{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:54:32Z","timestamp":1740146072124,"version":"3.37.3"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T00:00:00Z","timestamp":1476144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE15746, DE21376, DE023740"],"award-info":[{"award-number":["DE15746, DE21376, DE023740"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P01DE019759"],"award-info":[{"award-number":["1P01DE019759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P01DE019759"],"award-info":[{"award-number":["1P01DE019759"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43TW007377"],"award-info":[{"award-number":["D43TW007377"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007567"],"award-info":[{"award-number":["T32HL007567"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI36219"],"award-info":[{"award-number":["AI36219"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164075","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T13:26:46Z","timestamp":1476192406000},"page":"e0164075","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations of Toll-Like Receptor and \u03b2-Defensin Polymorphisms with Measures of Periodontal Disease (PD) in HIV+ North American Adults: An Exploratory Study"],"prefix":"10.1371","volume":"11","author":[{"given":"Rajeev K.","family":"Mehlotra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noemi B.","family":"Hall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barne","family":"Willie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Weinberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter A.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lance T.","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,10,11]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1600-0757.2012.00445.x","article-title":"Periodontal disease in HIV\/AIDS","volume":"60","author":"MI Ryder","year":"2012","journal-title":"Periodontol"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1089\/aid.2010.0320","article-title":"A prospective cohort study of periodontal disease measures and cardiovascular disease markers in HIV-infected adults","volume":"27","author":"LT Vernon","year":"2011","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1600-0757.2010.00358.x","article-title":"Periodontal innate immune mechanisms relevant to atherosclerosis and obesity","volume":"54","author":"SA Zelkha","year":"2010","journal-title":"Periodontol 2000"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/prd.12110","article-title":"Risk factors that may modify the innate and adaptive immune responses in periodontal diseases","volume":"71","author":"ET Knight","year":"2016","journal-title":"Periodontol 2000"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1902\/jop.2008.080213","article-title":"Mapping the pathogenesis of periodontitis: a new look","volume":"79","author":"KS Kornman","year":"2008","journal-title":"J Periodontol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-0757.2010.00340.x","article-title":"Genetic and environmental risk factors for chronic periodontitis and aggressive periodontitis","volume":"53","author":"A Stabholz","year":"2010","journal-title":"Periodontol 2000"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"ML Laine","year":"2012","journal-title":"Periodontol 2000"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1472-6831-14-84","article-title":"Genome wide association scan for chronic periodontitis implicates novel locus","volume":"14","author":"P Feng","year":"2014","journal-title":"BMC Oral Health"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1177\/0022034515570315","article-title":"A genome-wide association study of periodontitis in a Japanese population","volume":"94","author":"S Shimizu","year":"2015","journal-title":"J Dent Res"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/prd.12021","article-title":"Role of genetic factors in the pathogenesis of aggressive periodontitis","volume":"65","author":"AR Vieira","year":"2014","journal-title":"Periodontol 2000"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1111\/j.1600-0757.2010.00371.x","article-title":"Gene polymorphisms and periodontitis","volume":"56","author":"J Zhang","year":"2011","journal-title":"Periodontol 2000"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-0757.2010.00349.x","article-title":"Immunological differences and similarities between chronic periodontitis and aggressive periodontitis","volume":"53","author":"PJ Ford","year":"2010","journal-title":"Periodontol 2000"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1600-0757.2006.00179.x","article-title":"Toll-like receptors and their role in periodontal health and disease","volume":"43","author":"R Mahanonda","year":"2007","journal-title":"Periodontol 2000"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/prd.12093","article-title":"Diverse functions of defensins and other antimicrobial peptides in periodontal tissues","volume":"69","author":"H Dommisch","year":"2015","journal-title":"Periodontol 2000"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/jre.12187","article-title":"Relationship between expression of human gingival beta-defensins and levels of periodontopathogens in subgingival plaque","volume":"50","author":"P Wang","year":"2015","journal-title":"J Periodontal Res"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1111\/j.1601-0825.2011.01799.x","article-title":"Beta-defensins: what are they really doing in the oral cavity?","volume":"17","author":"G