{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T09:26:28Z","timestamp":1789809988814,"version":"4.0.1"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T00:00:00Z","timestamp":1473120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0162082","type":"journal-article","created":{"date-parts":[[2016,9,6]],"date-time":"2016-09-06T13:44:25Z","timestamp":1473169465000},"page":"e0162082","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Oxidative Stress, DNA Damage and DNA Repair in Female Patients with Diabetes Mellitus Type 2"],"prefix":"10.1371","volume":"11","author":[{"given":"Annemarie","family":"Grindel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Guggenberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Eichberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"P\u00f6ppelmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Gschaider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anela","family":"Tosevska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Briskey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Brath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Heinz","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,6]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.diabres.2013.11.002","article-title":"Global estimates of diabetes prevalence for 2013 and projections for 2035","volume":"103","author":"L Guariguata","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"9","key":"ref2","first-page":"4047","article-title":"Clinical review 135\u2014The importance of beta-cell failure in the development and progression of type 2 diabetes","volume":"86","author":"SE Kahn","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"7121","key":"ref3","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"SE Kahn","year":"2006","journal-title":"Nature"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1172\/JCI29103","article-title":"Islet beta cell failure in type 2 diabetes","volume":"116","author":"M Prentki","year":"2006","journal-title":"J Clin Invest"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1172\/JCI29189","article-title":"Insulin resistance and pancreatic beta cell failure","volume":"116","author":"M Kasuga","year":"2006","journal-title":"J Clin Invest"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM197608192950804","article-title":"Correlation of Glucose Regulation and Hemoglobin-A-IC in Diabetes-Mellitus","volume":"295","author":"RJ Koenig","year":"1976","journal-title":"N Engl J Med"},{"issue":"6865","key":"ref7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/414813a","article-title":"Biochemistry and molecular cell biology of diabetic complications","volume":"414","author":"M Brownlee","year":"2001","journal-title":"Nature"},{"issue":"32","key":"ref8","doi-asserted-by":"crossref","first-page":"5695","DOI":"10.2174\/1381612811319320005","article-title":"Hyperglycemia-induced Oxidative Stress and its Role in Diabetes Mellitus Related Cardiovascular Diseases","volume":"19","author":"TV Fiorentino","year":"2013","journal-title":"Curr Pharm Design"},{"issue":"7258","key":"ref9","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/bmj.321.7258.405","article-title":"Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study","volume":"321","author":"IM Stratton","year":"2000","journal-title":"Br Med J"},{"issue":"13","key":"ref10","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1161\/CIRCULATIONAHA.108.829176","article-title":"Trends in All-Cause and Cardiovascular Disease Mortality Among Women and Men With and Without Diabetes Mellitus in the Framingham Heart Study, 1950 to 2005","volume":"119","author":"SR Preis","year":"2009","journal-title":"Circulation"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4103\/0366-6999.157693","article-title":"Evidence for DNA Damage as a Biological Link Between Diabetes and Cancer","volume":"128","author":"SC Lee","year":"2015","journal-title":"Chin Med J"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1038\/bjc.2014.150","article-title":"Does cancer risk increase with HbA(1c), independent of diabetes?","volume":"110","author":"JC de Beer","year":"2014","journal-title":"Br J Cancer"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1677\/ERC-09-0087","article-title":"Diabetes and cancer","volume":"16","author":"P Vigneri","year":"2009","journal-title":"Endocrine-related cancer"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.arr.2012.02.001","article-title":"The role of DNA damage and repair in aging through the prism of Koch-like criteria","volume":"12","author":"AA Moskalev","year":"2013","journal-title":"Ageing Res Rev"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"2643","DOI":"10.1093\/carcin\/bgu225","article-title":"Base excision repair capacity in informing healthspan","volume":"35","author":"BM Brenerman","year":"2014","journal-title":"Carcinogenesis"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.advms.2015.04.001","article-title":"Analysis of oxidative DNA damage and its repair in Polish patients with diabetes mellitus type 2: Role in pathogenesis of diabetic neuropathy","volume":"60","author":"A Merecz","year":"2015","journal-title":"Advances in medical sciences"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.gene.2012.09.090","article-title":"Gene expression profiles displayed by peripheral blood mononuclear cells from patients with type 2 diabetes mellitus focusing on biological processes implicated on the pathogenesis of the disease","volume":"511","author":"FS Manoel-Caetano","year":"2012","journal-title":"Gene"},{"issue":"1\u20132","key":"ref18","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.mrfmmm.2004.05.011","article-title":"DNA