{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:24:32Z","timestamp":1774484672801,"version":"3.50.1"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161715","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T17:33:45Z","timestamp":1473874425000},"page":"e0161715","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Receptor for Advanced Glycation End Products (RAGE) Is Associated with Persistent Atrial Fibrillation"],"prefix":"10.1371","volume":"11","author":[{"given":"Terase F.","family":"Lancefield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila K.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melanie","family":"Freeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Velkoska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bryan","family":"Wai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piyush M.","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Horrigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Farouque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise M.","family":"Burrell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1001\/jama.285.18.2370","article-title":"Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study","volume":"285","author":"AS Go","year":"2001","journal-title":"JAMA"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.jacc.2011.05.061","article-title":"Structural abnormalities in atrial walls are associated with presence and persistency of atrial fibrillation but not with age","volume":"58","author":"PG Platonov","year":"2011","journal-title":"J Am Coll Cardiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.amjcard.2008.05.038","article-title":"Increased inflammatory cell infiltration in the atrial myocardium of patients with atrial fibrillation","volume":"102","author":"MC Chen","year":"2008","journal-title":"Am J Cardiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"16R","DOI":"10.1093\/glycob\/cwi053","article-title":"Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation","volume":"15","author":"R Ramasamy","year":"2005","journal-title":"Glycobiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1172\/JCI119180","article-title":"Increased accumulation of the glycoxidation product N(epsilon)-(carboxymethyl)lysine in human tissues in diabetes and aging","volume":"99","author":"ED Schleicher","year":"1997","journal-title":"J Clin Invest"},{"key":"ref6","first-page":"1699","article-title":"Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues","volume":"143","author":"J Brett","year":"1993","journal-title":"Am J Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","article-title":"Diabetes-associated sustained activation of the transcription factor nuclear factor-kappaB","volume":"50","author":"A Bierhaus","year":"2001","journal-title":"Diabetes"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1172\/JCI118175","article-title":"Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes","volume":"96","author":"AM Schmidt","year":"1995","journal-title":"J Clin Invest"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1042\/bj20021371","article-title":"Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury","volume":"370","author":"H Yonekura","year":"2003","journal-title":"Biochem J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ijcard.2012.05.042","article-title":"Decreased serum endogenous secretory receptor for advanced glycation endproducts and increased cleaved receptor for advanced glycation endproducts levels in patients with atrial fibrillation","volume":"158","author":"D Zhao","year":"2012","journal-title":"Int J Cardiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ijcard.2011.05.072","article-title":"Evidence for a role of advanced glycation end products in atrial fibrillation","volume":"157","author":"S Raposeiras-Roubin","year":"2012","journal-title":"Int J Cardiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ijcard.2012.08.055","article-title":"Decreased endogenous secretory RAGE and increased hsCRP levels in serum are associated with atrial fibrillation in patients undergoing coronary angiography","volume":"166","author":"X Yan","year":"2013","journal-title":"Int J Cardiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.hrthm.2011.12.016","article-title":"2012 HRS\/EHRA\/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design: a report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation","volume":"9","author":"H Calkins","year":"2012","journal-title":"Heart Rhythm"},{"key":"ref14","first-page":"2114","article-title":"American College of Cardiology key data elements and definitions for measuring the clinical management and outcomes of patients with acute coronary syndromes. A report of the American College of Cardiology Task Force on Clinical Data Standards (Acute Coronary Syndromes Writing Committee)","volume":"38","author":"CP Cannon","year":"2001","journal-title":"J Am Coll Cardiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.amjcard.2011.03.004","article-title":"Meta-analysis of cohort and case-control studies of type 2 diabetes mellitus and risk of atrial fibrillation","volume":"108","author":"RR Huxley","year":"2011","journal-title":"Am J Cardiol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1161\/CIRCRESAHA.114.303211","article-title":"The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms","volume":"114","author":"J Andrade","year":"2014","journal-title":"Circ Res"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.2337\/db11-0291","article-title":"Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial","volume":"60","author":"HM Colhoun","year":"2011","journal-title":"Diabetes"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/ndt\/gfm050","article-title":"Receptor for advanced glycation end products\u2014soluble form and gene polymorphisms in chronic haemodialysis patients","volume":"22","author":"M Kalousova","year":"2007","journal-title":"Nephrol Dial Transplant"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.atherosclerosis.2008.12.045","article-title":"Increased glycated albumin and decreased esRAGE levels are related to angiographic severity and extent of coronary artery disease in patients with type 2 diabetes","volume":"206","author":"L Lu","year":"2009","journal-title":"Atherosclerosis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.2337\/diacare.28.11.2716","article-title":"Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications","volume":"28","author":"N Katakami","year":"2005","journal-title":"Diabetes Care"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/eurjhf\/hfq231","article-title":"Increased serum high-mobility