{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T22:08:07Z","timestamp":1782598087103,"version":"3.54.5"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T00:00:00Z","timestamp":1476403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Cancer Council Malaysia (MAKNA)"},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164389","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T17:40:02Z","timestamp":1476466802000},"page":"e0164389","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating Nuclear Membrane Irregularity for the Classification of Cervical Squamous Epithelial Cells"],"prefix":"10.1371","volume":"11","author":[{"given":"Jing Rui","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nor Ashidi","family":"Mat Isa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewe Seng","family":"Ch\u2019ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1136\/ewjm.175.4.231","article-title":"Cervical cancer in the developing world","volume":"175","author":"J Sherris","year":"2001","journal-title":"Western Journal of Medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/dc.21234","article-title":"Cancer nucleus: Morphology and beyond","volume":"38","author":"P Dey","year":"2010","journal-title":"Diagnostic Cytopathology"},{"key":"ref3","first-page":"467","article-title":"Automated blood cancer detection using image processing based on fuzzy system","volume":"4","author":"NA Talukdar","year":"2014","journal-title":"International Journal of Advanced Research in Computer Science and Software Engineering"},{"key":"ref4","article-title":"Cell shape and the microenvironment regulate nuclear translocation of NF-\u03baB in breast epithelial and tumor cells","volume":"11","author":"JE Sero","year":"2015","journal-title":"Molecular Systems Biology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1155\/2012\/101536","article-title":"Recent advances in morphological cell Image analysis","volume":"2012","author":"S Chen","year":"2012","journal-title":"Computational and Mathematical Methods in Medicine"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e0142830","DOI":"10.1371\/journal.pone.0142830","article-title":"A fuzzy-c-means-clustering approach: Quantifying chromatin pattern of non-neoplastic cervical squamous cells","volume":"10","author":"JR Tang","year":"2015","journal-title":"PLoS ONE"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1159\/000326192","article-title":"Fine needle aspiration cytology of the thyroid","volume":"49","author":"S Jogai","year":"2005","journal-title":"Acta Cytologica"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1159\/000331093","article-title":"Fine needle aspiration cytology of Langerhans cell histiocytosis of the thyroid","volume":"43","author":"P Dey","year":"1999","journal-title":"Acta Cytologica"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1159\/000326500","article-title":"Fine needle aspiration cytology of lobular breast carcinoma","volume":"47","author":"L Rajesh","year":"2003","journal-title":"Acta Cytologica"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0002-9440(10)63958-2","article-title":"Abnormal nuclear shape in solid tumors reflects mitotic instability","volume":"158","author":"D Gisselsson","year":"2001","journal-title":"The American Journal of Pathology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrc1430","article-title":"Nuclear structure in cancer cells","volume":"4","author":"D Zink","year":"2004","journal-title":"Nature Reviews Cancer"},{"key":"ref12","doi-asserted-by":"crossref","unstructured":"Li Y, Naveed H, Liang J, Xu LX. Effects of mechanical properties on tumor invasion: Insights from a cellular model; 2014 26\u201330 Aug. 2014. pp. 6818\u20136821.","DOI":"10.1109\/EMBC.2014.6945194"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1109\/10.536902","article-title":"Morphological feature extraction for the classification of digital images of cancerous tissues","volume":"43","author":"JP Thiran","year":"1996","journal-title":"IEEE Transactions on Biomedical Engineering"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.4236\/jbise.2013.611128","article-title":"Carcinoma cell identification via optical microscopy and shape feature analysis","volume":"6","author":"A Chaddad","year":"2013","journal-title":"Journal of Biomedical Science and Engineering"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.mpdhp.2015.10.007","article-title":"Cytohistology of hepatocellular carcinoma","volume":"21","author":"A Wee","year":"2015","journal-title":"Diagnostic Histopathology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.juro.2013.07.059","article-title":"Coexisting hybrid malignancy in a solitary sporadic solid benign renal mass: Implications for treating patients following renal biopsy","volume":"191","author":"S Ginzburg","year":"2014","journal-title":"The Journal of Urology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e55628","DOI":"10.1371\/journal.pone.0055628","article-title":"Nuclear shape changes are induced by knockdown of the SWI\/SNF ATPase BRG1 and are independent of cytoskeletal connections","volume":"8","author":"KM Imbalzano","year":"2013","journal-title":"PLoS ONE"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/cyto.a.22612","article-title":"Simple computational technique to quantify nuclear shape asymmetry","volume":"37","author":"AG Nikonenko","year":"2015","journal-title":"Cytometry Part A"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/cyto.990090302","article-title":"Symmetry analysis of cell nuclei","volume":"9","author":"JP Panno","year":"1988","journal-title":"Cytometry"},{"key":"ref20","first-page":"706","article-title":"Morphological classification of cancerous cells; 1994","volume":"703","author":"JP Thiran","year":"1994"},{"key":"ref21","doi-asserted-by":"crossref","unstructured":"Al-Mamun MA, Ravenhill L, Hossain MA, Farid DM, Bass R. Fractal and image analysis of cytoskeletal changes in tumour cells due to the effects of maspin; 2014 1\u20134 June 2014. pp. 209\u2013212.","DOI":"10.1109\/BHI.2014.6864341"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Xing F, Yang L. Unsupervised shape prior modeling for cell segmentation in neuroendocrine tumor; 2015 16\u201319 April 2015. pp. 1443\u20131446.","DOI":"10.1109\/ISBI.2015.7164148"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1364\/AO.26.003301","article-title":"Automated cytologic screening system (CYBEST model 4): an integrated image cytometry system","volume":"26","author":"N Tanaka","year":"1987","journal-title":"Applied Optics"},{"key":"ref24","author":"D Solomon","year":"2004"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00500-008-0323-y","article-title":"KEEL: a software tool to assess evolutionary algorithms for data mining problems","volume":"13","author":"J Alcal\u00e1-Fdez","year":"2009","journal-title":"Soft Computing"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.swevo.2011.02.002","article-title":"A practical tutorial on the use of nonparametric statistical tests as a methodology for comparing evolutionary and swarm intelligence algorithms","volume":"1","author":"J Derrac","year":"2011","journal-title":"Swarm and Evolutionary Computation"},{"key":"ref27","first-page":"2677","article-title":"An extension on \u201cstatistical comparisons of classifiers over multiple data sets\u201d for all pairwise comparisons","volume":"9","author":"S Garc\u00eda","year":"2009","journal-title":"Journal of Machine Learning Research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/jcs.037333","article-title":"Sizing up the nucleus: nuclear shape, size and nuclear-envelope assembly","volume":"122","author":"M Webster","year":"2009","journal-title":"Journal of Cell Science"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1126\/science.1142034","article-title":"Blurring the boundary: The nuclear envelope extends its reach","volume":"318","author":"CL Stewart","year":"2007","journal-title":"Science"},{"key":"ref30","author":"R Nayar","year":"2015"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164389","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T13:12:51Z","timestamp":1749647571000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164389"}},"subtitle":[],"editor":[{"given":"Silvana","family":"Allodi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,14]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164389","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,14]]}}}