{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:59:49Z","timestamp":1787021989482,"version":"build-2736575974"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T00:00:00Z","timestamp":1477008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR6037\/GBD\/27\/372\/2012"],"award-info":[{"award-number":["BT\/PR6037\/GBD\/27\/372\/2012"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0164585","type":"journal-article","created":{"date-parts":[[2016,10,21]],"date-time":"2016-10-21T16:39:16Z","timestamp":1477067956000},"page":"e0164585","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":53,"title":["Biological Activity of Coumarin Derivatives as Anti-Leishmanial Agents"],"prefix":"10.1371","volume":"11","author":[{"given":"Vineetha","family":"Mandlik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohan","family":"Patil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramanamurthy","family":"Bopanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudipta","family":"Basu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shailza","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,21]]},"reference":[{"key":"ref1","article-title":"Use of antimony in the treatment of leishmaniasis: current status and future directions","author":"AK Haldar","year":"2011","journal-title":"Molecular biology international"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1128\/AAC.41.4.752","article-title":"Activity of liposomal amphotericin B against experimental cutaneous leishmaniasis","volume":"41","author":"V Yardley","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1517\/13543784.17.5.787","article-title":"Paromomycin in the treatment of leishmaniasis","volume":"17","author":"S Sundar","year":"2008","journal-title":"Expert opinion on investigational drugs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3347\/kjp.2011.49.1.17","article-title":"Miltefosine-induced apoptotic cell death on Leishmania major and L. tropica strains","volume":"49","author":"S Khademvatan","year":"2011","journal-title":"The Korean journal of parasitology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1128\/AAC.48.3.852-859.2004","article-title":"Miltefosine induces apoptosis-like death in Leishmania donovani promastigotes","volume":"48","author":"C Paris","year":"2004","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.pt.2005.08.026","article-title":"Chemotherapy of trypanosomiases and leishmaniasis","volume":"21","author":"SL Croft","year":"2005","journal-title":"Trends in parasitology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2174\/1568026023393011","article-title":"Natural products as trypanocidal, antileishmanial and antimalarial drugs","volume":"2","author":"A Fournet","year":"2002","journal-title":"Current Topics in medicinal chemistry"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.fitote.2008.10.009","article-title":"Alkaloids: Future prospective to combat leishmaniasis","volume":"80","author":"BB Mishra","year":"2009","journal-title":"Fitoterapia"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0031-9422(98)00497-X","article-title":"Bioactive phenolic glycosides from Amburana cearensis","volume":"50","author":"M Sauvain","year":"1999","journal-title":"Phytochemistry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1021\/np970030o","article-title":"Two new antiprotozoal 5-methylcoumarins from Vernonia brachycalyx","volume":"60","author":"HA Oketch-Rabah","year":"1997","journal-title":"Journal of Natural Products"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biopha.2008.08.024","article-title":"Structure\u2013activity relationship of (\u2212) mammea A\/BB derivatives against Leishmania amazonensis","volume":"62","author":"MA Brenzan","year":"2008","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1590\/S0100-879X2004001200010","article-title":"Aurapten, a coumarin with growth inhibition against Leishmania major promastigotes","volume":"37","author":"HB Napolitano","year":"2004","journal-title":"Brazilian journal of medical and biological research"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ardp.201500392","article-title":"Unraveling the Alkaline Phosphatase Inhibition, Anticancer, and Antileishmanial Potential of Coumarin\u2013Triazolothiadiazine Hybrids: Design, Synthesis, and Molecular Docking Analysis","volume":"349","author":"A Ibrar","year":"2016","journal-title":"Archiv der Pharmazie"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"13251","DOI":"10.3390\/molecules190913251","article-title":"Synthesis, leishmanicidal and cytotoxic activity of triclosan-chalcone, triclosan-chromone and triclosan-coumarin hybrids","volume":"19","author":"E Otero","year":"2014","journal-title":"Molecules"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.4103\/0974-8490.178650","article-title":"Anti-Leishmania activity of osthole","volume":"8","author":"EK Kermani","year":"2016","journal-title":"Pharmacognosy