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Specific binding to cultured cells","volume":"257","author":"DF Bowen-Pope","year":"1982","journal-title":"J Biol Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0092-8674(00)81270-2","article-title":"PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis","volume":"85","author":"H Bostr\u00f6m","year":"1996","journal-title":"Cell"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1242\/dev.124.14.2691","article-title":"The PDGF alpha receptor is required for neural crest cell development and for normal patterning of the somites","volume":"124","author":"P Soriano","year":"1997","journal-title":"Development"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1242\/dev.126.3.457","article-title":"Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice","volume":"126","author":"M Fruttiger","year":"1999","journal-title":"Development"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1242\/dev.126.12.2611","article-title":"Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle","volume":"126","author":"L Karlsson","year":"1999","journal-title":"Development"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1242\/dev.127.16.3457","article-title":"Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis","volume":"127","author":"L Karlsson","year":"2000","journal-title":"Development"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1083\/jcb.149.5.1019","article-title":"Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice","volume":"149","author":"L Gnessi","year":"2000","journal-title":"J Cell Biol. The Rockefeller University Press"},{"key":"ref8","first-page":"3213","article-title":"Platelet-derived growth factor and its receptors in human glioma tissue: expression of messenger RNA and protein suggests the presence of autocrine and paracrine loops","volume":"52","author":"M Hermanson","year":"1992","journal-title":"Cancer Res"},{"key":"ref9","first-page":"164","article-title":"Association of loss of heterozygosity on chromosome 17p with high platelet-derived growth factor alpha receptor expression in human malignant gliomas","volume":"56","author":"M Hermanson","year":"1996","journal-title":"Cancer Res"},{"key":"ref10","first-page":"35","article-title":"A new prognostic strategy for gastric carcinoma: mRNA expression of tumor growth-related factors in endoscopic biopsy specimens","volume":"226","author":"M Nakamura","year":"1997","journal-title":"Ann Surg. 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Blackwell Publishing Ltd"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"C561","DOI":"10.1152\/ajpcell.00080.2014","article-title":"Platelet-derived growth factor receptor-\u03b1-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles","volume":"307","author":"M Kurahashi","year":"2014","journal-title":"Am J Physiol, Cell Physiol. American Physiological Society"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.it.2013.10.002","article-title":"Regulation of hematopoietic stem cells by bone marrow stromal cells","volume":"35","author":"BA Anthony","year":"2014","journal-title":"Trends Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature13165","article-title":"Capillary pericytes regulate cerebral blood flow in health and disease","volume":"508","author":"CN Hall","year":"2014","journal-title":"Nature. 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Blackwell Publishing Ltd"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"251204","DOI":"10.1155\/2015\/251204","article-title":"Neurotrauma and inflammation: CNS and PNS responses","volume":"2015","author":"BS Mietto","year":"2015","journal-title":"Mediators Inflamm. Hindawi Publishing Corporation"},{"key":"ref46","first-page":"1932","article-title":"Progenitor cells identified by PDGFR-alpha expression in the developing and diseased human heart","volume":"22","author":"JJH Chong","year":"2013","journal-title":"Stem Cells Dev. Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA"},{"key":"ref47","first-page":"2879","article-title":"Defining skeletal muscle resident progenitors and their cell fate potentials","volume":"140","author":"A Pann\u00e9rec","year":"2013","journal-title":"Development. 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