damage and repair in type 2 diabetes mellitus","volume":"554","author":"J Blasiak","year":"2004","journal-title":"Mutat Res-Fundam Mol Mech Mutagen"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.diabres.2014.06.004","article-title":"One-week intervention period led to improvements in glycemic control and reduction in DNA damage levels in patients with type 2 diabetes mellitus","volume":"105","author":"DJ Xavier","year":"2014","journal-title":"Diabetes Res Clin Pract"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jcjd.2014.03.002","article-title":"The Investigation of the Oxidative Stress-Related Parameters in Type 2 Diabetes Mellitus","volume":"39","author":"O Aouacheri","year":"2015","journal-title":"Can J Diabetes"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1016\/j.jdiacomp.2013.07.005","article-title":"Association of biomarkers of inflammation and oxidative stress with the risk of chronic kidney disease in Type 2 diabetes mellitus in North Indian population","volume":"27","author":"S Gupta","year":"2013","journal-title":"J Diabetes Complications"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.bbadis.2011.12.003","article-title":"Oxidative stress, glutathione status, sirtuin and cellular stress response in type 2 diabetes","volume":"1822","author":"V Calabrese","year":"2012","journal-title":"Biochim Biophys Acta-Mol Basis Dis"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/09674845.2014.11669971","article-title":"Association of plasma proteins at multiple stages of glycation and antioxidant status with erythrocyte oxidative stress in patients with type 2 diabetes","volume":"71","author":"RS Tupe","year":"2014","journal-title":"Br J Biomed Sci"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/j.1365-2265.2011.04244.x","article-title":"The association of specific metabolites of lipid metabolism with markers of oxidative stress, inflammation and arterial stiffness in men with newly diagnosed type 2 diabetes","volume":"76","author":"CY Ha","year":"2012","journal-title":"Clin Endocrinol"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1016\/j.freeradbiomed.2012.03.002","article-title":"Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome","volume":"52","author":"AC Boon","year":"2012","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/mnfr.201200343","article-title":"Vegetables and PUFA-rich plant oil reduce DNA strand breaks in individuals with type 2 diabetes","volume":"57","author":"E Mullner","year":"2012","journal-title":"Mol Nutr Food Res"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/jhn.12168","article-title":"Impact of polyunsaturated vegetable oils on adiponectin levels, glycaemia and blood lipids in individuals with type 2 diabetes: a randomised, double-blind intervention study","volume":"27","author":"E Mullner","year":"2014","journal-title":"J Hum Nutr Diet"},{"issue":"4","key":"ref28","first-page":"E86","article-title":"General cardiovascular risk profile for use in primary care: The Framingham heart study","volume":"118","author":"RB D'Agostino","year":"2008","journal-title":"Circulation"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1996.0292","article-title":"The ferric reducing ability of plasma (FRAP) as a measure of &apos;&apos;antioxidant power&apos;&apos;: The FRAP assay","volume":"239","author":"IFF Benzie","year":"1996","journal-title":"Anal Biochem"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s00394-004-0432-z","article-title":"Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men","volume":"43","author":"A Ramel","year":"2004","journal-title":"Eur J Nutr"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"Fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"PJ Hissin","year":"1976","journal-title":"Anal Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0076-6879(94)33044-1","article-title":"Measurement of Protein Thiol-Groups and Glutathione in Plasma","volume":"233","author":"ML Hu","year":"1994","journal-title":"Methods Enzymol"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.freeradbiomed.2009.01.007","article-title":"Quantification of protein modification by oxidants","volume":"46","author":"CL Hawkins","year":"2009","journal-title":"Free Radic Biol Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jpba.2013.11.028","article-title":"Optimized method for quantification of total F-2-isoprostanes using gas chromatography-tandem mass spectrometry","volume":"90","author":"DR Briskey","year":"2014","journal-title":"J Pharm Biomed Anal"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1432-1033.1974.tb03714.x","article-title":"Involvement of Superoxide Anion Radical in Autoxidation of Pyrogallol and a Convenient Assay for Superoxide-Dismutase","volume":"47","author":"S Marklund","year":"1974","journal-title":"Eur J Biochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase In vitro","volume":"105","author":"H Aebi","year":"1984","journal-title":"Methods in Enzymology"},{"key":"ref37","article-title":"Red Cell Metabolism: A Manual of Biochemical Methods","author":"E Beutler","year":"1984"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mrgentox.2008.10.013","article-title":"DNA oxidation: Investigating its key role in environmental mutagenesis with the comet assay","volume":"674","author":"A Azqueta","year":"2009","journal-title":"Mutat Res Genet Toxicol Environ Mutagen"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.tiv.2012.12.006","article-title":"A comparative performance test of standard, medium- and high-throughput comet