{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:04:10Z","timestamp":1767830650522,"version":"3.49.0"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T00:00:00Z","timestamp":1473379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0162239","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T13:41:43Z","timestamp":1473428503000},"page":"e0162239","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Use of Selective Serotonin Reuptake Inhibitors and Risks of Stroke in Patients with Obsessive Compulsive Disorder: A Population-Based Study"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6911-1839","authenticated-orcid":true,"given":"Che-Sheng","family":"Chu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Po-Han","family":"Chou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ching-Heng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia-Jui","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuo-Hung","family":"Lan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Nestadt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,9,9]]},"reference":[{"key":"ref1","article-title":"Diagnostic and statistical manual of mental disorders","year":"2013"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mpr.1359","article-title":"Twelve-month and lifetime prevalence and lifetime morbid risk of anxiety and mood disorders in the United States","volume":"21","author":"RC Kessler","year":"2012","journal-title":"Int J Methods Psychiatr Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0193-953X(05)70176-3","article-title":"The epidemiology and cross-national presentation of obsessive-compulsive disorder","volume":"23","author":"E Horwath","year":"2000","journal-title":"Psychiatr Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.psychres.2009.04.005","article-title":"Quality of life and symptom dimensions of patients with obsessive-compulsive disorder","volume":"179","author":"IS Fontenelle","year":"2010","journal-title":"Psychiatry Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.cpr.2009.09.005","article-title":"Multiple pathways to functional impairment in obsessive-compulsive disorder","volume":"30","author":"Y Markarian","year":"2010","journal-title":"Clin Psychol Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"g2183","DOI":"10.1136\/bmj.g2183","article-title":"Obsessive-compulsive disorder","volume":"348","author":"D Veale","year":"2014","journal-title":"BMJ"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s11920-012-0268-9","article-title":"A 2012 evidence-based algorithm for the pharmacotherapy for obsessive-compulsive disorder","volume":"14","author":"DJ Stein","year":"2012","journal-title":"Curr Psychiatry Rep"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1161\/01.STR.0000018589.56991.BA","article-title":"Selective serotonin reuptake inhibitors and the risk of stroke: a population-based case-control study","volume":"33","author":"S Bak","year":"2002","journal-title":"Stroke"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00004850-200505000-00008","article-title":"Past use of selective serotonin reuptake inhibitors and the risk of cerebrovascular events in the elderly","volume":"20","author":"C Barbui","year":"2005","journal-title":"Int Clin Psychopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1345\/aph.1K369","article-title":"Risk of cerebrovascular events associated with antidepressant use in patients with depression: a population-based, nested case-control study","volume":"42","author":"Y Chen","year":"2008","journal-title":"Ann Pharmacother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1046\/j.1365-2125.2000.00216.x","article-title":"Intracranial haemorrhage and use of selective serotonin reuptake inhibitors","volume":"50","author":"FJ de Abajo","year":"2000","journal-title":"Br J Clin Pharmacol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1365-2125.2010.03797.x","article-title":"The use of antidepressants and the risk of haemorrhagic stroke: a nested case control study","volume":"71","author":"I Douglas","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.jagp.2013.01.018","article-title":"The association of selective serotonin reuptake inhibitors use and stroke in geriatric population","volume":"21","author":"CC Hung","year":"2013","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1161\/STROKEAHA.107.491472","article-title":"Selective serotonin reuptake inhibitors and risk of hemorrhagic stroke","volume":"38","author":"J Kharofa","year":"2007","journal-title":"Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1001\/archinternmed.2009.436","article-title":"Antidepressant use and risk of incident cardiovascular morbidity and mortality among postmenopausal women in the Women's Health Initiative study","volume":"169","author":"JW Smoller","year":"2009","journal-title":"Arch Intern Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1177\/070674370605101408","article-title":"Adverse cardiovascular events in antidepressant trials involving high-risk patients: a