{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:52Z","timestamp":1792101652149,"version":"4.4.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165314","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T17:48:02Z","timestamp":1477590482000},"page":"e0165314","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":69,"title":["Changes to the Aqueous Humor Proteome during Glaucoma"],"prefix":"10.1371","volume":"11","author":[{"given":"Martha Andrea","family":"Kaeslin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanspeter Ezriel","family":"Killer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril Adrian","family":"Fuhrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nauke","family":"Zeleny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas Robert","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Neutzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/j.ophtha.2014.11.030","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis (Ophthalmology 2014;121:2081\u201390)","volume":"122","author":"Y Tham","year":"2015","journal-title":"Ophthalmology"},{"issue":"18","key":"ref2","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma: a review","volume":"311","author":"RN Weinreb","year":"2014","journal-title":"JAMA"},{"issue":"Suppl 3","key":"ref3","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1177\/112067210301303S04","article-title":"Some current ideas on the pathogenesis and the role of neuroprotection in glaucomatous optic neuropathy","volume":"13","author":"NN Osborne","year":"2003","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1878-5085-5-11","article-title":"Flammer syndrome","volume":"5","author":"K Konieczka","year":"2014","journal-title":"EPMA J"},{"issue":"Suppl 5","key":"ref5","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1097\/IJG.0b013e3182934a0f","article-title":"Compartment syndromes of the optic nerve and open-angle glaucoma","volume":"22","author":"HE Killer","year":"2013","journal-title":"J Glaucoma"},{"issue":"13","key":"ref6","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1002\/pmic.201500423","article-title":"Human aqueous humor proteome in cataract, glaucoma, and pseudoexfoliation syndrome","volume":"16","author":"AA Kliuchnikova","year":"2016","journal-title":"Proteomics"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"V Chrysostomou","year":"2013","journal-title":"Curr Opin Pharmacol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"e29393","DOI":"10.1371\/journal.pone.0029393","article-title":"The mutational spectrum in a cohort of Charcot-Marie-Tooth disease type 2 among the Han Chinese in Taiwan","volume":"6","author":"KP Lin","year":"2011","journal-title":"PLoS One"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/ng1354","article-title":"Mutant small heat-shock protein 27 causes axonal Charcot-Marie-Tooth disease and distal hereditary motor neuropathy","volume":"36","author":"OV Evgrafov","year":"2004","journal-title":"Nat Genet"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1182\/blood.V84.3.898.898","article-title":"Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Creteil and PGK Amiens","volume":"84","author":"M Cohen-Solal","year":"1994","journal-title":"Blood"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0301-0082(99)00021-0","article-title":"Hippocampal cholinergic neurostimulating peptides (HCNP)","volume":"60","author":"K Ojika","year":"2000","journal-title":"Prog Neurobiol"},{"issue":"6751","key":"ref12","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/43894","article-title":"Familial dementia caused by polymerization of mutant neuroserpin","volume":"401","author":"RL Davis","year":"1999","journal-title":"Nature"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1523\/JNEUROSCI.15-03-02141.1995","article-title":"Cloning of neurotrimin defines a new subfamily of differentially expressed neural cell adhesion molecules","volume":"15","author":"AF Struyk","year":"1995","journal-title":"J Neurosci"},{"issue":"1","key":"ref14","first-page":"127","article-title":"Cloning of testican\/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology","volume":"191","author":"F Charbonnier","year":"1997","journal-title":"C R Seances Soc Biol Fil"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0945-053X(03)00036-2","article-title":"Testican-1 inhibits attachment of Neuro-2a cells","volume":"22","author":"HS Marr","year":"2003","journal-title":"Matrix Biol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3109\/03009734.2010.487951","article-title":"Effects of bisoprolol and cilazapril on the central retinal artery blood flow in patients with essential hypertension\u2014preliminary results","volume":"115","author":"A Madej","year":"2010","journal-title":"Ups J Med Sci"},{"key":"ref17","first-page":"1286","article-title":"Decreased carbohydrate metabolism enzyme activities in the glaucomatous trabecular meshwork","volume":"16","author":"AK Junk","year":"2010","journal-title":"Mol Vis"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1021\/pr1005372","article-title":"Proteome alterations in primary open angle glaucoma aqueous humor","volume":"9","author":"A Izzotti","year":"2010","journal-title":"J Proteome Res"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.survophthal.2012.08.010","article-title":"The role of inflammation in the pathogenesis of glaucoma","volume":"58","author":"R Vohra","year":"2013","journal-title":"Surv Ophthalmol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jprot.2013.12.006","article-title":"Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma","volume":"98","author":"H Gonzalez-Iglesias","year":"2014","journal-title":"J Proteomics"},{"key":"ref21","first-page":"417","article-title":"Uveoscleral drainage of aqueous humor: physiology and pharmacology","volume":"312","author":"A Bill","year":"1989","journal-title":"Prog Clin Biol Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0079-6123(08)01101-1","article-title":"Epidemiology of primary glaucoma: prevalence, incidence, and blinding effects","volume":"173","author":"C Cedrone","year":"2008","journal-title":"Prog Brain Res"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s00401-011-0921-0","article-title":"Neurodegeneration as a consequence of failed mitochondrial maintenance","volume":"123","author":"M Karbowski","year":"2012","journal-title":"Acta Neuropathol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.coph.2012.09.002","article-title":"Maintenance of retinal ganglion cell mitochondrial functions as a neuroprotective strategy in glaucoma","volume":"13","author":"NN Osborne","year":"2013","journal-title":"Curr Opin Pharmacol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exer.2012.07.011","article-title":"Aqueous humor oxidative stress proteomic levels in primary open angle glaucoma","volume":"103","author":"A Bagnis","year":"2012","journal-title":"Exp Eye Res"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1167\/iovs.05-0208","article-title":"Proteomic identification of oxidatively modified retinal proteins in a chronic pressure-induced rat model of glaucoma","volume":"46","author":"G Tezel","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology. The Gene Ontology Consortium","volume":"25","author":"M Ashburner","year":"2000","journal-title":"Nat Genet"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"D1049","DOI":"10.1093\/nar\/gku1179","article-title":"Gene Ontology Consortium: going forward","volume":"43","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"ref29","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.1093\/bioinformatics\/btp536","article-title":"QuickGO: a web-based tool for Gene Ontology searching","volume":"25","author":"D Binns","year":"2009","journal-title":"Bioinformatics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165314","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:18:46Z","timestamp":1601165926000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165314"}},"subtitle":[],"editor":[{"given":"Demetrios G.","family":"Vavvas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165314","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}