{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T16:26:20Z","timestamp":1784823980043,"version":"3.55.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T00:00:00Z","timestamp":1476835200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165060","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T17:38:12Z","timestamp":1476898692000},"page":"e0165060","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["A Common Profile of Disordered Angiogenic Factor Production and the Exacerbation of Inflammation in Early Preeclampsia, Late Preeclampsia, and Intrauterine Growth Restriction"],"prefix":"10.1371","volume":"11","author":[{"given":"Sebastian","family":"Kwiatkowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Do\u0142\u0119gowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kwiatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafa\u0142","family":"Rzepka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrzej","family":"Torb\u00e8","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Bednarek-J\u0119drzejek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1002\/pd.4412","article-title":"Stage-based approach to the management of fetal growth restriction","volume":"34","author":"F Figueras","year":"2014","journal-title":"Prenat Diagn"},{"key":"ref2","first-page":"177","article-title":"The role of spiral arteries in the pathogenesis of preeclampsia","volume":"1","author":"IA Brosens","year":"1972","journal-title":"Obset Gynecol Annu"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1111\/j.1471-0528.1981.tb02222.x","article-title":"Morphological changes of the spiral arteries in the placental bed in relation to preeclampsia and fetal growth retardation","volume":"88","author":"GG Gerretsen","year":"1981","journal-title":"Br J Obstet Gynaecol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/j.1471-0528.1986.tb07830.x","article-title":"Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants","volume":"93","author":"TY Khong","year":"1986","journal-title":"Br J Obstet Gynaecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1016\/j.ajpath.2013.01.001","article-title":"Reduced cystathionine y-lyase and increased miR-21 expression are associated with increased vascular resistance in growth-restricted pregnancies: hydrogen sulfide as a placental vasodilator","volume":"182","author":"T Cindrova-Davies","year":"2013","journal-title":"Am J Pathol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0028-2243(85)90077-2","article-title":"Chronic villitis of unknown etiology and maternal arterial lesions in preeclamptic pregnancies","volume":"20","author":"C Labarrere","year":"1985","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00428-011-1157-z","article-title":"Frequency and clinical significance of placental histological lesions in an unselected population at or near term","volume":"459","author":"S Pathak","year":"2011","journal-title":"Virchows Arch"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.preghy.2016.04.003","article-title":"A study of serum Apo A-1 and Apo B-100 levels in women with preeclampsia","volume":"6","author":"H Timur","year":"2016","journal-title":"Pregnancy Hypertens"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ajog.2006.01.014","article-title":"Placental angiogenic growth factor and uterine artery Doppler findings for characterization of different subset in preeclampsia and in isolated intrauterine growth restriction","volume":"195","author":"F Crispi","year":"2006","journal-title":"Am J Obset Gynecol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1161\/01.RES.0000147365.86159.f5","article-title":"Elevated placental soluble vascular endothelial growth factor receptor-1 inhibits angiogenesis in preeclampsia","volume":"95","author":"S Ahmad","year":"2004","journal-title":"Circ Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1172\/JCI17189","article-title":"Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia","volume":"111","author":"SE Maynard","year":"2003","journal-title":"J Clin Invest"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1042\/CS20060161","article-title":"Angiogenic growth factor in maternal and fetal serum in pregnancies complicated by intrauterine growth restriction","volume":"112","author":"W Wallner","year":"2007","journal-title":"Clin Sci (Lond)"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s11906-007-0088-1","article-title":"Inflammatory cytokines in the pathophysiology of hypertension during preeclampsia","volume":"9","author":"BD LaMarca","year":"2007","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"ref14","first-page":"34","article-title":"Predictive value of the sFlt1\/PlGF ratio for the diagnosis of preeclampsia in high-risk patients","volume":"218","author":"S Husse","year":"2014","journal-title":"Z