Diamond","year":"2011","journal-title":"Oral Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fcimb.2015.00099","article-title":"Salivary antimicrobial peptides in early detection of periodontitis","volume":"5","author":"GN Guncu","year":"2015","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00784-010-0396-8","article-title":"Microsatellite GT polymorphism in intron 2 of human Toll-like receptor (TLR) 2 gene and susceptibility to periodontitis","volume":"15","author":"M Folwaczny","year":"2011","journal-title":"Clin Oral Investig"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-051X.2009.01523.x","article-title":"Association of Toll-like receptor 9 haplotypes with chronic periodontitis in Czech population","volume":"37","author":"LI Holla","year":"2010","journal-title":"J Clin Periodontol"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1177\/0022034513504217","article-title":"Beta-defensin-2 genomic copy number variation and chronic periodontitis","volume":"92","author":"SW Jaradat","year":"2013","journal-title":"J Dent Res"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1600-051X.2011.01846.x","article-title":"Common genetic risk variants of <italic>TLR2<\/italic> are not associated with periodontitis in large European case-control populations","volume":"39","author":"GM Richter","year":"2012","journal-title":"J Clin Periodontol"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1600-0765.2010.01327.x","article-title":"Single nucleotide polymorphisms of pattern recognition receptors and chronic periodontitis","volume":"46","author":"SE Sahingur","year":"2011","journal-title":"J Periodontal Res"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"5129","DOI":"10.1007\/s11033-013-2616-1","article-title":"Toll-like receptor (<italic>TLR<\/italic>) and matrix metalloproteinase (<italic>MMP<\/italic>) polymorphisms and periodontitis susceptibility: a meta-analysis","volume":"40","author":"GG Song","year":"2013","journal-title":"Mol Biol Rep"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1902\/jop.2006.050058","article-title":"No association between selected candidate gene polymorphisms and severe chronic periodontitis","volume":"77","author":"JC Wohlfahrt","year":"2006","journal-title":"J Periodontol"},{"issue":"Suppl 1","key":"ref25","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1479-5876-10-S1-S9","article-title":"Clinical application of human \u03b2-defensin and CD14 gene polymorphism in evaluating the status of chronic inflammation","volume":"10","author":"WT Loo","year":"2012","journal-title":"J Transl Med"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/j.1600-051X.2009.01370.x","article-title":"TLR4 as a risk factor for periodontal disease: a reappraisal","volume":"36","author":"A Ozturk","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/gene.2009.75","article-title":"A 3&apos; UTR transition within <italic>DEFB1<\/italic> is associated with chronic and aggressive periodontitis","volume":"11","author":"AS Schaefer","year":"2010","journal-title":"Genes Immun"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/sj.gene.6364221","article-title":"Chronic periodontal disease is associated with single-nucleotide polymorphisms of the human <italic>TLR-4<\/italic> gene","volume":"6","author":"NW Schroder","year":"2005","journal-title":"Genes Immun"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1399-302X.2008.00448.x","article-title":"Immunohistochemical localization of Toll-like receptors 1\u201310 in periodontitis","volume":"23","author":"A Beklen","year":"2008","journal-title":"Oral Microbiol Immunol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1177\/0022034515611876","article-title":"Epigenetic modifications of histones in periodontal disease","volume":"95","author":"MD Martins","year":"2016","journal-title":"J Dent Res"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbrc.2012.10.016","article-title":"Toll-like receptor 2 heterodimers, TLR2\/6 and TLR2\/1 induce prostaglandin E production by osteoblasts, osteoclast formation and inflammatory periodontitis","volume":"428","author":"C Matsumoto","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1111\/j.1600-0765.2011.01353.x","article-title":"Periodontal ligament and gingival fibroblasts from periodontitis patients are more active in interaction with <italic>Porphyromonas gingivalis<\/italic>","volume":"46","author":"N Scheres","year":"2011","journal-title":"J Periodontal Res"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1111\/j.1462-5822.2005.00590.x","article-title":"Regulation of mammalian defensin expression by Toll-like receptor-dependent and independent signalling pathways","volume":"7","author":"O Froy","year":"2005","journal-title":"Cell Microbiol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.micinf.2005.07.006","article-title":"Toll-like receptor 2-mediated expression of \u03b2-defensin-2 in human corneal epithelial cells","volume":"8","author":"A Kumar","year":"2006","journal-title":"Microbes and infection \/ Institut Pasteur"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2334-8-87","article-title":"Induction of beta defensin 2 by NTHi requires TLR2 mediated MyD88 and IRAK-TRAF6-p38MAPK signaling pathway in human middle ear epithelial cells","volume":"8","author":"HY Lee","year":"2008","journal-title":"BMC Infect Dis"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1574-695X.2009.00586.x","article-title":"Toll-like receptor-4 (TLR4) mediates human \u03b2-defensin-2 (HBD-2) induction in response to Chlamydia pneumoniae in mononuclear