{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:02:45Z","timestamp":1773806565898,"version":"3.50.1"},"reference-count":117,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T00:00:00Z","timestamp":1477526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#79456 and #111017"],"award-info":[{"award-number":["#79456 and #111017"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012651","name":"Montreal Heart Institute Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012651","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165482","type":"journal-article","created":{"date-parts":[[2016,10,27]],"date-time":"2016-10-27T17:58:18Z","timestamp":1477591098000},"page":"e0165482","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Psychological Profiles in the Prediction of Leukocyte Telomere Length in Healthy Individuals"],"prefix":"10.1371","volume":"11","author":[{"given":"Louisia","family":"Starnino","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lambert","family":"Busque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Claude","family":"Tardif","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-5125","authenticated-orcid":true,"given":"Bianca","family":"D\u2019Antono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,10,27]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1161\/STROKEAHA.114.004815","article-title":"Chronic stress, depressive symptoms, anger, hostility, and risk of stroke and transient ischemic attack in the multi-ethnic study of atherosclerosis","volume":"45","author":"SA Everson-Rose","year":"2014","journal-title":"Stroke"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/JCN.0b013e31824af56e","article-title":"Critical review of factors predicting health-related quality of life in newly diagnosed coronary artery disease patients","volume":"28","author":"P Pragodpol","year":"2013","journal-title":"The Journal of cardiovascular nursing"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jacc.2008.11.044","article-title":"The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence","volume":"53","author":"Y Chida","year":"2009","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/eurpub\/ckr007","article-title":"Socio-economic differences in the health-related quality of life impact of cardiovascular conditions","volume":"22","author":"M Stafford","year":"2012","journal-title":"European journal of public health"},{"issue":"11","key":"ref5","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1037\/hea0000033","article-title":"Physical activity and depression predict event-free survival in heart transplant candidates","volume":"33","author":"H Spaderna","year":"2014","journal-title":"Health psychology: official journal of the Division of Health Psychology, American Psychological Association"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3999(97)00293-6","article-title":"Defensiveness and essential hypertension","volume":"45","author":"SJ Mann","year":"1998","journal-title":"Journal of psychosomatic research"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11883-010-0096-5","article-title":"Depression and coronary heart disease","volume":"12","author":"FM Khan","year":"2010","journal-title":"Current atherosclerosis reports"},{"issue":"1","key":"ref8","first-page":"102","article-title":"Psychological factors and coronary heart disease","volume":"9","author":"Z Khayyam-Nekouei","year":"2013","journal-title":"ARYA atherosclerosis"},{"key":"ref9","first-page":"1","article-title":"Hostility and the clinical course of outpatients with congestive heart failure","author":"C Rafanelli","year":"2015","journal-title":"Psychology & health"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3389\/fpsyg.2013.00384","article-title":"Social support, depression, and heart disease: a ten year literature review","volume":"4","author":"A Compare","year":"2013","journal-title":"Frontiers in psychology"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1161\/ATVBAHA.115.305838","article-title":"Leukocyte Telomere Length and Risks of Incident Coronary Heart Disease and Mortality in a Racially Diverse Population of Postmenopausal Women","volume":"35","author":"CL Carty","year":"2015","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"g4227","DOI":"10.1136\/bmj.g4227","article-title":"Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis","volume":"349","author":"PC Haycock","year":"2014","journal-title":"BMJ"},{"issue":"6808","key":"ref13","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/35040500","article-title":"Telomere states and cell fates","volume":"408","author":"EH Blackburn","year":"2000","journal-title":"Nature"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.atherosclerosis.2015.08.020","article-title":"Association of relative telomere length with cardiovascular disease in a large chronic kidney disease cohort: the GCKD study","volume":"242","author":"J Raschenberger","year":"2015","journal-title":"Atherosclerosis"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0531-5565(96)00005-8","article-title":"Telomeres, telomerase, and