{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T19:52:40Z","timestamp":1772221960745,"version":"3.50.1"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T00:00:00Z","timestamp":1478131200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["GAUK 120516\/B-BIO"],"award-info":[{"award-number":["GAUK 120516\/B-BIO"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["UNCE 204013"],"award-info":[{"award-number":["UNCE 204013"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Ministry of Education, Youth and Sports of the Czech Republic","award":["CEITEC 2020 (LQ1601)"],"award-info":[{"award-number":["CEITEC 2020 (LQ1601)"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166191","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T13:52:15Z","timestamp":1478181135000},"page":"e0166191","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["The Diversity of Yellow-Related Proteins in Sand Flies (Diptera: Psychodidae)"],"prefix":"10.1371","volume":"11","author":[{"given":"Michal","family":"Sima","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marian","family":"Novotny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Pravda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petra","family":"Sumova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Rohousova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"Volf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.ibmb.2010.08.002","article-title":"An insight into the sialome of bloodfeeding Nematocera","volume":"40","author":"JMC Ribeiro","year":"2010","journal-title":"Insect Biochem Mol Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.meegid.2014.07.028","article-title":"What&apos;s behind a sand fly bite? The profound effect of sand fly saliva on host hemostasis, inflammation and immunity","volume":"28","author":"M Abdeladhim","year":"2014","journal-title":"Infect Genet Evol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1017\/S003118200400681X","article-title":"Detection of species-specific antibody response of humans and mice bitten by sand flies","volume":"130","author":"I Rohousova","year":"2005","journal-title":"Parasitology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e84","DOI":"10.1371\/journal.pntd.0000084","article-title":"Enhanced <italic>Leishmania braziliensis<\/italic> infection following pre-exposure to sandfly saliva","volume":"1","author":"TR de Moura","year":"2007","journal-title":"PLoS Negl Trop Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1344","DOI":"10.1371\/journal.pntd.0001344","article-title":"Canine antibody response to <italic>Phlebotomus perniciosus<\/italic> bites negatively correlates with the risk of <italic>Leishmania infantum<\/italic> transmission","volume":"5","author":"M Vlkova","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e1296","DOI":"10.1371\/journal.pntd.0001296","article-title":"Serological markers of sand fly exposure to evaluate insecticidal nets against visceral leishmaniasis in India and Nepal: A cluster-randomized trial","volume":"5","author":"K Gidwani","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.4269\/ajtmh.2011.10-0598","article-title":"Characterization of the antibody response to the saliva of <italic>Phlebotomus papatasi<\/italic> in people living in endemic areas of cutaneous leishmaniasis","volume":"84","author":"S Marzouki","year":"2011","journal-title":"Am J Trop Med Hyg"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"15155","DOI":"10.1073\/pnas.96.26.15155","article-title":"Toward an understanding of the biochemical and pharmacological complexity of the saliva of a hematophagous sand fly <italic>Lutzomyia longipalpis<\/italic>","volume":"96","author":"R Charlab","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1084\/jem.194.3.331","article-title":"Toward a defined anti-<italic>Leishmania<\/italic> vaccine targeting vector antigens: characterization of a protective salivary protein","volume":"194","author":"JG Valenzuela","year":"2011","journal-title":"J Exp Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1242\/jeb.01185","article-title":"Identification of the most abundant secreted proteins from the salivary glands of the sand fly <italic>Lutzomyia longipalpis<\/italic>, vector of <italic>Leishmania chagasi<\/italic>","volume":"207","author":"JG Valenzuela","year":"2004","journal-title":"J Exp Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.vaccine.2005.07.085","article-title":"From transcriptome to immunome: Identification of DTH inducing proteins from a <italic>Phlebotomus ariasi<\/italic> salivary gland cDNA library","volume":"24","author":"F Oliveira","year":"2006","journal-title":"Vaccine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2164-7-52","article-title":"Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis","volume":"7","author":"JM Anderson","year":"2006","journal-title":"BMC Genomics"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/1471-2164-7-226","article-title":"High degree of conservancy among secreted salivary gland proteins from two geographically distant <italic>Phlebotomus duboscqi<\/italic> sandflies populations (Mali and Kenya)","volume":"7","author":"H Kato","year":"2006","journal-title":"BMC Genomics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/1471-2164-10-282","article-title":"Analysis of salivary transcripts and antigens of the sand fly <italic>Phlebotomus arabicus<\/italic>","volume":"10","author":"J Hostomska","year":"2009","journal-title":"BMC