{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:53:52Z","timestamp":1740146032171,"version":"3.37.3"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T00:00:00Z","timestamp":1473206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 2494"],"award-info":[{"award-number":["PIP 2494"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fundaci\u00f3n para la Lucha contra la Leucemia"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0162456","type":"journal-article","created":{"date-parts":[[2016,9,7]],"date-time":"2016-09-07T17:43:27Z","timestamp":1473270207000},"page":"e0162456","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["A B-Cell Superantigen Induces the Apoptosis of Murine and Human Malignant B Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Daniela","family":"Lorenzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Mundi\u00f1ano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Berguer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Nepomnaschy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Piazzon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,9,7]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1084\/jem.171.2.455","article-title":"The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells","volume":"171","author":"P Marrack","year":"1990","journal-title":"J Exp Med"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"6312","DOI":"10.4049\/jimmunol.162.11.6312","article-title":"Cutting edge: apoptosis of superantigen-activated T cells occurs preferentially after a discrete number of cell divisions in vivo","volume":"162","author":"T Renno","year":"1999","journal-title":"J Immunol"},{"issue":"6 Suppl","key":"ref3","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1007\/BF01540891","article-title":"B-cell superantigens: definition and potential impact on the immune response","volume":"15","author":"AI Levinson","year":"1995","journal-title":"J Clin Immunol"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0167-5699(97)01101-8","article-title":"B-cell superantigens","volume":"18","author":"GJ Silverman","year":"1997","journal-title":"Immunol Today"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1172\/JCI118051","article-title":"Superantigen properties of a human sialoprotein involved in gut-associated immunity","volume":"96","author":"GJ Silverman","year":"1995","journal-title":"J Clin Invest"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.4049\/jimmunol.172.5.2870","article-title":"In vivo VL-targeted activation-induced apoptotic supraclonal deletion by a microbial B cell toxin","volume":"172","author":"CS Goodyear","year":"2004","journal-title":"J Immunol"},{"issue":"5128","key":"ref7","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1126\/science.7690497","article-title":"Immunoglobulin VH3 gene products: natural ligands for HIV gp120","volume":"261","author":"L Berberian","year":"1993","journal-title":"Science"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.4049\/jimmunol.140.4.1194","article-title":"Protein L. A novel bacterial cell wall protein with affinity for Ig L chains","volume":"140","author":"L Bjorck","year":"1988","journal-title":"J Immunol"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.4049\/jimmunol.156.10.3608","article-title":"Staphylococcal enterotoxin D functions as a human B cell superantigen by rescuing VH4-expressing B cells from apoptosis","volume":"156","author":"R Domiati-Saad","year":"1996","journal-title":"J Immunol"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1073\/pnas.88.3.1074","article-title":"In vivo T-cell activation by staphylococcal enterotoxin B prevents outgrowth of a malignant tumor","volume":"88","author":"KA Newell","year":"1991","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/ijc.20941","article-title":"Preclinical evaluation of superantigen (staphylococcal enterotoxin B) in the intravesical immunotherapy of superficial bladder cancer","volume":"115","author":"FG Perabo","year":"2005","journal-title":"Int J Cancer"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1182\/blood.V89.6.2089","article-title":"A superantigen-antibody fusion protein for T-cell immunotherapy of human B-lineage malignancies","volume":"89","author":"C Gidlof","year":"1997","journal-title":"Blood"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.intimp.2009.04.013","article-title":"Immunotherapy with tumor-targeted superantigens (TTS) in combination with docetaxel results in synergistic anti-tumor effects","volume":"9","author":"A Sundstedt","year":"2009","journal-title":"Int Immunopharmacol"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"e15694","DOI":"10.1371\/journal.pone.0015694","article-title":"Superantigens increase the survival of mice bearing T cell lymphomas by inducing apoptosis of neoplastic cells","volume":"5","author":"J Mundinano","year":"2010","journal-title":"PloS one"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.4049\/jimmunol.121.1.339","article-title":"Characteristics of BALB\/C T cell lymphomas grown as continuous in vitro lines","volume":"121","author":"KJ Kim","year":"1978","journal-title":"J Immunol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4049\/jimmunol.122.2.549","article-title":"Establishment and characterization of BALB\/c lymphoma lines with B cell properties","volume":"122","author":"KJ Kim","year":"1979","journal-title":"J Immunol"},{"issue":"7","key":"ref17","first-page":"1300","article-title":"Surface IgM-kappa specificity on a Burkitt lymphoma cell in vivo and in derived culture lines","volume":"28","author":"E Klein","year":"1968","journal-title":"Cancer Res"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"e61347","DOI":"10.1371\/journal.pone.0061347","article-title":"B-cell lymphopoiesis is regulated by cathepsin L","volume":"8","author":"MN Badano","year":"2013","journal-title":"PLoS One"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-59745-395-0_23","article-title":"Tracing tolerance and immunity in vivo by CFSE-labeling of administered cells","volume":"380","author":"E Ingulli","year":"2007","journal-title":"Methods Mol