Geburtshilfe Neonatol"},{"issue":"18","key":"ref15","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.3109\/14767058.2014.880882","article-title":"Discordant clinical presentations of preeclampsia and intrauterine fetal growth restriction with similar pro- and anti-angiogenic profiles","volume":"27","author":"TI Alahakoon","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1515\/jpm-2013-0074","article-title":"The importance of repeated measurements of the sFlt-1\/PlGF ratio for the prediction of preeclampsia and intrauterine growth restriction","volume":"42","author":"K Schoofs","year":"2014","journal-title":"J Perinat Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"48487","DOI":"10.1074\/jbc.R400025200","article-title":"C-reactive protein","volume":"279","author":"S Black","year":"2004","journal-title":"J Biol Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"4815","DOI":"10.4049\/jimmunol.156.12.4815","article-title":"Expression of C-reactive protein by alveolar macrophages","volume":"156","author":"Q Dong","year":"1996","journal-title":"J Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1161\/01.ATV.0000081637.36475.BC","article-title":"Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein","volume":"23","author":"S Kobayashi","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1373\/clinchem.2008.115857","article-title":"Adeno-associated virus-mediated human C-reactive protein gene delivery causes endothelial dysfunction and hypertension in rats","volume":"55","author":"H Guan","year":"2009","journal-title":"Clin Chem"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1373\/clinchem.2008.119206","article-title":"Inhibition of endothelial nitric oxide synthase by C-reactive protein: clinical relevance","volume":"55","author":"I Jialal","year":"2009","journal-title":"Clin Chem"},{"issue":"5","key":"ref22","first-page":"689","article-title":"A comparative study of serum level of vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (ICAM-1) and high sensitive C\u2014reactive protein (hs-CRP) in normal and pre-eclamptic pregnancies","volume":"16","author":"M Farzadnia","year":"2013","journal-title":"Iran J Basic Med Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"709464","DOI":"10.5402\/2012\/709464","article-title":"Flow-mediated vasodilation is not attenuated in hypertensive pregnancies despite biochemical signs of inflammation","volume":"2012","author":"H Saarelainen","year":"2012","journal-title":"ISRN Obstet Gynecol"},{"issue":"9","key":"ref24","first-page":"1469","article-title":"Inflammatory markers in preeclamptic patients","volume":"49","author":"M Can","year":"2011","journal-title":"Clin Chem Lab Med"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"e2653","DOI":"10.1097\/MD.0000000000002653","article-title":"Prognostic value of cardiovascular disease risk factors measured in the first-trimester on the severity of preeclampsia","volume":"95","author":"PJ Cheng","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref26","first-page":"219","article-title":"The role of cytokines as inflammatory mediators in preeclampsia","volume":"20","author":"I Udenze","year":"2015","journal-title":"Pan Afr Med J"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.preghy.2014.03.001","article-title":"Different levels of IL-1\u03b1, IL-6, TNF-\u03b1, NF-\u03baB and PPAR-\u03b3 in monocyte cultures exposed by plasma preeclampsia and normotensive pregnancy","volume":"4","author":"B Rahardjo","year":"2014","journal-title":"Pregnancy Hypertens"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3109\/01443615.2012.721821","article-title":"Serum levels of adrenomedullin and inflammatory cytokines in women with term idiopathic intrauterine growth restriction","volume":"33","author":"AK Elfayomy","year":"2013","journal-title":"J Obstet Gynaecol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/14767058.2012.733747","article-title":"Angiogenic factors and acute-phase proteins in serum samples of preeclampsia and HELLP patients: a matched-pair analysis","volume":"26","author":"T Reimer","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00404-008-0874-2","article-title":"Plasma sFlt-1-to-PlGF ratio is correlated with inflammatory but not with oxidative stress in Chinese preeclamptic women","volume":"280","author":"YQ Ouyang","year":"2009","journal-title":"Arch Gynecol Obstet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T01:48:37Z","timestamp":1718848117000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165060"}},"subtitle":[],"editor":[{"given":"Eric","family":"Asselin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,19]]},"references-count":30,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165060","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,19]]}}}