{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:38:15Z","timestamp":1784767095865,"version":"3.55.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165443","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T23:03:46Z","timestamp":1481583826000},"page":"e0165443","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Immune-Inflammatory and Metabolic Effects of High Dose Furosemide plus Hypertonic Saline Solution (HSS) Treatment in Cirrhotic Subjects with Refractory Ascites"],"prefix":"10.1371","volume":"11","author":[{"given":"Antonino","family":"Tuttolomondo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Di Raimondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bellia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Clemente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Pecoraro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Maida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Simonetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Vassallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Di Bona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliana","family":"Gulotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcello","family":"Ciaccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"issue":"29","key":"ref1","doi-asserted-by":"crossref","first-page":"8927","DOI":"10.3748\/wjg.v21.i29.8927","article-title":"Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease","volume":"21","author":"D Santetti","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.dld.2005.03.010","article-title":"Nutritional state and energy balance in cirrhotic patients with or without hypermetabolism. Multicentre prospective study by the \u201cNutritional Problems in Gastroenterology\u201d Section of the Italian Society of Gastroenterology (SIGE)","volume":"37","author":"FW Guglielmi","year":"2005","journal-title":"Digestive and Liver Disease"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1128\/MCB.14.2.1431","article-title":"Cloning and characterization of the cDNA encoding a novel human pre-B-cell colonyenhancing factor","volume":"14","author":"B Samal","year":"1994","journal-title":"Mol Cell Biol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1126\/science.1097243","article-title":"Kishimoto Ket al. Visfatin: a protein secreted by visceral fat that mimics the effects of insulin","volume":"307","author":"A Fukuhara","year":"2005","journal-title":"Science"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12072-015-9616-2","article-title":"Adipocytokines and liver fibrosis stages in patients with chronic hepatitis B virus infection","volume":"9","author":"CS Hsu","year":"2015","journal-title":"Hepatol Int"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3748\/wjg.v21.i10.3020","article-title":"Adipokines levels are associated with the severity of liver disease in patients with alcoholic cirrhosis","volume":"21","author":"M Kalafateli","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.metabol.2014.10.012","article-title":"Leptin in nonalcoholic fatty liver disease: a narrative review","volume":"64","author":"SA Polyzos","year":"2015","journal-title":"Metabolism"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.bbadis.2015.10.028","article-title":"Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis","volume":"1862","author":"JD Coombes","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2036.2009.04040.x","article-title":"Clinical Trial: High-dose furosemide plus small-volume hypertonic saline solutions vs. repeated paracentesis as treatment of refractory ascites","volume":"30","author":"G Licata","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.numecd.2009.10.014","article-title":"Changes in natriuretic peptide and cytokine plasma levels in patients with heart failure, after treatment with high dose of furosemide plus hypertonic saline solution (HSS) and after a saline loading","volume":"21","author":"A Tuttolomondo","year":"2011","journal-title":"Nutr Metab Cardiovasc Dis"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/hep.510230122","article-title":"Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis. International Ascites Club","volume":"23","author":"V Arroyo","year":"1996","journal-title":"Hepatology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-230X-14-18","article-title":"Effects of paracentesis on hemodynamic parameters and respiratory function in critically ill patients","volume":"14","author":"V Phillip","year":"2014","journal-title":"BMC Gastroenterol"},{"issue":"42","key":"ref13","doi-asserted-by":"crossref","first-page":"6624","DOI":"10.3748\/wjg.v11.i42.6624","article-title":"Cytokine profile in Egyptian hepatitis C virus genotype-4 in relation to liver disease progression","volume":"11","author":"AR Zekri","year":"2005","journal-title":"World J Gastroenterol"},{"issue":"53","key":"ref14","first-page":"1569","article-title":"Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C","volume":"50","author":"S Kitaoka","year":"2003","journal-title":"Hepatogastroenterology"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510260337","article-title":"Effects of interferon treatment on the antiviral T-cell response in hepatitis C virus genotype 1b- and genotype 2c-infected patients","volume":"26","author":"G Missale","year":"1997","journal-title":"Hepatology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/hep.510240102","article-title":"Immunoregulatory