aging: origin of the theory","volume":"31","author":"AM Olovnikov","year":"1996","journal-title":"Experimental gerontology"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/ATVBAHA.108.167049","article-title":"Prognostic value of leukocyte telomere length in patients with stable coronary artery disease: data from the Heart and Soul Study","volume":"28","author":"R Farzaneh-Far","year":"2008","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1161\/ATVBAHA.110.205492","article-title":"Cellular ging reflected by leukocyte telomere length predicts advanced atherosclerosis and cardiovascular disease risk","volume":"30","author":"P Willeit","year":"2010","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/ng.2528","article-title":"Identification of seven loci affecting mean telomere length and their association with disease","volume":"45","author":"V Codd","year":"2013","journal-title":"Nature genetics"},{"issue":"16","key":"ref19","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1093\/jnci\/djg011","article-title":"Telomere dysfunction: a potential cancer predisposition factor","volume":"95","author":"X Wu","year":"2003","journal-title":"Journal of the National Cancer Institute"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"e40516","DOI":"10.1371\/journal.pone.0040516","article-title":"High phobic anxiety is related to lower leukocyte telomere length in women","volume":"7","author":"OI Okereke","year":"2012","journal-title":"PloS one"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"e64762","DOI":"10.1371\/journal.pone.0064762","article-title":"Posttraumatic stress disorder and not depression is associated with shorter leukocyte telomere length: findings from 3,000 participants in the population-based KORA F4 study","volume":"8","author":"KH Ladwig","year":"2013","journal-title":"PloS one"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"e17837","DOI":"10.1371\/journal.pone.0017837","article-title":"Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress\u2014preliminary findings","volume":"6","author":"OM Wolkowitz","year":"2011","journal-title":"PloS one"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/da.20749","article-title":"Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease","volume":"27","author":"N Hartmann","year":"2010","journal-title":"Depression and anxiety"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/mp.2014.89","article-title":"Depression, anxiety and telomere length in young adults: evidence from the National Health and Nutrition Examination Survey","volume":"20","author":"BL Needham","year":"2015","journal-title":"Molecular psychiatry"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.biopsych.2011.09.015","article-title":"Short telomeres in depression and the general population are associated with a hypocortisolemic state","volume":"71","author":"M Wikgren","year":"2012","journal-title":"Biological psychiatry"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.socscimed.2013.02.023","article-title":"Socioeconomic status, health behavior, and leukocyte telomere length in the National Health and Nutrition Examination Survey, 1999\u20132002","volume":"85","author":"BL Needham","year":"2013","journal-title":"Social science & medicine"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.biopsych.2006.02.004","article-title":"Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging","volume":"60","author":"NM Simon","year":"2006","journal-title":"Biological psychiatry"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/mp.2013.151","article-title":"Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study","volume":"19","author":"JE Verhoeven","year":"2014","journal-title":"Molecular psychiatry"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/ageing\/afp256","article-title":"Telomere length and psychological well-being in patients with chronic heart failure","volume":"39","author":"J Huzen","year":"2010","journal-title":"Age and ageing"},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"e49677","DOI":"10.1371\/journal.pone.0049677","article-title":"Up-regulation of leucocytes genes implicated in telomere dysfunction and cellular senescence correlates with depression and anxiety severity scores","volume":"7","author":"JR Teyssier","year":"2012","journal-title":"PloS one"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1097\/PSY.0b013e31821b1f6e","article-title":"Depression and leukocyte telomere length in patients with coronary heart disease: data from the Heart and Soul Study","volume":"73","author":"PW Hoen","year":"2011","journal-title":"Psychosomatic medicine"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"e48318","DOI":"10.1371\/journal.pone.0048318","article-title":"Depressive symptoms are not associated with leukocyte telomere length: findings from the Nova Scotia Health Survey (NSHS95), a population-based study","volume":"7","author":"JA Shaffer","year":"2012","journal-title":"PloS one"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1017\/S0033291712001766","article-title":"Association