cells","volume":"57","author":"C Romano Carratelli","year":"2009","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.4049\/jimmunol.173.9.5398","article-title":"\u03b2-defensin-2 expression is regulated by TLR signaling in intestinal epithelial cells","volume":"173","author":"P Vora","year":"2004","journal-title":"J Immunol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.4049\/jimmunol.173.2.1219","article-title":"Microbial DNA induces a host defense reaction of human respiratory epithelial cells","volume":"173","author":"J Platz","year":"2004","journal-title":"J Immunol"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.micinf.2006.01.008","article-title":"Induction of \u03b2-defensin 3 in keratinocytes stimulated by bacterial lipopeptides through toll-like receptor 2","volume":"8","author":"Y Sumikawa","year":"2006","journal-title":"Microbes and infection \/ Institut Pasteur"},{"issue":"47","key":"ref40","doi-asserted-by":"crossref","first-page":"18631","DOI":"10.1073\/pnas.0702130104","article-title":"Human \u03b2-defensin-3 activates professional antigen-presenting cells via Toll-like receptors 1 and 2","volume":"104","author":"N Funderburg","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1365-2567.2011.03475.x","article-title":"The Toll-like receptor 1\/2 agonists Pam(3) CSK(4) and human \u03b2-defensin-3 differentially induce interleukin-10 and nuclear factor-kappaB signalling patterns in human monocytes","volume":"134","author":"NT Funderburg","year":"2011","journal-title":"Immunology"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1189\/jlb.1111555","article-title":"Diminished responsiveness to human \u03b2-defensin-3 and decreased TLR1 expression on monocytes and mDCs from HIV-1-infected patients","volume":"92","author":"NT Funderburg","year":"2012","journal-title":"J Leukoc Biol"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1600-0528.2009.00485.x","article-title":"Characterizing traditionally defined periodontal disease in HIV+ adults","volume":"37","author":"LT Vernon","year":"2009","journal-title":"Community Dent Oral Epidemiol"},{"issue":"Suppl 1","key":"ref44","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/odi.12412","article-title":"Comorbidities associated with HIV and antiretroviral therapy (clinical sciences): a workshop report","volume":"22","author":"LT Vernon","year":"2016","journal-title":"Oral Dis"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"e76986","DOI":"10.1371\/journal.pone.0076986","article-title":"Effect of Nadir CD4+ T cell count on clinical measures of periodontal disease in HIV+ adults before and during immune reconstitution on HAART","volume":"8","author":"LT Vernon","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/gene.2014.54","article-title":"Association of <italic>Toll-like receptor<\/italic> polymorphisms with HIV status in North Americans","volume":"15","author":"B Willie","year":"2014","journal-title":"Genes Immun"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"e56976","DOI":"10.1371\/journal.pone.0056976","article-title":"Linear regression in genetic association studies","volume":"8","author":"P Buzkova","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref48","doi-asserted-by":"crossref","first-page":"e37662","DOI":"10.1371\/journal.pone.0037662","article-title":"Instrumental variable estimation of the causal effect of plasma 25-hydroxy-vitamin D on colorectal cancer risk: a mendelian randomization analysis","volume":"7","author":"E Theodoratou","year":"2012","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.jhealeco.2015.10.007","article-title":"Genetic markers as instrumental variables","volume":"45","author":"S von Hinke","year":"2016","journal-title":"J Health Econ"},{"issue":"0","key":"ref50","first-page":"1","article-title":"A review of instrumental variable estimators for Mendelian randomization","volume":"0","author":"S Burgess","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"Suppl 1","key":"ref51","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1111\/j.1834-7819.2009.01140.x","article-title":"Diagnosis and classification of periodontal disease","volume":"54","author":"J Highfield","year":"2009","journal-title":"Aust Dent J"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1600-051X.2009.01408.x","article-title":"A systematic review of definitions of periodontitis and methods that have been used to identify this disease","volume":"36","author":"A Savage","year":"2009","journal-title":"J Clin Periodontol"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"199","DOI":"10.2334\/josnusd.51.199","article-title":"Impact of different periodontitis case definitions on periodontal research","volume":"51","author":"FO Costa","year":"2009","journal-title":"J Oral Sci"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1902\/jop.2012.110664","article-title":"Update of the case definitions for population-based surveillance of periodontitis","volume":"83","author":"PI Eke","year":"2012","journal-title":"J Periodontol"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1600-0528.1987.tb00525.x","article-title":"Representativeness of the &quot;Ramfjord teeth&quot; for epidemiologic studies of gingivitis and periodontitis","volume":"15","author":"JL Fleiss","year":"1987","journal-title":"Community Dent Oral Epidemiol"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ygeno.2005.06.003","article-title":"Human defensin gene copy number polymorphisms: comprehensive analysis of independent variation in \u03b1- and \u03b2-defensin regions at 