{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:50:55Z","timestamp":1790247055167,"version":"4.1.0"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T00:00:00Z","timestamp":1478649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD062553"],"award-info":[{"award-number":["HD062553"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000052","name":"NIH Office of the Director","doi-asserted-by":"publisher","award":["DP5OD009134"],"award-info":[{"award-number":["DP5OD009134"]}],"id":[{"id":"10.13039\/100000052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD024064"],"award-info":[{"award-number":["HD024064"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HD061222"],"award-info":[{"award-number":["HD061222"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS066601"],"award-info":[{"award-number":["NS066601"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001819","name":"International Rett Syndrome Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0165550","type":"journal-article","created":{"date-parts":[[2016,11,9]],"date-time":"2016-11-09T18:52:18Z","timestamp":1478717538000},"page":"e0165550","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome"],"prefix":"10.1371","volume":"11","author":[{"given":"Christopher S.","family":"Ward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng-Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A.","family":"Herrera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney C.","family":"Samaco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan R.","family":"Pitcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Herron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven A.","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter E.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Glaze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan K.","family":"Percy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Neul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2016,11,9]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S0387-7604(85)80028-0","article-title":"Rett syndrome: Swedish approach to analysis of prevalence and cause","volume":"7","author":"B Hagberg","year":"1985","journal-title":"Brain & development"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/13810","article-title":"Rett syndrome is caused by mutations in X-linked MECP2, encoding methyl-CpG-binding protein 2","volume":"23","author":"RE Amir","year":"1999","journal-title":"Nature genetics"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1212\/01.wnl.0000291011.54508.aa","article-title":"Specific mutations in methyl-CpG-binding protein 2 confer different severity in Rett syndrome","volume":"70","author":"JL Neul","year":"2008","journal-title":"Neurology"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1002\/ana.22124","article-title":"Rett syndrome: revised diagnostic criteria and nomenclature","volume":"68","author":"JL Neul","year":"2010","journal-title":"Annals of neurology"},{"issue":"113","key":"ref5","doi-asserted-by":"crossref","first-page":"113ra25","DOI":"10.1126\/scitranslmed.3002982","article-title":"Pathogenesis of lethal cardiac arrhythmias in Mecp2 mutant mice: implication for therapy in Rett syndrome","volume":"3","author":"MD McCauley","year":"2011","journal-title":"Science translational medicine"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1203\/01.pdr.0000238302.84552.d0","article-title":"Autonomic nervous system dysregulation: breathing and heart rate perturbation during wakefulness in young girls with Rett syndrome","volume":"60","author":"DE Weese-Mayer","year":"2006","journal-title":"Pediatric research"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1055\/s-2002-23598","article-title":"MECP2 mutation in a boy with severe neonatal encephalopathy: clinical, neuropathological and molecular findings","volume":"33","author":"N Geerdink","year":"2002","journal-title":"Neuropediatrics"},{"issue":"40","key":"ref8","doi-asserted-by":"crossref","first-page":"10912","DOI":"10.1523\/JNEUROSCI.1869-07.2007","article-title":"Brain-derived neurotrophic factor expression and respiratory function improve after ampakine treatment in a mouse model of Rett syndrome","volume":"27","author":"M Ogier","year":"2007","journal-title":"J Neurosci"},{"issue":"50","key":"ref9","doi-asserted-by":"crossref","first-page":"11521","DOI":"10.1523\/JNEUROSCI.4373-05.2005","article-title":"Mecp2 deficiency disrupts norepinephrine and respiratory systems in mice","volume":"25","author":"JC Viemari","year":"2005","journal-title":"J Neurosci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2014.02.043","article-title":"Respiratory phenotypes are distinctly affected in mice with common Rett syndrome mutations MeCP2 T158A and R168X","volume":"267","author":"JM Bissonnette","year":"2014","journal-title":"Neuroscience"},{"issue":"28","key":"ref11","doi-asserted-by":"crossref","first-page":"10359","DOI":"10.1523\/JNEUROSCI.0057-11.2011","article-title":"MeCP2 is critical within HoxB1-derived tissues of mice for normal lifespan","volume":"31","author":"CS Ward","year":"2011","journal-title":"J