between anxiety but not depressive disorders and leukocyte telomere length after 2 years of follow-up in a population-based sample","volume":"43","author":"PW Hoen","year":"2013","journal-title":"Psychological medicine"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.biopsych.2011.08.020","article-title":"Hostility and cellular aging in men from the Whitehall II cohort","volume":"71","author":"L Brydon","year":"2012","journal-title":"Biological psychiatry"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/1756-0500-7-423","article-title":"Depressive symptoms and cytokine levels in Serum and Tumor Tissue in patients with an Astrocytoma: a pilot study","volume":"7","author":"AR Starkweather","year":"2014","journal-title":"BMC research notes"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.arr.2013.01.003","article-title":"A systematic review of leukocyte telomere length and age in adults","volume":"12","author":"A Muezzinler","year":"2013","journal-title":"Ageing research reviews"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1177\/070674370605100206","article-title":"Prevalence and incidence studies of anxiety disorders: a systematic review of the literature","volume":"51","author":"JM Somers","year":"2006","journal-title":"Canadian journal of psychiatry Revue canadienne de psychiatrie"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.exger.2013.12.004","article-title":"Gender and telomere length: systematic review and meta-analysis","volume":"51","author":"M Gardner","year":"2014","journal-title":"Experimental gerontology"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1203\/00006450-200209000-00012","article-title":"Telomere length in the newborn","volume":"52","author":"K Okuda","year":"2002","journal-title":"Pediatric research"},{"issue":"4","key":"ref40","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1474-9726.2008.00397.x","article-title":"Leukocyte telomeres are longer in African Americans than in whites: the National Heart, Lung, and Blood Institute Family Heart Study and the Bogalusa Heart Study","volume":"7","author":"SC Hunt","year":"2008","journal-title":"Aging cell"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1192\/bjp.177.6.486","article-title":"Gender differences in depression","volume":"177","author":"M Piccinelli","year":"2000","journal-title":"Critical review. The British journal of psychiatry: the journal of mental science"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1600-0447.1989.tb08584.x","article-title":"The incidence of specific DIS\/DSM-III mental disorders: data from the NIMH Epidemiologic Catchment Area Program","volume":"79","author":"WW Eaton","year":"1989","journal-title":"Acta psychiatrica Scandinavica"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"178","DOI":"10.3389\/fpsyg.2011.00178","article-title":"Gender Differences in Personality across the Ten Aspects of the Big Five","volume":"2","author":"YJ Weisberg","year":"2011","journal-title":"Frontiers in psychology"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"e10826","DOI":"10.1371\/journal.pone.0010826","article-title":"Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls","volume":"5","author":"L Kananen","year":"2010","journal-title":"PloS one"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1037\/h0047358","article-title":"A new scale of social desirability independent of psychopathology","volume":"24","author":"DP Crowne","year":"1960","journal-title":"J Consult Psychol"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1037\/0022-3514.46.3.598","article-title":"Two-component models of socially desirable responding","volume":"46","author":"DL Paulhus","year":"1984","journal-title":"Journal of personality and social psychology"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1037\/0278-6133.14.3.202","article-title":"Defensive hostility: relationship to multiple markers of cardiac ischemia in patients with coronary disease","volume":"14","author":"KF Helmers","year":"1995","journal-title":"Health psychology: official journal of the Division of Health Psychology, American Psychological Association"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00006842-200105000-00016","article-title":"Defensive hostility and coronary heart disease: a preliminary investigation of male veterans","volume":"63","author":"RS Jorgensen","year":"2001","journal-title":"Psychosomatic medicine"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1097\/00006842-199109000-00005","article-title":"Negative affectivity and repressive coping: pervasive influence on self-reported mood, health, and coronary-prone behavior","volume":"53","author":"J Denollet","year":"1991","journal-title":"Psychosomatic medicine"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1207\/S15324796ABM2501_05","article-title":"Defensiveness and 3-year blood pressure levels among young adults: the mediating effect of stress-reactivity","volume":"25","author":"T Rutledge","year":"2003","journal-title":"Annals of behavioral medicine: a publication of the Society of Behavioral