{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:23:01Z","timestamp":1790518981943,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","award":["UMR7339"],"award-info":[{"award-number":["UMR7339"]}],"id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health (US)","doi-asserted-by":"crossref","award":["R01CA113796, R01CA158467, R01CA138231"],"award-info":[{"award-number":["R01CA113796, R01CA158467, R01CA138231"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161803","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T17:45:03Z","timestamp":1472147103000},"page":"e0161803","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Expression of Cell-Surface Marker ABCB5 Causes Characteristic Modifications of Glucose, Amino Acid and Phospholipid Metabolism in the G3361 Melanoma-Initiating Cell Line"],"prefix":"10.1371","volume":"11","author":[{"given":"Norbert W.","family":"Lutz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pallavi","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Cozzone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus H.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature06489","article-title":"Identification of cells initiating human melanomas","volume":"451","author":"T Schatton","year":"2008","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1158\/0008-5472.CAN-14-0582","article-title":"ABCB5 maintains melanoma-initiating cells through a proinflammatory cytokine signaling circuit","volume":"74","author":"BJ Wilson","year":"2014","journal-title":"Cancer Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/0008-5472.CAN-10-3220","article-title":"Cancer stem cell niche: the place to be","volume":"71","author":"T Borovski","year":"2011","journal-title":"Cancer Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"23757","DOI":"10.1016\/S0021-9258(17)31580-6","article-title":"Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1","volume":"269","author":"GL Semenza","year":"1994","journal-title":"J Biol Chem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1158\/0008-5472.CAN-07-2678","article-title":"Hypoxia regulates choline kinase expression through hypoxia-inducible factor-1 alpha signaling in a human prostate cancer model","volume":"68","author":"K Glunde","year":"2008","journal-title":"Cancer Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jconrel.2011.03.032","article-title":"Multi-modal strategies for overcoming tumor drug resistance: hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology","volume":"155","author":"L Milane","year":"2011","journal-title":"J Control Release"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/cdd.2013.131","article-title":"Metabolic regulation of cancer cell side population by glucose through activation of the Akt pathway","volume":"21","author":"PP Liu","year":"2014","journal-title":"Cell Death Differ"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/stem.1273","article-title":"Effective elimination of cancer stem cells by a novel drug combination strategy","volume":"31","author":"S Yuan","year":"2013","journal-title":"Stem Cells"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1336","DOI":"10.1038\/cddis.2014.285","article-title":"Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment","volume":"5","author":"D Ciavardelli","year":"2014","journal-title":"Cell Death Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"250","DOI":"10.18632\/genesandcancer.23","article-title":"CD133-positive cancer stem cells from colo205 human colon adenocarcinoma cell line show resitance to chemitherapy and display a specific metabolomic prifile","volume":"5","author":"V Zangiacomi","year":"2014","journal-title":"Genes Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2014.03.003","article-title":"Targeting lactate dehydrogenase\u2014a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells","volume":"19","author":"H Xie","year":"2014","journal-title":"Cell Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s00401-013-1173-y","article-title":"Hypoxia and oxygenation induce a metabolic switch between pentose phosphate pathway and glycolysis in glioma stem-like cells","volume":"126","author":"A Kathagen","year":"2013","journal-title":"Acta Neuropathol"},{"issue":"38","key":"ref13","doi-asserted-by":"crossref","first-page":"16062","DOI":"10.1073\/pnas.1106704108","article-title":"Metabolic state of glioma stem cells and nontumorigenic cells","volume":"108","author":"E Vlashi","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1007\/s10334-005-0107-7","article-title":"Investigation of multidrug resistance in cultured human renal cell carcinoma cells by 31P-NMR spectroscopy and treatment survival assays","volume":"18","author":"NW Lutz","year":"2005","journal-title":"MAGMA"},{"key":"ref15","first-page":"1638","article-title":"The multidrug resistance phenotype: 31P nuclear magnetic resonance characterization and 2-deoxyglucose toxicity","volume":"51","author":"O Kaplan","year":"1991","journal-title":"Cancer Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00001813-199806000-00012","article-title":"Characterization of multidrug resistance and monitoring of tumor response by combined 31P and 1H nuclear magnetic resonance spectroscopic analysis","volume":"9","author":"PV Venkatesan","year":"1998","journal-title":"Anticancer Drugs"},{"key":"ref17","first-page":"4087","article-title":"Differences in phosphate metabolite levels in drug-sensitive and -resistant human breast cancer cell lines determined by 31P magnetic resonance spectroscopy","volume":"46","author":"JS Cohen","year":"1986","journal-title":"Cancer Res"},{"key":"ref18","first-page":"e51829","article-title":"Metabolomic analysis of rat brain by high resolution nuclear magnetic resonance spectroscopy of tissue extracts","volume":"91","author":"NW Lutz","year":"2014","journal-title":"J Vis Exp"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1021\/ac100515y","article-title":"Multiparametric optimization of (31)P NMR spectroscopic analysis of phospholipids in crude tissue extracts. 