{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:37:21Z","timestamp":1790764641906,"version":"4.1.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0163765","type":"journal-article","created":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T13:43:29Z","timestamp":1475761409000},"page":"e0163765","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["A Potential Magnetic Resonance Imaging Technique Based on Chemical Exchange Saturation Transfer for In Vivo \u03b3-Aminobutyric Acid Imaging"],"prefix":"10.1371","volume":"11","author":[{"given":"Gen","family":"Yan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuozhi","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meizhi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1177\/1073858402238515","article-title":"Book review: GABA and glutamate in the human brain","volume":"8","author":"O Petroff","year":"2002","journal-title":"The Neuroscientist"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1080\/10799890600920035","article-title":"Gaba a receptors in central nervous system disease: Anxiety, epilepsy, and insomnia","volume":"26","author":"H Moehler","year":"2006","journal-title":"Journal of Receptors and Signal Transduction"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/brain\/105.2.313","article-title":"A post-mortem study of the cholinergic and GABA systems in senile dementia","volume":"105","author":"M Rossor","year":"1982","journal-title":"Brain: a journal of neurology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/01.jcp.0000095349.32154.a5","article-title":"GABA and schizophrenia: a review of basic science and clinical studies","volume":"23","author":"A Wassef","year":"2003","journal-title":"Journal of clinical psychopharmacology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0730-725X(93)90418-D","article-title":"In vivo quantification of brain metabolites by 1H-MRS using water as an internal standard","volume":"11","author":"P Christiansen","year":"1993","journal-title":"Magnetic Resonance Imaging"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.3748\/wjg.v18.i10.1130","article-title":"Quantification of choline concentration following liver cell apoptosis using <sup>1<\/sup>H magnetic resonance spectroscopy","volume":"18","author":"Z Shen","year":"2012","journal-title":"World Journal of Gastroenterology: WJG"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1038\/npp.2012.142","article-title":"The impact of gabapentin administration on brain gaba and glutamate concentrations: A 7t 1h-mrs study","volume":"37","author":"K Cai","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"ref8","first-page":"7","article-title":"Magnetic resonance spectroscopy studies of GABA in neuropsychiatric disorders","volume":"64","author":"L Chang","year":"2002","journal-title":"The Journal of clinical psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/jmre.1999.1956","article-title":"A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (cest)","volume":"143","author":"K Ward","year":"2000","journal-title":"Journal of magnetic resonance"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/nm907","article-title":"Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI","volume":"9","author":"J Zhou","year":"2003","journal-title":"Nature medicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1038\/nature07017","article-title":"Magnetic resonance imaging of pH <italic>in vivo<\/italic> using hyperpolarized <sup>13<\/sup>c-labelled bicarbonate","volume":"453","author":"F Gallagher","year":"2008","journal-title":"Nature"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/mrm.22628","article-title":"Fast multi-slice ph-weighted chemical exchange saturation transfer (cest) MRI with unevenly segmented RF irradiation","volume":"65","author":"P Sun","year":"2011","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1002\/mrm.20989","article-title":"Amide proton transfer imaging of human brain tumors at 3T","volume":"56","author":"C Jones","year":"2006","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1073\/pnas.0707666105","article-title":"Assessment of glycosaminoglycan concentration <italic>in vivo<\/italic> by chemical exchange-dependent saturation transfer (gagcest)","volume":"105","author":"W Ling","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/nbm.2949","article-title":"Mapping glutamate in subcortical brain structures using high-resolution glucest mri","volume":"26","author":"K Cai","year":"2013","journal-title":"NMR in Biomedicine"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.neuroimage.2010.10.017","article-title":"In vivo mapping of brain myo-inositol","volume":"54","author":"M Haris","year":"2011","journal-title":"Neuroimage"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/nbm.2875","article-title":"Imaging of glutamate neurotransmitter alterations in Alzheimer&apos;s disease","volume":"26","author":"M Haris","year":"2013","journal-title":"NMR in Biomedicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/mrm.24641","article-title":"Method for high-resolution imaging of creatine in vivo using chemical exchange saturation transfer","volume":"71","author":"F Kogan","year":"2014","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nm.2615","article-title":"Magnetic resonance imaging of glutamate","volume":"18","author":"K Cai","year":"2012","journal-title":"Nature medicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"808","DOI":"10.3171\/jns.1980.53.6.0808","article-title":"An improved rat brain-tumor model","volume":"53","author":"N Kobayashi","year":"1980","journal-title":"Journal of neurosurgery"},{"key":"ref21","first-page":"732","article-title":"A comparison of the effects of ketamine, chloral hydrate and pentobarbital sodium anesthesia on isolated rat hearts and cardiomyocytes","volume":"12","author":"X Jiang","year":"2011","journal-title":"A comparison of the effects of ketamine, chloral hydrate and pentobarbital sodium anesthesia on isolated rat hearts and cardiomyocytes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/mrm.21873","article-title":"Water saturation shift referencing (WASSR) for chemical exchange saturation transfer (CEST) experiments","volume":"61","author":"M Kim","year":"2009","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.neuroimage.2013.03.072","article-title":"Imaging of glutamate in the spinal cord using GluCEST","volume":"77","author":"F Kogan","year":"2013","journal-title":"Neuroimage"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneumeth.2012.09.025","article-title":"MICEST: a potential tool for non-invasive detection of molecular changes in Alzheimer&apos;s disease","volume":"212","author":"M Haris","year":"2013","journal-title":"Journal of neuroscience methods"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/jcbfm.2013.79","article-title":"Imaging brain deoxyglucose uptake and metabolism by glucoCEST MRI","volume":"33","author":"FA Nasrallah","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/mrm.1910100113","article-title":"Magnetization transfer contrast (MTC) and tissue water proton relaxation <italic>in vivo<\/italic>","volume":"10","author":"S Wolff","year":"1989","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1002\/mrm.24560","article-title":"Quantitative characterization of nuclear overhauser enhancement and amide proton transfer effects in the human brain at 7 tesla","volume":"70","author":"D Liu","year":"2013","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1002\/mrm.24315","article-title":"MR imaging of the amide-proton transfer effect and the pH-insensitive nuclear overhauser effect at 9.4 T","volume":"69","author":"T Jin","year":"2013","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1002\/mrm.21387","article-title":"Quantitative description of the asymmetry in magnetization transfer effects around the water resonance in the human brain","volume":"58","author":"J Hua","year":"2007","journal-title":"Magnetic Resonance in Medicine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1002\/mrm.22891","article-title":"Saturation power dependence of amide proton transfer image contrasts in human brain tumors and strokes at 3 T","volume":"66","author":"X Zhao","year":"2011","journal-title":"Magnetic Resonance in Medicine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0163765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:52:40Z","timestamp":1540223560000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0163765"}},"subtitle":[],"editor":[{"given":"Quan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,6]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0163765","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,6]]}}}