{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T15:00:01Z","timestamp":1792249201459,"version":"4.4.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["LP0989701"],"award-info":[{"award-number":["LP0989701"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0163780","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T19:20:44Z","timestamp":1475695244000},"page":"e0163780","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Altered Immune Cytokine Expression Associated with KoRV B Infection and Season in Captive Koalas"],"prefix":"10.1371","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0865-9016","authenticated-orcid":true,"given":"Iona E.","family":"Maher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien P.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"key":"ref1","unstructured":"Department of Sustainability E, Water, Population and Communities (2013) Koala populations in Queensland, New South Wales and the Australian Capital Territory and national environment law. Avaliable: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.environment.gov.au\/biodiversity\/threatened\/publications\/koala-species-listing.html\" xlink:type=\"simple\">http:\/\/www.environment.gov.au\/biodiversity\/threatened\/publications\/koala-species-listing.html<\/ext-link>."},{"key":"ref2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7589\/2012-05-135","article-title":"A retrospective study of admission trends of koalas to a rehabilitation facility over 30 years","volume":"49","author":"JE Griffith","year":"2013","journal-title":"Journal of Wildlife Diseases"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1111\/j.1751-0813.1987.tb06059.x","article-title":"A mortality survey of free range koalas from the north coast of New South Wales","volume":"64","author":"P Canfield","year":"1987","journal-title":"Australian Veterinary Journal"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.7589\/0090-3558-19.2.123","article-title":"Causes of mortality and morbidity of wild koalas, <italic>Phascolarctos cinereus (Goldfuss)<\/italic>, in Victoria, Australia","volume":"19","author":"DL Obendorf","year":"1983","journal-title":"Journal of Wildlife Diseases"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1071\/PC070189","article-title":"The impact of fire and dogs on koalas at Port Stephens, New South Wales, using population viability analysis","volume":"13","author":"D Lunney","year":"2007","journal-title":"Pacific Conservation Biology"},{"key":"ref6","first-page":"150","article-title":"Wildlife &amp; climate change: towards robust conservation strategies for Australian fauna","author":"D Lunney","year":"2012"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1442-9993.1988.tb00993.x","article-title":"A koala (<italic>Phascolarctos cinereus Goldfuss<\/italic>) population crash during drought and heatwave conditions in south-western Queensland","volume":"13","author":"G Gordon","year":"1988","journal-title":"Australian Journal of Ecology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1071\/WR02029","article-title":"Koala mortality on roads in south-east Queensland: the koala speed-zone trial","volume":"30","author":"DS Dique","year":"2003","journal-title":"Wildlife Research"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1071\/WR10156","article-title":"Modelling climate-change-induced shifts in the distribution of the koala","volume":"38","author":"C Adams-Hosking","year":"2011","journal-title":"Wildlife Research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.biocon.2010.12.027","article-title":"Using integrated population modelling to quantify the implications of multiple threatening processes for a rapidly declining population","volume":"144","author":"JR Rhodes","year":"2011","journal-title":"Biological Conservation"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.7589\/2014-12-278","article-title":"The paradox of euthanizing koalas (<italic>Phascolarctos cinereus<\/italic>) to save populations from elimination","volume":"51","author":"DP Wilson","year":"2015","journal-title":"Journal of Wildlife Diseases"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetmic.2013.02.026","article-title":"Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas","volume":"165","author":"A Polkinghorne","year":"2013","journal-title":"Veterinary Microbiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1099\/vir.0.80547-0","article-title":"Real-time reverse transcriptase PCR for the endogenous koala retrovirus reveals an association between plasma viral load and neoplastic disease in koalas","volume":"86","author":"R Tarlinton","year":"2005","journal-title":"Journal of General Virology"},{"key":"ref14","first-page":"303","article-title":"Lymphoid neoplasia in the koala (<italic>Phascolarctos cinereus<\/italic>)\u2014A review and classification of 31 cases","volume":"27","author":"AJ Spencer","year":"1996","journal-title":"Journal of Zoo and Wildlife Medicine"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/j.1751-0813.1998.tb12337.x","article-title":"Lymphoid neoplasia in the koala","volume":"76","author":"JH Connolly","year":"1998","journal-title":"Australian Veterinary Journal"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/JVI.74.9.4264-4272.2000","article-title":"The nucleotide sequence of koala (<italic>Phascolarctos cinereus<\/italic>) retrovirus: a novel type C endogenous virus related to Gibbon ape leukemia virus","volume":"74","author":"JJ Hanger","year":"2000","journal-title":"Journal of