{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:12:06Z","timestamp":1782303126747,"version":"3.54.5"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL076278"],"award-info":[{"award-number":["HL076278"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL089440"],"award-info":[{"award-number":["HL089440"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0161931","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T17:41:38Z","timestamp":1473183698000},"page":"e0161931","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["I\u03baB\u03b6 Regulates Human Monocyte Pro-Inflammatory Responses Induced by Streptococcus pneumoniae"],"prefix":"10.1371","volume":"11","author":[{"given":"Kruthika","family":"Sundaram","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd. Akhlakur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srabani","family":"Mitra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daren L.","family":"Knoell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shireen A.","family":"Woodiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7079-5633","authenticated-orcid":true,"given":"Mark D.","family":"Wewers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"issue":"9693","key":"ref1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0140-6736(09)61204-6","article-title":"Burden of disease caused by Streptococcus pneumoniae in children younger than 5 years: global estimates","volume":"374","author":"KL O'Brien","year":"2009","journal-title":"Lancet"},{"issue":"9963","key":"ref2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","article-title":"Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"385","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S0002-9343(99)00050-9","article-title":"Is Streptococcus pneumoniae the leading cause of pneumonia of unknown etiology? A microbiologic study of lung aspirates in consecutive patients with community-acquired pneumonia","volume":"106","author":"A Ruiz-Gonzalez","year":"1999","journal-title":"Am J Med"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S1473-3099(04)00938-7","article-title":"Streptococcus pneumoniae colonisation: the key to pneumococcal disease","volume":"4","author":"D Bogaert","year":"2004","journal-title":"Lancet Infect Dis"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1128\/MMBR.65.2.187-207.2001","article-title":"Pneumococcal virulence factors: structure and function","volume":"65","author":"MJ Jedrzejas","year":"2001","journal-title":"Microbiol Mol Biol Rev"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010215","article-title":"The pneumococcus: epidemiology, microbiology, and pathogenesis","volume":"3","author":"B Henriques-Normark","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"A Kadioglu","year":"2008","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1165\/rcmb.2003-0312OC","article-title":"Monocyte recruitment into the lungs in pneumococcal pneumonia","volume":"30","author":"Y Goto","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"7353","DOI":"10.4049\/jimmunol.166.12.7353","article-title":"Role of chemokines and formyl peptides in pneumococcal pneumonia-induced monocyte\/macrophage recruitment","volume":"166","author":"I Fillion","year":"2001","journal-title":"J Immunol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1128\/IAI.66.3.912-922.1998","article-title":"Cytokine kinetics and other host factors in response to pneumococcal pulmonary infection in mice","volume":"66","author":"Y Bergeron","year":"1998","journal-title":"Infect Immun"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.jpeds.2003.10.034","article-title":"Primary immunodeficiency to pneumococcal infection due to a defect in Toll-like receptor signaling","volume":"144","author":"AJ Currie","year":"2004","journal-title":"J Pediatr"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/j.1462-5822.2011.01746.x","article-title":"Recognition of Streptococcus pneumoniae by the innate immune system","volume":"14","author":"U Koppe","year":"2012","journal-title":"Cell Microbiol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1165\/rcmb.2010-0210OC","article-title":"Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia","volume":"45","author":"LA Pittet","year":"2011","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.4049\/jimmunol.178.3.1896","article-title":"Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia","volume":"178","author":"LJ Quinton","year":"2007","journal-title":"J Immunol"},{"issue":"Pt 2","key":"ref15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1099\/mic.0.28551-0","article-title":"Innate immunity and the pneumococcus","volume":"152","author":"GK Paterson","year":"2006","journal-title":"Microbiology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0014-5793(00)02185-2","article-title":"MAIL, a novel nuclear I kappa B protein that potentiates LPS-induced IL-6 production","volume":"485","author":"H Kitamura","year":"2000","journal-title":"FEBS Lett"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.4049\/jimmunol.0802736","article-title":"MAIL Regulates Human Monocyte IL-6 Production","volume":"183","author":"S Seshadri","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"29","key":"ref18","doi-asserted-by":"crossref","first-page":"27657","DOI":"10.1074\/jbc.M103426200","article-title":"A