cytokines in chronic hepatitis C virus infection: pre- and posttreatment with interferon alfa","volume":"24","author":"TV Cacciarelli","year":"1996","journal-title":"Hepatology"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/030006059602400302","article-title":"Serum interleukin 2 and soluble interleukin 2 receptor in chronic active hepatitis C: effect of interferon therapy","volume":"24","author":"H Simsek","year":"1996","journal-title":"J Int Med Res"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/hep.23031","article-title":"Sites and mechanisms of insulin resistance in nonobese, nondiabetic patients with chronic hepatitis C","volume":"50","author":"E Vanni","year":"2009","journal-title":"Hepatology"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1002\/hep.23961","article-title":"Critical role of the liver in the induction of systemic inflammation in rats with preascitic cirrhosis","volume":"52","author":"M \u00dabeda","year":"2010","journal-title":"Hepatology"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/01.mog.0000182863.96421.47","article-title":"Role of inflammation in nonalcoholic steatohepatitis","volume":"21","author":"S Choi","year":"2005","journal-title":"Curr Opin Gastroenterol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/hep.20826","article-title":"Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease","volume":"42","author":"Z Li","journal-title":"Hepatology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1111\/liv.12335","article-title":"Strain dependence of dietinduced NASH and liver fibrosis in obese mice is linked to diabetes and inflammatory phenotype","volume":"34","author":"GC Farrell","year":"2014","journal-title":"Liver Int"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134089","article-title":"Differential Immunometabolic Phenotype in Th1 and Th2 Dominant Mouse Strains in Response to High-Fat Feeding","volume":"10","author":"N Jovicic","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0192-0561(95)00015-T","article-title":"Levels of soluble intercellular adhesion molecule 1, eicosanoids and cytokines in ascites of patients with liver cirrhosis, peritoneal cancer and spontaneous bacterial peritonitis","volume":"17","author":"WM Pruimboom","year":"1995","journal-title":"Int J Immunopharmacol"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1600-0676.1995.tb00683.x","article-title":"High interleukin-6 production within the peritoneal cavity in decompensated cirrhosis and malignancy-related ascites","volume":"15","author":"DJ Bac","year":"1995","journal-title":"Liver"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/MEG.0000000000000516","article-title":"Factors related to increased resting energy expenditure in men with liver cirrhosis","volume":"28","author":"C Prieto-Fr\u00edas","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1023\/B:DDAS.0000017451.48031.b6","article-title":"High ascitic fluid leptin levels in patients with decompensated liver cirrhosis and sterile ascites: relationship with TNF-\u03b1 levels","volume":"49","author":"E Giannini","year":"2004","journal-title":"Dig Dis Sci"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1111\/j.1478-3231.2010.02266.x","article-title":"B-type natriuretic peptide is related to cardiac function and prognosis in hospitalized patients with decompensated cirrhosis","volume":"30","author":"J Pimenta","year":"2010","journal-title":"Liver International"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/0016-5085(90)90966-5","article-title":"Atrial volume in cirrhosis: relationship to blood volume and plasma concentration of atrial natriuretic factor","volume":"99","author":"WG Rector Jr","year":"1990","journal-title":"Gastroenterology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1042\/cs1010621","article-title":"Brain natriuretic peptide: is it a predictor of cardiornyopathy in cirrhosis?","volume":"101","author":"F Wong","year":"2001","journal-title":"Clin Sci (Lond)"},{"key":"ref31","first-page":"539412","article-title":"The end-organ impairment in liver cirrhosis: appointments for critical care","volume":"2012","author":"A Figueiredo","year":"2012","journal-title":"Crit Care Res Pract"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1136\/gut.52.10.1511","article-title":"Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: relation to cardiovascular dysfunction and severity of disease","volume":"52","author":"JH Henriksen","year":"2003","journal-title":"Gut"},{"issue":"12","key":"ref33","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nm1295-1311","article-title":"Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action","volume":"1","author":"RC Frederich","year":"1995","journal-title":"Nat Med"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1172\/JCI119717","article-title":"Entrainment of the diurnal rhythm of plasma leptin to meal timing","volume":"100","author":"DA Schoeller","year":"1997","journal-title":"J Clin Invest"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165443","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:36:38Z","timestamp":1588998998000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165443"}},"subtitle":[],"editor":[{"given":"Jose Ignacio","family":"Herrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":34,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165443","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]}}}