{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:38:43Z","timestamp":1789000723581,"version":"build-2803163510"},"reference-count":65,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164094","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T17:52:36Z","timestamp":1477590756000},"page":"e0164094","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":78,"title":["Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL\/6 Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Richard Jay","family":"Smeyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles B.","family":"Breckenridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Beck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Zadory","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Minnema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas C.","family":"Sturgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Z.","family":"Travis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis L.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip A.","family":"Botham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/toxsci\/kfl125","article-title":"Divergent mechanisms of paraquat, MPP+, and rotenone toxicity: oxidation of thioredoxin and caspase-3 activation","volume":"95","author":"S Ramachandiran","year":"2007","journal-title":"Toxicol Sci"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0006-2952(92)90234-A","article-title":"Role of lipid peroxidation and DNA damage in paraquat toxicity and the interaction of paraquat with ionizing radiation","volume":"43","author":"B Peter","year":"1992","journal-title":"Biochem Pharmacol"},{"issue":"5\u20136","key":"ref3","first-page":"375","article-title":"Mechanism of cytotoxicity of paraquat. II. Organ specificity of paraquat-stimulated lipid peroxidation in the inner membrane of mitochondria","volume":"45","author":"K Yamada","year":"1993","journal-title":"Exp Toxicol Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1289\/ehp.7616139","article-title":"Paraquat toxicity: proposed mechanism of action involving lipid peroxidation","volume":"16","author":"JS Bus","year":"1976","journal-title":"Environmental Health Perspectives"},{"issue":"1152","key":"ref5","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1098\/rstb.1985.0170","article-title":"Paraquat toxicity","volume":"311","author":"LL Smith","year":"1985","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"4","key":"ref6","first-page":"385","article-title":"Evidence that paraquat is able to cross the blood-brain barrier to a different extent in rats of various age","volume":"6","author":"MT Corasaniti","year":"1991","journal-title":"Funct Neurol"},{"issue":"1\u20132","key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0006-8993(01)02577-X","article-title":"Carrier-mediated processes in blood\u2014brain barrier penetration and neural uptake of paraquat","volume":"906","author":"K Shimizu","year":"2001","journal-title":"Brain Res"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1124\/jpet.107.123554","article-title":"Transport of paraquat by human organic cation transporters and multidrug and toxic compound extrusion family","volume":"322","author":"Y Chen","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"issue":"51","key":"ref9","doi-asserted-by":"crossref","first-page":"20766","DOI":"10.1073\/pnas.1115141108","article-title":"Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3","volume":"108","author":"PM Rappold","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/toxsci\/kfi304","article-title":"Paraquat neurotoxicity is distinct from that of MPTP and rotenone","volume":"88","author":"JR Richardson","year":"2005","journal-title":"Toxicol Sci"},{"key":"ref11","first-page":"129","article-title":"Paraquat is not a Substrate for the Dopamine Transporter and does not Bind to Dopamine D1 and D2 Receptors in the Rat and Mouse Striatum","volume":"202","author":"AJ Foster","year":"2004","journal-title":"Toxicology"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1212\/WNL.48.6.1583","article-title":"Environmental risk factors and Parkinson&apos;s disease: a case-control study in Taiwan","volume":"48","author":"HH Liou","year":"1997","journal-title":"Neurology"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.parkreldis.2013.09.023","article-title":"Dietary fat intake, pesticide use, and Parkinson&apos;s disease","volume":"20","author":"F Kamel","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1289\/ehp.1002839","article-title":"Rotenone, paraquat, and Parkinson&apos;s disease","volume":"119","author":"CM Tanner","year":"2011","journal-title":"Environmental Health Perspectives"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1093\/aje\/kwk024","article-title":"Pesticide exposure and self-reported Parkinson&apos;s disease in the agricultural health study","volume":"165","author":"F Kamel","year":"2007","journal-title":"Am J Epidemiol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1002\/ajim.20788","article-title":"Occupational factors and risk of Parkinson&apos;s disease: A population-based case-control study","volume":"53","author":"JA Firestone","year":"2010","journal-title":"Am J Ind Med"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.yrtph.2011.10.004","article-title":"Paraquat and Parkinson&apos;s disease: an overview of the epidemiology and a review of two recent studies","volume":"62","author":"JS Mandel","year":"2012","journal-title":"Regulatory Toxicology and Pharmacology"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"e0151841","DOI":"10.1371\/journal.pone.0151841","article-title":"Association between Parkinson\u2019s Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis","volume":"11","author":"CB Breckenridge","year":"2016","journal-title":"PLoS ONE"},{"issue":"1\u20132","key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(98)01192-5","article-title":"Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss","volume":"823","author":"AI