novel IkappaB protein, IkappaB-zeta, induced by proinflammatory stimuli, negatively regulates nuclear factor-kappaB in the nuclei","volume":"276","author":"S Yamazaki","year":"2001","journal-title":"J Biol Chem"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"12485","DOI":"10.1074\/jbc.C100075200","article-title":"Isolation of a novel interleukin-1-inducible nuclear protein bearing ankyrin-repeat motifs","volume":"276","author":"H Haruta","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","first-page":"7444","DOI":"10.1074\/jbc.M412738200","article-title":"Positive and negative regulation of nuclear factor-kappaB-mediated transcription by IkappaB-zeta, an inducible nuclear protein","volume":"280","author":"M Motoyama","year":"2005","journal-title":"J Biol Chem"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"5559","DOI":"10.4049\/jimmunol.176.9.5559","article-title":"IL-1beta-specific up-regulation of neutrophil gelatinase-associated lipocalin is controlled by IkappaB-zeta","volume":"176","author":"JB Cowland","year":"2006","journal-title":"J Immunol"},{"issue":"22","key":"ref22","doi-asserted-by":"crossref","first-page":"15309","DOI":"10.1074\/jbc.M708289200","article-title":"Requirements for two proximal NF-kappaB binding sites and IkappaB-zeta in IL-17A-induced human beta-defensin 2 expression by conducting airway epithelium","volume":"283","author":"CY Kao","year":"2008","journal-title":"J Biol Chem"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cyto.2008.08.004","article-title":"A synergistic role for IL-1\u03b2 and TNF\u03b1 in monocyte-derived IFN\u03b3 inducing activity","volume":"44","author":"RM Raices","year":"2008","journal-title":"Cytokine"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1182\/blood-2010-07-294702","article-title":"IkappaBzeta augments IL-12- and IL-18-mediated IFN-gamma production in human NK cells","volume":"117","author":"Y Kannan","year":"2011","journal-title":"Blood"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1183\/09031936.00200009","article-title":"Legionella pneumophila-induced IkappaBzeta-dependent expression of interleukin-6 in lung epithelium","volume":"37","author":"J Lorenz","year":"2011","journal-title":"Eur Respir J"},{"issue":"19","key":"ref26","doi-asserted-by":"crossref","first-page":"14088","DOI":"10.1074\/jbc.M109.017129","article-title":"Induction of neutrophil gelatinase-associated lipocalin expression by co-stimulation with interleukin-17 and tumor necrosis factor-alpha is controlled by IkappaB-zeta but neither by C\/EBP-beta nor C\/EBP-delta","volume":"285","author":"JR Karlsen","year":"2010","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0083-6729(06)74012-2","article-title":"IkappaB-zeta: an inducible regulator of nuclear factor-kappaB","volume":"74","author":"T Muta","year":"2006","journal-title":"Vitam Horm"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1165\/rcmb.2014-0370OC","article-title":"House Dust Mite Allergens and the Induction of Monocyte Interleukin 1beta Production That Triggers an IkappaBzeta-Dependent Granulocyte Macrophage Colony-Stimulating Factor Release from Human Lung Epithelial Cells","volume":"53","author":"K Sundaram","year":"2015","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/gene.2009.76","article-title":"NFKBIZ polymorphisms and susceptibility to pneumococcal disease in European and African populations","volume":"11","author":"SJ Chapman","year":"2010","journal-title":"Genes Immun"},{"issue":"53","key":"ref30","doi-asserted-by":"crossref","first-page":"55493","DOI":"10.1074\/jbc.M409770200","article-title":"Targeted disruption of MAIL, a nuclear IkappaB protein, leads to severe atopic dermatitis-like disease","volume":"279","author":"T Shiina","year":"2004","journal-title":"J Biol Chem"},{"issue":"8","key":"ref31","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1167\/iovs.08-1691","article-title":"Stat6-independent tissue inflammation occurs selectively on the ocular surface and perioral skin of IkappaBzeta-\/- mice","volume":"49","author":"M Ueta","year":"2008","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1073\/pnas.0504271103","article-title":"Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and release","volume":"103","author":"MA Gavrilin","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/IAI.66.2.820-822.1998","article-title":"Adherence of Streptococcus pneumoniae to human bronchial epithelial cells (BEAS-2B)","volume":"66","author":"JE Adamou","year":"1998","journal-title":"Infect Immun"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/IAI.66.4.1439-1444.1998","article-title":"Adherence of Streptococcus pneumoniae to respiratory epithelial cells is inhibited by sialylated oligosaccharides","volume":"66","author":"R Barthelson","year":"1998","journal-title":"Infect Immun"},{"issue":"Suppl 1","key":"ref35","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000195751","article-title":"Attachment of Streptococcus pneumoniae to human pharyngeal epithelial cells","volume":"55","author":"B Andersson","year":"1989","journal-title":"Respiration"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"5358","DOI":"10.4049\/jimmunol.0802736","article-title":"MAIL regulates human monocyte IL-6 production","volume":"183","author":"S Seshadri","year":"2009","journal-title":"J Immunol"},{"key":"ref37","unstructured":"Xu F, Droemann D, Fau-Rupp J, Rupp J, Fau-Shen H, Shen H, et al. Modulation of the inflammatory response to Streptococcus pneumoniae in a model of acute lung tissue infection. (1535\u20134989 (Electronic))."