{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T16:52:51Z","timestamp":1784998371586,"version":"3.55.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T00:00:00Z","timestamp":1475452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164090","type":"journal-article","created":{"date-parts":[[2016,10,3]],"date-time":"2016-10-03T17:48:19Z","timestamp":1475516899000},"page":"e0164090","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Blood Component Therapy and Coagulopathy in Trauma: A Systematic Review of the Literature from the Trauma Update Group"],"prefix":"10.1371","volume":"11","author":[{"given":"Daniele","family":"Poole","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Cortegiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Chieregato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Pellegrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvio","family":"De Blasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Mengoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Volpi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Grossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Gianesello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanni","family":"Orzalesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Fossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osvaldo","family":"Chiara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Coniglio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gordini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Trauma Update Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,3]]},"reference":[{"key":"ref1","unstructured":"WHO. Violence and injury prevention. Global status report on road safety 2015."},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1097\/MCC.0000000000000152","article-title":"Transfusion strategy in multiple trauma patients","volume":"20","author":"OM Theusinger","year":"2014","journal-title":"Current opinion in critical care"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy","volume":"54","author":"K Brohi","year":"2003","journal-title":"The Journal of trauma"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/MCC.0000000000000158","article-title":"Acute traumatic coagulopathy","volume":"20","author":"A Cap","year":"2014","journal-title":"Current opinion in critical care"},{"issue":"7303","key":"ref5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1136\/bmj.323.7303.42","article-title":"Systematic reviews in health care: Assessing the quality of controlled clinical trials","volume":"323","author":"P Juni","year":"2001","journal-title":"Bmj"},{"issue":"Suppl 1","key":"ref6","doi-asserted-by":"crossref","first-page":"i71","DOI":"10.1093\/bja\/aet376","article-title":"Update on massive transfusion","volume":"111","author":"HP Pham","year":"2013","journal-title":"British journal of anaesthesia"},{"issue":"12","key":"ref7","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1007\/s00134-014-3510-6","article-title":"Overoptimism in the interpretation of statistics: the ethical role of statistical reviewers in medical journals","volume":"40","author":"D Poole","year":"2014","journal-title":"Intensive care medicine"},{"key":"ref8","article-title":"Evidence-based medicine has been hijacked: a report to David Sackett","author":"JP Ioannidis","year":"2016","journal-title":"Journal of clinical epidemiology"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"e113676","DOI":"10.1371\/journal.pone.0113676","article-title":"Systematic review of the literature and evidence-based recommendations for antibiotic prophylaxis in trauma: results from an Italian consensus of experts","volume":"9","author":"D Poole","year":"2014","journal-title":"PloS one"},{"issue":"7168","key":"ref10","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/bmj.317.7168.1309","article-title":"Confidence intervals for the number needed to treat","volume":"317","author":"DG Altman","year":"1998","journal-title":"Bmj"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jclinepi.2010.07.015","article-title":"GRADE guidelines: 3. Rating the quality of evidence","volume":"64","author":"H Balshem","year":"2011","journal-title":"Journal of clinical epidemiology"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/j.jclinepi.2011.06.004","article-title":"GRADE guidelines: 9. Rating up the quality of evidence","volume":"64","author":"GH Guyatt","year":"2011","journal-title":"Journal of clinical epidemiology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jclinepi.2010.07.017","article-title":"GRADE guidelines: 4. Rating the quality of evidence\u2014study limitations (risk of bias)","volume":"64","author":"GH Guyatt","year":"2011","journal-title":"Journal of clinical epidemiology"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"644","DOI":"10.7326\/0003-4819-138-8-200304150-00012","article-title":"Multivariable analysis: a primer for readers of medical research","volume":"138","author":"MH Katz","year":"2003","journal-title":"Annals of internal medicine"},{"issue":"8","key":"ref15","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1503\/cmaj.060410","article-title":"The appropriateness of asymmetry tests for publication bias in meta-analyses: a large survey","volume":"176","author":"JP Ioannidis","year":"2007","journal-title":"CMAJ: Canadian Medical Association journal = journal de l'Association medicale canadienne"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"657","DOI":"10.7326\/0003-4819-134-8-200104170-00011","article-title":"The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials","volume":"134","author":"D Moher","year":"2001","journal-title":"Annals of internal medicine"},{"issue":"10","key":"ref17","first-page":"979","article-title":"Logistic regression in the medical literature: standards for use and reporting, with particular attention to one medical domain","volume":"54","author":"SC Bagley","year":"2001","journal-title":"Journal of clinical epidemiology"},{"issue":"3","key":"ref18","first-page":"411","article-title":"What you see may not be what you get: a brief, nontechnical introduction to overfitting in regression-type models","volume":"66","author":"MA Babyak","year":"2004","journal-title":"Psychosomatic medicine"},{"issue":"12","key":"ref19","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/0895-4356(95)00048-8","article-title":"Importance of events per independent variable in proportional hazards regression analysis. II. Accuracy and precision of regression estimates","volume":"48","author":"P Peduzzi","year":"1995","journal-title":"Journal of clinical epidemiology"},{"issue":"8","key":"ref20","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/0895-4356(96)00025-X","article-title":"Inappropriate use of bivariable analysis to screen risk factors for use in multivariable analysis","volume":"49","author":"GW Sun","year":"1996","journal-title":"Journal of clinical epidemiology"},{"issue":"11","key":"ref21","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.jclinepi.2004.04.003","article-title":"Automated variable selection methods for logistic regression produced unstable models for predicting acute myocardial infarction mortality","volume":"57","author":"PC Austin","year":"2004","journal-title":"Journal of clinical