group box-1 and cleaved receptor for advanced glycation endproducts levels and decreased endogenous secretory receptor for advanced glycation endproducts levels in diabetic and non-diabetic patients with heart failure","volume":"13","author":"LJ Wang","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.atherosclerosis.2011.01.024","article-title":"Association of serum soluble receptor for advanced glycation end-products with subclinical cerebrovascular disease: the Northern Manhattan Study (NOMAS)","volume":"216","author":"BI Hudson","year":"2011","journal-title":"Atherosclerosis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2337\/db12-1528","article-title":"sRAGE and risk of diabetes, cardiovascular disease and death","volume":"62","author":"E Selvin","year":"2013","journal-title":"Diabetes"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.arcmed.2009.06.008","article-title":"RAGE gene polymorphisms are associated with circulating levels of endogenous secretory RAGE but not with coronary artery disease in Chinese patients with type 2 diabetes mellitus","volume":"40","author":"WH Peng","year":"2009","journal-title":"Arch Med Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.metabol.2006.09.013","article-title":"Association of the Gly82Ser polymorphism in the receptor for advanced glycation end products (RAGE) gene with circulating levels of soluble RAGE and inflammatory markers in nondiabetic and nonobese Koreans","volume":"56","author":"Y Jang","year":"2007","journal-title":"Metabolism"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/jhg.2010.85","article-title":"Association of polymorphisms in the RAGE gene with serum CRP levels and coronary artery disease in the Chinese Han population","volume":"55","author":"J Gao","year":"2010","journal-title":"J Hum Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/sj.gene.6363861","article-title":"RAGE and arthritis: the G82S polymorphism amplifies the inflammatory response","volume":"3","author":"MA Hofmann","year":"2002","journal-title":"Genes Immun"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1093\/eurjhf\/hfq117","article-title":"Soluble receptor of advanced glycation end products levels are related to ischaemic aetiology and extent of coronary disease in chronic heart failure patients, independent of advanced glycation end products levels: New Roles for Soluble RAGE","volume":"12","author":"S Raposeiras-Roubin","year":"2010","journal-title":"Eur J Heart Fail"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cardfail.2007.10.019","article-title":"Soluble Receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure","volume":"14","author":"Y Koyama","year":"2008","journal-title":"J Card Fail"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.ajpath.2015.04.018","article-title":"Atrial fibrillation coincides with the advanced glycation end product N(epsilon)-(carboxymethyl)lysine in the atrium","volume":"185","author":"MP Begieneman","year":"2015","journal-title":"Am J Pathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"E323","DOI":"10.1152\/ajpendo.00024.2008","article-title":"Cardiac inflammation associated with a Western diet is mediated via activation of RAGE by AGEs","volume":"295","author":"C Tikellis","year":"2008","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1080\/14017430802651803","article-title":"Activated nuclear factor-kappaB and increased tumor necrosis factor-alpha in atrial tissue of atrial fibrillation","volume":"43","author":"YC Qu","year":"2009","journal-title":"Scand Cardiovasc J"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.mvr.2005.10.002","article-title":"Telmisartan inhibits expression of a receptor for advanced glycation end products (RAGE) in angiotensin-II-exposed endothelial cells and decreases serum levels of soluble RAGE in patients with essential hypertension","volume":"70","author":"K Nakamura","year":"2005","journal-title":"Microvasc Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1161\/01.RES.0000065620.39919.20","article-title":"A breaker of advanced glycation end products attenuates diabetes-induced myocardial structural changes","volume":"92","author":"R Candido","year":"2003","journal-title":"Circ Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.mvr.2007.09.004","article-title":"Serum levels of soluble form of receptor for advanced glycation end products (sRAGE) are positively associated with circulating AGEs and soluble form of VCAM-1 in patients with type 2 diabetes","volume":"76","author":"K Nakamura","year":"2008","journal-title":"Microvasc Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1111\/j.1540-8167.2006.00528.x","article-title":"What are arrhythmogenic substrates in diabetic rat atria?","volume":"17","author":"T Kato","year":"2006","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1540-8167.2007.01037.x","article-title":"AGEs-RAGE system mediates atrial structural remodeling in the diabetic rat","volume":"19","author":"T Kato","year":"2008","journal-title":"J Cardiovasc Electrophysiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3760\/cma.j.issn.0366-6999.2010.05.017","article-title":"Intra-coronary administration of soluble receptor for advanced glycation end-products attenuates cardiac remodeling with decreased myocardial transforming growth factor-beta1 expression and fibrosis in minipigs with ischemia-reperfusion injury","volume":"123","author":"L Lu","year":"2010","journal-title":"Chin Med J"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2010.01.043","article-title":"Prevention of atrial fibrillation by Renin-Angiotensin system inhibition a meta-analysis","volume":"55","author":"MP Schneider","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1536\/ihj.14-107","article-title":"Beneficial effects of pioglitazone on retardation of persistent atrial fibrillation progression in diabetes mellitus patients","volume":"55","author":"B Liu","year":"2014","journal-title":"Int Heart J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1517\/13543784.2015.1001490","article-title":"Receptor for advanced glycation endproduct modulators: a new therapeutic target in Alzheimer&apos;s disease","volume":"24","author":"D Walker","year":"2015","journal-title":"Expert Opin Investig Drugs"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T10:40:11Z","timestamp":1718793611000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161715"}},"subtitle":[],"editor":[{"given":"Tim D","family":"Oury","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,14]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161715","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,14]]}}}