{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:40:54Z","timestamp":1783024854512,"version":"3.54.6"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0163608","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T15:13:42Z","timestamp":1475680422000},"page":"e0163608","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of Approaches for Stroke Prophylaxis in Patients with Non-Valvular Atrial Fibrillation: Network Meta-Analyses of Randomized Controlled Trials"],"prefix":"10.1371","volume":"11","author":[{"given":"Navkaranbir S.","family":"Bajaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8982-0595","authenticated-orcid":true,"given":"Rajat","family":"Kalra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nirav","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taimoor","family":"Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Godara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Ather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garima","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tilak","family":"Pasala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas T.","family":"Whitfield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"McGiffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa I.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven G.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita A.","family":"Limdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"issue":"9989","key":"ref1","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0140-6736(14)61774-8","article-title":"50 year trends in atrial fibrillation prevalence, incidence, risk factors, and mortality in the Framingham Heart Study: a cohort study","volume":"386","author":"RB Schnabel","year":"2015","journal-title":"Lancet"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1001\/jama.2014.7692","article-title":"Stroke incidence and mortality trends in US communities, 1987 to 2011","volume":"312","author":"S Koton","year":"2014","journal-title":"JAMA"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.amjcard.2014.05.045","article-title":"Impact of atrial fibrillation and heart failure, independent of each other and in combination, on mortality in community-dwelling older adults","volume":"114","author":"NS Bajaj","year":"2014","journal-title":"Am J Cardiol"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJMoa1009638","article-title":"Rivaroxaban versus warfarin in nonvalvular atrial fibrillation","volume":"365","author":"MR Patel","year":"2011","journal-title":"N Engl J Med"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1056\/NEJMoa1107039","article-title":"Apixaban versus warfarin in patients with atrial fibrillation","volume":"365","author":"CB Granger","year":"2011","journal-title":"N Engl J Med"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJMoa0905561","article-title":"Dabigatran versus warfarin in patients with atrial fibrillation","volume":"361","author":"SJ Connolly","year":"2009","journal-title":"N Engl J Med"},{"issue":"22","key":"ref7","doi-asserted-by":"crossref","first-page":"2093","DOI":"10.1056\/NEJMoa1310907","article-title":"Edoxaban versus warfarin in patients with atrial fibrillation","volume":"369","author":"RP Giugliano","year":"2013","journal-title":"N Engl J Med"},{"key":"ref8","unstructured":"WATCHMAN LAA Closure Technology. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf13\/p130013a.pdf\" xlink:type=\"simple\">http:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf13\/p130013a.pdf<\/ext-link>. Accessed 4 November 2015."},{"issue":"19","key":"ref9","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1001\/jama.2014.15192","article-title":"Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial","volume":"312","author":"VY Reddy","year":"2014","journal-title":"JAMA"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jacc.2014.04.029","article-title":"Prospective randomized evaluation of the Watchman Left Atrial Appendage Closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial","volume":"64","author":"DR Holmes Jr.","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"20","key":"ref11","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1161\/CIRCULATIONAHA.112.115410","article-title":"Efficacy and safety of the novel oral anticoagulants in atrial fibrillation: a systematic review and meta-analysis of the literature","volume":"126","author":"F Dentali","year":"2012","journal-title":"Circulation"},{"issue":"9921","key":"ref12","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/S0140-6736(13)62343-0","article-title":"Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials","volume":"383","author":"CT Ruff","year":"2014","journal-title":"Lancet"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"e004301","DOI":"10.1136\/bmjopen-2013-004301","article-title":"Systematic review and network meta-analysis comparing antithrombotic agents for the prevention of stroke and major bleeding in patients with atrial fibrillation","volume":"4","author":"C Cameron","year":"2014","journal-title":"BMJ Open"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jacc.2012.03.019","article-title":"Indirect comparisons of new oral anticoagulant drugs for efficacy and safety when used for stroke prevention in atrial fibrillation","volume":"60","author":"GY