{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T12:13:46Z","timestamp":1778501626258,"version":"3.51.4"},"reference-count":42,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T00:00:00Z","timestamp":1476057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cResearch Program on Hepatitis\u201d from the Japan Agency for Medical Research and Development, AMED","award":["16fk0210101h0001"],"award-info":[{"award-number":["16fk0210101h0001"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164418","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T17:37:18Z","timestamp":1476121038000},"page":"e0164418","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Genome-Wide Association Study Identifies ZNF354C Variants Associated with Depression from Interferon-Based Therapy for Chronic Hepatitis C"],"prefix":"10.1371","volume":"11","author":[{"given":"Kayoko","family":"Matsunami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nao","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuho","family":"Ikeo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Licht","family":"Toyo-oka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takeuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kentaro","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiro","family":"Tamori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyuki","family":"Nomura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yoshiji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatoshi","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohiko","family":"Masaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuro","family":"Hayakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Ide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noritomo","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fusao","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Hino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nishiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiaki","family":"Okuse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Nojiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunobu","family":"Sawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsushi","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Joh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,10,10]]},"reference":[{"key":"ref1","unstructured":"World Health Organizartion (WHO). Hepatitis C. Fact sheet n.164. Available from <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/mediacentre\/factsheets\/fs164\/en\/index.html#\" xlink:type=\"simple\">http:\/\/www.who.int\/mediacentre\/factsheets\/fs164\/en\/index.html#<\/ext-link>."},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/gut.2003.030353","article-title":"Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis C","volume":"53","author":"H Yoshida","year":"2004","journal-title":"Gut"},{"issue":"13","key":"ref3","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1056\/NEJMoa020047","article-title":"Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection","volume":"347","author":"MW Fried","year":"2002","journal-title":"The New England journal of medicine"},{"issue":"9941","key":"ref4","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0140-6736(14)60494-3","article-title":"Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial","volume":"384","author":"IM Jacobson","year":"2014","journal-title":"Lancet (London, England)"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1002\/hep.24724","article-title":"Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders","volume":"55","author":"K Chayama","year":"2012","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ng.449","article-title":"Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C","volume":"41","author":"Y Tanaka","year":"2009","journal-title":"Nat Genet"},{"issue":"5 Suppl 1","key":"ref7","doi-asserted-by":"crossref","first-page":"S237","DOI":"10.1002\/hep.1840360730","article-title":"Side effects of therapy of hepatitis C and their management","volume":"36","author":"MW Fried","year":"2002","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.jhep.2005.11.046","article-title":"Depression, anemia and health-related quality of life in chronic hepatitis C","volume":"44","author":"AA Dan","year":"2006","journal-title":"Journal of hepatology"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1176\/appi.ajp.157.6.867","article-title":"Neuropsychiatric symptoms associated with hepatitis C and interferon alpha: A review","volume":"157","author":"E Dieperink","year":"2000","journal-title":"The American journal of psychiatry"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000086605","article-title":"Promoter polymorphisms of the interferon-alpha receptor gene and development of Interferon-induced depressive symptoms in patients with chronic hepatitis C: preliminary findings","volume":"52","author":"K Yoshida","year":"2005","journal-title":"Neuropsychobiology"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/mp.2008.48","article-title":"Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment","volume":"14","author":"SJ Bull","year":"2009","journal-title":"Molecular psychiatry"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s00702-010-0525-1","article-title":"Interferon-gamma (+874) T\/A genotypes and risk of IFN-alpha-induced depression","volume":"118","author":"G Oxenkrug","year":"2011","journal-title":"Journal of neural transmission (Vienna, Austria: 1996)"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.biopsych.2008.08.009","article-title":"Risk for depression during interferon-alpha treatment is affected by the serotonin transporter polymorphism","volume":"65","author":"FE Lotrich","year":"2009","journal-title":"Biological psychiatry"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1053\/j.gastro.2007.02.053","article-title":"Serotonin-1A receptor gene HTR1A variation predicts interferon-induced depression in chronic hepatitis C","volume":"132","author":"MR Kraus","year":"2007","journal-title":"Gastroenterology"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.pnpbp.2009.02.020","article-title":"Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response","volume":"33","author":"SJ Tsai","year":"2009","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0165-1781(02)00106-3","article-title":"Cross-cultural validation of the Beck Depression Inventory-II in Japan","volume":"110","author":"M Kojima","year":"2002","journal-title":"Psychiatry research"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"810","DOI":"10.4088\/JCP.v69n0514","article-title":"Depression comorbidity and antidepressant use in veterans with chronic hepatitis C: results from a retrospective chart review","volume":"69","author":"JA Nelligan","year":"2008","journal-title":"The Journal of clinical psychiatry"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1872-034X.2011.00930.x","article-title":"Occurrence of clinical depression during combination therapy with pegylated interferon alpha or natural human interferon beta plus ribavirin","volume":"42","author":"H Nomura","year":"2012","journal-title":"Hepatology