{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T04:28:31Z","timestamp":1789100911023,"version":"build-2803163510"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KNDD2","award":["FKZ 01 GI 1005D"],"award-info":[{"award-number":["FKZ 01 GI 1005D"]}]},{"name":"NGFNplus","award":["01GS08133"],"award-info":[{"award-number":["01GS08133"]}]},{"name":"HELMA","award":["HA215"],"award-info":[{"award-number":["HA215"]}]},{"name":"NGFNplus","award":["01GS0850"],"award-info":[{"award-number":["01GS0850"]}]},{"name":"Infrafrontier","award":["01KX1012"],"award-info":[{"award-number":["01KX1012"]}]},{"name":"EU","award":["EUMODIC LSHG-2006-037188"],"award-info":[{"award-number":["EUMODIC LSHG-2006-037188"]}]},{"name":"NGFN","award":["NGFN 01GR"],"award-info":[{"award-number":["NGFN 01GR"]}]},{"name":"NGFNplus","award":["PNA-01GS08129-5"],"award-info":[{"award-number":["PNA-01GS08129-5"]}]},{"name":"EFRE\/Kowi","award":["C\/4-EFRE-11\/2008\/KA"],"award-info":[{"award-number":["C\/4-EFRE-11\/2008\/KA"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164298","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T17:37:15Z","timestamp":1477589835000},"page":"e0164298","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sphingomyelin Synthase 1 Is Essential for Male Fertility in Mice"],"prefix":"10.1371","volume":"11","author":[{"given":"Anke","family":"Wittmann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus O. W.","family":"Grimm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Scherthan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Horsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Beckers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Gailus-Durner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hrab\u011b de Angelis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven J.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal C.","family":"Burton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Razansky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Tr\u00fcmbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Aichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel Karl","family":"Walch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Calzada-Wack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frauke","family":"Neff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Wurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Floss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.febslet.2009.12.032","article-title":"Very long chain sphingolipids: tissue expression, function and synthesis","volume":"584","author":"R Sandhoff","year":"2010","journal-title":"FEBS Lett"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/sj.emboj.7600034","article-title":"Identification of a family of animal sphingomyelin synthases","volume":"23","author":"K Huitema","year":"2004","journal-title":"EMBO J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.bbalip.2008.07.002","article-title":"The domain responsible for sphingomyelin synthase (SMS) activity","volume":"1781","author":"C Yeang","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1083\/jcb.200903152","article-title":"Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER","volume":"185","author":"AM Vacaru","year":"2009","journal-title":"J Cell Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.gene.2005.07.036","article-title":"The mouse sphingomyelin synthase 1 (SMS1) gene is alternatively spliced to yield multiple transcripts and proteins","volume":"363","author":"Z Yang","year":"2005","journal-title":"Gene"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.gene.2011.04.010","article-title":"Human sphingomyelin synthase 1 gene (SMS1): organization, multiple mRNA splice variants and expression in adult tissues","volume":"481","author":"AV Rozhkova","year":"2011","journal-title":"Gene"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0014-5793(90)80659-7","article-title":"Sphingomyelin is synthesized in the cis Golgi","volume":"261","author":"D Jeckel","year":"1990","journal-title":"FEBS Lett"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1042\/BJ20071240","article-title":"Sphingomyelin synthases regulate production of diacylglycerol at the Golgi","volume":"414","author":"M Villani","year":"2008","journal-title":"Biochem J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/35036052","article-title":"Lipid rafts and signal transduction","volume":"1","author":"K Simons","year":"2000","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nature13474","article-title":"Lipid landscapes and pipelines in membrane homeostasis","volume":"510","author":"JC Holthuis","year":"2014","journal-title":"Nature"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/1743-7075-8-89","article-title":"Subcellular targeting domains of sphingomyelin synthase 1 and 2","volume":"8","author":"C Yeang","year":"2011","journal-title":"Nutr Metab (Lond)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/978-1-4020-8831-5_15","article-title":"Multiple roles for sphingolipids in steroid hormone biosynthesis","volume":"49","author":"NC