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in GWA studies through improved imputation accuracy and CNV tagging","volume":"20","author":"I Surakka","year":"2010","journal-title":"Genome Res"},{"issue":"7571","key":"ref59","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nature14962","article-title":"The UK10K project identifies rare variants in health and disease","volume":"526","author":"UK Consortium","year":"2015","journal-title":"Nature"},{"issue":"10","key":"ref60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13073-014-0083-5","article-title":"Using genetically isolated populations to understand the genomic basis of disease","volume":"6","author":"E Zeggini","year":"2014","journal-title":"Genome medicine"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/ije\/dyp330","article-title":"Thirty-five-year trends in cardiovascular risk factors in Finland","volume":"39","author":"E Vartiainen","year":"2010","journal-title":"Int J Epidemiol"},{"issue":"6","key":"ref62","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"BN Howie","year":"2009","journal-title":"PLoS Genet"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"S Purcell","year":"2007","journal-title":"American journal of human genetics"},{"issue":"7","key":"ref64","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ng2088","article-title":"A new multipoint method for genome-wide association studies by imputation of genotypes","volume":"39","author":"J Marchini","year":"2007","journal-title":"Nat Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/1471-2105-11-288","article-title":"GWAMA: software for genome-wide association meta-analysis","volume":"11","author":"R Magi","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"7414","key":"ref66","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"JP Higgins","year":"2003","journal-title":"Bmj"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1111\/j.0006-341X.1999.00997.x","article-title":"Genomic control for association studies","volume":"55","author":"B Devlin","year":"1999","journal-title":"Biometrics"},{"issue":"18","key":"ref68","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/bioinformatics\/btq419","article-title":"LocusZoom: regional visualization of genome-wide association scan results","volume":"26","author":"RJ 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