{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:16:00Z","timestamp":1791400560182,"version":"4.3.3"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T00:00:00Z","timestamp":1475625600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164117","type":"journal-article","created":{"date-parts":[[2016,10,5]],"date-time":"2016-10-05T17:39:16Z","timestamp":1475689156000},"page":"e0164117","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Homogeneous Inflammatory Gene Profiles Induced in Human Dermal Fibroblasts in Response to the Three Main Species of Borrelia\u00a0burgdorferi sensu lato"],"prefix":"10.1371","volume":"11","author":[{"given":"Mariam","family":"Meddeb","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wassila","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Cagnard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Nadaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Grillon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Barthel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie Josiane","family":"De Martino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beno\u00eet","family":"Jaulhac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Boulanger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6889-515X","authenticated-orcid":true,"given":"Fr\u00e9d\u00e9ric","family":"Schramm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,5]]},"reference":[{"issue":"9814","key":"ref1","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(11)60103-7","article-title":"Lyme borreliosis","volume":"379","author":"G Stanek","year":"2012","journal-title":"Lancet"},{"issue":"11","key":"ref2","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1001\/jama.2013.278331","article-title":"CDC estimates 300,000 US cases of Lyme disease annually","volume":"310","author":"BM Kuehn","year":"2013","journal-title":"JAMA"},{"issue":"27","key":"ref3","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.27.19906-en","article-title":"Lyme borreliosis in Europe","volume":"16","author":"A Rizzoli","year":"2011","journal-title":"Euro Surveill"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3201\/eid2106.141516","article-title":"Oligoarthritis caused by <italic>Borrelia bavariensis<\/italic>, Austria, 2014","volume":"21","author":"M Markowicz","year":"2015","journal-title":"Emerg Infect Dis"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.3201\/eid1207.060077","article-title":"Lyme borreliosis and <italic>Borrelia spielmanii<\/italic>","volume":"12","author":"V Maraspin","year":"2006","journal-title":"Emerg Infect Dis"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"3540","DOI":"10.1128\/JCM.01032-08","article-title":"Detection of <italic>Borrelia bissettii<\/italic> in cardiac valve tissue of a patient with endocarditis and aortic valve stenosis in the Czech Republic","volume":"46","author":"N Rudenko","year":"2008","journal-title":"J Clin Microbiol"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1574-6968.2009.01498.x","article-title":"Molecular detection of <italic>Borrelia bissettii<\/italic> DNA in serum samples from patients in the Czech Republic with suspected borreliosis","volume":"292","author":"N Rudenko","year":"2009","journal-title":"FEMS Microbiol Lett"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1128\/JCM.42.3.1316-1318.2004","article-title":"First isolation of <italic>Borrelia lusitaniae<\/italic> from a human patient","volume":"42","author":"M Collares-Pereira","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.3201\/eid1009.030439","article-title":"<italic>Borrelia valaisiana<\/italic> in cerebrospinal fluid","volume":"10","author":"E Diza","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"ref10","first-page":"1","article-title":"Curr Probl Dermatol","volume":"37","author":"G Baranton","year":"2009"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"e22926","DOI":"10.1371\/journal.pone.0022926","article-title":"Biodiversity of <italic>Borrelia burgdorferi<\/italic> strains in tissues of Lyme disease patients","volume":"6","author":"D Brisson","year":"2011","journal-title":"PloS ONE"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"e101009","DOI":"10.1371\/journal.pone.0101009","article-title":"Population bottlenecks during the infectious cycle of the Lyme disease spirochete <italic>Borrelia burgdorferi<\/italic>","volume":"9","author":"RO Rego","year":"2014","journal-title":"PloS ONE"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"FO Nestle","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.4049\/jimmunol.157.7.2998","article-title":"Human dendritic cells phagocytose and process <italic>Borrelia burgdorferi<\/italic>","volume":"157","author":"L