Lucki","year":"2008","journal-title":"Subcell Biochem"},{"issue":"17","key":"ref13","doi-asserted-by":"crossref","first-page":"4792","DOI":"10.1093\/hmg\/ddv204","article-title":"Male meiotic cytokinesis requires ceramide synthase 3-dependent sphingolipids with unique membrane anchors","volume":"24","author":"M Rabionet","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1194\/jlr.M006429","article-title":"Differentiation-related changes in lipid classes with long-chain and very long-chain polyenoic fatty acids in rat spermatogenic cells","volume":"51","author":"GM Oresti","year":"2010","journal-title":"J Lipid Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/ATVBAHA.112.251538","article-title":"Impact of sphingomyelin synthase 1 deficiency on sphingolipid metabolism and atherosclerosis in mice","volume":"32","author":"Z Li","year":"2012","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1210\/endo.139.7.6117","article-title":"Characterization of the testis and epididymis in mouse models of human Tay Sachs and Sandhoff diseases and partial determination of accumulated gangliosides","volume":"139","author":"J Trasler","year":"1998","journal-title":"Endocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"12147","DOI":"10.1073\/pnas.95.21.12147","article-title":"Complex gangliosides are essential in spermatogenesis of mice: possible roles in the transport of testosterone","volume":"95","author":"K Takamiya","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"22623","DOI":"10.1074\/jbc.C000200200","article-title":"Requirement of seminolipid in spermatogenesis revealed by UDP-galactose: Ceramide galactosyltransferase-deficient mice","volume":"275","author":"H Fujimoto","year":"2000","journal-title":"J Biol Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0002-9440(10)64267-8","article-title":"Reproductive pathology and sperm physiology in acid sphingomyelinase-deficient mice","volume":"161","author":"A Butler","year":"2002","journal-title":"Am J Pathol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1172\/JCI29224","article-title":"Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility","volume":"116","author":"Y Yildiz","year":"2006","journal-title":"J Clin Invest"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/mrd.20559","article-title":"Sperm defects in mice lacking a functional Niemann-Pick C1 protein","volume":"73","author":"J Fan","year":"2006","journal-title":"Mol Reprod Dev"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7221","DOI":"10.1073\/pnas.0502273102","article-title":"Genomewide production of multipurpose alleles for the functional analysis of the mouse genome","volume":"102","author":"F Schn\u00fctgen","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/978-1-59745-471-1_25","article-title":"Systemic first-line phenotyping","volume":"530","author":"V Gailus-Durner","year":"2009","journal-title":"Methods Mol Biol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nprot.2011.351","article-title":"Volumetric real-time multispectral optoacoustic tomography of biomarkers","volume":"6","author":"D Razansky","year":"2011","journal-title":"Nat Protoc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1118\/1.597429","article-title":"Photoacoustic ultrasound (PAUS)\u2014reconstruction tomography","volume":"22","author":"RA Kruger","year":"1995","journal-title":"Med Phys"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1088\/0031-9155\/52\/1\/010","article-title":"Quantitative spatially resolved measurement of tissue chromophore concentrations using photoacoustic spectroscopy: application to the measurement of blood oxygenation and haemoglobin concentration","volume":"52","author":"J Laufer","year":"2007","journal-title":"Phys Med Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2891","DOI":"10.1364\/OL.32.002891","article-title":"Multispectral photoacoustic imaging of fluorochromes in small animals","volume":"32","author":"D Razansky","year":"2007","journal-title":"Opt Lett"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/0003-2697(85)90442-7","article-title":"Measurement of protein using bicinchoninic acid","volume":"150","author":"PK Smith","year":"1985","journal-title":"Anal Biochem"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"7713","DOI":"10.1016\/j.chroma.2011.07.073","article-title":"From brain to food: analysis of phosphatidylcholins, lyso-phosphatidylcholins and phosphatidylcholin-plasmalogens derivates in Alzheimer&apos;s disease human post mortem brains and mice model via mass spectrometry","volume":"1218","author":"MO Grimm","year":"2011","journal-title":"J Chromatogr A"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1006\/abio.1996.9915","article-title":"Ceramide profiling of complex lipid mixtures by electrospray ionization mass spectrometry","volume":"244","author":"M Gu","year":"1997","journal-title":"Anal Biochem"},{"key":"ref31","article-title":"The use of alternative polyadenylation in the tissue-specific regulation of human SMS1 gene expression","author":"LV Dergunova","year":"2013","journal-title":"Mol Biol