{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:00:23Z","timestamp":1778670023543,"version":"3.51.4"},"reference-count":27,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T00:00:00Z","timestamp":1472083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161872","type":"journal-article","created":{"date-parts":[[2016,8,25]],"date-time":"2016-08-25T17:42:11Z","timestamp":1472146931000},"page":"e0161872","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Novel SCN5A Mutation Associated with Drug Induced Brugada Type ECG"],"prefix":"10.1371","volume":"11","author":[{"given":"Isik","family":"Turker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeru","family":"Makiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Vatta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Ueyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Ai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Horie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,8,25]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.2165\/00003495-200666160-00003","article-title":"Pilsicainide for atrial fibrillation","volume":"66","author":"K Kumagai","year":"2006","journal-title":"Drugs"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1253\/circj.71.1805","article-title":"Mechanisms of the preventive effect of pilsicainide on atrial fibrillation originating from the pulmonary vein","volume":"71","author":"M Hirose","year":"2007","journal-title":"Circulation journal: official journal of the Japanese Circulation Society"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1253\/circj.71.546","article-title":"Discrimination of Brugada syndrome patients from individuals with the saddle-back type ST-segment elevation using a marker of the standard 12-lead electrocardiography","volume":"71","author":"K Nakazawa","year":"2007","journal-title":"Circulation journal: official journal of the Japanese Circulation Society"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1016\/j.hrthm.2006.08.027","article-title":"High-frequency potentials developed in wavelet-transformed electrocardiogram as a novel indicator for detecting Brugada syndrome","volume":"3","author":"K Yodogawa","year":"2006","journal-title":"Heart rhythm: the official journal of the Heart Rhythm Society"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jelectrocard.2005.06.005","article-title":"Acquired forms of the Brugada syndrome","volume":"38","author":"W Shimizu","year":"2005","journal-title":"Journal of electrocardiology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/europace\/eum244","article-title":"Pilsicainide-induced Brugada-type ECG and ventricular arrhythmias originating from the left posterior fascicle in a case with Brugada syndrome associated with idiopathic left ventricular tachycardia","volume":"10","author":"T Ueyama","year":"2008","journal-title":"Europace: European pacing, arrhythmias, and cardiac electrophysiology: journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1111\/j.1540-8159.2007.00728.x","article-title":"Incidence and initial characteristics of pilsicainide-induced ventricular arrhythmias in patients with Brugada syndrome","volume":"30","author":"M Chinushi","year":"2007","journal-title":"Pacing and clinical electrophysiology: PACE"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1540-8167.2005.40711.x","article-title":"A novel missense mutation in the SCN5A gene associated with Brugada syndrome bidirectionally affecting blocking actions of antiarrhythmic drugs","volume":"16","author":"H Itoh","year":"2005","journal-title":"Journal of cardiovascular electrophysiology"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/j.1540-8167.2007.00777.x","article-title":"A common SCN5A variant alters the responsiveness of human sodium channels to class I antiarrhythmic agents","volume":"18","author":"M Shuraih","year":"2007","journal-title":"Journal of cardiovascular electrophysiology"},{"key":"ref10","unstructured":"Single nucleotide polymorphism (SNP) database. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ncbi.nlm.nih.gov\/snp\" xlink:type=\"simple\">http:\/\/www.ncbi.nlm.nih.gov\/snp<\/ext-link>."},{"key":"ref11","unstructured":"1000 Genomes Browser Database. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/browser.1000genomes.org\/index.html\" xlink:type=\"simple\">http:\/\/browser.1000genomes.org\/index.html<\/ext-link>."},{"key":"ref12","unstructured":"NHLBI Exome Sequencing Project (ESP) Database Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/evs.gs.washington.edu\/EVS\" xlink:type=\"simple\">http:\/\/evs.gs.washington.edu\/EVS<\/ext-link>."},{"key":"ref13","unstructured":"UCSC Genome Browser."},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1161\/01.RES.66.2.565","article-title":"Effects of quinidine on the sodium current of guinea pig ventricular myocytes. Evidence for a drug-associated rested state with altered kinetics","volume":"66","author":"DJ Snyders","year":"1990","journal-title":"Circulation research"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1161\/hh0701.089668","article-title":"Novel arrhythmogenic mechanism revealed by a long-QT syndrome mutation in the cardiac Na(+) channel","volume":"88","author":"H Abriel","year":"2001","journal-title":"Circulation research"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/(SICI)1096-8628(19991029)86:5<470::AID-AJMG13>3.0.CO;2-Y","article-title":"Sodium channel abnormalities are infrequent in patients with long QT syndrome: identification of two novel SCN5A mutations","volume":"86","author":"D Wattanasirichaigoon","year":"1999","journal-title":"American journal of medical genetics"},{"issue":"9","key":"ref17","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/hmg\/4.9.1603","article-title":"Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia","volume":"4","author":"Q Wang","year":"1995","journal-title":"Human molecular genetics"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1161\/hc3501.095361","article-title":"De novo mutation in the SCN5A gene associated with early onset of sudden infant death","volume":"104","author":"H Wedekind","year":"2001","journal-title":"Circulation"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1136\/jmg.40.2.141","article-title":"The use of genotype-phenotype correlations in mutation analysis for the long QT syndrome","volume":"40","author":"IM Van Langen","year":"2003","journal-title":"Journal of medical genetics"},{"issue":"Suppl 1","key":"ref20","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1111\/j.1540-8167.2006.00388.x","article-title":"The role of sodium channel current in modulating transmural dispersion of repolarization and arrhythmogenesis","volume":"17","author":"C Antzelevitch","year":"2006","journal-title":"Journal of cardiovascular electrophysiology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"H354","DOI":"10.1152\/ajpheart.2001.280.1.H354","article-title":"Accelerated inactivation in a mutant Na(+) channel associated with idiopathic ventricular fibrillation","volume":"280","author":"X Wan","year":"2001","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"24","key":"ref22","doi-asserted-by":"crossref","first-page":"3680","DOI":"10.1161\/CIRCULATIONAHA.105.520999","article-title":"Cardiac histological substrate in patients with clinical phenotype of Brugada syndrome","volume":"112","author":"A Frustaci","year":"2005","journal-title":"Circulation"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1085\/jgp.69.4.497","article-title":"Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction","volume":"69","author":"B Hille","year":"1977","journal-title":"The Journal of general physiology"},{"issue":"5179","key":"ref24","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1126\/science.8085162","article-title":"Molecular determinants of state-dependent block of Na+ channels by local anesthetics","volume":"265","author":"DS Ragsdale","year":"1994","journal-title":"Science"},{"issue":"17","key":"ref25","doi-asserted-by":"crossref","first-page":"9270","DOI":"10.1073\/pnas.93.17.9270","article-title":"Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels","volume":"93","author":"DS Ragsdale","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"25","key":"ref26","doi-asserted-by":"crossref","first-page":"14126","DOI":"10.1073\/pnas.94.25.14126","article-title":"Sodium channel selectivity filter regulates antiarrhythmic drug binding","volume":"94","author":"A Sunami","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1254\/jjp.58.365","article-title":"Modes of the Na channel blocking action of pilsicainide, a new antiarrhythmic agent, in cardiac cells","volume":"58","author":"Y Hattori","year":"1992","journal-title":"Japanese journal of pharmacology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161872","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:15:52Z","timestamp":1589040952000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161872"}},"subtitle":[],"editor":[{"given":"Vladimir E.","family":"Bondarenko","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,25]]},"references-count":27,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161872","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,25]]}}}