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insufficiency among adults following increased folic acid food fortification in Canada","volume":"93","author":"JG Ray","year":"2002","journal-title":"Can J Public Health"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1007\/BF03405255","article-title":"Long-term effects of folic acid fortification and B-vitamin supplementation on total folate, homocysteine, methylmalonic acid and cobalamin in older adults","volume":"99","author":"AA Garcia","year":"2008","journal-title":"Can J Public Health"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"363","DOI":"10.7326\/0003-4819-131-5-199909070-00008","article-title":"Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiologic evidence","volume":"131","author":"JW Eikelboom","year":"1999","journal-title":"Ann Intern Med"},{"key":"ref24","first-page":"251","article-title":"Plasma homocysteine levels are independently associated with alterations of large artery stiffness in men but not in women","volume":"12","author":"L Sheng","year":"2015","journal-title":"J Geriatr Cardiol"},{"key":"ref25","unstructured":"Canada Statistics. Vitamin D levels of Canadians, 2012 to 2013. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.statcan.gc.ca\/pub\/82-625-x\/2014001\/article\/14125-eng.htm\" xlink:type=\"simple\">http:\/\/www.statcan.gc.ca\/pub\/82-625-x\/2014001\/article\/14125-eng.htm<\/ext-link>. 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