systematic review of randomized trials","volume":"51","author":"JR Swenson","year":"2006","journal-title":"Can J Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1176\/appi.ajp.2010.10071064","article-title":"Association of cerebrovascular events with antidepressant use: a case-crossover study","volume":"168","author":"CS Wu","year":"2011","journal-title":"Am J Psychiatry"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1016\/j.comppsych.2011.01.002","article-title":"Prevalence, correlates, and disease patterns of antidepressant use in Taiwan","volume":"52","author":"CC Kuo","year":"2011","journal-title":"Compr Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1176\/appi.ajp.2011.11020336","article-title":"Do antidepressants raise the risk of stroke?","volume":"168","author":"JW Smoller","year":"2011","journal-title":"Am J Psychiatry"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1161\/STROKEAHA.113.001147","article-title":"Depression and risk of stroke in midaged women: a prospective longitudinal study","volume":"44","author":"CA Jackson","year":"2013","journal-title":"Stroke"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.psym.2012.03.007","article-title":"Panic disorder and risk of stroke: a population-based study","volume":"53","author":"PH Chou","year":"2012","journal-title":"Psychosomatics"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/archneur.1997.00550160012009","article-title":"Association between migraine and stroke in a large-scale epidemiological study of the United States","volume":"54","author":"KR Merikangas","year":"1997","journal-title":"Arch Neurol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1192\/bjp.bp.111.092098","article-title":"Prevalence of autoimmune diseases in in-patients with schizophrenia: nationwide population-based study","volume":"200","author":"SJ Chen","year":"2012","journal-title":"Br J Psychiatry"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1176\/ps.2007.58.4.554","article-title":"Trends in the use of psychotropic drugs in Taiwan: a population-based national health insurance study, 1997\u20132004","volume":"58","author":"IC Chien","year":"2007","journal-title":"Psychiatr Serv"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jpsychires.2015.06.017","article-title":"Risk of depressive disorders in women undergoing hysterectomy: A population-based follow-up study","volume":"68","author":"PH Chou","year":"2015","journal-title":"J Psychiatr Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.psym.2013.06.003","article-title":"Prevalence of gastroesophageal reflux disease in major depressive disorder: a population-based study","volume":"55","author":"PH Chou","year":"2014","journal-title":"Psychosomatics"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.schres.2016.03.027","article-title":"Use of atypical antipsychotics and risks of cataract development in patients with schizophrenia: A population-based, nested case-control study","volume":"174","author":"PH Chou","year":"2016","journal-title":"Schizophr Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s00787-012-0369-3","article-title":"Prevalence of allergic rhinitis in patients with attention-deficit\/hyperactivity disorder: a population-based study","volume":"22","author":"PH Chou","year":"2013","journal-title":"Eur Child Adolesc Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.genhosppsych.2012.02.001","article-title":"Physical complications of severe, chronic obsessive-compulsive disorder: a comparison with general psychiatric inpatients","volume":"34","author":"LM Drummond","year":"2012","journal-title":"Gen Hosp Psychiatry"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.genhosppsych.2012.10.004","article-title":"Metabolic syndrome and obsessive-compulsive disorder: a naturalistic Italian study","volume":"35","author":"U Albert","year":"2013","journal-title":"Gen Hosp Psychiatry"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.jstrokecerebrovasdis.2010.12.005","article-title":"Chronic kidney disease in patients with ischemic stroke","volume":"21","author":"Y Tsukamoto","year":"2012","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1212\/01.wnl.0000229099.62706.a3","article-title":"Renal dysfunction and risk of ischemic stroke or TIA in patients with cardiovascular disease","volume":"67","author":"N Koren-Morag","year":"2006","journal-title":"Neurology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1093\/eurheartj\/ehq472","article-title":"Primary prevention of stroke: blood pressure, lipids, and heart failure","volume":"32","author":"M Endres","year":"2011","journal-title":"Eur Heart J"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00018-011-0840-1","article-title":"Metabolic syndrome as a risk factor for neurological disorders","volume":"69","author":"AA Farooqui","year":"2012","journal-title":"Cell Mol Life Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00592-010-0251-z","article-title":"Metabolic syndrome and vascular risk: a 9-year follow-up among the aged in