Genomics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e47347","DOI":"10.1371\/journal.pone.0047347","article-title":"Updating the salivary gland transcriptome of <italic>Phlebotomus papatasi<\/italic> (Tunisian Strain): The search for sand fly-secreted immunogenic proteins for humans","volume":"7","author":"M Abdeladhim","year":"2012","journal-title":"PLoS One"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e1660","DOI":"10.1371\/journal.pntd.0001660","article-title":"Salivary gland transcriptomes and proteomes of <italic>Phlebotomus tobbi<\/italic> and <italic>Phlebotomus sergenti<\/italic>, vectors of leishmaniasis","volume":"6","author":"I Rohousova","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"e2242","DOI":"10.1371\/journal.pntd.0002242","article-title":"Functional transcriptomics of wild-caught <italic>Lutzomyia intermedia<\/italic> salivary glands: identification of a protective salivary protein against <italic>Leishmania braziliensis<\/italic> infection","volume":"7","author":"TR de Moura","year":"2013","journal-title":"PLoS Negl Trop Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/imb.12015","article-title":"The characterization of the <italic>Phlebotomus papatasi<\/italic> transcriptome","volume":"22","author":"J Abrudan","year":"2013","journal-title":"Insect Mol Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.meegid.2012.08.024","article-title":"Analysis of salivary gland transcripts of the sand fly <italic>Lutzomyia ayacuchensis<\/italic>, a vector of Andean-type cutaneous leishmaniasis","volume":"13","author":"H Kato","year":"2013","journal-title":"Infect Genet Evol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e2709","DOI":"10.1371\/journal.pntd.0002709","article-title":"Comparative analysis of salivary gland transcriptomes of <italic>Phlebotomus orientalis<\/italic> sand flies from endemic and non-endemic foci of visceral leishmaniasis","volume":"8","author":"M Vlkova","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e0004771","DOI":"10.1371\/journal.pntd.0004771","article-title":"Molecular diversity between salivary proteins from New World and Old World sand flies with emphasis on <italic>Bichromomyia olmeca<\/italic>, the sand fly vector of <italic>Leishmania mexicana<\/italic> in Mesoamerica","volume":"10","author":"M Adeladhim","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/BF00488465","article-title":"Identification of a yellow gene-specific protein in <italic>Drosophila melanogaster<\/italic> by two-dimensional gel-electrophoresis","volume":"21","author":"WG Nash","year":"1983","journal-title":"Biochem Genet"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1080\/00218839.1992.11101256","article-title":"Identification and partial characterization of the major royal jelly protein of the honey-bee (<italic>Apis mellifera L<\/italic>)","volume":"31","author":"J Hanes","year":"1992","journal-title":"J Apic Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/S0965-1748(01)00072-8","article-title":"Cloning and characterization of a dopachrome conversion enzyme from the yellow fever mosquito, <italic>Aedes aegypti<\/italic>","volume":"31","author":"JK Johnson","year":"2001","journal-title":"Insect Biochem Mol Biol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1186\/1471-2164-11-213","article-title":"An insight into the sialome of <italic>Glossina morsitans morsitans<\/italic>","volume":"11","author":"J Alves-Silva","year":"2010","journal-title":"BMC Genomics"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"32383","DOI":"10.1074\/jbc.M111.268904","article-title":"Structure and function of a \u2018\u2018yellow\u201d protein from saliva of the sand fly <italic>Lutzomyia longipalpis<\/italic> that confers protective immunity against <italic>Leishmania major<\/italic> infection","volume":"286","author":"X Xu","year":"2011","journal-title":"J Biol Chem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuroscience.2006.12.021","article-title":"5-HT acts on nociceptive primary afferents through an indirect mechanism to induce hyperalgesia in the subcutaneous tissue","volume":"145","author":"MCG Oliveira","year":"2007","journal-title":"Neuroscience"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.pain.2007.10.031","article-title":"Norepinephrine-induced nociception and vasoconstrictor hypersensitivity in rats with chronic post-ischemia pain","volume":"137","author":"DN Xanthos","year":"2008","journal-title":"Pain"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"6294","DOI":"10.1046\/j.1432-1033.2002.03349.x","article-title":"Characterization of the lectin from females of <italic>Phlebotomus duboscqi<\/italic> sand flies","volume":"269","author":"P Volf","year":"2002","journal-title":"Eur J Biochem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e638","DOI":"10.1371\/journal.pntd.0000638","article-title":"Discovery of markers of exposure specific to bites of <italic>Lutzomyia longipalpis<\/italic>, the vector of <italic>Leishmania infantum<\/italic> chagasi in Latin America","volume":"4","author":"C Teixeira","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"e649","DOI":"10.1371\/journal.pntd.0000649","article-title":"Using recombinant proteins from <italic>Lutzomyia longipalpis<\/italic> saliva to estimate human vector exposure in visceral leishmaniasis endemic areas","volume":"4","author":"AP Souza","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.vetpar.2014.02.045","article-title":"High levels of anti-<italic>Phlebotomus perniciosus<\/italic> saliva antibodies in