{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:53:09Z","timestamp":1793123589273,"version":"4.5.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T00:00:00Z","timestamp":1477612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL112597"],"award-info":[{"award-number":["R01HL112597"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL120659"],"award-info":[{"award-number":["R01HL120659"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007254","name":"Creighton University","doi-asserted-by":"publisher","award":["George Haddix President's Grant"],"award-info":[{"award-number":["George Haddix President's Grant"]}],"id":[{"id":"10.13039\/100007254","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165492","type":"journal-article","created":{"date-parts":[[2016,10,28]],"date-time":"2016-10-28T17:34:14Z","timestamp":1477676054000},"page":"e0165492","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":65,"title":["TREM-1, HMGB1 and RAGE in the Shoulder Tendon: Dual Mechanisms for Inflammation Based on the Coincidence of Glenohumeral Arthritis"],"prefix":"10.1371","volume":"11","author":[{"given":"Finosh G.","family":"Thankam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew F.","family":"Dilisio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas E.","family":"Dietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5445-0013","authenticated-orcid":true,"given":"Devendra K.","family":"Agrawal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/cts.12308","article-title":"Triggering Receptor Expressed on Myeloid Cells in Cutaneous Melanoma: TREMs in Melanoma","volume":"8","author":"AH Nguyen","year":"2015","journal-title":"Clin Transl Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11010-016-2710-5","article-title":"Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions","volume":"417","author":"FG Thankam","year":"2016","journal-title":"Mol Cell Biochem"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"691","DOI":"10.4252\/wjsc.v7.i4.691","article-title":"Stem cell therapy in the management of shoulder rotator cuff disorders","volume":"7","author":"MV Mora","year":"2015","journal-title":"World J Stem Cells"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jse.2011.09.020","article-title":"Cytokines in rotator cuff degeneration and repair","volume":"21","author":"A Bedi","year":"2012","journal-title":"J Shoulder Elbow Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/35074114","article-title":"TREM-1 amplifies inflammation and is a crucial mediator of septic shock","volume":"410","author":"A Bouchon","year":"2001","journal-title":"Nature"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.mehy.2011.10.042","article-title":"Soluble triggering receptor expressed on myeloid cells-1 as a new therapeutic molecule in rheumatoid arthritis","volume":"78","author":"T-H Kim","year":"2012","journal-title":"Med Hypotheses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1093\/rheumatology\/kep235","article-title":"TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines","volume":"48","author":"J Kuai","year":"2009","journal-title":"Rheumatology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1586\/1744666X.2014.866519","article-title":"Emerging roles for triggering receptor expressed on myeloid cells receptor family signaling in inflammatory diseases","volume":"10","author":"CJ Pelham","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"key":"ref9","article-title":"Triggering receptor expressed on myeloid cells-1 (TREM-1): a new player in antiviral immunity?","volume":"5","author":"K Roe","year":"2014","journal-title":"Front Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1084\/jem.192.4.565","article-title":"High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes","volume":"192","author":"U Andersson","year":"2000","journal-title":"J Exp Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/rheumatology\/ket134","article-title":"The role of high mobility group box chromosomal protein 1 in rheumatoid arthritis","volume":"52","author":"Y Chen","year":"2013","journal-title":"Rheumatology"},{"key":"ref12","article-title":"Advanced glycation end products in idiopathic frozen shoulders","author":"KR Hwang","year":"2016","journal-title":"J Shoulder Elbow Surg"},{"key":"ref13","first-page":"e425","article-title":"High-mobility Group Box Protein-1, Matrix Metalloproteinases, and Vitamin D in Keloids and Hypertrophic Scars: Plast Reconstr Surg\u2014Glob Open","volume":"3","author":"DE Lee","year":"2015"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090633","article-title":"The Burden of Musculoskeletal Conditions","volume":"9","author":"C Palazzo","year":"2014","journal-title":"PLoS ONE"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0049-0172(95)80020-4","article-title":"Acute-phase proteins in osteoarthritis","volume":"25","author":"JD Sipe","year":"1995","journal-title":"Semin Arthritis Rheum"},{"key":"ref16","first-page":"1486","article-title":"The C-reactive protein but not erythrocyte sedimentation rate is associated with clinical severity in patients with osteoarthritis of the knee or hip","volume":"24","author":"F Wolfe","year":"1997","journal-title":"J Rheumatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1600-0838.1997.tb00124.x","article-title":"Histopathological findings in chronic tendon disorders","volume":"7","author":"M J\u00e4rvinen","year":"2007","journal-title":"Scand J Med Sci Sports"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/036354657600400404","article-title":"A classification of achilles tendon disease","volume":"4","author":"G Puddu","year":"1976","journal-title":"Am J Sports Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1136\/bjsports-2012-091957","article-title":"Tendons\u2014time to revisit inflammation","volume":"48","author":"JD Rees","year":"2014","journal-title":"Br J Sports Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1002\/art.22426","article-title":"Tenocyte responses to mechanical loading in vivo: a role for local insulin-like growth factor 1 signaling in early tendinosis in rats","volume":"56","author":"A Scott","year":"2007","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11926-012-0272-4","article-title":"Managing Macrophages in Rheumatoid Arthritis by Reform or Removal","volume":"14","author":"J Li","year":"2012","journal-title":"Curr Rheumatol Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6774","DOI":"10.1038\/ncomms7774","article-title":"MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease","volume":"6","author":"NL Millar","year":"2015","journal-title":"Nat Commun"},{"key":"ref23","first-page":"1","article-title":"Triggering receptor expressed on myeloid cells and 5\u2019adenosine monophosphate-activated protein kinase in the inflammatory response: a potential therapeutic target","author":"FG Thankam","year":"2016","journal-title":"Expert Rev Clin Immunol"},{"key":"ref24","article-title":"Vitamin D and the immunomodulation of rotator cuff injury","volume":"123","author":"D Agrawal","year":"2016","journal-title":"J Inflamm Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1517\/13543776.2014.977865","article-title":"Triggering receptor expressed on myeloid cells receptor family modulators: a patent review","volume":"24","author":"CJ Pelham","year":"2014","journal-title":"Expert Opin Ther Pat"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1136\/ard.2008.089557","article-title":"Elevated synovial expression of triggering receptor expressed on myeloid cells 1 in patients with septic arthritis or rheumatoid arthritis","volume":"68","author":"CE Collins","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e0115116","DOI":"10.1371\/journal.pone.0115116","article-title":"Inactivation of DAP12 in PMN Inhibits TREM1-Mediated Activation in Rheumatoid Arthritis","volume":"10","author":"X Chen","year":"2015","journal-title":"PLOS ONE"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-015-0059-4","article-title":"Adipose-derived mesenchymal stromal cells modulate tendon fibroblast responses to macrophage-induced inflammation in vitro","volume":"6","author":"CN Manning","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"e0154802","DOI":"10.1371\/journal.pone.0154802","article-title":"Dendritic Cells Expressing Triggering Receptor Expressed on Myeloid Cells-1 Correlate with Plaque Stability in Symptomatic and Asymptomatic Patients with Carotid Stenosis","volume":"11","author":"V Rai","year":"2016","journal-title":"PLOS ONE"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting Edge: Inflammatory Responses Can Be Triggered by TREM-1, a Novel Receptor Expressed on Neutrophils and Monocytes","volume":"164","author":"A Bouchon","year":"2000","journal-title":"J Immunol"},{"key":"ref31","article-title":"Emerging roles for HMGB1 protein in immunity, inflammation, and cancer","volume":"101","author":"E Ranzato","year":"2015","journal-title":"ImmunoTargets Ther"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.2119\/molmed.2013.00164","article-title":"The Role of HMGB1 in the Pathogenesis of Inflammatory and Autoimmune Diseases","volume":"20","author":"M Magna","year":"2014","journal-title":"Mol Med"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1189\/jlb.1212662","article-title":"The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis","volume":"93","author":"H Yang","year":"2013","journal-title":"J Leukoc Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1146\/annurev.immunol.021908.132603","article-title":"HMGB1 and RAGE in inflammation and cancer","volume":"28","author":"GP Sims","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"22527","DOI":"10.3390\/ijms160922527","article-title":"The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma","volume":"16","author":"X Wang","year":"2015","journal-title":"A Review. Int J Mol Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"3977","DOI":"10.1158\/0008-5472.CAN-12-0938","article-title":"The Proinflammatory Myeloid Cell Receptor TREM-1 Controls Kupffer Cell Activation and Development of Hepatocellular Carcinoma","volume":"72","author":"J Wu","year":"2012","journal-title":"Cancer Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.yexmp.2012.04.006","article-title":"Vitamin D deficiency induces cardiac hypertrophy and inflammation in epicardial adipose tissue in hypercholesterolemic swine","volume":"93","author":"GK Gupta","year":"2012","journal-title":"Exp Mol Pathol"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1101\/pdb.prot4986","article-title":"Hematoxylin and Eosin Staining of Tissue and Cell Sections","volume":"2008","author":"AH Fischer","year":"2008","journal-title":"Cold Spring Harb Protoc"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jor.22191","article-title":"Substance P enhances collagen remodeling and MMP-3 expression by human tenocytes","volume":"31","author":"G Fong","year":"2013","journal-title":"J Orthop Res"},{"key":"ref40","article-title":"Vitamin D Supplementation Reduces Airway Hyperresponsiveness and Allergic Airway Inflammation in a Murine Model","author":"T Agrawal","year":"2013","journal-title":"Clin Exp Allergy"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.7150\/ijms.7231","article-title":"Gene Expression Analysis of <italic>TREM1<\/italic> and <italic>GRK2<\/italic> in Polymorphonuclear Leukocytes as the Surrogate Biomarkers of Acute Bacterial Infections","volume":"11","author":"T Ubagai","year":"2014","journal-title":"Int J Med Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165492","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T16:04:44Z","timestamp":1589040284000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165492"}},"subtitle":[],"editor":[{"given":"Thomas","family":"Abraham","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,10,28]]},"references-count":41,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2016,10,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165492","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,28]]}}}