Neurosci"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/ejhg.2008.192","article-title":"Xq28 duplication presenting with intestinal and bladder dysfunction and a distinctive facial appearance","volume":"17","author":"J Clayton-Smith","year":"2009","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1212\/01.wnl.0000296826.61499.26","article-title":"Lower urinary tract symptoms in dementia with Lewy bodies, Parkinson disease, and Alzheimer disease","volume":"70","author":"GN Ransmayr","year":"2008","journal-title":"Neurology"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1464-410X.1985.tb08987.x","article-title":"Vesico-urethral function in Huntington&apos;s chorea","volume":"57","author":"JS Wheeler","year":"1985","journal-title":"British journal of urology"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3122\/jabfm.2015.01.140065","article-title":"Rate of urinary retention in adults with down syndrome: a prospective study","volume":"28","author":"B Chicoine","year":"2015","journal-title":"J Am Board Fam Med"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.jpurol.2013.07.004","article-title":"Uroflowmetry in the management of lower urinary tract symptoms of children and adolescents with cerebral palsy","volume":"10","author":"JA Fernandes Silva","year":"2014","journal-title":"J Pediatr Urol"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/ana.22154","article-title":"Rett syndrome diagnostic criteria: lessons from the Natural History Study","volume":"68","author":"AK Percy","year":"2010","journal-title":"Annals of neurology"},{"key":"ref18","unstructured":"Leary S, Underwood W, Anthony R, Cartner S, Corey D, Grandin T, et al. AVMA guidelines for the euthanasia of animals: 2013 edition. 2013."},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/85906","article-title":"Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice","volume":"27","author":"RZ Chen","year":"2001","journal-title":"Nature genetics"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/85899","article-title":"A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome","volume":"27","author":"J Guy","year":"2001","journal-title":"Nature genetics"},{"issue":"5815","key":"ref21","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1126\/science.1138389","article-title":"Reversal of neurological defects in a mouse model of Rett syndrome","volume":"315","author":"J Guy","year":"2007","journal-title":"Science"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/nau.20552","article-title":"Voided stain on paper method for analysis of mouse urination","volume":"27","author":"Y Sugino","year":"2008","journal-title":"Neurourology and urodynamics"},{"issue":"7","key":"ref23","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nature methods"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/mds.870050303","article-title":"Rett syndrome and associated movement disorders","volume":"5","author":"PM FitzGerald","year":"1990","journal-title":"Mov Disord"},{"issue":"24","key":"ref25","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1001\/jama.1976.03260500014014","article-title":"Letter: Urinary retention as complication of levodopa therapy","volume":"235","author":"S Jotkowitz","year":"1976","journal-title":"JAMA"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0022-5347(17)57158-X","article-title":"The anticholinergic effects of dicyclomine hydrochloride in uninhibited neurogenic bladder dysfunction","volume":"120","author":"CP Fischer","year":"1978","journal-title":"J Urol"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/hmg\/dds406","article-title":"Female Mecp2(+\/-) mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies","volume":"22","author":"RC Samaco","year":"2013","journal-title":"Human molecular genetics"},{"issue":"Pt 1","key":"ref28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1203\/01.pdr.0000203157.31924.4a","article-title":"Separate respiratory phenotypes in methyl-CpG-binding protein 2 (Mecp2) deficient mice","volume":"59","author":"JM Bissonnette","year":"2006","journal-title":"Pediatric research"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1001\/jama.298.2.179","article-title":"Recurrent urinary tract infections in children: risk factors and association with prophylactic antimicrobials","volume":"298","author":"PH Conway","year":"2007","journal-title":"JAMA"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1651-2227.1998.tb01502.x","article-title":"Incidence rate of first-time symptomatic urinary tract infection in children under 6 years of age","volume":"87","author":"S M\u00e5rild","year":"1998","journal-title":"Acta Paediatr"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3109\/00365598709180286","article-title":"Acute urinary retention in women: a prospective study of 18 consecutive cases","volume":"21","author":"P Klarskov","year":"1987","journal-title":"Scand J Urol Nephrol"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"497","DOI":"10.7326\/0003-4819-126-7-199704010-00001","article-title":"Comparison of dietary calcium with supplemental calcium and other nutrients