","article-title":"Kupffer cell\u2013derived interleukin 10 is responsible for impaired bacterial clearance in bile duct\u2013ligated mice","volume":"40","author":"T Abe","year":"2004","journal-title":"Hepatology"},{"issue":"4","key":"ref83","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/path.1711490408","article-title":"Mast cells in acute hepatitis","volume":"149","author":"KA Bardadin","year":"1986","journal-title":"The Journal of Pathology"},{"issue":"5","key":"ref84","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s004280050276","article-title":"Distribution of intrahepatic mast cells in various hepatobiliary disorders","volume":"433","author":"M Yamashiro","year":"1998","journal-title":"Virchows Archiv"},{"issue":"3","key":"ref85","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1365-2796.2003.01302.x","article-title":"Extracellular role of HMGB1 in inflammation and sepsis","volume":"255","author":"H Wang","year":"2004","journal-title":"Journal of Internal Medicine"},{"issue":"5","key":"ref86","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1189\/jlb.0404242","article-title":"Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14-and TNF-dependent mechanisms","volume":"76","author":"G Chen","year":"2004","journal-title":"Journal of Leukocyte Biology"},{"issue":"12","key":"ref87","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1084\/jem.20070247","article-title":"HMGB1 release induced by liver ischemia involves Toll-like receptor 4\u2013dependent reactive oxygen species production and calcium-mediated signaling","volume":"204","author":"A Tsung","year":"2007","journal-title":"The Journal of Experimental Medicine"},{"issue":"3","key":"ref88","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0300-2977(98)00156-9","article-title":"The central role of monocytes in the pathogenesis of sepsis: consequences for immunomonitoring and treatment","volume":"55","author":"J Haveman","year":"1999","journal-title":"The Netherlands Journal of Medicine"},{"issue":"3","key":"ref89","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1189\/jlb.0912437","article-title":"Current trends in inflammatory and immunomodulatory mediators in sepsis","volume":"93","author":"M Aziz","year":"2013","journal-title":"Journal of Leukocyte Biology"},{"issue":"Suppl 2","key":"ref90","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1440-1746.2011.07003.x","article-title":"Hepatoprotective and anti-inflammatory cytokines in alcoholic liver disease","volume":"27","author":"B Gao","year":"2012","journal-title":"Journal of Gastroenterology and Hepatology"},{"issue":"18","key":"ref91","doi-asserted-by":"crossref","first-page":"8602","DOI":"10.1073\/pnas.91.18.8602","article-title":"Monocyte deactivation by interleukin 10 via inhibition of tyrosine kinase activity and the Ras signaling pathway","volume":"91","author":"Y Geng","year":"1994","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"ref92","doi-asserted-by":"crossref","first-page":"811","DOI":"10.4049\/jimmunol.153.2.811","article-title":"IL-10 inhibits transcription of cytokine genes in human peripheral blood mononuclear cells","volume":"153","author":"P Wang","year":"1994","journal-title":"The Journal of Immunology"},{"issue":"16","key":"ref93","doi-asserted-by":"crossref","first-page":"9558","DOI":"10.1074\/jbc.270.16.9558","article-title":"Interleukin (IL)-10 inhibits nuclear factor B (NFB) activation in human monocytes IL-10 and IL-4 suppress cytokine synthesis by different mechanisms","volume":"270","author":"P Wang","year":"1995","journal-title":"Journal of Biological Chemistry"},{"issue":"45","key":"ref94","doi-asserted-by":"crossref","first-page":"31868","DOI":"10.1074\/jbc.274.45.31868","article-title":"Interleukin-10 signaling blocks inhibitor of \u03baB kinase activity and nuclear factor \u03baB DNA binding","volume":"274","author":"AJ Schottelius","year":"1999","journal-title":"Journal of Biological Chemistry"},{"issue":"8","key":"ref95","doi-asserted-by":"crossref","first-page":"4475","DOI":"10.4049\/jimmunol.169.8.4475","article-title":"Neutrophil influx in response to a peritoneal infection with Salmonella is delayed in lipopolysaccharide-binding protein or CD14-deficient mice","volume":"169","author":"KK Yang","year":"2002","journal-title":"The Journal of Immunology"},{"issue":"11","key":"ref96","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"C Shi","year":"2011","journal-title":"Nature Reviews Immunology"},{"issue":"4","key":"ref97","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/ni1051","article-title":"Locomotion of