Brooks","year":"1999","journal-title":"Brain Res"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/nbdi.2002.0507","article-title":"Environmental risk factors and Parkinson&apos;s disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat","volume":"10","author":"AL McCormack","year":"2002","journal-title":"Neurobiology of Disease"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"e29447","DOI":"10.1371\/journal.pone.0029447","article-title":"Genetic dissection of strain dependent paraquat-induced neurodegeneration in the substantia nigra pars compacta","volume":"7","author":"Y Jiao","year":"2012","journal-title":"PLoS One"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuro.2013.03.005","article-title":"Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL\/6J mice","volume":"37","author":"CB Breckenridge","year":"2013","journal-title":"Neurotoxicology"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.yrtph.2013.12.010","article-title":"Dietary administration of paraquat for 13weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL\/6J mice","volume":"68","author":"DJ Minnema","year":"2014","journal-title":"Regulatory Toxicology and Pharmacology"},{"key":"ref24","first-page":"287","article-title":"Movement Disorders: Genetics and Models","author":"V Jackson-Lewis","year":"2015"},{"key":"ref25","article-title":"Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL\/6J Mice","author":"Y Jiao","year":"2015","journal-title":"J Parkinsons Dis"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.neuroscience.2009.04.031","article-title":"A comparison of model-based (2D) and design-based (3D) stereological methods for estimating cell number in the substantia nigra pars compacta (SNpc) of the C57BL\/6J Mouse","volume":"161","author":"ZC Baquet","year":"2009","journal-title":"Neuroscience"},{"key":"ref27","article-title":"The Mouse Brain in Stereotaxic Coordinates","author":"G Paxinos","year":"2001"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1096-9861(19960603)369:3<361::AID-CNE3>3.0.CO;2-3","article-title":"Midbrain dopaminergic neurons in the mouse: Computer-assited mapping","volume":"369","author":"EL Nelson","year":"1996","journal-title":"J Comp Neurol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"M Abercrombie","year":"1946","journal-title":"Anat Rec"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/j.neuroscience.2005.06.086","article-title":"Estimators of the precision of stereological estimates: an example based on the CA1 pyramidal cell layer of rats","volume":"136","author":"L Slomianka","year":"2005","journal-title":"Neuroscience"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00401-009-0622-0","article-title":"Microglia: biology and pathology","volume":"119","author":"MB Graeber","year":"2010","journal-title":"Acta Neuropathol"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"e0124047","DOI":"10.1371\/journal.pone.0124047","article-title":"Induction of microglia activation after infection with the non-neurotropic A\/CA\/04\/2009 H1N1 influenza virus","volume":"10","author":"S Sadasivan","year":"2015","journal-title":"PLoS One"},{"key":"ref33","article-title":"Statistical Methods","author":"GW Snedecor","year":"1980"},{"key":"ref34","first-page":"28","article-title":"The generalization of &quot;Student&apos;s&quot; problem when different propulation variances are involved","volume":"34","author":"BL Welsh","year":"1947","journal-title":"Biometrika"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/gm566","article-title":"Genetics and genomics of Parkinson&apos;s disease","volume":"6","author":"MK Lin","year":"2014","journal-title":"Genome Med"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1289\/ehp.0900852","article-title":"Well-water consumption and Parkinson&apos;s disease in rural California","volume":"117","author":"NM Gatto","year":"2009","journal-title":"Environmental Health Perspectives"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1212\/01.wnl.0000180361.74060.70","article-title":"Occupation and parkinsonism in three movement disorders clinics","volume":"65","author":"SM Goldman","year":"2005","journal-title":"Neurology"},{"issue":"Suppl 1","key":"ref38","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s10654-011-9581-6","article-title":"Epidemiology and etiology of Parkinson&apos;s disease: a review of the evidence","volume":"26","author":"K Wirdefeldt","year":"2011","journal-title":"Eur J Epidemiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-pharmtox-011613-135937","article-title":"Environmental toxins and Parkinson&apos;s disease","volume":"54","author":"SM Goldman","year":"2014","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2011.03.005","article-title":"Gene-environment interactions: key to unraveling the mystery of Parkinson&apos;s disease","volume":"94","author":"HM Gao","year":"2011","journal-title":"Prog Neurobiol"},{"issue":"8","key":"ref41","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1212\/WNL.40.8.1218","article-title":"Environmental risk factors in Parkinson&apos;s disease","volume":"40","author":"W Koller","year":"1990","journal-title":"Neurology"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.0610978104","article-title":"GSTpi expression mediates dopaminergic neuron sensitivity in experimental parkinsonism","volume":"104","author":"M Smeyne","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1289\/ehp.0800277","article-title":"Dopamine transporter genetic variants and pesticides in Parkinson&apos;s disease","volume":"117","author":"BR Ritz","year":"2009","journal-title":"Environmental Health Perspectives"},{"issue":"1\u20132","key":"ref44","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11010-008-9728-2","article-title":"Polymorphism in environment responsive genes and association with Parkinson disease","volume":"312","author":"M Singh","year":"2008","journal-title":"Mol Cell Biochem"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1097\/00008571-200305000-00004","article-title":"Polymorphism in