Filgueira","year":"1996","journal-title":"J Immunol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-3083.2003.01284.x","article-title":"Interaction between <italic>Borrelia burgdorferi<\/italic> and immature human dendritic cells","volume":"58","author":"J Suhonen","year":"2003","journal-title":"Scand J Immunol"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1128\/IAI.67.3.1107-1115.1999","article-title":"<italic>Borrelia burgdorferi<\/italic> spirochetes induce mast cell activation and cytokine release","volume":"67","author":"J Talkington","year":"1999","journal-title":"Infect Immun"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1128\/IAI.00482-10","article-title":"Antialarmin effect of tick saliva during the transmission of Lyme disease","volume":"79","author":"C Marchal","year":"2011","journal-title":"Infect Immun"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1038\/jid.2009.73","article-title":"Defensin is suppressed by tick salivary gland extract during the <italic>in vitro<\/italic> interaction of resident skin cells with <italic>Borrelia burgdorferi<\/italic>","volume":"129","author":"CM Marchal","year":"2009","journal-title":"J Invest Dermatol"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"e40046","DOI":"10.1371\/journal.pone.0040046","article-title":"Microarray analyses of inflammation response of human dermal fibroblasts to different strains of <italic>Borrelia burgdorferi<\/italic> sensu stricto","volume":"7","author":"F Schramm","year":"2012","journal-title":"PloS ONE"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbrc.2003.11.177","article-title":"Guideline to reference gene selection for quantitative real-time PCR","volume":"313","author":"A Radonic","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng1201-365","article-title":"Minimum information about a microarray experiment (MIAME)-toward standards for microarray data","volume":"29","author":"A Brazma","year":"2001","journal-title":"Nat Genet"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plasmid.2004.10.006","article-title":"The plasmids of <italic>Borrelia burgdorferi<\/italic>: essential genetic elements of a pathogen","volume":"53","author":"PE Stewart","year":"2005","journal-title":"Plasmid"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI39401","article-title":"Live imaging reveals a biphasic mode of dissemination of <italic>Borrelia burgdorferi<\/italic> within ticks","volume":"119","author":"SM Dunham-Ems","year":"2009","journal-title":"J Clin Invest"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"4145","DOI":"10.1128\/JCM.39.11.4145-4148.2001","article-title":"Use of quantitative PCR to measure density of <italic>Borrelia burgdorferi<\/italic> in the midgut and salivary glands of feeding tick vectors","volume":"39","author":"J Piesman","year":"2001","journal-title":"J Clin Microbiol"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1128\/IAI.00464-10","article-title":"Effect of <italic>Borrelia burgdorferi<\/italic> OspC at the site of inoculation in mouse skin","volume":"78","author":"S Antonara","year":"2010","journal-title":"Infect Immun"},{"issue":"7","key":"ref26","doi-asserted-by":"crossref","first-page":"e0133195","DOI":"10.1371\/journal.pone.0133195","article-title":"Heterogeneity of Borrelia burgdorferi Sensu Stricto Population and Its Involvement in Borrelia Pathogenicity: Study on Murine Model with Specific Emphasis on the Skin Interface","volume":"10","author":"A Kern","year":"2015","journal-title":"PloS ONE"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrg1749","article-title":"Microarray data analysis: from disarray to consolidation and consensus","volume":"7","author":"DB Allison","year":"2006","journal-title":"Nat Rev Genet"},{"issue":"20","key":"ref28","doi-asserted-by":"crossref","first-page":"12877","DOI":"10.1073\/pnas.162488599","article-title":"Diversity, topographic differentiation, and positional memory in human fibroblasts","volume":"99","author":"HY Chang","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/sj.jid.5700986","article-title":"A systems biology approach to anatomic diversity of skin","volume":"128","author":"JL Rinn","year":"2008","journal-title":"J Invest Dermatol"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1371\/journal.pgen.0020119","article-title":"Anatomic demarcation by positional variation in fibroblast gene expression programs","volume":"2","author":"JL Rinn","year":"2006","journal-title":"PLoS Genet"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s15010-004-3042-z","article-title":"Comparison of erythema migrans caused by <italic>Borrelia afzelii<\/italic> and <italic>Borrelia garinii<\/italic>","volume":"32","author":"M