assays","volume":"27","author":"A Azqueta","year":"2013","journal-title":"Toxicol Vitro"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.freeradbiomed.2011.05.020","article-title":"Simplified method for the collection, storage, and comet assay analysis of DNA damage in whole blood","volume":"51","author":"K Al-Salmani","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.dnarep.2013.07.011","article-title":"Measurement of DNA base and nucleotide excision repair activities in mammalian cells and tissues using the comet assay\u2014A methodological overview","volume":"12","author":"A Azqueta","year":"2013","journal-title":"DNA Repair"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"issue":"7","key":"ref43","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s11255-015-1004-2","article-title":"Relationship of adiponectin to markers of oxidative stress in type 2 diabetic patients: influence of incipient diabetes-associated kidney disease","volume":"47","author":"CI Bondor","year":"2015","journal-title":"Int Urol Nephrol"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jdiacomp.2015.03.015","article-title":"Oxidized HDL and LDL in adolescents with type 2 diabetes compared to normal weight and obese peers","volume":"29","author":"MT Marin","year":"2015","journal-title":"J Diabetes Complications"},{"issue":"8","key":"ref45","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/dmrr.1011","article-title":"Association between oxidized LDL, obesity and type 2 diabetes in a population-based cohort, the Health, Aging and Body Composition Study","volume":"25","author":"OT Njajou","year":"2009","journal-title":"Diabetes-Metab Res Rev"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"3265","DOI":"10.3390\/ijms14023265","article-title":"Oxidative Stress as an Underlying Contributor in the Development of Chronic Complications in Diabetes Mellitus","volume":"14","author":"SD Bandeira","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.4103\/1947-2714.109193","article-title":"Antioxidant Enzymes and Lipid Peroxidation in Type 2 Diabetes Mellitus Patients with and without Nephropathy","volume":"5","author":"M Kumawat","year":"2013","journal-title":"North American journal of medical sciences"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11745-010-3401-8","article-title":"Serum Oxidized-LDL is Associated with Diabetes Duration Independent of Maintaining Optimized Levels of LDL-Cholesterol","volume":"45","author":"M Nakhjavani","year":"2010","journal-title":"Lipids"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"S111","DOI":"10.1007\/s00592-009-0149-9","article-title":"DNA damage evaluated by comet assay in Mexican patients with type 2 diabetes mellitus","volume":"47","author":"E Ibarra-Costilla","year":"2010","journal-title":"Acta Diabetol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.mrfmmm.2015.01.016","article-title":"Assessment of DNA damage and mRNA\/miRNA transcriptional expression profiles in hyperglycemic versus non-hyperglycemic patients with type 2 diabetes mellitus","volume":"776","author":"DJ Xavier","year":"2015","journal-title":"Mutat Res-Fundam Mol Mech Mutagen"},{"issue":"1\u20132","key":"ref51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0027-5107(02)00143-4","article-title":"Assessment of DNA base oxidation and glutathione level in patients with type 2 diabetes","volume":"505","author":"Y Dincer","year":"2002","journal-title":"Mutat Res-Fundam Mol Mech Mutagen"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1464-5491.2005.01647.x","article-title":"Inter-relationships between DNA damage, ascorbic acid and glycaemic control in Type 2 diabetes mellitus","volume":"22","author":"SW Choi","year":"2005","journal-title":"Diabetic Med"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1128\/MCB.14.1.68","article-title":"An interaction between the mammalian DNA-repair protein XRCC1 and DNA ligase-III","volume":"14","author":"KW Caldecott","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1146\/annurev.biochem.77.061306.123941","article-title":"Eukaryotic DNA ligases: Structural and functional insights","volume":"77","author":"T Ellenberger","year":"2008","journal-title":"Annual Review of Biochemistry"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/01.mco.0000172574.64019.98","article-title":"Insulin resistance: sex matters","volume":"8","author":"B Mittendorfer","year":"2005","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.atherosclerosis.2007.11.016","article-title":"Rosuvastatin protects against oxidative stress and DNA damage in vitro via upregulation of glutathione synthesis","volume":"199","author":"N Schupp","year":"2008","journal-title":"Atherosclerosis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.yjmcc.2015.07.005","article-title":"The role of DNA damage and repair in atherosclerosis: A review","volume":"86","author":"NR Shah","year":"2015","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1158\/1940-6207.CAPR-11-0536","article-title":"Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage","volume":"5","author":"C Algire","year":"2012","journal-title":"Cancer Prev Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0162082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T14:03:10Z","timestamp":1540216990000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0162082"}},"subtitle":[],"editor":[{"given":"V\u00edctor","family":"S\u00e1nchez-Margalet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,6]]},"references-count":58,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0162082","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,6]]}}}