Finland","volume":"48","author":"M Salminen","year":"2011","journal-title":"Acta Diabetol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/mp.2009.50","article-title":"Meta-analysis of the dose-response relationship of SSRI in obsessive-compulsive disorder","volume":"15","author":"MH Bloch","year":"2010","journal-title":"Mol Psychiatry"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1192\/bjp.174.4.297","article-title":"Effectiveness of antidepressants. Meta-analysis of dose-effect relationships in randomised clinical trials","volume":"174","author":"P Bollini","year":"1999","journal-title":"Br J Psychiatry"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0033-3182(96)71592-X","article-title":"Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors","volume":"37","author":"BP Skop","year":"1996","journal-title":"Psychosomatics"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00001721-199711000-00006","article-title":"Effects of serotonin on platelet activation in whole blood","volume":"8","author":"N Li","year":"1997","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"Suppl 3","key":"ref40","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1097\/00005344-198706103-00006","article-title":"Pathophysiological relevance of serotonin","volume":"10","author":"PA van Zwieten","year":"1987","journal-title":"J Cardiovasc Pharmacol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0165-0327(90)90123-P","article-title":"Effects of fluoxetine treatment of platelet 3H-imipramine binding, 5-HT uptake and 5-HT content in major depressive disorder","volume":"20","author":"A Wgner","year":"1990","journal-title":"J Affect Disord"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1067\/mcp.2000.110456","article-title":"Paroxetine decreases platelet serotonin storage and platelet function in human beings","volume":"68","author":"N Hergovich","year":"2000","journal-title":"Clin Pharmacol Ther"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jad.2011.08.013","article-title":"Decreased serotonin content and reduced agonist-induced aggregation in platelets of patients chronically medicated with SSRI drugs","volume":"136","author":"Y Bismuth-Evenzal","year":"2012","journal-title":"J Affect Disord"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1160\/TH08-12-0810","article-title":"Serotonergic mechanisms enhance platelet-mediated thrombogenicity","volume":"102","author":"AM Galan","year":"2009","journal-title":"Thromb Haemost"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1161\/hc4101.097519","article-title":"Selective serotonin reuptake inhibitors and myocardial infarction","volume":"104","author":"WH Sauer","year":"2001","journal-title":"Circulation"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2165\/00002018-200427140-00006","article-title":"Current use of selective serotonin reuptake inhibitors and risk of acute myocardial infarction","volume":"27","author":"RG Schlienger","year":"2004","journal-title":"Drug Saf"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1161\/STROKEAHA.114.005302","article-title":"Impact of prestroke selective serotonin reuptake inhibitor treatment on stroke severity and mortality","volume":"45","author":"JK Mortensen","year":"2014","journal-title":"Stroke"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1212\/WNL.0b013e318271f848","article-title":"Selective serotonin reuptake inhibitors and brain hemorrhage: a meta-analysis","volume":"79","author":"DG Hackam","year":"2012","journal-title":"Neurology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1474-4422(12)70005-4","article-title":"Diabetes, hyperglycaemia, and acute ischaemic stroke","volume":"11","author":"MJ Luitse","year":"2012","journal-title":"Lancet Neurol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1093\/aje\/kwt219","article-title":"The relationship of mental and behavioral disorders to all-cause mortality in a 27-year follow-up of 4 epidemiologic catchment area samples","volume":"178","author":"WW Eaton","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/pds.2087","article-title":"Validation of the National Health Insurance Research Database with ischemic stroke cases in Taiwan","volume":"20","author":"CL Cheng","year":"2011","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/pds.1518","article-title":"Validation of ICD-9 codes with a high positive predictive value for incident strokes resulting in hospitalization using Medicaid health data","volume":"17","author":"CL Roumie","year":"2008","journal-title":"Pharmacoepidemiol Drug Saf"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0162239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T05:50:33Z","timestamp":1568353833000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0162239"}},"subtitle":[],"editor":[{"given":"Gianluigi","family":"Forloni","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,9]]},"references-count":52,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0162239","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,9]]}}}