{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T02:59:20Z","timestamp":1791946760392,"version":"4.3.4"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161759","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T13:40:59Z","timestamp":1472823659000},"page":"e0161759","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":139,"title":["Impaired Tight Junctions in Atopic Dermatitis Skin and in a Skin-Equivalent Model Treated with Interleukin-17"],"prefix":"10.1371","volume":"11","author":[{"given":"Takuo","family":"Yuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Tobiishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Kusaka-Kikushima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Ota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Tokura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/35067088","article-title":"Multifunctional strands in tight junctions","volume":"2","author":"S Tsukita","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"a002907","DOI":"10.1101\/cshperspect.a002907","article-title":"Molecular basis of the core structure of tight junctions","volume":"2","author":"M Furuse","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature05659","article-title":"Scratching the surface of skin development","volume":"445","author":"E Fuchs","year":"2007","journal-title":"Nature"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1078\/0171-9335-00244","article-title":"Organization and formation of the tight junction system in human epidermis and cultured keratinocytes","volume":"81","author":"JM Brandner","year":"2002","journal-title":"Eur J Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1083\/jcb.200110122","article-title":"Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice","volume":"156","author":"M Furuse","year":"2002","journal-title":"J Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/jid.2010.385","article-title":"Characterization of tight junctions and their disruption by UVB in human epidermis and cultured keratinocytes","volume":"131","author":"T Yuki","year":"2011","journal-title":"J Invest Dermatol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.1084\/jem.20091527","article-title":"External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers","volume":"206","author":"A Kubo","year":"2009","journal-title":"J Exp Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1084\/jem.20111718","article-title":"Langerhans cell antigen capture through tight junctions confers preemptive immunity in experimental staphylococcal scalded skin syndrome","volume":"208","author":"T Ouchi","year":"2011","journal-title":"J Exp Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1038\/jid.2012.437","article-title":"Activation of epidermal toll-like receptor 2 enhances tight junction function: implications for atopic dermatitis and skin barrier repair","volume":"133","author":"IH Kuo","year":"2013","journal-title":"J Invest Dermatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3230","DOI":"10.4049\/jimmunol.1100058","article-title":"Activation of TLR2 enhances tight junction barrier in epidermal keratinocytes","volume":"187","author":"T Yuki","year":"2011","journal-title":"J Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jdermsci.2012.11.595","article-title":"Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing","volume":"69","author":"T Yuki","year":"2013","journal-title":"J Dermatol Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jdermsci.2013.01.002","article-title":"Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice","volume":"70","author":"T Sugawara","year":"2013","journal-title":"J Dermatol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.jaci.2010.10.018","article-title":"Tight junction defects in patients with atopic dermatitis","volume":"127","author":"A De Benedetto","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2353\/ajpath.2009.080973","article-title":"Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines","volume":"175","author":"N Kirschner","year":"2009","journal-title":"Am J Pathol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/j.1365-2133.2006.07642.x","article-title":"Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis","volume":"156","author":"S Peltonen","year":"2007","journal-title":"Br J Dermatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/ng1767","article-title":"Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis","volume":"38","author":"CN Palmer","year":"2006","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jaci.2007.04.031","article-title":"Cytokine modulation of atopic dermatitis filaggrin skin expression","volume":"120","author":"MD Howell","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1016\/j.jaci.2012.01.068","article-title":"Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice","volume":"129","author":"H Kawasaki","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/jid.2011.393","article-title":"One remarkable molecule: filaggrin","volume":"132","author":"SJ Brown","year":"2012","journal-title":"J Invest Dermatol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1242\/jcs.033969","article-title":"Filaggrin in the frontline: role in skin barrier