{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:52:41Z","timestamp":1789771961491,"version":"4.0.1"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T00:00:00Z","timestamp":1473811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2012-39903"],"award-info":[{"award-number":["AGL2012-39903"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["AGL2015-68738-R"],"award-info":[{"award-number":["AGL2015-68738-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["521-2011-6353"],"award-info":[{"award-number":["521-2011-6353"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001862","name":"Svenska Forskningsr\u00e5det Formas","doi-asserted-by":"publisher","award":["221-2011-512"],"award-info":[{"award-number":["221-2011-512"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Council in Southeast Sweden","award":["FORSS, 378091\/312971"],"award-info":[{"award-number":["FORSS, 378091\/312971"]}]},{"DOI":"10.13039\/501100003176","name":"Ministerio de Educaci\u00f3n, Cultura y Deporte","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007801","name":"Fundaci\u00f3n S\u00e9neca","doi-asserted-by":"publisher","award":["19892\/GERM\/15"],"award-info":[{"award-number":["19892\/GERM\/15"]}],"id":[{"id":"10.13039\/100007801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0162958","type":"journal-article","created":{"date-parts":[[2016,9,14]],"date-time":"2016-09-14T17:47:22Z","timestamp":1473875242000},"page":"e0162958","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":46,"title":["Glutathione Peroxidase 5 Is Expressed by the Entire Pig Male Genital Tract and Once in the Seminal Plasma Contributes to Sperm Survival and In Vivo Fertility"],"prefix":"10.1371","volume":"11","author":[{"given":"Isabel","family":"Barranco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asta","family":"Tvarijonaviciute","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Perez-Pati\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Vicente-Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inmaculada","family":"Parrilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose J.","family":"Ceron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio A.","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heriberto","family":"Rodriguez-Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,9,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1439-0531.2011.01865.x","article-title":"Stress and dietary factors modify boar sperm for processing","volume":"46","author":"L Radomil","year":"2011","journal-title":"Reprod Domest Anim"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1556\/AVet.2011.034","article-title":"Impact of oxidative stress on male fertility\u2014a review","volume":"59","author":"E Tvrd\u00e1","year":"2011","journal-title":"Acta Vet Hung"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1016\/j.theriogenology.2008.06.007","article-title":"Influence of seminal plasma on the kinematics of boar spermatozoa during freezing","volume":"70","author":"H Rodriguez-Martinez","year":"2008","journal-title":"Theriogenology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"536","DOI":"10.2164\/jandrol.110.012583","article-title":"Seminal plasma: an essential attribute to spermatozoa","volume":"33","author":"NS Juyena","year":"2012","journal-title":"J Androl"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.bbagen.2013.06.030","article-title":"In vitro measurements and interpretation of total antioxidant capacity","volume":"1840","author":"CG Fraga","year":"2014","journal-title":"Biochim Biophys Acta"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"18538","DOI":"10.1038\/srep18538","article-title":"High total antioxidant capacity of the porcine seminal plasma (SP-TAC) relates to sperm survival and fertility","volume":"5","author":"I Barranco","year":"2015","journal-title":"Sci Rep"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.2527\/jas.2005-766","article-title":"Determination of intracellular reactive oxygen species and high mitochondrial membrane potential in Percoll-treated viable boar sperm using fluorescence-activated flow cytometry","volume":"84","author":"HD Guthrie","year":"2006","journal-title":"J Anim Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1095\/biolreprod.109.076471","article-title":"Reactive oxygen species and boar sperm function","volume":"81","author":"BJ Awda","year":"2009","journal-title":"Biol Reprod"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.2527\/jas.2009-2583","article-title":"Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity","volume":"88","author":"E Chabory","year":"2010","journal-title":"J Anim Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2164\/jandrol.110.012823","article-title":"Glutathione peroxidases at work on epididymal spermatozoa: an example of the dual effect of reactive oxygen species on mammalian male fertilizing ability","volume":"32","author":"A Noblanc","year":"2011","journal-title":"J Androl"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1016\/j.bbagen.2012.11.020","article-title":"Glutathione peroxidases","volume":"1830","author":"R Brigelius-Floh\u00e9","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"188","DOI":"10.2164\/jandrol.109.007583","article-title":"Seminal plasma proteins as potential markers of relative fertility in boars","volume":"31","author":"S Novak","year":"2010","journal-title":"J Androl"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.anireprosci.2015.12.001","article-title":"Triosephosphate isomerase (TPI) and epididymal secretory glutathione peroxidase (GPX5) are markers for boar sperm quality","volume":"165","author":"I Vilagran","year":"2016","journal-title":"Anim