Lip","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jcin.2013.11.010","article-title":"Percutaneous left atrial appendage occlusion for stroke prophylaxis in nonvalvular atrial fibrillation: a systematic review and analysis of observational studies","volume":"7","author":"NS Bajaj","year":"2014","journal-title":"JACC Cardiovasc Interv"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ijcard.2015.11.181","article-title":"Comparison of Watchman device with new oral anti-coagulants in patients with atrial fibrillation: A network meta-analysis","volume":"205","author":"E Koifman","year":"2016","journal-title":"Int J Cardiol"},{"issue":"7387","key":"ref17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1136\/bmj.326.7387.472","article-title":"Validity of indirect comparison for estimating efficacy of competing interventions: empirical evidence from published meta-analyses","volume":"326","author":"F Song","year":"2003","journal-title":"BMJ"},{"issue":"5","key":"ref18","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jclinepi.2007.06.006","article-title":"Adjusted indirect comparison may be less biased than direct comparison for evaluating new pharmaceutical interventions","volume":"61","author":"F Song","year":"2008","journal-title":"J Clin Epidemiol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"A Liberati","year":"2009","journal-title":"PLoS Med"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"777","DOI":"10.7326\/M14-2385","article-title":"The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations","volume":"162","author":"B Hutton","year":"2015","journal-title":"Ann Intern Med"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1111\/j.1538-7836.2005.01204.x","article-title":"Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients","volume":"3","author":"S Schulman","year":"2005","journal-title":"J Thromb Haemost"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0197-2456(95)00134-4","article-title":"Assessing the quality of reports of randomized clinical trials: is blinding necessary?","volume":"17","author":"AR Jadad","year":"1996","journal-title":"Control Clin Trials"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"g5630","DOI":"10.1136\/bmj.g5630","article-title":"A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis","volume":"349","author":"MA Puhan","year":"2014","journal-title":"BMJ"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"D Moher","year":"2009","journal-title":"PLoS Med"},{"issue":"20","key":"ref25","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1002\/sim.1875","article-title":"Combination of direct and indirect evidence in mixed treatment comparisons","volume":"23","author":"G Lu","year":"2004","journal-title":"Stat Med"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/1536867X1101100206","article-title":"Multivariate random-effects meta-regression: Updates to mvmeta","volume":"11","author":"IR White","year":"2011","journal-title":"Stata Journal"},{"issue":"10","key":"ref27","doi-asserted-by":"crossref","first-page":"e76654","DOI":"10.1371\/journal.pone.0076654","article-title":"Graphical tools for network meta-analysis in STATA","volume":"8","author":"A Chaimani","year":"2013","journal-title":"PloS one"},{"key":"ref28","author":"HC Romesburg","year":"1985"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1056\/NEJMoa1007432","article-title":"Apixaban in patients with atrial fibrillation","volume":"364","author":"SJ Connolly","year":"2011","journal-title":"N Engl J Med"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.amjmed.2014.05.003","article-title":"Stroke and bleeding risk co-distribution in real-world patients with atrial fibrillation: the Euro Heart Survey","volume":"127","author":"M Marcucci","year":"2014","journal-title":"Am J Med"},{"key":"ref31","unstructured":"FDA Executive summary. Prepared for the October 8, 2014 meeting of the Circulatory System Devices Panel. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fda.gov\/downloads\/AdvisoryCommittees\/CommitteesMeetingMaterials\/MedicalDevices\/MedicalDevicesAdvisoryCommittee\/CirculatorySystemDevicesPanel\/UCM417199.pdf\" xlink:type=\"simple\">http:\/\/www.fda.gov\/downloads\/AdvisoryCommittees\/CommitteesMeetingMaterials\/MedicalDevices\/MedicalDevicesAdvisoryCommittee\/CirculatorySystemDevicesPanel\/UCM417199.pdf<\/ext-link>. Accessed 4 November 2015."},{"issue":"21","key":"ref32","first-page":"e1","article-title":"2014 AHA\/ACC\/HRS guideline for the management of patients with atrial fibrillation: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines and the Heart Rhythm Society","volume":"64","author":"CT January","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"130","DOI":"10.7326\/0003-4819-159-2-201307160-00008","article-title":"Conceptual and technical challenges in network meta-analysis","volume":"159","author":"A Cipriani","year":"2013","journal-title":"Ann Intern Med"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0163608","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,14]],"date-time":"2019-09-14T04:58:50Z","timestamp":1568437130000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0163608"}},"subtitle":[],"editor":[{"given":"Gianpaolo","family":"Reboldi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0163608","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}