{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T06:11:09Z","timestamp":1790316669362,"version":"4.1.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK62338"],"award-info":[{"award-number":["R01DK62338"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["16EIA26720006"],"award-info":[{"award-number":["16EIA26720006"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Office of China Postdoctoral Council","award":["International Postdoctoral Exchange Fellowship Program 2014"],"award-info":[{"award-number":["International Postdoctoral Exchange Fellowship Program 2014"]}]},{"name":"Lillian Goldman Charitable Trust"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161525","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T17:40:47Z","timestamp":1472146847000},"page":"e0161525","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["Regulation of Polycystin-1 Function by Calmodulin Binding"],"prefix":"10.1371","volume":"11","author":[{"given":"Nicholas","family":"Doerr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin R.","family":"Kipp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse J.","family":"Benza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Pletnev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengis S.","family":"Pavlov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Staruschenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashraf M.","family":"Mohieldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maki","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surya M.","family":"Nauli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Weimbs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/978-94-007-0265-3_16","article-title":"TRPP channels and polycystins","volume":"704","author":"A Hofherr","year":"2011","journal-title":"Adv Exp Med Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev.med.60.101707.125712","article-title":"Polycystic kidney disease","volume":"60","author":"PC Harris","year":"2009","journal-title":"Annu Rev Med"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"382","DOI":"10.7326\/0003-4819-159-6-201309170-00004","article-title":"Cost-effectiveness of tolvaptan in autosomal dominant polycystic kidney disease","volume":"159","author":"KF Erickson","year":"2013","journal-title":"Ann Intern Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1007\/978-3-642-54215-2_27","article-title":"The TRPP subfamily and polycystin-1 proteins","volume":"222","author":"M Semmo","year":"2014","journal-title":"Handb Exp Pharmacol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"SM Nauli","year":"2003","journal-title":"Nat Genet"},{"issue":"13","key":"ref6","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1074\/jbc.M110483200","article-title":"Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2","volume":"277","author":"P Delmas","year":"2002","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","article-title":"The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro","volume":"251","author":"SC Parnell","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1096\/fj.03-0319fje","article-title":"Gating of the polycystin ion channel signaling complex in neurons and kidney cells","volume":"18","author":"P Delmas","year":"2004","journal-title":"Faseb Journal"},{"issue":"22","key":"ref9","doi-asserted-by":"crossref","first-page":"19566","DOI":"10.1074\/jbc.M201875200","article-title":"Polycystin-1 activation of c-Jun N-terminal kinase and AP-1 is mediated by heterotrimeric G proteins","volume":"277","author":"SC Parnell","year":"2002","journal-title":"J Biol Chem"},{"issue":"19","key":"ref10","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1073\/pnas.1103816108","article-title":"Polycystin-1 regulates STAT activity by a dual mechanism","volume":"108","author":"JJ Talbot","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref11","article-title":"The Cleaved Cytoplasmic Tail of Polycystin-1 Regulates Src-Dependent STAT3 Activation","author":"JJ Talbot","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.devcel.2005.12.005","article-title":"Polycystin-1, STAT6, and P100 function in a pathway that transduces ciliary mechanosensation and is activated in polycystic kidney disease","volume":"10","author":"SH Low","year":"2006","journal-title":"Developmental cell"},{"issue":"44","key":"ref13","doi-asserted-by":"crossref","first-page":"18067","DOI":"10.1073\/pnas.1111966108","article-title":"Signal transducer and activator of transcription-6 (STAT6) inhibition suppresses renal cyst growth in polycystic kidney disease","volume":"108","author":"EE Olsan","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"e9239","DOI":"10.1371\/journal.pone.0009239","article-title":"Carboxy terminal tail of polycystin-1 regulates localization of TSC2 to repress mTOR","volume":"5","author":"R Dere","year":"2010","journal-title":"PLoS One"},{"issue":"14","key":"ref15","doi-asserted-by":"crossref","first-page":"5466","DOI":"10.1073\/pnas.0509694103","article-title":"The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease","volume":"103","author":"JM Shillingford","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1074\/jbc.274.8.4947","article-title":"The polycystic kidney disease 1 gene product modulates Wnt signaling","volume":"274","author":"E Kim","year":"1999","journal-title":"J Biol Chem"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.devcel.2011.10.028","article-title":"The gamma-secretase cleavage product of polycystin-1 regulates TCF and CHOP-mediated transcriptional activation through a p300-dependent mechanism","volume":"22","author":"D Merrick","year":"2012","journal-title":"Developmental cell"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"6013","DOI":"10.1074\/jbc.273.11.6013","article-title":"The polycystic kidney disease 1 gene product mediates protein kinase C alpha-dependent and c-Jun N-terminal kinase-dependent activation of the transcription factor AP-1","volume":"273","author":"T Arnould","year":"1998","journal-title":"J Biol Chem"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ki.2015.207","article-title":"A polycystin-centric view of cyst formation and disease: the polycystins