Medicine"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1018775807593","article-title":"Defensive coping in relation to casual blood pressure and self-reported daily hassles and life events","volume":"21","author":"I Nykl\u00ed\u010dek","year":"1998","journal-title":"Journal of behavioral medicine"},{"issue":"5","key":"ref52","first-page":"758","article-title":"A quantitative review of prospective evidence linking psychological factors with hypertension development","volume":"64","author":"T Rutledge","year":"2002","journal-title":"Psychosomatic medicine"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1469-8986.2009.00943.x","article-title":"Physiological stress responses in defensive individuals: age and sex matter","volume":"47","author":"K Levesque","year":"2010","journal-title":"Psychophysiology"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.biopsycho.2008.12.003","article-title":"Defensiveness and metabolic syndrome: impact of sex and age","volume":"80","author":"K L\u00e9vesque","year":"2009","journal-title":"Biol Psychol"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1007\/s12160-014-9639-2","article-title":"Sex differences in the prediction of metabolic burden from physiological responses to stress","volume":"49","author":"C Gentile","year":"2015","journal-title":"Annals of behavioral medicine: a publication of the Society of Behavioral Medicine"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/j.1469-8986.2012.01397.x","article-title":"Cognitive depressive symptoms associated with delayed heart rate recovery following interpersonal stress in healthy men and women","volume":"49","author":"JL Gordon","year":"2012","journal-title":"Psychophysiology"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"616","DOI":"10.3109\/10253890.2013.835395","article-title":"Sex-specific interaction effects of age, occupational status, and workplace stress on psychiatric symptoms and allostatic load among healthy Montreal workers","volume":"16","author":"RP Juster","year":"2013","journal-title":"Stress"},{"issue":"5","key":"ref58","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jpsychores.2014.02.010","article-title":"The relation between hostility and concurrent levels of inflammation is sex, age, and measure dependent","volume":"76","author":"J Boisclair Demarble","year":"2014","journal-title":"Journal of psychosomatic research"},{"issue":"9","key":"ref59","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1111\/psyp.12231","article-title":"Three-year stability of cardiovascular and autonomic nervous system responses to psychological stress","volume":"51","author":"AI Dragomir","year":"2014","journal-title":"Psychophysiology"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1037\/a0035625","article-title":"Naturalistic interpersonal behavior patterns differentiate depression and anxiety symptoms in the community","volume":"61","author":"LM Rappaport","year":"2014","journal-title":"Journal of counseling psychology"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1037\/0022-006X.56.6.893","article-title":"An inventory for measuring clinical anxiety: psychometric properties","volume":"56","author":"AT Beck","year":"1988","journal-title":"J Consult Clin Psychol"},{"key":"ref62","first-page":"b9","article-title":"Beck depression inventory-II","author":"AT Beck","year":"1996"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1037\/0278-6133.20.2.112","article-title":"Psychometric evaluation of the Beck Depression Inventory-II with primary care medical patients","volume":"20","author":"RC Arnau","year":"2001","journal-title":"Health Psychology"},{"issue":"6","key":"ref64","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1037\/h0060667","article-title":"Proposed hostility and pharisaic-virtue scales for the MMPI","volume":"38","author":"WW Cook","year":"1954","journal-title":"Journal of Applied Psychology"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1037\/0278-6133.4.6.503","article-title":"What's so unhealthy about hostility? Construct validity and psychosocial correlates of the Cook and Medley Ho scale","volume":"4","author":"TW Smith","year":"1985","journal-title":"Health Psychol"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1097\/00006842-198303000-00008","article-title":"Hostility, CHD incidence, and total mortality: a 25-year follow-up study of 255 physicians","volume":"45","author":"JC Barefoot","year":"1983","journal-title":"Psychosomatic medicine"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1037\/h0047358","article-title":"A new scale of social desirability independent of psychopathology","volume":"24","author":"DP Crowne","year":"1960","journal-title":"Journal of consulting psychology"},{"issue":"3","key":"ref68","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2466\/pr0.1983.53.3.963","article-title":"Data on the Marlowe-Crowne and Edwards social desirability scales","volume":"53","author":"MD Crino","year":"1983","journal-title":"Psychological Reports"},{"issue":"10","key":"ref69","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/30.10.e47","article-title":"Telomere