function and disease","volume":"122","author":"A Sandilands","year":"2009","journal-title":"J Cell Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2500\/aap.2006.27.2887","article-title":"Immune dysregulation in atopic dermatitis","volume":"27","author":"M Miraglia del Giudice","year":"2006","journal-title":"Allergy Asthma Proc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jdermsci.2012.04.004","article-title":"A group of atopic dermatitis without IgE elevation or barrier impairment shows a high Th1 frequency: possible immunological state of the intrinsic type","volume":"67","author":"R Kabashima-Kubo","year":"2012","journal-title":"J Dermatol Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2013.04.046","article-title":"Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis","volume":"132","author":"M Suarez-Farinas","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1600-0625.2006.00539.x","article-title":"Tight junction proteins in keratinocytes: localization and contribution to barrier function","volume":"16","author":"T Yuki","year":"2007","journal-title":"Exp Dermatol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1111\/all.12184","article-title":"Immunology of atopic eczema: overcoming the Th1\/Th2 paradigm","volume":"68","author":"K Eyerich","year":"2013","journal-title":"Allergy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1038\/jid.2008.111","article-title":"Possible pathogenic role of Th17 cells for atopic dermatitis","volume":"128","author":"C Koga","year":"2008","journal-title":"J Invest Dermatol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1083\/jcb.147.1.195","article-title":"Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier","volume":"147","author":"N Sonoda","year":"1999","journal-title":"J Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1600-0625.2011.01412.x","article-title":"IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion","volume":"21","author":"D Gutowska-Owsiak","year":"2012","journal-title":"Exp Dermatol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cyto.2014.03.003","article-title":"An innovative three-dimensional model of normal human skin to study the proinflammatory psoriatic effects of tumor necrosis factor-alpha and interleukin-17","volume":"68","author":"E Donetti","year":"2014","journal-title":"Cytokine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2004.07.022","article-title":"Claudin-1 gene mutations in neonatal sclerosing cholangitis associated with ichthyosis: a tight junction disease","volume":"127","author":"S Hadj-Rabia","year":"2004","journal-title":"Gastroenterology"},{"issue":"Suppl 78","key":"ref31","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1398-9995.2004.00569.x","article-title":"Consensus guidelines in diagnosis and treatment of atopic dermatitis","volume":"59","author":"LF Eichenfield","year":"2004","journal-title":"Allergy"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/jid.2012.507","article-title":"Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes","volume":"133","author":"N Kirschner","year":"2013","journal-title":"J Invest Dermatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4081\/dr.2009.e1","article-title":"Tight junctions in Hailey-Hailey and Darier&apos;s diseases","volume":"1","author":"L Raiko","year":"2009","journal-title":"Dermatol Reports"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1111\/j.1365-2133.2004.06029.x","article-title":"Tight junction-associated proteins (occludin, ZO-1, claudin-1, claudin-4) in squamous cell carcinoma and Bowen&apos;s disease","volume":"151","author":"K Morita","year":"2004","journal-title":"Br J Dermatol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s004030100221","article-title":"Altered expression of occludin and tight junction formation in psoriasis","volume":"293","author":"Y Yoshida","year":"2001","journal-title":"Arch Dermatol Res"},{"key":"ref36","first-page":"222","article-title":"Mammalian occludin in epithelial cells: its expression and subcellular distribution","volume":"73","author":"M Saitou","year":"1997","journal-title":"Eur J Cell Biol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1046\/j.1523-1747.2002.01774.x","article-title":"Molecular architecture of tight junctions of periderm differs from that of the maculae occludentes of epidermis","volume":"118","author":"K Morita","year":"2002","journal-title":"J Invest Dermatol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.0022-202X.2004.22317.x","article-title":"Relationship between NMF (lactate and potassium) content and the physical properties of the stratum corneum in healthy subjects","volume":"122","author":"N Nakagawa","year":"2004","journal-title":"J Invest Dermatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161759","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:26:33Z","timestamp":1588962393000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161759"}},"subtitle":[],"editor":[{"given":"Michael","family":"Koval","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,2]]},"references-count":38,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161759","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,2]]}}}