revisited","volume":"88","author":"AC Ong","year":"2015","journal-title":"Kidney Int"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"e12305","DOI":"10.1371\/journal.pone.0012305","article-title":"Identification of a polycystin-1 cleavage product, P100, that regulates store operated Ca entry through interactions with STIM1","volume":"5","author":"OM Woodward","year":"2010","journal-title":"PLoS One"},{"issue":"20","key":"ref21","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1093\/hmg\/ddn208","article-title":"Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling","volume":"17","author":"M Lal","year":"2008","journal-title":"Hum Mol Genet"},{"issue":"26","key":"ref22","doi-asserted-by":"crossref","first-page":"16981","DOI":"10.1073\/pnas.252484899","article-title":"Cleavage of polycystin-1 requires the receptor for egg jelly domain and is disrupted by human autosomal-dominant polycystic kidney disease 1-associated mutations","volume":"99","author":"F Qian","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1681\/ASN.V124834","article-title":"Polycystin: new aspects of structure, function, and regulation","volume":"12","author":"PD Wilson","year":"2001","journal-title":"J Am Soc Nephrol"},{"issue":"6815","key":"ref24","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents","volume":"408","author":"K Hanaoka","year":"2000","journal-title":"Nature"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","article-title":"PKD1 interacts with PKD2 through a probable coiled-coil domain","volume":"16","author":"F Qian","year":"1997","journal-title":"Nat Genet"},{"issue":"13","key":"ref26","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"L Tsiokas","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI21753","article-title":"Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus","volume":"114","author":"V Chauvet","year":"2004","journal-title":"J Clin Invest"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/emboj\/18.2.297","article-title":"The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease","volume":"18","author":"M Bycroft","year":"1999","journal-title":"EMBO J"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s00894-007-0201-z","article-title":"Rational proteomics of PKD1. I. Modeling the three dimensional structure and ligand specificity of the C_lectin binding domain of Polycystin-1","volume":"13","author":"V Pletnev","year":"2007","journal-title":"J Mol Model"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"HM Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0969-2126(96)00006-8","article-title":"Structure of the regulatory domain of scallop myosin at 2 A resolution: implications for regulation","volume":"4","author":"A Houdusse","year":"1996","journal-title":"Structure"},{"issue":"6469","key":"ref32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/368306a0","article-title":"Structure of the regulatory domain of scallop myosin at 2.8 A resolution","volume":"368","author":"X Xie","year":"1994","journal-title":"Nature"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/1471-2164-7-183","article-title":"Thirteen is enough: the myosins of Dictyostelium discoideum and their light chains","volume":"7","author":"M Kollmar","year":"2006","journal-title":"BMC Genomics"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1023\/A:1011320027914","article-title":"Calmodulin target database","volume":"1","author":"KL Yap","year":"2000","journal-title":"J Struct Funct Genomics"},{"key":"ref35","unstructured":"Calmodulin Target Database [Internet]. 2002 [cited 1\/2\/2006]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/calcium.uhnres.utoronto.ca\/ctdb\/ctdb\/home.html\" xlink:type=\"simple\">http:\/\/calcium.uhnres.utoronto.ca\/ctdb\/ctdb\/home.html<\/ext-link>."},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1096\/fasebj.11.5.9141499","article-title":"Sequence motifs for calmodulin recognition","volume":"11","author":"AR Rhoads","year":"1997","journal-title":"Faseb J"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1681\/ASN.2006121387","article-title":"Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease","volume":"18","author":"S Rossetti","year":"2007","journal-title":"J Am Soc Nephrol"},{"issue":"52","key":"ref38","doi-asserted-by":"crossref","first-page":"36431","DOI":"10.1074\/jbc.M109.068916","article-title":"Polycystin-1 interacts with inositol 1,4,5-trisphosphate receptor to modulate intracellular Ca2+ signaling with implications for polycystic kidney disease","volume":"284","author":"Y Li","year":"2009","journal-title":"J Biol Chem"},{"issue":"23","key":"ref39","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex","volume":"277","author":"LJ Newby","year":"2002","journal-title":"J Biol Chem"},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1128\/MCB.01259-08","article-title":"Polycystin-1 regulates extracellular signal-regulated kinase-dependent phosphorylation of tuberin to control cell size through mTOR and its downstream effectors S6K and 4EBP1","volume":"29","author":"G Distefano","year":"2009","journal-title":"Mol Cell Biol"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nm.3092","article-title":"Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy","volume":"19","author":"I Rowe","year":"2013","journal-title":"Nat Med"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1161\/CIRCRESAHA.108.192765","article-title":"Ciliary polycystin-2 is a mechanosensitive calcium channel involved in nitric oxide signaling cascades","volume":"104","author":"WA AbouAlaiwi","year":"2009","journal-title":"Circ Res"},{"issue":"52","key":"ref43","doi-asserted-by":"crossref","first-page":"21462","DOI":"10.1073\/pnas.1216830110","article-title":"G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease","volume":"109","author":"M Kwon","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/ng1520","article-title":"Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin","volume":"37","author":"EA Otto","year":"2005","journal-title":"Nat Genet"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00439-002-0696-4","article-title":"The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin","volume":"110","author":"D