Virology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nature04841","article-title":"Retroviral invasion of the koala genome","volume":"442","author":"RE Tarlinton","year":"2006","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/molbev\/msu275","article-title":"Proliferation of Endogenous Retroviruses in the Early Stages of a Host Germ Line Invasion","volume":"32","author":"Y Ishida","year":"2015","journal-title":"Molecular Biology and Evolution"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1023\/A:1024455415443","article-title":"The evolution, distribution and diversity of endogenous retroviruses","volume":"26","author":"R Gifford","year":"2003","journal-title":"Virus Genes"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"9943","DOI":"10.1128\/JVI.01385-13","article-title":"Identification of a novel subgroup of koala retrovirus from koalas in Japanese zoos","volume":"87","author":"T Shojima","year":"2013","journal-title":"Journal of Virology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"11547","DOI":"10.1073\/pnas.1304704110","article-title":"An exogenous retrovirus isolated from koalas with malignant neoplasias in a US zoo","volume":"110","author":"W Xu","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.3390\/v7031258","article-title":"Genetic Diversity of Koala Retroviral Envelopes","volume":"7","author":"W Xu","year":"2015","journal-title":"Viruses"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/1742-4690-10-108","article-title":"Koala retroviruses: characterization and impact on the life of koalas","volume":"10","author":"J Denner","year":"2013","journal-title":"Retrovirology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.3390\/v3091681","article-title":"Viral determinants of FeLV infection and pathogenesis: lessons learned from analysis of a natural cohort","volume":"3","author":"LL Bolin","year":"2011","journal-title":"Viruses"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"17506","DOI":"10.1073\/pnas.0704313104","article-title":"Changes in viral protein function that accompany retroviral endogenization","volume":"104","author":"NM Oliveira","year":"2007","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1751-0813.2012.00964.x","article-title":"Prevalence of koala retrovirus in geographically diverse populations in Australia","volume":"90","author":"G Simmons","year":"2012","journal-title":"Australian Veterinary Journal"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.vetmic.2013.02.026","article-title":"Recent advances in understanding the biology, epidemiology and control of chlamydial infections in koalas","volume":"165","author":"A Polkinghorne","year":"2013","journal-title":"Veterinary Microbiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"309","DOI":"10.7589\/2014-07-176","article-title":"The prevalence and clinical significance of Chlamydia infection in island and mainland populations of Victorian koalas (<italic>Phascolarctos cinereus<\/italic>)","volume":"51","author":"JL Patterson","year":"2015","journal-title":"Journal of Wildlife Diseases"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3853\/j.1835-4211.24.2014.1612","article-title":"An examination of disease in captive Australian koalas (<italic>Phascolarctos cinereus<\/italic>) and potential links to koala retrovirus (KoRV)","volume":"24","author":"AK Gillett","year":"2014","journal-title":"Technical Reports of the Australian Museum (online)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.biocon.2016.03.018","article-title":"Koala translocations and Chlamydia: Managing risk in the effort to conserve native species","volume":"197","author":"C Waugh","year":"2016","journal-title":"Biological Conservation"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8000","article-title":"Widespread seasonal gene expression reveals annual differences in human immunity and physiology","volume":"6","author":"XC Dopico","year":"2015","journal-title":"Nature Communications"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cyto.2003.08.005","article-title":"Seasonal variation in whole blood cytokine production after LPS stimulation in normal individuals","volume":"24","author":"P Myrianthefs","year":"2003","journal-title":"Cytokine"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-2249.2010.04315.x","article-title":"Regulation of cytokine responses by seasonality of vitamin D status in healthy individuals","volume":"164","author":"AL Khoo","year":"2011","journal-title":"Clinical and Experimental Immunology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/pim.12036","article-title":"Wild rodents as a model to discover genes and pathways underlying natural variation in infectious disease susceptibility","volume":"35","author":"A Turner","year":"2013","journal-title":"Parasite Immunology"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-016-2701-7","article-title":"Seasonal immunoregulation in a naturally-occurring vertebrate","volume":"17","author":"M Brown","year":"2016","journal-title":"BMC Genomics"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/cimm.2000.1623","article-title":"Seasonal variations in cytokine expression and cell-mediated immunity in male rhesus monkeys","volume":"200","author":"DR Mann","year":"2000","journal-title":"Cellular Immunology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1078\/1438-4639-00172","article-title":"Seasonal influences on immunological parameters in HIV-infected homosexual men: searching for the immunomodulating effects of sunlight","volume":"205","author":"F