measurement by quantitative PCR","volume":"30","author":"RM Cawthon","year":"2002","journal-title":"Nucleic acids research"},{"issue":"9","key":"ref70","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/gerona\/glp065","article-title":"No association between telomere length and blood cell counts in elderly individuals","volume":"64","author":"L Mollica","year":"2009","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/j.1469-8986.1991.tb01017.x","article-title":"The reliability and specificity of delta versus residualized change as measures of cardiovascular reactivity to behavioral challenges","volume":"28","author":"MM Llabre","year":"1991","journal-title":"Psychophysiology"},{"key":"ref72","first-page":"2013","article-title":"Do telomeres adapt to physiological stress? Exploring the effect of exercise on telomere length and telomere-related proteins","author":"AT Ludlow","year":"2013","journal-title":"BioMed research international"},{"issue":"12","key":"ref73","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1249\/MSS.0000000000000720","article-title":"Physical Activity, Physical Fitness, and Leukocyte Telomere Length: The Cardiovascular Health Study","volume":"47","author":"L Soares-Miranda","year":"2015","journal-title":"Medicine and science in sports and exercise"},{"issue":"4","key":"ref74","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1111\/acer.13005","article-title":"Associations Between Alcohol Consumption and Leukocyte Telomere Length Modified by a Common Polymorphism of ALDH2","volume":"40","author":"C Shin","year":"2016","journal-title":"Alcoholism: Clinical and Experimental Research"},{"issue":"4","key":"ref75","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1002\/ijc.25999","article-title":"Shortened telomeres in individuals with abuse in alcohol consumption","volume":"129","author":"S Pavanello","year":"2011","journal-title":"International Journal of Cancer"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/107424840400900308","article-title":"C-reactive protein increases oxygen radical generation by neutrophils","volume":"9","author":"K Prasad","year":"2004","journal-title":"Journal of cardiovascular pharmacology and therapeutics"},{"issue":"7","key":"ref77","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","article-title":"Oxidative stress shortens telomeres","volume":"27","author":"T von Zglinicki","year":"2002","journal-title":"Trends in biochemical sciences"},{"issue":"2","key":"ref78","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.fertnstert.2014.10.035","article-title":"Inflammatory biomarkers and telomere length in women with polycystic ovary syndrome","volume":"103","author":"DCC Pedroso","year":"2015","journal-title":"Fertility and sterility"},{"issue":"9","key":"ref79","doi-asserted-by":"crossref","first-page":"E1671","DOI":"10.1210\/jc.2014-1161","article-title":"Increased body mass index, elevated C-reactive protein, and short telomere length","volume":"99","author":"L Rode","year":"2014","journal-title":"The Journal of Clinical Endocrinology & Metabolism"},{"issue":"2","key":"ref80","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF00846547","article-title":"Blood-pressure responses during social interaction in high-and low-cynically hostile males","volume":"12","author":"TW Smith","year":"1989","journal-title":"Journal of Behavioral Medicine"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/00006842-200105000-00016","article-title":"Defensive hostility and coronary heart disease: a preliminary investigation of male veterans","volume":"63","author":"RS Jorgensen","year":"2001","journal-title":"Psychosomatic Medicine"},{"issue":"5","key":"ref82","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1097\/00004872-199105000-00003","article-title":"Psychological, biological and health behavior predictors of blood pressure changes in middle-aged women","volume":"9","author":"JH Markovitz","year":"1991","journal-title":"Journal of Hypertension"},{"issue":"3","key":"ref83","doi-asserted-by":"crossref","first-page":"412","DOI":"10.5535\/arm.2016.40.3.412","article-title":"Predictors of Depressive Mood in Patients With Isolated Cerebellar Stroke: A Retrospective Study","volume":"40","author":"DJ Koh","year":"2016","journal-title":"Annals of Rehabilitation Medicine"},{"issue":"6","key":"ref84","doi-asserted-by":"crossref","first-page":"e67227","DOI":"10.1371\/journal.pone.0067227","article-title":"The relationship between leukocyte mitochondrial DNA copy number and telomere length in community-dwelling elderly women","volume":"8","author":"J-H Kim","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"717","DOI":"10.3758\/BF03206553","article-title":"SPSS and SAS procedures for estimating indirect effects in simple mediation models","volume":"36","author":"KJ Preacher","year":"2004","journal-title":"Behavior research methods, instruments, & computers: a journal of the Psychonomic Society, Inc"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1158\/1055-9965.EPI-14-0992","article-title":"Depressive