{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T06:07:05Z","timestamp":1763705225161,"version":"3.37.3"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T00:00:00Z","timestamp":1477872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science, Technology and Innovation Grant of Shenzhen Municipality","award":["JCYJ20140416141331532"],"award-info":[{"award-number":["JCYJ20140416141331532"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0162877","type":"journal-article","created":{"date-parts":[[2016,10,31]],"date-time":"2016-10-31T13:38:56Z","timestamp":1477921136000},"page":"e0162877","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["New Findings, Classification and Long-Term Follow-Up Study Based on MRI Characterization of Brainstem Encephalitis Induced by Enterovirus 71"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7832-3702","authenticated-orcid":true,"given":"Hongwu","family":"Zeng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiqiu","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yungen","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weibin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranran","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonker","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaiyi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changhong","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin K. L.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,10,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1056\/NEJM199909233411302","article-title":"Neurologic complications in children with enterovirus 71 infection","volume":"341","author":"CC Huang","year":"1999","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1056\/NEJM199909233411301","article-title":"An epidemic of enterovirus 71 infection in Taiwan. Taiwan Enterovirus Epidemic Working Group","volume":"341","author":"M Ho","year":"1999","journal-title":"N Engl J Med"},{"key":"ref3","first-page":"1742","article-title":"Neurologic complications in children with enterovirus 71-infected hand-foot-mouth disease: clinical features, MRI findings and follow-up study","volume":"92","author":"K Liu","year":"2012","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"ref4","first-page":"1889","article-title":"MR imaging findings of enteroviral encephaloymelitis: an outbreak in Taiwan","volume":"20","author":"WC Shen","year":"1999","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00234-011-0979-3","article-title":"MRI and associated clinical characteristics of EV71-induced brainstem encephalitis in children with hand-foot-mouth disease","volume":"54","author":"H Zeng","year":"2012","journal-title":"Neuroradiology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00234-011-0921-8","article-title":"Enterovirus 71-related encephalomyelitis: usual and unusual magnetic resonance imaging findings","volume":"54","author":"S Jang","year":"2012","journal-title":"Neuroradiology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S1474-4422(10)70209-X","article-title":"Clinical features, diagnosis, and management of enterovirus 71","volume":"9","author":"MH Ooi","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e87603","DOI":"10.1371\/journal.pone.0087603","article-title":"Study on risk factors for severe hand, foot and mouth disease in China","volume":"9","author":"W Li","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e88","DOI":"10.1542\/peds.109.6.e88","article-title":"Risk factors of enterovirus 71 infection and associated hand, foot, and mouth disease\/herpangina in children during an epidemic in Taiwan","volume":"109","author":"LY Chang","year":"2002","journal-title":"Pediatrics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3346\/jkms.2013.28.1.120","article-title":"Risk factors for neurologic complications of hand, foot and mouth disease in the Republic of Korea, 2009","volume":"28","author":"SJ Kim","year":"2013","journal-title":"J Korean Med Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jocn.2013.04.032","article-title":"Clinico-radiological spectrum in enterovirus 71 infection involving the central nervous system in children","volume":"21","author":"KY Lee","year":"2014","journal-title":"J Clin Neurosci"},{"key":"ref12","first-page":"338","article-title":"Critical care and therapy based different illness state of 80 patients with severe hand-foot-and-mouth disease seen in Shenzhen","volume":"47","author":"YX He","year":"2009","journal-title":"Zhonghua Er Ke Za Zhi"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1038\/modpathol.3880222","article-title":"Acute encephalomyelitis during an outbreak of enterovirus type 71 infection in Taiwan: report of an autopsy case with pathologic, immunofluorescence, and molecular studies","volume":"13","author":"C Hsueh","year":"2000","journal-title":"Mod Pathol"},{"key":"ref14","first-page":"81","article-title":"Pathology of enterovirus 71 infection: an autopsy study of 5 cases","volume":"38","author":"M Lu","year":"2009","journal-title":"Zhonghua Bing Li Xue Za Zhi"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1586\/14787210.2014.895666","article-title":"Update of enterovirus 71 infection: epidemiology, pathogenesis and vaccine","volume":"12","author":"SM Wang","year":"2014","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3109\/00207454.2012.657379","article-title":"MRI findings of neurological complications in hand-foot-mouth disease by enterovirus 71 infection","volume":"122","author":"J Li","year":"2012","journal-title":"Int J Neurosci"},{"key":"ref17","first-page":"220","article-title":"Autopsy report of two cases with enterovirus type 71 infection brainstem encephalitis and literature review","volume":"48","author":"D Wei","year":"2010","journal-title":"Zhonghua Er Ke Za Zhi"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0162877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T04:18:55Z","timestamp":1540268335000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0162877"}},"subtitle":[],"editor":[{"given":"Dewen","family":"Hu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,31]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0162877","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,10,31]]}}}