{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T23:29:37Z","timestamp":1784590177376,"version":"3.55.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T00:00:00Z","timestamp":1472169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas (BR)"},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161884","type":"journal-article","created":{"date-parts":[[2016,8,26]],"date-time":"2016-08-26T13:28:16Z","timestamp":1472218096000},"page":"e0161884","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Mortality Predictors in Patients with Severe Dengue in the State of Amazonas, Brazil"],"prefix":"10.1371","volume":"11","author":[{"given":"Rosemary Costa","family":"Pinto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel Barros de","family":"Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino Cl\u00e1udio de","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanderson de Souza","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Augusto dos","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Fernandes da","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Sadahiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ueleres","family":"Braga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,8,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"e1760","DOI":"10.1371\/journal.pntd.0001760","article-title":"Refining the global spatial limits of dengue virus transmission by evidence-based consensus","volume":"6","author":"OJ Brady","year":"2012","journal-title":"PLOS Negl Trop Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"S Bhatt","year":"2013","journal-title":"Nature"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0065-3527(08)60342-5","article-title":"Impact of dengue\/dengue hemorrhagic fever on the developing world","volume":"53","author":"DJ Gubler","year":"1999","journal-title":"Adv Virus Res"},{"key":"ref4","year":"2015"},{"key":"ref5","unstructured":"Funda\u00e7\u00e3o de Vigil\u00e2ncia em Sa\u00fade do Amazonas. Boletim de Vigil\u00e2ncia em Sa\u00fade (in Portuguese)\u2014Bol. Number 15. Manaus\u2014AM; 2014."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"A361","DOI":"10.1136\/jech.2011.142976m.35","article-title":"Change in the epidemiologic pattern of occurrence of dengue and dengue hemorrhagic fever in Brazil","author":"MDCN Costa","year":"2011","journal-title":"Journal of Epidemiology & Community Health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1590\/0037-8682-0145-2015","article-title":"Trends and factors associated with dengue mortality and fatality in Brazil","volume":"48","author":"ES Paix\u00e3o","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref8","first-page":"476","article-title":"Exanthematous diseases and the first epidemic of dengue to occur in Manaus, Amazonas State, Brazil, during 1998\u20131999","volume":"37","author":"RMP De Figueiredo","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref9","article-title":"Dengue em crian\u00e7a: aspectos cl\u00ednicos e epidemiol\u00f3gicos, Manaus, Estado do Amazonas, no per\u00edodo de 2006 e 2007","author":"L Rocha","year":"2009","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e100535","DOI":"10.1371\/journal.pone.0100535","article-title":"Clinical and virological descriptive study in the 2011 outbreak of dengue in the Amazonas, Brazil","volume":"9","author":"CA Martins V do","year":"2014","journal-title":"PLOS ONE"},{"key":"ref11","unstructured":"Funda\u00e7\u00e3o de Vigil\u00e2ncia em Sa\u00fade do Amazonas. Boletim de Vigil\u00e2ncia em Sa\u00fade (in Portuguese)\u2014Bol. Number 12. Manaus\u2014AM; 2012."},{"key":"ref12","year":"2009"},{"key":"ref13","year":"2002"},{"key":"ref14","article-title":"Prognostic indicators for dengue infection severity","author":"S Pongpan","year":"2013","journal-title":"Prognostic indicators for dengue infection severity"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1590\/0037-8682-1579-2013","article-title":"Factors related to severe dengue during an epidemic in Vitoria, State of Espirito Santo, Brazil, 2011","volume":"46","author":"CR Vicente","year":"2013","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.4269\/ajtmh.2012.11-0074","article-title":"Factors associated with dengue mortality in Latin America and the Caribbean, 1995\u20132009: an ecological study","volume":"86","author":"FA D\u00edaz-Quijano","year":"2012","journal-title":"Am J Trop Med Hyg"},{"key":"ref17","year":"2011"},{"key":"ref18","doi-asserted-by":"crossref","unstructured":"Hosmer D, Lemeshow S. Applied logistic regression. 2004;","DOI":"10.1002\/0470011815.b2a10029"},{"key":"ref19","unstructured":"Jr DH. Model building strategies and methods for logistic regression. \u2026 Logist Regression, \u2026. 2000; Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/9781118548387.ch4\/summary\" xlink:type=\"simple\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/9781118548387.ch4\/summary<\/ext-link>"},{"key":"ref20","year":"2009"},{"key":"ref21","first-page":"2373","article-title":"Death from dengue fever as a sentinel event for evaluation of quality of healthcare: a case study in two municipalities in Northeast Brazil, 2008","volume":"27","author":"AC Figueir\u00f3","year":"2011","journal-title":"Cad sa\u00fade p\u00fablica"},{"key":"ref22","year":"2011"},{"key":"ref23","author":"RA dos Passos","year":"2012"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"670","DOI":"10.4269\/ajtmh.11-0774","article-title":"Determinants of mortality from severe dengue in Brazil: a population-based case-control study","volume":"88","author":"GH Moraes","year":"2013","journal-title":"Am J Trop Med Hyg"},{"key":"ref25","first-page":"362","article-title":"Dengue severity in the elderly in Puerto Rico","volume":"13","author":"EJ Garc\u00eda-Rivera","year":"2003","journal-title":"Rev Panam salud p\u00fablica = Pan Am J public Heal"},{"key":"ref26","article-title":"Improvement of Case-Management: A Key Factor to Reduce Case-Fatality Rate of Dengue Haemorrhagic Fever in Southern Viet Nam","author":"N Hung","year":"2003","journal-title":"Dengue Bull"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1086\/318453","article-title":"Noninvasive measurement of microvascular leakage in patients with dengue hemorrhagic fever","volume":"32","author":"DB Bethell","year":"2001","journal-title":"Clin Infect Dis"},{"key":"ref28","first-page":"476","article-title":"Do young adults with uncomplicated dengue fever need hospitalisation? A retrospective analysis of clinical and laboratory features","volume":"49","author":"DC Lye","year":"2008","journal-title":"Singapore Med J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161884","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T20:32:05Z","timestamp":1568320325000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161884"}},"subtitle":[],"editor":[{"given":"Dermot","family":"Cox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,8,26]]},"references-count":28,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161884","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,8,26]]}}}