Reprod Sci"},{"key":"ref14","article-title":"Will AI in pigs become more efficient?","author":"J Roca","year":"2015","journal-title":"Theriogenology"},{"key":"ref15","article-title":"The mu (\u03bc) and delta (\u03b4) opioid receptors modulate boar sperm motility","author":"A Vicente-Carrillo","year":"2016","journal-title":"Mol Reprod Dev"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4327","DOI":"10.2527\/jas.2012-5040","article-title":"Relationship of flow cytometric sperm integrity assessments with boar fertility performance under optimized field conditions","volume":"90","author":"ML Broekhuijse","year":"2012","journal-title":"J Anim Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/andr.12009","article-title":"Comparative analysis of boar seminal plasma proteome from different freezability ejaculates and identification of Fibronectin 1 as sperm freezability marker","volume":"3","author":"I Vilagran","year":"2015","journal-title":"Andrology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/andr.309","article-title":"The activity of paraoxonase type 1 (PON-1) in boar seminal plasma and its relationship with sperm quality, functionality, and in vivo fertility","volume":"3","author":"I Barranco","year":"2015","journal-title":"Andrology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-0897.2011.01033.x","article-title":"Seminal plasma proteins: what role do they play?","volume":"66","author":"H Rodriguez-Martinez","year":"2011","journal-title":"Am J Reprod Immunol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X","article-title":"Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase","volume":"47","author":"P Vernet","year":"1997","journal-title":"Mol Reprod Dev"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/molehr\/4.9.841","article-title":"Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract","volume":"4","author":"K Williams","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.theriogenology.2005.01.008","article-title":"GPX5 orthologs of the mouse epididymis-restricted and sperm-bound selenium-independent glutathione peroxidase are not expressed with the same quantitative and spatial characteristics in large domestic animals","volume":"64","author":"E Grignard","year":"2005","journal-title":"Theriogenology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1002\/mrd.10136","article-title":"GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations","volume":"63","author":"H Rejraji","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2005.12.027","article-title":"The antioxidant glutathione peroxidase family and spermatozoa: a complex story","volume":"250","author":"JR Drevet","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1071\/RD08008","article-title":"GPX5, the selenium-independent glutathione peroxidase-encoding single copy gene is differentially expressed in mouse epididymis","volume":"20","author":"T Zhang","year":"2008","journal-title":"Reprod Fertil Dev"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.theriogenology.2007.08.016","article-title":"Localization and characterization of glutathione peroxidase (GPx) in boar accessory sex glands, seminal plasma, and spermatozoa and activity of GPx in boar semen","volume":"69","author":"L Jelezarsky","year":"2008","journal-title":"Theriogenology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1515\/BC.2003.070","article-title":"Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)","volume":"384","author":"SG Moreno","year":"2003","journal-title":"Biol Chem"},{"key":"ref28","article-title":"Non-viable sperm in the ejaculate: Lethal escorts for contemporary viable sperm","author":"J Roca","year":"2016","journal-title":"Anim Reprod Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1093\/humrep\/dev302","article-title":"A novel antioxidant formulation designed to treat male infertility associated with oxidative stress: promising preclinical evidence from animal models","volume":"31","author":"P Gharagozloo","year":"2016","journal-title":"Hum Reprod"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.anireprosci.2003.08.007","article-title":"Variability in relationships between semen quality and estimates of in vivo and in vitro fertility in boars","volume":"81","author":"JM Popwell","year":"2004","journal-title":"Anim Reprod Sci"},{"key":"ref31","first-page":"2074","article-title":"Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice","volume":"119","author":"E Chabory","year":"2009","journal-title":"J Clin Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0304-4165(97)00016-0","article-title":"Molecular cloning and characterization of the epididymis-specific glutathione peroxidase-like protein secreted in the porcine epididymal fluid","volume":"1336","author":"N Okamura","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.theriogenology.2007.12.004","article-title":"Sperm chromatin structure integrity in liquid stored boar semen and its relationships with field fertility","volume":"69","author":"GB Boe-Hansen","year":"2008","journal-title":"Theriogenology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"A Agarwal","year":"2012","journal-title":"Reprod Biol Endocrinol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0162958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:44:10Z","timestamp":1588999450000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0162958"}},"subtitle":[],"editor":[{"given":"Jo\u00ebl R","family":"Drevet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,14]]},"references-count":34,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0162958","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,14]]}}}