research: the official journal of the Japan Society of Hepatology"},{"key":"ref19","article-title":"Manual for the Beck Depression Inventory-II","author":"AT Beck","year":"1996"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1207\/s15327752jpa6703_13","article-title":"Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients","volume":"67","author":"AT Beck","year":"1996","journal-title":"Journal of personality assessment"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ab.2007.02.005","article-title":"Further development of multiplex single nucleotide polymorphism typing method, the DigiTag2 assay","volume":"364","author":"N Nishida","year":"2007","journal-title":"Analytical biochemistry"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"e1000529","DOI":"10.1371\/journal.pgen.1000529","article-title":"A flexible and accurate genotype imputation method for the next generation of genome-wide association studies","volume":"5","author":"BN Howie","year":"2009","journal-title":"PLoS genetics"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuron.2010.06.018","article-title":"New neurons clear the path of astrocytic processes for their rapid migration in the adult brain","volume":"67","author":"N Kaneko","year":"2010","journal-title":"Neuron"},{"issue":"1\u20132","key":"ref24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-4781(99)00239-0","article-title":"Characterisation, chromosomal localisation and expression of the mouse Kid3 gene","volume":"1490","author":"RP Watson","year":"2000","journal-title":"Biochimica et biophysica acta"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1177\/002215540205000711","article-title":"Temporal and spatial expression of a novel zinc finger transcription factor, AJ18, in developing murine skeletal tissues","volume":"50","author":"A Jheon","year":"2002","journal-title":"The journal of histochemistry and cytochemistry: official journal of the Histochemistry Society"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1073\/pnas.94.6.2374","article-title":"cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components","volume":"94","author":"A Colige","year":"1997","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"21","key":"ref27","doi-asserted-by":"crossref","first-page":"18282","DOI":"10.1074\/jbc.M010885200","article-title":"Characterization of a novel KRAB\/C2H2 zinc finger transcription factor involved in bone development","volume":"276","author":"AH Jheon","year":"2001","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"41","DOI":"10.4088\/JCP.v66n0106","article-title":"Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction","volume":"66","author":"CL Raison","year":"2005","journal-title":"The Journal of clinical psychiatry"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.0022-202X.2004.23406.x","article-title":"Novel types of mutation responsible for the dermatosparactic type of Ehlers-Danlos syndrome (Type VIIC) and common polymorphisms in the ADAMTS2 gene","volume":"123","author":"A Colige","year":"2004","journal-title":"The Journal of investigative dermatology"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1002\/hep.21868","article-title":"ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice","volume":"46","author":"F Kesteloot","year":"2007","journal-title":"Hepatology (Baltimore, Md)"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.stemcr.2014.05.015","article-title":"Mechanisms for interferon-alpha-induced depression and neural stem cell dysfunction","volume":"3","author":"LS Zheng","year":"2014","journal-title":"Stem cell reports"},{"issue":"Suppl 2","key":"ref32","first-page":"5","article-title":"Functional annotation of putative regulatory elements at cancer susceptibility Loci","volume":"13","author":"SA Rosse","year":"2014","journal-title":"Cancer informatics"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/bfgp\/elm002","article-title":"Functional analysis of the role of POK transcriptional repressors","volume":"6","author":"JA Costoya","year":"2007","journal-title":"Briefings in functional genomics & proteomics"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"405","DOI":"10.5483\/BMBRep.2014.47.7.075","article-title":"Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells","volume":"47","author":"JH Lim","year":"2014","journal-title":"BMB Rep"},{"issue":"36","key":"ref35","doi-asserted-by":"crossref","first-page":"5890","DOI":"10.2174\/138161212803523554","article-title":"The role of oxidative stress in depressive disorders","volume":"18","author":"TM Michel","year":"2012","journal-title":"Current pharmaceutical design"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1210\/en.2012-2187","article-title":"Two populations of glucocorticoid receptor-binding sites in the male rat hippocampal genome","volume":"154","author":"JA Polman","year":"2013","journal-title":"Endocrinology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1471-2202-13-118","article-title":"A genome-wide signature of glucocorticoid receptor binding in neuronal PC12 cells","volume":"13","author":"JA Polman","year":"2012","journal-title":"BMC Neurosci"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.pnpbp.2004.11.003","article-title":"Cytokines and major depression","volume":"29","author":"OJ Schiepers","year":"2005","journal-title":"Progress in neuro-psychopharmacology & biological psychiatry"},{"issue":"Suppl","key":"ref39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0924-977X(95)00039-R","article-title":"The potential role of excessive cortisol induced by HPA hyperfunction in the pathogenesis of depression","volume":"5","author":"PE Stokes","year":"1995","journal-title":"European neuropsychopharmacology: the journal of the European College of Neuropsychopharmacology"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"17855","DOI":"10.1038\/srep17855","article-title":"Mapping the genetic diversity of HLA haplotypes in the Japanese populations","volume":"5","author":"WY Saw","year":"2015","journal-title":"Sci Rep"},{"issue":"11","key":"ref41","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s100380200092","article-title":"Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Single-nucleotide polymorphism","volume":"47","author":"H Haga","year":"2002","journal-title":"Journal of human genetics"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ajhg.2008.08.019","article-title":"Japanese population structure, based on SNP genotypes from 7003 individuals compared to other ethnic groups: effects on population-based association studies","volume":"83","author":"Y Yamaguchi-Kabata","year":"2008","journal-title":"American journal of human genetics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164418","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T18:23:17Z","timestamp":1540232597000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164418"}},"subtitle":[],"editor":[{"given":"Chen-Hua","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,10]]},"references-count":42,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164418","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,10]]}}}