monocytes on endothelium is a critical step during extravasation","volume":"5","author":"AR Schenkel","year":"2004","journal-title":"Nature Immunology"},{"key":"ref98","author":"SP Otto","year":"2007"},{"key":"ref99","author":"JI Steinfeld","year":"1998"},{"issue":"1","key":"ref100","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1182\/blood-2010-08-265892","article-title":"Cytokine release from innate immune cells: association with diverse membrane trafficking pathways","volume":"118","author":"P Lacy","year":"2011","journal-title":"Blood"},{"issue":"4","key":"ref101","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1152\/physiol.00017.2010","article-title":"Pathways for cytokine secretion","volume":"25","author":"AC Stanley","year":"2010","journal-title":"Physiology"},{"key":"ref102","author":"DL Nelson","year":"2008"},{"issue":"28","key":"ref103","doi-asserted-by":"crossref","first-page":"21053","DOI":"10.1016\/S0021-9258(19)36892-9","article-title":"Characterization of interleukin-10 receptors on human and mouse cells","volume":"268","author":"JC Tan","year":"1993","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"ref104","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1084\/jem.190.4.585","article-title":"The major receptor for C-reactive protein on leukocytes is Fc\u03b3 receptor II","volume":"190","author":"D Bharadwaj","year":"1999","journal-title":"The Journal of Experimental Medicine"},{"issue":"3","key":"ref105","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4049\/jimmunol.154.3.1307","article-title":"Activation of the 55 kDa TNF receptor is necessary and sufficient for TNF-induced liver failure, hepatocyte apoptosis, and nitrite release","volume":"154","author":"M Leist","year":"1995","journal-title":"The Journal of Immunology"},{"issue":"5","key":"ref106","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1083\/jcb.201203170","article-title":"Neutrophil extracellular traps: is immunity the second function of chromatin?","volume":"198","author":"V Brinkmann","year":"2012","journal-title":"The Journal of Cell Biology"},{"issue":"6884","key":"ref107","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1038\/417091a","article-title":"Neutrophil elastase targets virulence factors of enterobacteria","volume":"417","author":"Y Weinrauch","year":"2002","journal-title":"Nature"},{"key":"ref108","unstructured":"R. 3.1.2. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cran.r-project.org\/bin\/windows\/base\/old\/3.1.2\/\" xlink:type=\"simple\">https:\/\/cran.r-project.org\/bin\/windows\/base\/old\/3.1.2\/<\/ext-link>."},{"issue":"9","key":"ref109","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1046\/j.1462-5822.2003.00296.x","article-title":"Dynamics of bacterial growth and distribution within the liver during Salmonella infection","volume":"5","author":"M Sheppard","year":"2003","journal-title":"Cellular Microbiology"},{"issue":"2","key":"ref110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/QCO.0b013e328343b70d","article-title":"Why should we measure bacterial load when treating community-acquired pneumonia?","volume":"24","author":"G Waterer","year":"2011","journal-title":"Current Opinion in Infectious Diseases"},{"issue":"1","key":"ref111","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1006\/mpat.2000.0405","article-title":"Early responses to Salmonella typhimurium infection in mice occur at focal lesions in infected organs","volume":"30","author":"SA Khan","year":"2001","journal-title":"Microbial Pathogenesis"},{"issue":"5425","key":"ref112","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"H Wang","year":"1999","journal-title":"Science"},{"issue":"1","key":"ref113","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1073\/pnas.2434651100","article-title":"Reversing established sepsis with antagonists of endogenous high-mobility group box 1","volume":"101","author":"H Yang","year":"2004","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"Suppl 2","key":"ref114","doi-asserted-by":"crossref","first-page":"S391","DOI":"10.1086\/374753","article-title":"High mobility group box-1 as a therapeutic target downstream of tumor necrosis factor","volume":"187","author":"CJ Czura","year":"2003","journal-title":"Journal of Infectious Diseases"},{"issue":"11","key":"ref115","doi-asserted-by":"crossref","first-page":"6266","DOI":"10.4049\/jimmunol.0904160","article-title":"Monocyte trafficking to hepatic sites of bacterial infection is chemokine independent and directed by focal intercellular adhesion molecule-1 expression","volume":"184","author":"C