research"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.bmcl.2015.12.085","article-title":"Antileishmanial activity of novel indolyl\u2013coumarin hybrids: Design, synthesis, biological evaluation, molecular docking study and in silico ADME prediction","volume":"26","author":"JN Sangshetti","year":"2016","journal-title":"Bioorganic & medicinal chemistry letters"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.phytol.2014.04.009","article-title":"New antileishmanial sesquiterpene coumarins from Ferula narthex Boiss","volume":"9","author":"S Bashir","year":"2014","journal-title":"Phytochemistry Letters"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1021\/ci049714+","article-title":"ZINC-a free database of commercially available compounds for virtual screening","volume":"45","author":"JJ Irwin","year":"2005","journal-title":"Journal of chemical information and modeling"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.addr.2012.09.019","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"64","author":"CA Lipinski","year":"2012","journal-title":"Advanced drug delivery reviews"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2615","DOI":"10.1021\/jm020017n","article-title":"Molecular properties that influence the oral bioavailability of drug candidates","volume":"45","author":"DF Veber","year":"2002","journal-title":"Journal of medicinal chemistry"},{"key":"ref21","unstructured":"ROCS; OpenEye Scientific Software:Santa Fe, NM"},{"key":"ref22","unstructured":"ACD\/Chemsketch, version 5.12, Advanced Chemistry Development, Inc., Toronto, ON, Canada, Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.acdlabs.com\" xlink:type=\"simple\">http:\/\/www.acdlabs.com<\/ext-link>"},{"key":"ref23","unstructured":"Field-Based QSAR, version 2014\u20133, Schr\u00f6dinger, LLC, New York, NY, (2014)."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"7584","DOI":"10.1021\/am5090226","article-title":"Dual drug conjugated nanoparticle for simultaneous targeting of mitochondria and nucleus in cancer cells","volume":"7","author":"A Mallick","year":"2015","journal-title":"ACS applied materials & interfaces"},{"key":"ref25","unstructured":"Rasband WS. Image J, version 1.41. Maryland, Bethesda: National Institutes of Health"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.4049\/jimmunol.126.4.1614","article-title":"Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis","volume":"126","author":"C Taswell","year":"1981","journal-title":"The Journal of Immunology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.phytochem.2006.11.002","article-title":"Sesquiterpene coumarins from Ferula szowitsiana and in vitro antileishmanial activity of 7-prenyloxycoumarins against promastigotes","volume":"68","author":"M Iranshahi","year":"2007","journal-title":"Phytochemistry"},{"key":"ref28","article-title":"The antiacetylcholinesterase and antileishmanial activities of Canarium patentinervium Miq","author":"R Mogana","year":"2014","journal-title":"BioMed research international"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1016\/S0968-0896(99)00138-8","article-title":"Synthesis and antifungal activity of coumarins and angular furanocoumarins","volume":"7","author":"S Sardari","year":"1999","journal-title":"Bioorganic & medicinal chemistry"},{"issue":"1\u20132","key":"ref30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1515\/znc-2008-1-205","article-title":"Antifungal activity of coumarins","volume":"63","author":"C Montagner","year":"2008","journal-title":"Zeitschrift f\u00fcr Naturforschung C"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.ejpb.2013.08.014","article-title":"Molecular mechanism underlying antileishmanial effect of oxabicyclo [3.3. 1] nonanones: inhibition of key redox enzymes of the pathogen","volume":"85","author":"P Saudagar","year":"2013","journal-title":"European Journal of Pharmaceutics and Biopharmaceutics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.ejmech.2012.04.034","article-title":"Iridoid glucosides from Nyctanthes arbortristis result in increased reactive oxygen species and cellular redox homeostasis imbalance in Leishmania parasite","volume":"54","author":"AK Shukla","year":"2012","journal-title":"European journal of medicinal chemistry"},{"key":"ref33","first-page":"93","article-title":"A morphological assessment of the stimulatory effect of coumarin on macrophages","volume":"59","author":"NB Piller","year":"1978","journal-title":"British journal of experimental pathology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0164585","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T11:27:29Z","timestamp":1692530849000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0164585"}},"subtitle":[],"editor":[{"given":"Imtaiyaz","family":"Hassan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,21]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0164585","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,21]]}}}