Termorshuizen","year":"2002","journal-title":"International Journal of Hygiene and Environmental Health"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetimm.2012.04.010","article-title":"Expression and in vitro upregulation of MHCII in koala lymphocytes","volume":"147","author":"Q Lau","year":"2012","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e280","DOI":"10.7717\/peerj.280","article-title":"Expression profiles of the immune genes CD4, CD8\u03b2, IFN\u03b3, IL-4, IL-6 and IL-10 in mitogen-stimulated koala lymphocytes (<italic>Phascolarctos cinereus<\/italic>) by qRT-PCR","volume":"2","author":"IE Maher","year":"2014","journal-title":"PeerJ"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/BF01956463","article-title":"Seasonal variation in peripheral blood leukocyte subsets and in serum interleukin-6, and soluble interleukin-2 and-6 receptor concentrations in normal volunteers","volume":"50","author":"M Maes","year":"1994","journal-title":"Experientia"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"e59958","DOI":"10.1371\/journal.pone.0059958","article-title":"Preliminary Characterisation of Tumor Necrosis Factor Alpha and Interleukin-10 Responses to <italic>Chlamydia pecorum<\/italic> Infection in the Koala (<italic>Phascolarctos cinereus<\/italic>)","volume":"8","author":"M Mathew","year":"2013","journal-title":"Plos One"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.dci.2014.05.015","article-title":"Interleukin 17A is an immune marker for chlamydial disease severity and pathogenesis in the koala (<italic>Phascolarctos cinereus<\/italic>)","volume":"46","author":"M Mathew","year":"2014","journal-title":"Developmental & Comparative Immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nature Protocols"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e76664","DOI":"10.1371\/journal.pone.0076664","article-title":"The duration of <italic>Chlamydia muridarum<\/italic> genital tract infection and associated chronic pathological changes are reduced in IL-17 knockout mice but protection is not increased further by immunization","volume":"8","author":"DW Andrew","year":"2013","journal-title":"PLoS ONE"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1097\/QAD.0b013e3283344895","article-title":"HIV-1 infection is characterized by profound depletion of CD161+ Th17 cells and gradual decline in regulatory T cells","volume":"24","author":"A Prendergast","year":"2010","journal-title":"AIDS"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1097\/QAI.0000000000000389","article-title":"Early HIV-1 infection is associated with reduced frequencies of cervical Th17 cells","volume":"68","author":"LR McKinnon","year":"2015","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/COH.0b013e3283364846","article-title":"Th17 cell dynamics in HIV infection","volume":"5","author":"NR Klatt","year":"2010","journal-title":"Current Opinion in HIV and AIDS"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"a006866","DOI":"10.1101\/cshperspect.a006866","article-title":"HIV: cell binding and entry","volume":"2","author":"CB Wilen","year":"2012","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1128\/IAI.59.10.3774-3777.1991","article-title":"Role of L3T4-bearing T-cell populations in experimental murine chlamydial salpingitis","volume":"59","author":"DV Landers","year":"1991","journal-title":"Infection and Immunity"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.158.7.3344","article-title":"Immunity to <italic>Chlamydia trachomatis<\/italic> is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways","volume":"158","author":"LL Perry","year":"1997","journal-title":"The Journal of Immunology"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1128\/IAI.65.6.1993-1999.1997","article-title":"<italic>Chlamydia trachomatis<\/italic> genital tract infection of antibody-deficient gene knockout mice","volume":"65","author":"H Su","year":"1997","journal-title":"Infection and immunity"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1046\/j.1365-2249.1996.d01-792.x","article-title":"T helper type\u20101 (Th1)\/Th2 profiles of peripheral blood mononuclear cells (PBMC); responses to antigens of <italic>Chlamydia trachomatis<\/italic> in subjects with severe trachomatous scarring","volume":"105","author":"M Holland","year":"1996","journal-title":"Clinical & Experimental Immunology"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0167-5699(93)90208-3","article-title":"A Th 1\u2192 Th 2 switch is a critical step in the etiology of HIV infection","volume":"14","author":"M Clerici","year":"1993","journal-title":"Immunology Today"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0165-2427(99)00147-6","article-title":"The effects of feline retroviruses on cytokine expression","volume":"72","author":"ML Linenberger","year":"1999","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-1759(03)00244-8","article-title":"Development of antibodies to feline IFN-\u03b3 as tools to elucidate the cellular immune responses to FeLV","volume":"279","author":"EM Graham","year":"2003","journal-title":"Journal of Immunological Methods"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.vetimm.2008.01.011","article-title":"Lentivirus-induced immune dysregulation","volume":"123","author":"MB Tompkins","year":"2008","journal-title":"Veterinary Immunology and Immunopathology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.rvsc.2015.02.008","article-title":"Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega","volume":"99","author":"RO Leal","year":"2015","journal-title":"Research