{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T10:44:29Z","timestamp":1766486669408,"version":"3.37.3"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T00:00:00Z","timestamp":1477353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"JSS University Research Fellowship and student"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164559","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T17:33:37Z","timestamp":1477416817000},"page":"e0164559","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Comparative Assessment of Vitamin-B12, Folic Acid and Homocysteine Levels in Relation to p53 Expression in Megaloblastic Anemia"],"prefix":"10.1371","volume":"11","author":[{"given":"Manish K.","family":"Yadav","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nandini M.","family":"Manoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9167-9271","authenticated-orcid":true,"given":"SubbaRao V.","family":"Madhunapantula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,10,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3121\/cmr.4.3.236","article-title":"Megaloblastic anemia and other causes of macrocytosis","volume":"4","author":"F Aslinia","year":"2006","journal-title":"Clin Med Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"64","DOI":"10.4103\/2249-4863.152255","article-title":"A study of the prevalence of serum vitamin B12 and folic Acid deficiency in Western maharashtra","volume":"4","author":"SK Mahajan","year":"2015","journal-title":"J Family Med Prim Care"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.3748\/wjg.15.5121","article-title":"Pernicious anemia: new insights from a gastroenterological point of view","volume":"15","author":"E Lahner","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"269","DOI":"10.4088\/PCC.08l00707","article-title":"Vitamin b(1)(2) deficiency and depression in the elderly: review and case report","volume":"11","author":"S Hanna","year":"2009","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4103\/0301-4738.179720","article-title":"Bilateral macular hemorrhage due to megaloblastic anemia: A rare case report","volume":"64","author":"SK Vaggu","year":"2016","journal-title":"Indian J Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1182\/blood-2002-09-2746","article-title":"Cobalamin deficiency with and without neurologic abnormalities: differences in homocysteine and methionine metabolism","volume":"101","author":"R Carmel","year":"2003","journal-title":"Blood"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"534","DOI":"10.2174\/1389202914666131210210559","article-title":"Homocysteine Level and Mechanisms of Injury in Parkinson&apos;s Disease as Related to MTHFR, MTR, and MTHFD1 Genes Polymorphisms and L-Dopa Treatment","volume":"14","author":"A Rozycka","year":"2013","journal-title":"Curr Genomics"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1474-4422(03)00438-1","article-title":"Homocysteine and Alzheimer&apos;s disease","volume":"2","author":"MS Morris","year":"2003","journal-title":"Lancet Neurol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"a011601","DOI":"10.1101\/cshperspect.a011601","article-title":"Erythropoiesis: development and differentiation","volume":"3","author":"E Dzierzak","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref10","first-page":"243","article-title":"The intersection between DNA damage response and cell death pathways","volume":"34","author":"S Nowsheen","year":"2012","journal-title":"Exp Oncol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.nutr.24.012003.132306","article-title":"New insights into erythropoiesis: the roles of folate, vitamin B12, and iron","volume":"24","author":"MJ Koury","year":"2004","journal-title":"Annu Rev Nutr"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1515\/CCLM.2003.155","article-title":"Effects of vitamin B12 and folate deficiencies on DNA methylation and carcinogenesis in rat liver","volume":"41","author":"L Brunaud","year":"2003","journal-title":"Clin Chem Lab Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3945\/an.111.000992","article-title":"Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate&apos;s role","volume":"3","author":"KS Crider","year":"2012","journal-title":"Adv Nutr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.molmed.2006.07.007","article-title":"DNA damage-induced cell death by apoptosis","volume":"12","author":"WP Roos","year":"2006","journal-title":"Trends Mol Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/carcin\/23.6.1025","article-title":"The onset of p53-dependent DNA repair or apoptosis is determined by the level of accumulated damaged DNA","volume":"23","author":"H Offer","year":"2002","journal-title":"Carcinogenesis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1016\/S0006-2952(03)00510-0","article-title":"DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling","volume":"66","author":"B Kaina","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/mutage\/17.2.149","article-title":"p53 regulation of DNA excision repair pathways","volume":"17","author":"ML Smith","year":"2002","journal-title":"Mutagenesis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1038\/sj.onc.1206541","article-title":"The onset of p53-dependent apoptosis plays a role in terminal differentiation of human normoblasts","volume":"22","author":"S