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Leishmaniases. Epidemiological Report of the Americas 2015 [cited 2015]. 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An\u00e1lisis de los perfiles de expresi\u00f3n g\u00e9nica en los procesos de diferenciaci\u00f3n de Leishmania infantum mediante microarrays de ADN. E-Prints Complutense: Universidad Complutense de Madrid; 2011."},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1021\/pr400923g","article-title":"Identification of virulence factors in Leishmania infantum strains by a proteomic approach","volume":"13","author":"S da Fonseca Pires","year":"2014","journal-title":"J Proteome Res"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/cbf.1107","article-title":"Protein kinase A activity is associated with metacyclogenesis in Leishmania amazonensis","volume":"22","author":"M Genestra","year":"2004","journal-title":"Cell biochemistry and function"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1111\/j.1365-2958.2011.07950.x","article-title":"Identification of a protein kinase A regulatory subunit from Leishmania having importance in metacyclogenesis through induction of autophagy","volume":"83","author":"A Bhattacharya","year":"2012","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1046\/j.1432-1327.1999.00122.x","article-title":"Molecular cloning, cell localization and binding affinity to DNA replication proteins of the p36\/LACK protective antigen from Leishmania infantum","volume":"259","author":"G Gonzalez-Aseguinolaza","year":"1999","journal-title":"Eur J Biochem"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"e113837","DOI":"10.1371\/journal.pone.0113837","article-title":"An Insight into the proteome of Crithidia fasciculata choanomastigotes as a comparative approach to axenic growth, peanut lectin agglutination and differentiation of Leishmania spp. promastigotes","volume":"9","author":"PJ Alcolea","year":"2014","journal-title":"PLoS One"},{"issue":"48","key":"ref42","doi-asserted-by":"crossref","first-page":"6695","DOI":"10.1016\/j.vaccine.2009.08.091","article-title":"Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection","volume":"27","author":"I Ramos","year":"2009","journal-title":"Vaccine"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/0166-6851(82)90021-4","article-title":"A comparative study of Leishmania mexicana amastigotes and promastigotes. 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