Shi","year":"2010","journal-title":"The Journal of Immunology"},{"issue":"6","key":"ref116","doi-asserted-by":"crossref","first-page":"2514","DOI":"10.4049\/jimmunol.157.6.2514","article-title":"Bacteria in the bloodstream are trapped in the liver and killed by immigrating neutrophils","volume":"157","author":"SH Gregory","year":"1996","journal-title":"The Journal of Immunology"},{"issue":"5","key":"ref117","doi-asserted-by":"crossref","first-page":"H2031","DOI":"10.1152\/ajpheart.01058.2004","article-title":"Adipokines: molecular links between obesity and atheroslcerosis","volume":"288","author":"DC Lau","year":"2005","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"3","key":"ref118","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00134-002-1209-6","article-title":"C-reactive protein: a valuable marker of sepsis","volume":"28","author":"P P\u00f3voa","year":"2002","journal-title":"Intensive Care Medicine"},{"issue":"1","key":"ref119","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1128\/IAI.01127-06","article-title":"Differential clearance and immune responses to tick cell-derived versus macrophage culture-derived Ehrlichia chaffeensis in mice","volume":"75","author":"RR Ganta","year":"2007","journal-title":"Infection and Immunity"},{"issue":"1","key":"ref120","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/jcb.23348","article-title":"The role of kupffer cells in rat liver regeneration revealed by cell\u2010specific microarray analysis","volume":"113","author":"CS Xu","year":"2012","journal-title":"Journal of Cellular Biochemistry"},{"issue":"Suppl 1","key":"ref121","doi-asserted-by":"crossref","first-page":"P174","DOI":"10.1186\/cc3237","article-title":"C-reactive protein as a marker of septic shock and outcome in the intensive care unit","volume":"9","author":"M Theodorakopoulou","year":"2005","journal-title":"Critical Care"},{"issue":"11","key":"ref122","doi-asserted-by":"crossref","first-page":"4733","DOI":"10.1128\/IAI.64.11.4733-4738.1996","article-title":"Balance of inflammatory cytokines related to severity and mortality of murine sepsis","volume":"64","author":"KR Walley","year":"1996","journal-title":"Infection and Immunity"},{"issue":"1","key":"ref123","doi-asserted-by":"crossref","first-page":"20","DOI":"10.4049\/jimmunol.124.1.20","article-title":"Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene","volume":"124","author":"A O'brien","year":"1980","journal-title":"The Journal of Immunology"},{"issue":"3","key":"ref124","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.182.3.655","article-title":"The Ity\/Lsh\/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene","volume":"182","author":"S Vidal","year":"1995","journal-title":"The Journal of Experimental 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Sund\u00e9n-Cullberg","year":"2005","journal-title":"Critical Care Medicine"},{"issue":"4","key":"ref128","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1097\/01.CCM.0000259534.68873.2A","article-title":"Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis*","volume":"35","author":"DC Angus","year":"2007","journal-title":"Critical Care Medicine"},{"issue":"1","key":"ref129","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.cca.2009.06.029","article-title":"TNF-\u03b1\/IL-10 ratio and C-reactive protein as markers of the inflammatory response in CAD-prone North Indian patients with acute myocardial infarction","volume":"408","author":"B Goswami","year":"2009","journal-title":"Clinica Chimica Acta"},{"issue":"1","key":"ref130","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.cyto.2007.02.023","article-title":"Tumour necrosis factor-alpha (TNF\u03b1) and interleukin-10 are crucial mediators in post-operative systemic inflammatory response and determine the occurrence of complications after major abdominal surgery","volume":"37","author":"I Dimopoulou","year":"2007","journal-title":"Cytokine"},{"issue":"2","key":"ref131","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1111\/j.1365-2249.1991.tb05636.x","article-title":"Low CD4\/CD8 T lymphocyte ratio in acute myocardial infarction","volume":"83","author":"H Syrj\u00e4l\u00e4","year":"1991","journal-title":"Clinical & Experimental Immunology"},{"issue":"1","key":"ref132","doi-asserted-by":"crossref","first-page":"e25","DOI":"10.1016\/j.jss.2011.10.006","article-title":"Preoperative CD4 count or CD4\/CD8 ratio as a useful indicator for postoperative sepsis in HIV-infected patients undergoing abdominal operations","volume":"174","author":"XJ Xia","year":"2012","journal-title":"Journal of Surgical