Biol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.4049\/jimmunol.170.4.1854","article-title":"Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc epsilon RI+ cells through interaction with the kappa light chains of IgE","volume":"170","author":"A Genovese","year":"2003","journal-title":"J Immunol"},{"issue":"Pt 3","key":"ref21","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1042\/bst0310716","article-title":"Immunoglobulin-binding domains: Protein L from Peptostreptococcus magnus","volume":"31","author":"NG Housden","year":"2003","journal-title":"Biochem Soc Trans"},{"issue":"1\u20132","key":"ref22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.imlet.2003.10.016","article-title":"Down-modulation of the antigen receptor by a superantigen for human B cells","volume":"92","author":"M Viau","year":"2004","journal-title":"Immunol Lett"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/IAI.72.6.3515-3523.2004","article-title":"Specific in vivo deletion of B-cell subpopulations expressing human immunoglobulins by the B-cell superantigen protein L","volume":"72","author":"M Viau","year":"2004","journal-title":"Infect Immun"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.4049\/jimmunol.178.5.2636","article-title":"Cutting Edge: Bim is required for superantigen-mediated B cell death","volume":"178","author":"CS Goodyear","year":"2007","journal-title":"J Immunol"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.157.3.1200","article-title":"Complement activation by a B cell superantigen","volume":"157","author":"LM Kozlowski","year":"1996","journal-title":"J Immunol"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1084\/jem.20020552","article-title":"Death by a B cell superantigen: In vivo VH-targeted apoptotic supraclonal B cell deletion by a Staphylococcal Toxin","volume":"197","author":"CS Goodyear","year":"2003","journal-title":"J Exp Med"},{"issue":"6874","key":"ref27","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/415922a","article-title":"BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes","volume":"415","author":"P Bouillet","year":"2002","journal-title":"Nature"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1182\/blood.V84.5.1402.1402","article-title":"The B7-2 (B70) costimulatory molecule expressed by monocytes and activated B lymphocytes is the CD86 differentiation antigen","volume":"84","author":"P Engel","year":"1994","journal-title":"Blood"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrc1560","article-title":"The role of apoptosis in cancer development and treatment response","volume":"5","author":"JM Brown","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0092-8674(02)00625-6","article-title":"Apoptosis: a link between cancer genetics and chemotherapy","volume":"108","author":"RW Johnstone","year":"2002","journal-title":"Cell"},{"issue":"51","key":"ref31","doi-asserted-by":"crossref","first-page":"49511","DOI":"10.1074\/jbc.M208086200","article-title":"Nerve growth factor (NGF) down-regulates the Bcl-2 homology 3 (BH3) domain-only protein Bim and suppresses its proapoptotic activity by phosphorylation","volume":"277","author":"SC Biswas","year":"2002","journal-title":"J Biol Chem"},{"issue":"24","key":"ref32","doi-asserted-by":"crossref","first-page":"7254","DOI":"10.1158\/1078-0432.CCR-07-1598","article-title":"BCL-2 family proteins: critical checkpoints of apoptotic cell death","volume":"13","author":"NN Danial","year":"2007","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molcel.2009.09.030","article-title":"Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis","volume":"36","author":"H Kim","year":"2009","journal-title":"Mol Cell"},{"issue":"13","key":"ref34","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1128\/MCB.23.13.4701-4712.2003","article-title":"Nonredundant role of Bax and Bak in Bid-mediated apoptosis","volume":"23","author":"PF Cartron","year":"2003","journal-title":"Mol Cell Biol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.molcel.2013.08.048","article-title":"BID preferentially activates BAK while BIM preferentially activates BAX, affecting chemotherapy response","volume":"51","author":"KA Sarosiek","year":"2013","journal-title":"Mol Cell"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1735","DOI":"10.1038\/cddis.2015.105","article-title":"Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax","volume":"6","author":"C Hockings","year":"2015","journal-title":"Cell Death Dis"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1084\/jem.189.11.1815","article-title":"Dephosphorylation targets Bcl-2 for ubiquitin-dependent degradation: a link between the apoptosome and the proteasome pathway","volume":"189","author":"S Dimmeler","year":"1999","journal-title":"The Journal of experimental medicine"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1158\/1078-0432.CCR-09-1638","article-title":"Expression of mutated IGHV3-23 genes in chronic lymphocytic leukemia identifies a disease subset with peculiar clinical and biological features","volume":"16","author":"R Bomben","year":"2010","journal-title":"Clin Cancer Res"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/leu.2008.379","article-title":"Molecular evidence for EBV and CMV persistence in a subset of patients with chronic lymphocytic leukemia expressing stereotyped IGHV4-34 B-cell receptors","volume":"23","author":"E Kostareli","year":"2009","journal-title":"Leukemia"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nri1853","article-title":"Confounding B-cell defences: lessons from a staphylococcal superantigen","volume":"6","author":"GJ Silverman","year":"2006","journal-title":"Nat Rev Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0162456","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T00:18:54Z","timestamp":1692490734000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0162456"}},"subtitle":[],"editor":[{"given":"Saeid","family":"Ghavami","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,7]]},"references-count":40,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,7]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0162456","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,9,7]]}}}