Peller","year":"2003","journal-title":"Oncogene"},{"key":"ref19","first-page":"874","article-title":"Cytoplasmic overexpression of p53 and p21(ras) in megaloblastic anemia","volume":"85","author":"E Schulz","year":"2000","journal-title":"Haematologica"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1182\/blood.V96.9.3249","article-title":"Apoptosis in megaloblastic anemia occurs during DNA synthesis by a p53-independent, nucleoside-reversible mechanism","volume":"96","author":"MJ Koury","year":"2000","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1182\/blood.V76.5.871.871","article-title":"Clinical spectrum and diagnosis of cobalamin deficiency","volume":"76","author":"SP Stabler","year":"1990","journal-title":"Blood"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1212\/WNL.45.8.1435","article-title":"Current concepts in the diagnosis of cobalamin deficiency","volume":"45","author":"R Green","year":"1995","journal-title":"Neurology"},{"key":"ref23","first-page":"71","article-title":"Peripheral blood film\u2014a review","volume":"12","author":"AS Adewoyin","year":"2014","journal-title":"Ann Ib Postgrad Med"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.foodchem.2013.12.033","article-title":"Competitive chemiluminescent enzyme immunoassay for vitamin B12 analysis in human milk","volume":"153","author":"D Hampel","year":"2014","journal-title":"Food Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1309\/G035-P2MM-D1TM-T5QE","article-title":"Cell block cytology. Improved preparation and its efficacy in diagnostic cytology","volume":"114","author":"NA Nathan","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"ref26","first-page":"679","article-title":"p53 mediates DNA damaging drug-induced apoptosis through a caspase-9-dependent pathway in SH-SY5Y neuroblastoma cells","volume":"1","author":"H Cui","year":"2002","journal-title":"Mol Cancer Ther"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1176\/jnp.12.3.389","article-title":"Dementia associated with vitamin B(12) deficiency: presentation of two cases and review of the literature","volume":"12","author":"N Goebels","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.3390\/nu5114521","article-title":"Cobalamin deficiency: clinical picture and radiological findings","volume":"5","author":"C Briani","year":"2013","journal-title":"Nutrients"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1016\/B978-0-7020-4087-0.00061-9","article-title":"The neurology of folic acid deficiency","volume":"120","author":"EH Reynolds","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"ref30","first-page":"172","article-title":"Megaloblastic anaemia: prevalence and causative factors","volume":"20","author":"U Khanduri","year":"2007","journal-title":"Natl Med J India"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"P Ganguly","year":"2015","journal-title":"Nutr J"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.mrfmmm.2011.11.003","article-title":"Folate (vitamin B9) and vitamin B12 and their function in the maintenance of nuclear and mitochondrial genome integrity","volume":"733","author":"M Fenech","year":"2012","journal-title":"Mutat Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nm.2063","article-title":"A p53-dependent mechanism underlies macrocytic anemia in a mouse model of human 5q- syndrome","volume":"16","author":"JL Barlow","year":"2010","journal-title":"Nat Med"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/carcin\/bgi312","article-title":"Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells","volume":"27","author":"P Novakovic","year":"2006","journal-title":"Carcinogenesis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1126\/science.7973727","article-title":"Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen","volume":"266","author":"ML Smith","year":"1994","journal-title":"Science"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1038\/sj.onc.1208474","article-title":"Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities","volume":"24","author":"G He","year":"2005","journal-title":"Oncogene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.onc.1205020","article-title":"Caspase 9 is required for p53-dependent apoptosis and chemosensitivity in a human ovarian cancer cell line","volume":"21","author":"GS Wu","year":"2002","journal-title":"Oncogene"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53","volume":"7","author":"K Nakano","year":"2001","journal-title":"Mol Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1101\/gad.1103603","article-title":"Integral role of Noxa in p53-mediated apoptotic response","volume":"17","author":"T Shibue","year":"2003","journal-title":"Genes Dev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrd4236","article-title":"Drugging the p53 pathway: understanding the route to clinical efficacy","volume":"13","author":"KH Khoo","year":"2014","journal-title":"Nat Rev Drug Discov"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T22:50:48Z","timestamp":1601160648000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164559"}},"subtitle":[],"editor":[{"given":"Klaus","family":"Roemer","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,25]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164559","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2016,10,25]]}}}