symptoms and short telomere length are associated with increased mortality in bladder cancer patients","volume":"24","author":"J Lin","year":"2015","journal-title":"Cancer epidemiology, biomarkers & prevention: a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"469070","DOI":"10.1155\/2013\/469070","article-title":"Major depressive disorder and measures of cellular aging: an integrative review","volume":"2013","author":"PA Kinser","year":"2013","journal-title":"Nursing research and practice"},{"issue":"1","key":"ref88","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1037\/0882-7974.14.1.170","article-title":"Age differences in response to conformity pressure for emotional and nonemotional material","volume":"14","author":"M Pasupathi","year":"1999","journal-title":"Psychology and aging"},{"issue":"2","key":"ref89","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1037\/0033-2909.120.2.293","article-title":"Elevated blood pressure and personality: a meta-analytic review","volume":"120","author":"RS Jorgensen","year":"1996","journal-title":"Psychological bulletin"},{"issue":"12","key":"ref90","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1073\/pnas.1322145111","article-title":"Shorter telomeres with high telomerase activity are associated with raised allostatic load and impoverished psychosocial resources","volume":"111","author":"A Zalli","year":"2014","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.jpsychores.2013.05.010","article-title":"The metabolic costs of hostility in healthy adult men and women: cross-sectional and prospective analyses","volume":"75","author":"B D'Antono","year":"2013","journal-title":"J Psychosom Res"},{"issue":"5","key":"ref92","first-page":"982","article-title":"Cynical hostility and carotid atherosclerosis in African American and white women: the Study of Women's Health Across the Nation (SWAN) Heart Study","volume":"152","author":"SA Everson-Rose","year":"2006","journal-title":"American Heart Journal"},{"issue":"4","key":"ref93","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1080\/13548506.2012.736623","article-title":"Psychometric properties of the Cook Medley Hostility Scale and its association with inflammatory markers in African Americans","volume":"18","author":"DT Mwendwa","year":"2013","journal-title":"Psychology, health & medicine"},{"issue":"2","key":"ref94","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1037\/hea0000129","article-title":"Hostility and the risk of peptic ulcer in the GAZEL cohort","volume":"34","author":"C Lemogne","year":"2015","journal-title":"Health Psychology"},{"issue":"6","key":"ref95","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1093\/ije\/31.6.1227","article-title":"Psychosocial risk factors for heart disease in France and Northern Ireland: the Prospective Epidemiological Study of Myocardial Infarction (PRIME)","volume":"31","author":"D Sykes","year":"2002","journal-title":"International journal of epidemiology"},{"key":"ref96","unstructured":"Berm\u00fadez J, S\u00e1nchez-Elvira A, Fern\u00e1ndez E, editors. Contenido del Inventario de Hostilidad de Cook y Medley (ICM): implicaciones pronocoronarias. Comunicaci\u00f3n presentada al IV Congreso de Evaluaci\u00f3n Psicol\u00f3gica, Santiago de Compostela; 1994."},{"issue":"2","key":"ref97","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0167-8760(97)00096-2","article-title":"Parental history of hypertension and hostility moderate cardiovascular responses to interpersonal conflict","volume":"28","author":"SB Miller","year":"1998","journal-title":"International Journal of Psychophysiology"},{"key":"ref98","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.psyneuen.2014.07.011","article-title":"Longitudinal changes of telomere length and epigenetic age related to traumatic stress and post-traumatic stress disorder","volume":"51","author":"MP Boks","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"5","key":"ref99","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1192\/bjp.bp.114.151027","article-title":"Anxiety disorders and accelerated cellular ageing","volume":"206","author":"JE Verhoeven","year":"2015","journal-title":"The British journal of psychiatry: the journal of mental science"},{"issue":"11","key":"ref100","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1038\/mp.2013.183","article-title":"Internalizing disorders and leukocyte telomere erosion: a prospective study of depression, generalized anxiety disorder and post-traumatic stress disorder","volume":"19","author":"I Shalev","year":"2014","journal-title":"Molecular psychiatry"},{"issue":"2","key":"ref101","doi-asserted-by":"crossref","first-page":"e1000375","DOI":"10.1371\/journal.pgen.1000375","article-title":"The individual blood cell telomere attrition rate is telomere length dependent","volume":"5","author":"K Nordfjall","year":"2009","journal-title":"PLoS Genet"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"81","DOI":"10.18632\/aging.100007","article-title":"The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men","volume":"1","author":"ES