Rep"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"30701","DOI":"10.1074\/jbc.270.51.30701","article-title":"Role of ceramide in cellular senescence","volume":"270","author":"ME Venable","year":"1995","journal-title":"J Biol Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1677\/JOE-06-0002","article-title":"Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes","volume":"192","author":"NP Lee","year":"2007","journal-title":"J Endocrinol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"16583","DOI":"10.1073\/pnas.0406325101","article-title":"Dynamic histone modifications mark sex chromosome inactivation and reactivation during mammalian spermatogenesis","volume":"101","author":"AM Khalil","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1159\/000087508","article-title":"Histone H3 lysine 4 dimethylation is enriched on the inactive sex chromosomes in male meiosis but absent on the inactive X in female somatic cells","volume":"112","author":"AM Khalil","year":"2006","journal-title":"Cytogenet Genome Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1095\/biolreprod.107.062265","article-title":"Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis","volume":"77","author":"M Godmann","year":"2007","journal-title":"Biol Reprod"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng789","article-title":"Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin","volume":"30","author":"AH Peters","year":"2002","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0960-9822(02)00660-7","article-title":"Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation","volume":"12","author":"JE Mermoud","year":"2002","journal-title":"Curr Biol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1002\/eji.201141555","article-title":"Immunogenic cell death of human ovarian cancer cells induced by cytosolic poly(I:C) leads to myeloid cell maturation and activates NK cells","volume":"41","author":"K K\u00fcbler","year":"2011","journal-title":"Eur J Immunol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5858","DOI":"10.1074\/jbc.273.10.5858","article-title":"DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139","volume":"273","author":"EP Rogakou","year":"1998","journal-title":"J Biol Chem"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/85830","article-title":"Recombinational DNA double-strand breaks in mice precede synapsis","volume":"27","author":"SK Mahadevaiah","year":"2001","journal-title":"Nat Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1095\/biolreprod.102.008672","article-title":"DNA double-strand breaks and gamma-H2AX signaling in the testis","volume":"68","author":"G Hamer","year":"2003","journal-title":"Biol Reprod"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/emboj.2008.156","article-title":"Delta6-desaturase (FADS2) deficiency unveils the role of omega3- and omega6-polyunsaturated fatty acids","volume":"27","author":"W Stoffel","year":"2008","journal-title":"EMBO J"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod.110.087452","article-title":"The blood-testis and blood-epididymis barriers are more than just their tight junctions","volume":"84","author":"P Mital","year":"2011","journal-title":"Biol Reprod"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/intimm\/dxs008","article-title":"CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice","volume":"24","author":"L Dong","year":"2012","journal-title":"Int Immunol"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/S0021-9258(18)46009-7","article-title":"Novel molecular species of sphingomyelin containing 2-hydroxylated polyenoic very-long-chain fatty acids in mammalian testes and spermatozoa","volume":"267","author":"BS Robinson","year":"1992","journal-title":"J Biol Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1095\/biolreprod63.4.1129","article-title":"Sphingomyelin modulates capacitation of human sperm in vitro","volume":"63","author":"NL Cross","year":"2000","journal-title":"Biol Reprod"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/humupd\/2.3.246","article-title":"Lipids of the sperm plasma membrane: from polyunsaturated fatty acids considered as markers of sperm function to possible scavenger therapy","volume":"2","author":"A Lenzi","year":"1996","journal-title":"Hum Reprod Update"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1113\/jphysiol.2012.235846","article-title":"Deficiency of sphingomyelin synthase-1 but not sphingomyelin synthase-2 causes hearing impairments in mice","volume":"590","author":"MH Lu","year":"2012","journal-title":"J Physiol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.1074\/jbc.M110.179176","article-title":"Mitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice","volume":"286","author":"M Yano","year":"2011","journal-title":"J Biol Chem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1161\/ATVBAHA.108.168682","article-title":"Sphingomyelin synthase 2 deficiency attenuates NFkappaB activation","volume":"28","author":"TK Hailemariam","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"28544","DOI":"10.1074\/jbc.M111.255646","article-title":"Dynamic modification of sphingomyelin in lipid