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Free statistical software: EZR (Easy R) on R commander. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.jichi.ac.jp\/saitama-sct\/SaitamaHP.files\/statmedEN.html\" xlink:type=\"simple\">http:\/\/www.jichi.ac.jp\/saitama-sct\/SaitamaHP.files\/statmedEN.html<\/ext-link>. Accessed 1 March 2012."},{"key":"ref10","first-page":"705","article-title":"Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells","volume":"10","author":"L Whitesell","year":"1996","journal-title":"Mol Endocrinol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0163-7258(98)00013-8","article-title":"The 90-kDa molecular chaperone family: structure, function, and clinical applications. 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