},{"key":"ref38","unstructured":"Karin M. The regulation of AP-1 activity by mitogen-activated protein kinases. (0021\u20139258 (Print))."},{"key":"ref39","unstructured":"Schmeck B, Zahlten J, Fau-Moog K, Moog K, Fau-van Laak V, van Laak V, et al. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. (0021\u20139258 (Print))."},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1167\/iovs.04-1055","article-title":"Spontaneous ocular surface inflammation and goblet cell disappearance in I kappa B zeta gene-disrupted mice","volume":"46","author":"M Ueta","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1128\/IAI.64.9.3772-3777.1996","article-title":"Uptake of Streptococcus pneumoniae by respiratory epithelial cells","volume":"64","author":"UM Talbot","year":"1996","journal-title":"Infection and Immunity"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.jaci.2010.11.039","article-title":"Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter","volume":"127","author":"N Mushtaq","year":"2011","journal-title":"J Allergy Clin Immunol"},{"key":"ref43","unstructured":"Mayer AK, Muehmer M, Fau-Mages J, Mages J, Fau-Gueinzius K, Gueinzius K, et al. Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells. (0022\u20131767 (Print))."},{"issue":"7293","key":"ref44","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1038\/nature08922","article-title":"IkappaBzeta regulates T(H)17 development by cooperating with ROR nuclear receptors","volume":"464","author":"K Okamoto","year":"2010","journal-title":"Nature"},{"issue":"Suppl 1","key":"ref45","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S0140-6736(15)60367-1","article-title":"Regulation of neutrophilic inflammation in lung injury induced by community-acquired pneumonia","volume":"385","author":"R Jose","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1165\/rcmb.2013-0114OC","article-title":"Roles of lung epithelium in neutrophil recruitment during pneumococcal pneumonia","volume":"50","author":"K Yamamoto","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4049\/jimmunol.168.1.372","article-title":"IL-18 improves the early antimicrobial host response to pneumococcal pneumonia","volume":"168","author":"FN Lauw","year":"2002","journal-title":"J Immunol"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1183\/09031936.02.00295102","article-title":"Systemic cytokine levels in community-acquired pneumonia and their association with disease severity","volume":"20","author":"G Antunes","year":"2002","journal-title":"Eur Respir J"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.4049\/jimmunol.1101413","article-title":"Local delivery of GM-CSF protects mice from lethal pneumococcal pneumonia","volume":"187","author":"K Steinwede","year":"2011","journal-title":"J Immunol"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1086\/514062","article-title":"Interleukin-6 gene-deficient mice show impaired defense against pneumococcal pneumonia","volume":"176","author":"T van der Poll","year":"1997","journal-title":"J Infect Dis"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1086\/424522","article-title":"An outbreak of conjunctivitis due to a novel unencapsulated Streptococcus pneumoniae among military trainees","volume":"39","author":"NF Crum","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"18","key":"ref52","doi-asserted-by":"crossref","first-page":"15587","DOI":"10.1074\/jbc.M212829200","article-title":"Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved","volume":"278","author":"NW Schroder","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref53","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1073\/pnas.0435928100","article-title":"Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection","volume":"100","author":"R Malley","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref54","first-page":"237","article-title":"Toll-like receptor 2 contributes to antibacterial defence against pneumolysin-deficient pneumococci","volume":"10","author":"MC Dessing","year":"2008","journal-title":"Cellular microbiology"},{"issue":"2","key":"ref55","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0006-291X(02)03082-6","article-title":"Essential roles for NF-kappa B and a Toll\/IL-1 receptor domain-specific signal(s) in the induction of I kappa B-zeta","volume":"301","author":"A Eto","year":"2003","journal-title":"Biochem Biophys Res Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0161931","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T23:56:09Z","timestamp":1692489369000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0161931"}},"subtitle":[],"editor":[{"given":"Samithamby","family":"Jeyaseelan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":55,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0161931","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}