Epel","year":"2009","journal-title":"Aging (Albany NY)"},{"issue":"5","key":"ref103","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a003558","article-title":"Telomerase: an RNP enzyme synthesizes DNA","volume":"3","author":"EH Blackburn","year":"2011","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"4","key":"ref104","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bbi.2009.11.018","article-title":"Dynamics of telomerase activity in response to acute psychological stress","volume":"24","author":"ES Epel","year":"2010","journal-title":"Brain, behavior, and immunity"},{"issue":"8","key":"ref105","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1751-9004.2011.00368.x","article-title":"Restorative biological processes and health","volume":"5","author":"TF Robles","year":"2011","journal-title":"Social and personality psychology compass"},{"issue":"6","key":"ref106","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1037\/a0013342","article-title":"Chronic psychosocial factors and acute physiological responses to laboratory-induced stress in healthy populations: a quantitative review of 30 years of investigations","volume":"134","author":"Y Chida","year":"2008","journal-title":"Psychol Bull"},{"issue":"11","key":"ref107","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/j.biopsych.2007.01.012","article-title":"Associations between anxiety, depression, and the metabolic syndrome","volume":"62","author":"MR Skilton","year":"2007","journal-title":"Biological psychiatry"},{"issue":"12","key":"ref108","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1177\/070674370605101202","article-title":"Recent evidence linking coronary heart disease and depression","volume":"51","author":"N Frasure-Smith","year":"2006","journal-title":"Canadian journal of psychiatry Revue canadienne de psychiatrie"},{"issue":"13","key":"ref109","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1161\/CIRCULATIONAHA.109.853895","article-title":"Association of leukocyte telomere length with echocardiographic left ventricular mass: the Framingham heart study","volume":"120","author":"RS Vasan","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"ref110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1093\/aje\/kwq142","article-title":"Association between left ventricular mass and telomere length in a population study","volume":"172","author":"T Kuznetsova","year":"2010","journal-title":"American journal of epidemiology"},{"issue":"11","key":"ref111","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1093\/carcin\/bgv133","article-title":"Association of leukocyte telomere length in peripheral blood leukocytes with endometrial cancer risk in Caucasian Americans","volume":"36","author":"Y Sun","year":"2015","journal-title":"Carcinogenesis"},{"issue":"12","key":"ref112","doi-asserted-by":"crossref","first-page":"e113387","DOI":"10.1371\/journal.pone.0113387","article-title":"Long leukocyte telomere length at diagnosis is a risk factor for dementia progression in idiopathic parkinsonism","volume":"9","author":"S Degerman","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref113","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/s00406-008-0842-7","article-title":"Association of the s allele of the 5-HTTLPR with neuroticism-related traits and temperaments in a psychiatrically healthy population","volume":"259","author":"X Gonda","year":"2009","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"issue":"5292","key":"ref114","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","article-title":"Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region","volume":"274","author":"KP Lesch","year":"1996","journal-title":"Science"},{"issue":"4","key":"ref115","doi-asserted-by":"crossref","first-page":"e94442","DOI":"10.1371\/journal.pone.0094442","article-title":"Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese","volume":"9","author":"P Li","year":"2014","journal-title":"PloS one"},{"issue":"2","key":"ref116","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1177\/0022146515582100","article-title":"Race-Ethnicity, Poverty, Urban Stressors, and Telomere Length in a Detroit Community-based Sample","volume":"56","author":"AT Geronimus","year":"2015","journal-title":"Journal of health and social behavior"},{"issue":"1","key":"ref117","doi-asserted-by":"crossref","first-page":"e0146723","DOI":"10.1371\/journal.pone.0146723","article-title":"Race, Ethnicity, Psychosocial Factors, and Telomere Length in a Multicenter Setting","volume":"11","author":"SM Lynch","year":"2016","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165482","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T06:48:06Z","timestamp":1718866086000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165482"}},"subtitle":[],"editor":[{"given":"Gabriele","family":"Saretzki","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,27]]},"references-count":117,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165482","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,27]]}}}