Logar","year":"2004","journal-title":"Infection"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/0036554021000026978","article-title":"Characteristics of erythema migrans in <italic>Borrelia afzelii<\/italic> and <italic>Borrelia garinii<\/italic> infections","volume":"35","author":"SA Carlsson","year":"2003","journal-title":"Scand J Infect Dis"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1089\/vbz.2010.0230","article-title":"Comparison of erythema migrans caused by <italic>Borrelia burgdorferi<\/italic> and <italic>Borrelia garinii<\/italic>","volume":"11","author":"F Strle","year":"2011","journal-title":"Vector Borne Zoonotic Dis"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.4049\/jimmunol.158.7.3285","article-title":"<italic>Borrelia burgdorferi<\/italic> activates nuclear factor-kappa B and is a potent inducer of chemokine and adhesion molecule gene expression in endothelial cells and fibroblasts","volume":"158","author":"K Ebnet","year":"1997","journal-title":"J Immunol"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1128\/IAI.00263-07","article-title":"Chemokine signatures in the skin disorders of Lyme borreliosis in Europe: predominance of CXCL9 and CXCL10 in erythema migrans and acrodermatitis and CXCL13 in lymphocytoma","volume":"75","author":"RR M\u00fcllegger","year":"2007","journal-title":"Infect Immun"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1086\/524022","article-title":"Higher mRNA levels of chemokines and cytokines associated with macrophage activation in erythema migrans skin lesions in patients from the United States than in patients from Austria with Lyme borreliosis","volume":"46","author":"KL Jones","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/nri1604","article-title":"Mechanisms of type-I- and type-II-interferon-mediated signalling","volume":"5","author":"LC Platanias","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"e100174","DOI":"10.1371\/journal.pone.0100174","article-title":"Induction of type I and type III interferons by <italic>Borrelia burgdorferi<\/italic> correlates with pathogenesis and requires linear plasmid 36","volume":"9","author":"MA Krupna-Gaylord","year":"2014","journal-title":"PloS ONE"},{"issue":"12","key":"ref39","doi-asserted-by":"crossref","first-page":"8492","DOI":"10.4049\/jimmunol.181.12.8492","article-title":"A critical role for type I IFN in arthritis development following <italic>Borrelia burgdorferi<\/italic> infection of mice","volume":"181","author":"JC Miller","year":"2008","journal-title":"J Immunol"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1128\/IAI.01070-09","article-title":"The Lyme disease spirochete <italic>Borrelia burgdorferi<\/italic> utilizes multiple ligands, including RNA, for interferon regulatory factor 3-dependent induction of type I interferon-responsive genes","volume":"78","author":"JC Miller","year":"2010","journal-title":"Infect Immun"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.4049\/jimmunol.1201095","article-title":"Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in <italic>Borrelia burgdorferi<\/italic>-infected joint tissue","volume":"189","author":"RB Lochhead","year":"2012","journal-title":"J Immunol"},{"issue":"20","key":"ref42","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.15252\/embj.201489055","article-title":"Scaling of immune responses against intracellular bacterial infection","volume":"33","author":"Z Abdullah","year":"2014","journal-title":"EMBO J"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1093\/infdis\/167.5.1074","article-title":"Invasion of human skin fibroblasts by the Lyme disease spirochete, <italic>Borrelia burgdorferi<\/italic>","volume":"167","author":"MS Klempner","year":"1993","journal-title":"J Infect Dis"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1128\/IAI.01188-10","article-title":"Invasion of eukaryotic cells by <italic>Borrelia burgdorferi<\/italic> requires \u03b21 integrins and Src kinase activity","volume":"79","author":"J Wu","year":"2011","journal-title":"Infect Immun"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/nri.2015.8","article-title":"Self-regulation and cross-regulation of pattern-recognition receptor signalling in health and disease","volume":"16","author":"X Cao","year":"2016","journal-title":"Nat Rev Immunol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164117","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:12:03Z","timestamp":1749600723000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164117"}},"subtitle":[],"editor":[{"given":"Brian","family":"Stevenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,5]]},"references-count":45,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164117","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,5]]}}}