in Veterinary Science"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1046\/j.1525-1381.1999.99210.x","article-title":"Human retroviruses: their role in cancer","volume":"111","author":"WA Blattner","year":"1999","journal-title":"Proceedings of the Association of American Physicians"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1749-6632.1998.tb09119.x","article-title":"Immunosuppression by retroviruses: implications for xenotransplantation","volume":"862","author":"J Denner","year":"1998","journal-title":"Annals of the New York Academy of Sciences"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.virol.2014.10.036","article-title":"Sequence variation of koala retrovirus transmembrane protein p15E among koalas from different geographic regions","volume":"475","author":"Y Ishida","year":"2015","journal-title":"Virology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1742-4690-2-52","article-title":"Retroviral superinfection resistance","volume":"2","author":"M Nethe","year":"2005","journal-title":"Retrovirology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1126\/science.272.5265.1167","article-title":"Prognosis in HIV-1 infection predicted by the quantity of virus in plasma","volume":"272","author":"JW Mellors","year":"1996","journal-title":"Science"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1128\/JVI.70.4.2503-2507.1996","article-title":"Plasma viral RNA load predicts disease progression in accelerated feline immunodeficiency virus infection","volume":"70","author":"LJ Diehl","year":"1996","journal-title":"Journal of Virology"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.virusres.2015.01.002","article-title":"Lack of antiviral antibody response in koalas infected with koala retroviruses (KoRV)","volume":"198","author":"U Fiebig","year":"2015","journal-title":"Virus Research"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1186\/1471-2164-15-786","article-title":"A transcriptome resource for the koala (<italic>Phascolarctos cinereus<\/italic>): insights into koala retrovirus transcription and sequence diversity","volume":"15","author":"M Hobbs","year":"2014","journal-title":"BMC Genomics"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.febslet.2013.10.046","article-title":"Heterogeneity of koala retrovirus isolates","volume":"588","author":"S Shimode","year":"2014","journal-title":"FEBS Letters"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1638\/2007-0106.1","article-title":"Hip dysplasia in koalas (<italic>Phascolarctos cinereus<\/italic>) at the San Diego Zoo","volume":"39","author":"GW Pye","year":"2008","journal-title":"Journal of Zoo and Wildlife Medicine"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1638\/2008-0107.1","article-title":"Shoulder dysplasia in koalas (<italic>Phascolarctos cinereus<\/italic>) at San Diego Zoo","volume":"40","author":"GW Pye","year":"2009","journal-title":"Journal of Zoo and Wildlife Medicine"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1017\/S0025315407055567","article-title":"The impact of stress on cytokine and haptoglobin mRNA expression in blood samples from harbour porpoises (<italic>Phocoena phocoena<\/italic>)","volume":"87","author":"S Fonfara","year":"2007","journal-title":"Journal of the Marine Biological Association of the United Kingdom"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1071\/ZO99034","article-title":"A review of feeding and diet selection in koalas (<italic>Phascolarctos cinereus<\/italic>)","volume":"48","author":"BD Moore","year":"2000","journal-title":"Australian Journal of Zoology"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1600-079X.1995.tb00184.x","article-title":"Minireview: The influence of season, photoperiod, and pineal melatonin on immune function","volume":"19","author":"RJ Nelson","year":"1995","journal-title":"Journal of Pineal Research"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.it.2004.02.001","article-title":"Seasonal immune function and sickness responses","volume":"25","author":"RJ Nelson","year":"2004","journal-title":"Trends in Immunology"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1097\/01.qai.0000223028.55080.9d","article-title":"Impact of inversion of the CD4\/CD8 ratio on the natural history of HIV-1 infection","volume":"42","author":"JB Margolick","year":"2006","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref75","first-page":"114","article-title":"CD4 percentage, CD4 number, and CD4: CD8 ratio in HIV infection: which to choose and how to use","volume":"2","author":"JM Taylor","year":"1989","journal-title":"Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2684","DOI":"10.3390\/v4112684","article-title":"Clinical aspects of feline retroviruses: a review","volume":"4","author":"K Hartmann","year":"2012","journal-title":"Viruses"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1751-0813.2012.00963.x","article-title":"Diagnosis, treatment and outcomes for koala chlamydiosis at a rehabilitation facility (1995\u20132005)","volume":"90","author":"JE Griffith","year":"2012","journal-title":"Australian Veterinary Journal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0163780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:25:40Z","timestamp":1749601540000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0163780"}},"subtitle":[],"editor":[{"given":"Peter","family":"Prentis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":77,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0163780","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}