2. Line width and spectral resolution","volume":"82","author":"NW Lutz","year":"2010","journal-title":"Anal Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1021\/ac100514n","article-title":"Multiparametric optimization of (31)P NMR spectroscopic analysis of phospholipids in crude tissue extracts. 1. Chemical shift and signal separation","volume":"82","author":"NW Lutz","year":"2010","journal-title":"Anal Chem"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"e157","DOI":"10.1371\/journal.pone.0000157","article-title":"Metabolic fingerprints of altered brain growth, osmoregulation and neurotransmission in a Rett syndrome model","volume":"2","author":"A Viola","year":"2007","journal-title":"PLOS ONE"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1080\/01621459.1967.10482916","article-title":"The Kolmogorov-Smirnov test for normality with mean and variance unknown","volume":"62","author":"HW Lilliefors","year":"1967","journal-title":"J Amer Stat Assn"},{"key":"ref23","article-title":"Biometry","author":"RR Sokal","year":"1995"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1126\/science.1160809","article-title":"Understanding the Warburg effect: the metabolic requirements of cell proliferation","volume":"324","author":"MG Vander Heiden","year":"2009","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1038\/srep04927","article-title":"Beyond Warburg effect\u2014dual metabolic nature of cancer cells","volume":"4","author":"J Xie","year":"2014","journal-title":"Sci Rep"},{"key":"ref26","first-page":"250","article-title":"Recombinant human interleukin (IL)-1 beta-mediated regulation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) stabilization, nuclear translocation and activation requires an antioxidant\/reactive oxygen species (ROS)-sensitive mechanism","volume":"13","author":"JJ Haddad","year":"2002","journal-title":"Eur Cytokine Netw"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.2174\/138955709788922610","article-title":"HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms","volume":"9","author":"A Marin-Hernandez","year":"2009","journal-title":"Mini Rev Med Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"9400","DOI":"10.1074\/jbc.274.14.9400","article-title":"Cellular responses to excess phospholipid","volume":"274","author":"I Baburina","year":"1999","journal-title":"J Biol Chem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/jcs.02821","article-title":"Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase","volume":"119","author":"XH Zhang","year":"2006","journal-title":"J Cell Sci"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1085\/jgp.8.6.519","article-title":"The Metabolism of Tumors in the Body","volume":"8","author":"O Warburg","year":"1927","journal-title":"J Gen Physiol"},{"key":"ref31","first-page":"497","article-title":"Increasing the antioxidant defense in WEHI7.2 cells results in a more tumor-like metabolic profile","volume":"15","author":"ME Tome","year":"2005","journal-title":"Int J Mol Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.bbamcr.2004.05.004","article-title":"Overexpression of catalase or Bcl-2 alters glucose and energy metabolism concomitant with dexamethasone resistance","volume":"1693","author":"ME Tome","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3892\/etm.2012.487","article-title":"Lymphoma cells with increased anti-oxidant defenses acquire chemoresistance","volume":"3","author":"ME Tome","year":"2012","journal-title":"Exp Ther Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1007\/s00432-014-1727-y","article-title":"A cisplatin-resistant head and neck cancer cell line with cytoplasmic p53(mut) exhibits ATP-binding cassette transporter upregulation and high glutathione levels","volume":"140","author":"M Tonigold","year":"2014","journal-title":"J Cancer Res Clin Oncol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.bbamcr.2003.08.002","article-title":"Overexpression of catalase or Bcl-2 delays or prevents alterations in phospholipid metabolism during glucocorticoid-induced apoptosis in WEHI7.2 cells","volume":"1642","author":"ME Tome","year":"2003","journal-title":"Biochim Biophys Acta"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161803","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T01:44:31Z","timestamp":1657158271000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161803"}},"subtitle":[],"editor":[{"given":"Jonathan M","family":"Peterson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161803","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}