Morgan","year":"2002","journal-title":"Hum Genet"},{"issue":"9","key":"ref46","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1242\/dev.00407","article-title":"The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia","volume":"130","author":"D Watanabe","year":"2003","journal-title":"Development"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.yexcr.2013.10.012","article-title":"Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations","volume":"320","author":"H Kim","year":"2014","journal-title":"Exp Cell Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/BF01076559","article-title":"PEST sequences in calmodulin-binding proteins","volume":"149\u2013150","author":"JA Barnes","year":"1995","journal-title":"Mol Cell Biochem"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"F521","DOI":"10.1152\/ajprenal.00355.2004","article-title":"Expression of polycystin-1 enhances endoplasmic reticulum calcium uptake and decreases capacitative calcium entry in ATP-stimulated MDCK cells","volume":"289","author":"KM Hooper","year":"2005","journal-title":"American journal of physiology Renal physiology"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1159\/000330080","article-title":"Polycystin-1, 2, and STIM1 interact with IP(3)R to modulate ER Ca release through the PI3K\/Akt pathway","volume":"27","author":"NG Santoso","year":"2011","journal-title":"Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology"},{"issue":"29","key":"ref51","doi-asserted-by":"crossref","first-page":"26541","DOI":"10.1074\/jbc.M302590200","article-title":"Ca2+-dependent potentiation of the nonselective cation channel TRPV4 is mediated by a C-terminal calmodulin binding site","volume":"278","author":"R Strotmann","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"6423","DOI":"10.1074\/jbc.M411089200","article-title":"Regulation of the Ca2+ sensitivity of the nonselective cation channel TRPM4","volume":"280","author":"B Nilius","year":"2005","journal-title":"J Biol Chem"},{"issue":"14","key":"ref53","doi-asserted-by":"crossref","first-page":"9076","DOI":"10.1074\/jbc.M510422200","article-title":"Regulation of the transient receptor potential channel TRPM2 by the Ca2+ sensor calmodulin","volume":"281","author":"Q Tong","year":"2006","journal-title":"J Biol Chem"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0143416002001550","article-title":"Ca(2+)-calmodulin regulates receptor-operated Ca(2+) entry activity of TRPC6 in HEK-293 cells","volume":"32","author":"G Boulay","year":"2002","journal-title":"Cell Calcium"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S1097-2765(02)00506-3","article-title":"Calmodulin regulates Ca(2+)-dependent feedback inhibition of store-operated Ca(2+) influx by interaction with a site in the C terminus of TrpC1","volume":"9","author":"BB Singh","year":"2002","journal-title":"Mol Cell"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1073\/pnas.051632698","article-title":"Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain","volume":"98","author":"Z Zhang","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"13","key":"ref57","doi-asserted-by":"crossref","first-page":"8002","DOI":"10.1073\/pnas.1337252100","article-title":"Structural determinant of TRPV1 desensitization interacts with calmodulin","volume":"100","author":"M Numazaki","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"14","key":"ref58","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1128\/MCB.01319-10","article-title":"Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone","volume":"31","author":"T de Groot","year":"2011","journal-title":"Mol Cell Biol"},{"issue":"Pt 1","key":"ref59","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.2006.118661","article-title":"Dynamic but not constitutive association of calmodulin with rat TRPV6 channels enables fine tuning of Ca2+-dependent inactivation","volume":"577","author":"I Derler","year":"2006","journal-title":"J Physiol"},{"key":"ref60","article-title":"2-Deoxy-d-Glucose Ameliorates PKD Progression","author":"M Chiaravalli","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"38","key":"ref61","doi-asserted-by":"crossref","first-page":"36786","DOI":"10.1074\/jbc.M306536200","article-title":"Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells","volume":"278","author":"DH Grimm","year":"2003","journal-title":"J Biol Chem"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1083\/jcb.200603132","article-title":"Apical targeting of syntaxin 3 is essential for epithelial cell polarity","volume":"173","author":"N Sharma","year":"2006","journal-title":"J Cell Biol"},{"issue":"Pt 12 Pt 1","key":"ref63","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: model-building tools for molecular graphics","volume":"60","author":"P Emsley","year":"2004","journal-title":"Acta crystallographica Section D, Biological crystallography"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1107\/S0021889878013308","article-title":"A graphics model building and refinement system for macromolecules","volume":"11","author":"TA Jones","year":"1978","journal-title":"Journal of Applied Crystallography"},{"issue":"24","key":"ref65","doi-asserted-by":"crossref","first-page":"25582","DOI":"10.1074\/jbc.M402829200","article-title":"The N-terminal extracellular domain is required for polycystin-1-dependent channel activity","volume":"279","author":"V Babich","year":"2004","journal-title":"J Biol Chem"},{"issue":"9","key":"ref66","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1161\/CIRCULATIONAHA.107.710111","article-title":"Endothelial cilia are fluid shear sensors that regulate calcium signaling and nitric oxide production through polycystin-1","volume":"117","author":"SM Nauli","year":"2008","journal-title":"Circulation"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161525","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T01:43:57Z","timestamp":1657158237000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161525"}},"subtitle":[],"editor":[{"given":"Stuart E","family":"Dryer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":66,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161525","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}