{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:36:26Z","timestamp":1761129386053,"version":"3.37.3"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T00:00:00Z","timestamp":1475107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","award":["Not appicable"],"award-info":[{"award-number":["Not appicable"]}],"id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute for Health Research Health Protection Research Unit (NIHR HPRU) in Evaluation of Interventions at University of Bristol","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]},{"name":"NIH (Pepfar supplement) and Canadian Institute of Health Research. This work is produced by the authors under the terms of the research training fellowships issued by the NIHR.","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0163435","type":"journal-article","created":{"date-parts":[[2016,9,29]],"date-time":"2016-09-29T15:11:37Z","timestamp":1475161897000},"page":"e0163435","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pneumococcal Serotypes Colonise the Nasopharynx in Children at Different Densities"],"prefix":"10.1371","volume":"11","author":[{"given":"Fernanda","family":"Rodrigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Danon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Begonia","family":"Morales-Aza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulina","family":"Sikora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valtyr","family":"Thors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muriel","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Gould","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Hinds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Finn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,9,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1086\/423820","article-title":"Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children","volume":"190","author":"AB Brueggemann","year":"2004","journal-title":"J Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1086\/313609","article-title":"The contribution of specific pneumococcal serogroups to different disease manifestations: implications for conjugate vaccine formulation and use, part II","volume":"30","author":"WP Hausdorff","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.epidem.2010.03.005","article-title":"Evidence that pneumococcal serotype replacement in Massachusetts following conjugate vaccination is now complete","volume":"2","author":"WP Hanage","year":"2010","journal-title":"Epidemics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e1001017","DOI":"10.1371\/journal.pmed.1001017","article-title":"Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study","volume":"8","author":"S Flasche","year":"2011","journal-title":"PLoS Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1000476","DOI":"10.1371\/journal.ppat.1000476","article-title":"Pneumococcal capsular polysaccharide structure predicts serotype prevalence","volume":"5","author":"DM Weinberger","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"A Kadioglu","year":"2008","journal-title":"Nat Rev Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/21645515.2015.1090069","article-title":"Population density profiles of nasopharyngeal carriage of 5 bacterial species in pre-school children measured using quantitative PCR offer potential insights into the dynamics of transmission","volume":"12","author":"V Thors","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1017\/S0022172400031879","article-title":"The Significance of Pneumococcal Types","volume":"27","author":"F Griffith","year":"1928","journal-title":"J Hyg (Lond)"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e1001903","DOI":"10.1371\/journal.pmed.1001903","article-title":"The PneuCarriage Project: A Multi-Centre Comparative Study to Identify the Best Serotyping Methods for Examining Pneumococcal Carriage in Vaccine Evaluation Studies","volume":"12","author":"C Satzke","year":"2015","journal-title":"PLoS Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e102045","DOI":"10.1371\/journal.pone.0102045","article-title":"Streptococcus pneumoniae in saliva of Dutch primary school children","volume":"9","author":"AL Wyllie","year":"2014","journal-title":"PLoS One"},{"key":"ref11","unstructured":"Hinds J, Gould K, Witney A, Baldry S, Lambersten L. Investigation of serotype diversity, non-typeable isolates and nasopharyngeal co-colonization by microarray-based molecular serotyping of Streptococcus pneumoniae.; 2010; Tel Aviv, Israel. pp. 129."},{"key":"ref12","unstructured":"Gould K, Pond M, Baldry S, Turner P, Bently S, Hinds J. Evaluation and optimization of methods to facilitate direct analysis of nasopharyngeal swabs by microarray-based molecular serotyping.; 2010; Tel Aviv, Israel."},{"key":"ref13","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2105-12-88","article-title":"Empirical Bayesian models for analysing molecular serotyping microarrays","volume":"12","author":"R Newton","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"ref14","unstructured":"R Core Team (2015). R: A language and environment for statistical computing. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.R-project.org\/\" xlink:type=\"simple\">http:\/\/www.R-project.org\/<\/ext-link>. Accessed 26 February 2015."},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1371\/journal.pmed.0020015","article-title":"Are anticapsular antibodies the primary mechanism of protection against invasive pneumococcal disease?","volume":"2","author":"M Lipsitch","year":"2005","journal-title":"PLoS Med"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.1215947","article-title":"Niche and neutral effects of acquired immunity permit coexistence of pneumococcal serotypes","volume":"335","author":"S Cobey","year":"2012","journal-title":"Science"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.7717\/peerj.97","article-title":"Non-pneumococcal mitis-group streptococci confound detection of pneumococcal capsular serotype-specific loci in upper respiratory tract","volume":"1","author":"Mda G Carvalho","year":"2013","journal-title":"PeerJ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0163435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:55:03Z","timestamp":1588971303000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0163435"}},"subtitle":[],"editor":[{"given":"Jose","family":"Melo-Cristino","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,9,29]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0163435","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,9,29]]}}}