as factors affecting the risk for kidney stones in women","volume":"126","author":"GC Curhan","year":"1997","journal-title":"Ann Intern Med"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/sj.ki.5000150","article-title":"Renal stone epidemiology in Rochester, Minnesota: an update","volume":"69","author":"JC Lieske","year":"2006","journal-title":"Kidney Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"937268","DOI":"10.1155\/2013\/937268","article-title":"Prevalence and Predictors of Urinary Tract Infections among Children with Cerebral Palsy in Makurdi, Nigeria","volume":"2013","author":"EA An\u00edgil\u00e1j\u00e9","year":"2013","journal-title":"Int J Nephrol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1136\/adc.68.6.739","article-title":"Lower urinary tract dysfunction in cerebral palsy","volume":"68","author":"CJ Reid","year":"1993","journal-title":"Arch Dis Child"},{"key":"ref36","article-title":"Lower urinary tract symptoms and urodynamic findings in children and adults with cerebral palsy: A systematic review","author":"B Samijn","year":"2016","journal-title":"Neurourol Urodyn"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"189","DOI":"10.5527\/wjn.v5.i2.189","article-title":"Experimental models of renal calcium stones in rodents","volume":"5","author":"H Bilbault","year":"2016","journal-title":"World J Nephrol"},{"issue":"11","key":"ref38","doi-asserted-by":"crossref","first-page":"F1296","DOI":"10.1152\/ajprenal.00074.2014","article-title":"Spontaneous voiding by mice reveals strain-specific lower urinary tract function to be a quantitative genetic trait","volume":"306","author":"W Yu","year":"2014","journal-title":"Am J Physiol Renal Physiol"},{"issue":"3","key":"ref39","first-page":"296","article-title":"Urethral obstruction by seminal coagulum is associated with medetomidine-ketamine anesthesia in male mice on C57BL\/6J and mixed genetic backgrounds","volume":"48","author":"S Wells","year":"2009","journal-title":"Journal of the American Association for Laboratory Animal Science: JAALAS"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1528-1157.2003.11402.x","article-title":"Sexual dysfunction and sudden death in epileptic male EL mice: inheritance and prevention with the ketogenic diet","volume":"44","author":"MT Todorova","year":"2003","journal-title":"Epilepsia"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1292\/jvms.61.53","article-title":"Obstructive uropathy and hydronephrosis in male KK-Ay mice: a report of cases","volume":"61","author":"H Ninomiya","year":"1999","journal-title":"The Journal of veterinary medical science \/ the Japanese Society of Veterinary Science"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1258\/002367782781110205","article-title":"Urethral plug\u2014a new secondary male sex characteristic in rat and other rodents","volume":"16","author":"I Kunstyr","year":"1982","journal-title":"Laboratory animals"},{"key":"ref43","first-page":"233","article-title":"Obstructive genitourinary disease in male STR\/IN mice","volume":"41","author":"L Sokoloff","year":"1962","journal-title":"The American journal of pathology"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1258\/002367778780953116","article-title":"Self-mutilation of the penis in C57BL\/6N mice","volume":"12","author":"CC Hong","year":"1978","journal-title":"Laboratory animals"},{"issue":"3","key":"ref45","first-page":"282","article-title":"Incidence of obstructive uropathy in male B6C3F1 mice on a 24-month carcinogenicity study and its apparent prevention by ochratoxin A","volume":"36","author":"AM Bendele","year":"1986","journal-title":"Laboratory animal science"},{"issue":"1","key":"ref46","first-page":"8","article-title":"Obstructive uropathy in group caged male B6C3F1 mice on a 24-month carcinogenicity study","volume":"37","author":"CN Rao","year":"1987","journal-title":"Laboratory animal science"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1111\/j.1460-9568.2007.05466.x","article-title":"Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome","volume":"25","author":"JC Roux","year":"2007","journal-title":"The European journal of neuroscience"},{"issue":"Suppl 1","key":"ref48","first-page":"71","article-title":"Rett syndrome: analysis of deaths in the British survey","volume":"6","author":"AM Kerr","year":"1997","journal-title":"European child & adolescent psychiatry"},{"issue":"9","key":"ref49","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/ng.2714","article-title":"A suppressor screen in Mecp2 mutant mice implicates cholesterol metabolism in Rett syndrome","volume":"45","author":"CM Buchovecky","year":"2013","journal-title":"Nature genetics"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0165550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:42:59Z","timestamp":1589010179000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0165550"}},"subtitle":[],"editor":[{"given":"Nicoletta","family":"Landsberger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,9]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0165550","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,9]]}}}