microdomains controls development of obesity, fatty liver, and type 2 diabetes","volume":"286","author":"S Mitsutake","year":"2011","journal-title":"J Biol Chem"},{"key":"ref53","article-title":"Sphingomyelin Synthase 2 Activity and Liver Steatosis: An Effect of Ceramide-Mediated Proliferator-Activated Receptor gamma2 Suppression","author":"Y Li","year":"2013","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1161\/ATVBAHA.109.185223","article-title":"Sphingomyelin synthase 2 is one of the determinants for plasma and liver sphingomyelin levels in mice","volume":"29","author":"J Liu","year":"2009","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1194\/jlr.M900230-JLR200","article-title":"Sphingomyelin synthase SMS2 displays dual activity as ceramide phosphoethanolamine synthase","volume":"50","author":"P Ternes","year":"2009","journal-title":"J Lipid Res"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"18141","DOI":"10.1074\/jbc.M700708200","article-title":"Ceramides and sphingomyelins with high proportions of very long-chain polyunsaturated fatty acids in mammalian germ cells","volume":"282","author":"NE Furland","year":"2007","journal-title":"J Biol Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jemt.20786","article-title":"Surfing the wave, cycle, life history, and genes\/proteins expressed by testicular germ cells. Part 5: intercellular junctions and contacts between germs cells and Sertoli cells and their regulatory interactions, testicular cholesterol, and genes\/proteins associated with more than one germ cell generation","volume":"73","author":"L Hermo","year":"2010","journal-title":"Microsc Res Tech"},{"issue":"Pt 1","key":"ref58","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1242\/jcs.103.1.81","article-title":"Cell-, age- and stage-dependent distribution of connexin43 gap junctions in testes","volume":"103","author":"MS Risley","year":"1992","journal-title":"J Cell Sci"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.ydbio.2010.07.014","article-title":"Major involvement of connexin 43 in seminiferous epithelial junction dynamics and male fertility","volume":"346","author":"D Carette","year":"2010","journal-title":"Dev Biol"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e23644","DOI":"10.1371\/journal.pone.0023644","article-title":"Sphingomyelin synthases regulate protein trafficking and secretion","volume":"6","author":"M Subathra","year":"2011","journal-title":"PLoS One"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1095\/biolreprod52.2.211","article-title":"Interactions between germ cells and Sertoli cells in the testis","volume":"52","author":"MD Griswold","year":"1995","journal-title":"Biol Reprod"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1093\/jn\/87.1.63","article-title":"Effect of dietary linoleic acid, vitamin E and ethoxyguin on fertility of male chickens","volume":"87","author":"GH Arscott","year":"1965","journal-title":"J Nutr"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1194\/jlr.M011346","article-title":"ELOVL2 controls the level of n-6 28:5 and 30:5 fatty acids in testis, a prerequisite for male fertility and sperm maturation in mice","volume":"52","author":"D Zadravec","year":"2011","journal-title":"J Lipid Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.anireprosci.2012.02.002","article-title":"The role of omega-3 polyunsaturated fatty acids in reproduction of sheep and cattle","volume":"131","author":"CE Gulliver","year":"2012","journal-title":"Anim Reprod Sci"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1476-511X-12-33","article-title":"Effect of different dietary omega-3\/omega-6 fatty acid ratios on reproduction in male rats","volume":"12","author":"L Yan","year":"2013","journal-title":"Lipids Health Dis"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3945\/ajcn.112.042432","article-title":"High dietary intake of saturated fat is associated with reduced semen quality among 701 young Danish men from the general population","volume":"97","author":"TK Jensen","year":"2013","journal-title":"Am J Clin Nutr"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1194\/jlr.M001180","article-title":"Docosahexaenoic acid supplementation fully restores fertility and spermatogenesis in male delta-6 desaturase-null mice","volume":"51","author":"M Roqueta-Rivera","year":"2010","journal-title":"J Lipid Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1172\/JCI41303","article-title":"The key role of vitamin A in spermatogenesis","volume":"120","author":"CA Hogarth","year":"2010","journal-title":"J Clin Invest"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1074\/jbc.M800870200","article-title":"Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide synthase-3","volume":"283","author":"M Rabionet","year":"2008","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:47:31Z","timestamp":1718866051000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164298"}},"subtitle":[],"editor":[{"given":"Jo\u00ebl R","family":"Drevet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164298","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}