Research"},{"issue":"6","key":"ref133","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.4049\/jimmunol.181.6.3733","article-title":"Macrophage polarization in bacterial infections","volume":"181","author":"M Benoit","year":"2008","journal-title":"The Journal of Immunology"},{"issue":"suppl 2","key":"ref134","first-page":"ii11","article-title":"Surviving the first hours in sepsis: getting the basics right (an intensivist&apos;s perspective)","volume":"66","author":"R Daniels","year":"2011","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"8","key":"ref135","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1097\/CCM.0000000000000330","article-title":"Empiric antibiotic treatment reduces mortality in severe sepsis and septic shock from the first hour: results from a guideline-based performance improvement program*","volume":"42","author":"R Ferrer","year":"2014","journal-title":"Critical Care Medicine"},{"issue":"9107","key":"ref136","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/S0140-6736(05)60602-2","article-title":"Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock","volume":"351","author":"E Abraham","year":"1998","journal-title":"The Lancet"},{"issue":"7","key":"ref137","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1097\/00003246-200107001-00037","article-title":"Anti-tumor necrosis factor therapy in sepsis: update on clinical trials and lessons learned","volume":"29","author":"K Reinhart","year":"2001","journal-title":"Critical Care Medicine"},{"issue":"11","key":"ref138","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1002\/eji.200737295","article-title":"Role of T cells in a murine model of Escherichia coli sepsis","volume":"37","author":"SM van Schaik","year":"2007","journal-title":"European Journal of Immunology"},{"key":"ref139","author":"JI Gallin","year":"1992"},{"issue":"12","key":"ref140","doi-asserted-by":"crossref","first-page":"7473","DOI":"10.4049\/jimmunol.0802831","article-title":"B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production","volume":"182","author":"Y Souwer","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"1","key":"ref141","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jiec.2010.01.009","article-title":"Kinetics of Salmonella typhimurium binding with antibody by immunoassays using a surface plasmon resonance biosensor","volume":"16","author":"KH Chung","year":"2010","journal-title":"Journal of Industrial and Engineering Chemistry"},{"issue":"8","key":"ref142","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1007\/s00134-007-0691-2","article-title":"High-mobility group box 1 protein plasma concentrations during septic shock","volume":"33","author":"S Gibot","year":"2007","journal-title":"Intensive Care Medicine"},{"issue":"12","key":"ref143","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jama.1995.03520360048038","article-title":"Efficacy and safety of monoclonal antibody to human tumor necrosis factor \u03b1 in patients with sepsis syndrome: a randomized, controlled, double-blind, multicenter clinical trial","volume":"273","author":"E Abraham","year":"1995","journal-title":"Jama"},{"issue":"9","key":"ref144","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00003246-199609000-00002","article-title":"INTERSEPT: an international, multicenter, placebo-controlled trial of monoclonal antibody to human tumor necrosis factor-alpha in patients with sepsis","volume":"24","author":"J Cohen","year":"1996","journal-title":"Critical Care Medicine"},{"issue":"9","key":"ref145","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1097\/00003246-200009001-00002","article-title":"Pathophysiologic basis of sepsis: considerations for future strategies of intervention","volume":"28","author":"MP Glauser","year":"2000","journal-title":"Critical Care Medicine"},{"issue":"2","key":"ref146","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis","volume":"348","author":"RS Hotchkiss","year":"2003","journal-title":"New England Journal of Medicine"},{"issue":"16","key":"ref147","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.2174\/138161209788453248","article-title":"Scientific and clinical challenges in sepsis","volume":"15","author":"L Ulloa","year":"2009","journal-title":"Current pharmaceutical design"},{"issue":"1","key":"ref148","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/vec.12272","article-title":"The role of antimicrobials in the treatment of sepsis and critical illness\u2010related bacterial infections: Examination of the evidence","volume":"25","author":"I 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