epidemiology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.7326\/0003-4819-145-5-200609050-00009","article-title":"Do OSCAR winners live longer than less successful peers? A reanalysis of the evidence","volume":"145","author":"MP Sylvestre","year":"2006","journal-title":"Annals of internal medicine"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/biomet\/70.1.41","article-title":"The central role of the propensity score in observational studies for causal effects","volume":"70","author":"PR Rosenbaum","year":"1983","journal-title":"Biometrika"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"e1000100","DOI":"10.1371\/journal.pmed.1000100","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration","volume":"6","author":"A Liberati","year":"2009","journal-title":"PLoS medicine"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.TA.0000075338.21177.EF","article-title":"Early coagulopathy predicts mortality in trauma","volume":"55","author":"JB MacLeod","year":"2003","journal-title":"The Journal of trauma"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"R52","DOI":"10.1186\/cc13798","article-title":"Prevalence, predictors and outcome of hypofibrinogenaemia in trauma: a multicentre observational study","volume":"18","author":"JS Hagemo","year":"2014","journal-title":"Critical care"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.injury.2009.09.029","article-title":"Fresh frozen plasma (FFP) use during massive blood transfusion in trauma resuscitation","volume":"41","author":"B Mitra","year":"2010","journal-title":"Injury"},{"issue":"2 Suppl 3","key":"ref28","doi-asserted-by":"crossref","first-page":"S329","DOI":"10.1097\/TA.0b013e318227edd3","article-title":"High ratios of plasma and platelets to packed red blood cells do not affect mortality in nonmassively transfused patients","volume":"71","author":"CN Sambasivan","year":"2011","journal-title":"The Journal of trauma"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1538-7836.2012.04752.x","article-title":"Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes","volume":"10","author":"C Rourke","year":"2012","journal-title":"Journal of thrombosis and haemostasis: JTH"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1001\/2013.jamasurg.387","article-title":"The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks","volume":"148","author":"JB Holcomb","year":"2013","journal-title":"JAMA surgery"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/SLA.0b013e31818990ed","article-title":"Early aggressive use of fresh frozen plasma does not improve outcome in critically injured trauma patients","volume":"248","author":"TM Scalea","year":"2008","journal-title":"Annals of surgery"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/TA.0b013e3182032e0b","article-title":"High plasma to red blood cell ratios are associated with lower mortality rates in patients receiving multiple transfusion (4<\/ = red blood cell units<10) during acute trauma resuscitation","volume":"70","author":"A Wafaisade","year":"2011","journal-title":"The Journal of trauma"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1423-0410.2011.01466.x","article-title":"The effect of FFP:RBC ratio on morbidity and mortality in trauma patients based on transfusion prediction score","volume":"101","author":"MA Borgman","year":"2011","journal-title":"Vox sanguinis"},{"issue":"2 Suppl 3","key":"ref34","doi-asserted-by":"crossref","first-page":"S318","DOI":"10.1097\/TA.0b013e318227edbb","article-title":"Increased platelet:RBC ratios are associated with improved survival after massive transfusion","volume":"71","author":"JB Holcomb","year":"2011","journal-title":"The Journal of trauma"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1097\/TA.0b013e31817e5c77","article-title":"Impact of plasma transfusion in massively transfused trauma patients","volume":"66","author":"PG Teixeira","year":"2009","journal-title":"The Journal of trauma"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jamcollsurg.2010.01.031","article-title":"Impact of plasma transfusion in trauma patients who do not require massive transfusion","volume":"210","author":"K Inaba","year":"2010","journal-title":"Journal of the American College of Surgeons"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jama.2015.12","article-title":"Transfusion of plasma, platelets, and red blood cells in a 1:1:1 vs a 1:1:2 ratio and mortality in patients with severe trauma: the PROPPR randomized clinical trial","volume":"313","author":"JB Holcomb","year":"2015","journal-title":"Jama"},{"issue":"9734","key":"ref38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0140-6736(10)60835-5","article-title":"Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial","volume":"376","author":"H Shakur","year":"2010","journal-title":"Lancet"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1741-7015-9-103","article-title":"Developing risk prediction models for type 2 diabetes: a systematic review of methodology and reporting","volume":"9","author":"GS Collins","year":"2011","journal-title":"BMC medicine"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1741-7015-8-20","article-title":"Reporting methods in studies developing prognostic models in cancer: a review","volume":"8","author":"S Mallett","year":"2010","journal-title":"BMC medicine"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1378\/chest.123.3.923","article-title":"An appraisal of multivariable logistic models in the pulmonary and critical care literature","volume":"123","author":"M Moss","year":"2003","journal-title":"Chest"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0197-2456(81)90001-5","article-title":"Introduction to sample size determination and power analysis for clinical trials","volume":"2","author":"JM Lachin","year":"1981","journal-title":"Controlled clinical trials"},{"issue":"7003","key":"ref43","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1136\/bmj.311.7003.485","article-title":"Absence of evidence is not evidence of absence","volume":"311","author":"DG Altman","year":"1995","journal-title":"Bmj"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/bjh.13580","article-title":"A practical guideline for the haematological management of major haemorrhage","volume":"170","author":"BJ Hunt","year":"2015","journal-title":"British journal of haematology"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13054-016-1265-x","article-title":"The European guideline on management of major bleeding and coagulopathy following trauma: fourth edition","volume":"20","author":"R Rossaint","year":"2016","journal-title":"Critical care"},{"issue":"2 Suppl","key":"ref46","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1097\/TA.0b013e318160a57b","article-title":"The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital","volume":"64","author":"HK Stinger","year":"2008","journal-title":"The Journal of trauma"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T16:17:53Z","timestamp":1657383473000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164090"}},"subtitle":[],"editor":[{"given":"Hugo","family":"ten Cate","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,3]]},"references-count":46,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164090","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,3]]}}}