the P-glycoprotein drug transporter MDR1 gene: a possible link between environmental and genetic factors in Parkinson&apos;s disease","volume":"13","author":"M Drozdzik","year":"2003","journal-title":"Pharmacogenetics"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1074\/jbc.M708597200","article-title":"Complex I is the major site of mitochondrial superoxide production by paraquat","volume":"283","author":"HM Cocheme","year":"2008","journal-title":"J Biol Chem"},{"issue":"6","key":"ref47","first-page":"437","article-title":"Mechanism of cytotoxicity of paraquat. III. The effects of acute paraquat exposure on the electron transport system in rat mitochondria","volume":"46","author":"T Fukushima","year":"1994","journal-title":"Exp Toxicol Pathol"},{"issue":"31","key":"ref48","doi-asserted-by":"crossref","first-page":"32626","DOI":"10.1074\/jbc.M404596200","article-title":"The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway","volume":"279","author":"J Peng","year":"2004","journal-title":"J Biol Chem"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1602\/neurorx.2.3.484","article-title":"Toxin-induced models of Parkinson&apos;s disease","volume":"2","author":"J Bove","year":"2005","journal-title":"NeuroRx"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.nbd.2006.10.008","article-title":"Microglial activation as a priming event leading to paraquat-induced dopaminergic cell degeneration","volume":"25","author":"MG Purisai","year":"2007","journal-title":"Neurobiol Dis"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.molbrainres.2004.11.005","article-title":"Redox cycling of the herbicide paraquat in microglial cultures","volume":"134","author":"D Bonneh-Barkay","year":"2005","journal-title":"Mol Brain Res"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1046\/j.1471-4159.2003.01621.x","article-title":"Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration","volume":"85","author":"AL McCormack","year":"2003","journal-title":"Journal of Neurochemistry"},{"issue":"12","key":"ref53","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1002\/syn.20456","article-title":"Behavioral and histopathological consequences of paraquat intoxication in mice: effects of alpha-synuclein over-expression","volume":"61","author":"PO Fernagut","year":"2007","journal-title":"Synapse (New York, NY)"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuroscience.2013.03.002","article-title":"PACAP deficiency sensitizes nigrostriatal dopaminergic neurons to paraquat-induced damage and modulates central and peripheral inflammatory activation in mice","volume":"240","author":"MB Watson","year":"2013","journal-title":"Neuroscience"},{"issue":"4","key":"ref55","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1369\/0022155411398488","article-title":"Factors influencing the degradation of archival formalin-fixed paraffin-embedded tissue sections","volume":"59","author":"R Xie","year":"2011","journal-title":"J Histochem Cytochem"},{"key":"ref56","first-page":"191","article-title":"Does paraquat (PQ) mimic MPP+ toxicity?","volume":"32","author":"DE Woolley","year":"1989","journal-title":"Proc West Pharmacol Soc"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"54","DOI":"10.2174\/156720209787466055","article-title":"Fluorogold induces persistent neurological deficits and circling behavior in mice over-expressing human mutant tau","volume":"6","author":"Z He","year":"2009","journal-title":"Current neurovascular research"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(91)90778-R","article-title":"Fluoro-Gold&apos;s toxicity makes it inferior to True Blue for long-term studies of dorsal root ganglion neurons and motoneurons","volume":"128","author":"WT Garrett","year":"1991","journal-title":"Neurosci Lett"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.expneurol.2007.02.011","article-title":"Rapid glia expression and release of proinflammatory cytokines in experimental Klebsiella pneumoniae meningoencephalitis","volume":"205","author":"LL Wen","year":"2007","journal-title":"Experimental Neurology"},{"issue":"29","key":"ref60","doi-asserted-by":"crossref","first-page":"26880","DOI":"10.1074\/jbc.M502031200","article-title":"Amyloid formation modulates the biological activity of a bacterial protein","volume":"280","author":"S Bieler","year":"2005","journal-title":"J Biol Chem"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.neurobiolaging.2011.01.008","article-title":"Cognitive impairment and increased Abeta levels induced by paraquat exposure are attenuated by enhanced removal of mitochondrial H(2)O(2)","volume":"33","author":"L Chen","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.neurobiolaging.2011.02.016","article-title":"Interferon-gamma plays a role in paraquat-induced neurodegeneration involving oxidative and proinflammatory pathways","volume":"33","author":"EN Mangano","year":"2012","journal-title":"Neurobiology of Aging"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfm223","article-title":"Paraquat: the red herring of Parkinson&apos;s disease research","volume":"100","author":"GW Miller","year":"2007","journal-title":"Toxicol Sci"},{"issue":"5","key":"ref64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/jbt.21552","article-title":"The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects","volume":"28","author":"BC Jones","year":"2014","journal-title":"J Biochem Mol Toxicol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neuro.2013.05.010","article-title":"Response to Breckenridge et al. (2013)","volume":"38","author":"BC Jones","year":"2013","journal-title":"Neurotoxicology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:48:05Z","timestamp":1718866085000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164094"}},"subtitle":[],"editor":[{"given":"Mal\u00fa G.","family":"Tansey","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":65,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164094","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}