8p22-p23","volume":"86","author":"RM Linzmeier","year":"2005","journal-title":"Genomics"},{"issue":"4","key":"ref57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/iji.12021","article-title":"Variation in human \u03b2-defensin genes: new insights from a multi-population study","volume":"40","author":"RK Mehlotra","year":"2013","journal-title":"Int J Immunogenet"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/ERC-09-0176","article-title":"Association of testicular germ cell tumor with polymorphisms in estrogen receptor and steroid metabolism genes","volume":"17","author":"A Ferlin","year":"2010","journal-title":"Endocr Relat Cancer"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/383251","article-title":"A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other","volume":"74","author":"DR Nyholt","year":"2004","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/ije\/29.4.722","article-title":"An introduction to instrumental variables for epidemiologists","volume":"29","author":"S Greenland","year":"2000","journal-title":"Int J Epidemiol"},{"issue":"Suppl 7","key":"ref61","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1186\/1753-6561-3-s7-s45","article-title":"Mendelian randomization in family data","volume":"3","author":"NJ Morris","year":"2009","journal-title":"BMC Proc"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.jaci.2008.04.039","article-title":"Toll-like receptor heterodimer variants protect from childhood asthma","volume":"122","author":"MS Kormann","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"21517","DOI":"10.3402\/jom.v5i0.21517","article-title":"Binding properties of <italic>Treponema denticola<\/italic> lipooligosaccharide","volume":"5","author":"D Grenier","year":"2013","journal-title":"J Oral Microbiol"},{"issue":"2","key":"ref64","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/odi.12085","article-title":"Evaluation of salivary biomarker profiles following non-surgical management of chronic periodontitis","volume":"20","author":"S Prakasam","year":"2014","journal-title":"Oral Dis"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1600-0765.2010.01311.x","article-title":"Soluble CD14 induces cytokine release by human oral epithelial cells","volume":"46","author":"K Feghali","year":"2011","journal-title":"J Periodontal Res"},{"issue":"10","key":"ref66","doi-asserted-by":"crossref","first-page":"e48","DOI":"10.1902\/jop.2013.120739","article-title":"Increased nucleic acid receptor expression in chronic periodontitis","volume":"84","author":"SE Sahingur","year":"2013","journal-title":"J Periodontol"},{"issue":"3","key":"ref67","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/0970-9290.29879","article-title":"Expression of Toll-like receptors 2 and 4 in gingivitis and chronic periodontitis","volume":"17","author":"SM Sarah","year":"2006","journal-title":"Indian J Dent Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2174\/1874210600903010154","article-title":"The relationship between bleeding on probing and subgingival deposits. An endoscopical evaluation","volume":"3","author":"L Checchi","year":"2009","journal-title":"Open Dent J"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1902\/jop.2012.120362","article-title":"Induction of toll-like receptor expression by <italic>Porphyromonas gingivalis<\/italic>","volume":"84","author":"N Wara-aswapati","year":"2013","journal-title":"J Periodontol"},{"key":"ref70","first-page":"415057","article-title":"Genetic diversity of toll-like receptors and immunity to <italic>M<\/italic>. <italic>leprae<\/italic> infection","volume":"2012","author":"BE Hart","year":"2012","journal-title":"J Trop Med"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/sj.gene.6364405","article-title":"A polymorphism in human <italic>TLR2<\/italic> is associated with increased susceptibility to tuberculous meningitis","volume":"8","author":"NT Thuong","year":"2007","journal-title":"Genes Immun"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1007\/s00436-010-1932-9","article-title":"Association between Toll-like receptor 2 (<italic>TLR2<\/italic>) polymorphisms and asymptomatic bancroftian filariasis","volume":"107","author":"A Junpee","year":"2010","journal-title":"Parasitol Res"},{"issue":"7","key":"ref73","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/gene.2010.14","article-title":"Single nucleotide polymorphisms in toll-like receptor 6 are associated with altered lipopeptide- and mycobacteria-induced interleukin-6 secretion","volume":"11","author":"MS Shey","year":"2010","journal-title":"Genes Immun"},{"issue":"8","key":"ref74","doi-asserted-by":"crossref","first-page":"e1002174","DOI":"10.1371\/journal.ppat.1002174","article-title":"Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants","volume":"7","author":"AK Randhawa","year":"2011","journal-title":"PLoS Pathog"},{"issue":"5","key":"ref75","doi-asserted-by":"crossref","first-page":"563","DOI":"10.4161\/rna.20231","article-title":"The role of the 3&apos; untranslated region in post-transcriptional regulation of protein expression in mammalian cells","volume":"9","author":"E Matoulkova","year":"2012","journal-title":"RNA Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:56:35Z","timestamp":1588971395000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164075"}},"subtitle":[],"editor":[{"given":"Graham R.","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,11]]},"references-count":75,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164075","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,10,11]]}}}