different vertebrate hosts from the re-emerging leishmaniosis focus in Madrid, Spain","volume":"202","author":"I Martin-Martin","year":"2014","journal-title":"Vet Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e0003855","DOI":"10.1371\/journal.pntd.0003855","article-title":"Canine antibodies against salivary recombinant proteins of <italic>Phlebotomus perniciosus<\/italic>: A longitudinal study in an endemic focus of canine leishmaniasis","volume":"9","author":"T Kostalova","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e0004553","DOI":"10.1371\/journal.pntd.0004553","article-title":"Recombinant salivary proteins of <italic>Phlebotomus orientalis<\/italic> are suitable antigens to measure exposure of domestic animals to sand fly bites","volume":"10","author":"M Sima","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1038\/jid.2012.205","article-title":"Immunity to sand fly salivary protein LJM11 modulates host response to vector-transmitted <italic>Leishmania<\/italic> conferring ulcer-free protection","volume":"132","author":"R Gomes","year":"2012","journal-title":"J Invest Dermatol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"e1000441","DOI":"10.1371\/journal.ppat.1000441","article-title":"Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for <italic>Leishmania<\/italic>","volume":"5","author":"N Collin","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/nmeth.1701","article-title":"SignalP 4.0: discriminating signal peptides from transmembrane regions","volume":"8","author":"TN Petersen","year":"2001","journal-title":"Nat Methods"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1093\/bioinformatics\/btm404","article-title":"Clustal W and clustal X version 2.0","volume":"23","author":"MA Larkin","year":"2007","journal-title":"Bioinformatics"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/bioinformatics\/bti263","article-title":"ProtTest: selection of best-fit models of protein evolution","volume":"21","author":"F Abascal","year":"2005","journal-title":"Bioinformatics"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/bioinformatics\/18.3.502","article-title":"TREE-PUZZLE: maximum likelihood phylogenetic analysis using quartets and parallel computing","volume":"18","author":"HA Schmidt","year":"2002","journal-title":"Bioinformatics"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1093\/oxfordjournals.molbev.a026378","article-title":"Statistical tests of gamma-distributed rate heterogeneity in models of sequence evolution in phylogenetics","volume":"17","author":"N Goldman","year":"2000","journal-title":"Mol Biol Evol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1093\/molbev\/msm092","article-title":"MEGA4: Molecular evolutionary genetics analysis (MEGA) software version 4.0","volume":"24","author":"K Tamura","year":"2007","journal-title":"Mol Biol Evol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/msb.2011.75","article-title":"Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega","volume":"7","author":"F Sievers","year":"2011","journal-title":"Mol Syst Biol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/emboj.2013.79","article-title":"Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology","volume":"32","author":"C Steentoft","year":"2013","journal-title":"EMBO J"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1093\/glycob\/cwm050","article-title":"NetCGlyc 1.0: Prediction of mammalian C-mannosylation sites","volume":"17","author":"K Julenius","year":"2007","journal-title":"Glycobiology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"HM Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/pro.5560030923","article-title":"Derivation of rules for comparative protein modeling from a database of protein-structure alignments","volume":"3","author":"A Sali","year":"1994","journal-title":"Protein Sci"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"10037","DOI":"10.1073\/pnas.181342398","article-title":"Electrostatics of nanosystems: application to microtubules and the ribosome","volume":"98","author":"NA Baker","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1758-2946-5-39","article-title":"MOLE 2.0: advanced approach for analysis of biomacromolecular channels","volume":"5","author":"D Sehnal","year":"2013","journal-title":"J Cheminform"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/protein\/5.5.373","article-title":"Hydrophobicity and structural classes in proteins","volume":"5","author":"H Cid","year":"1992","journal-title":"Protein Eng Des Sel"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1101\/gr.849004","article-title":"WebLogo: A sequence logo generator","volume":"14","author":"GE Crooks","year":"2004","journal-title":"Genome Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e0004322","DOI":"10.1371\/journal.pntd.0004322","article-title":"Intradermal immunization of <italic>Leishmania donovani<\/italic> centrin knock-out parasites in combination with salivary protein LJM19 from sand fly vector induces a durable protective immune response in hamsters","volume":"10","author":"JA Fiuza","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.actatropica.2011.12.004","article-title":"Individual variability of salivary gland proteins in three <italic>Phlebotomus<\/italic> species","volume":"122","author":"I Rohousova","year":"2012","journal-title":"Acta Trop"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2583.2000.00168.x","article-title":"Phylogenetic relationships of Phlebotomine sandflies inferred from small subunit nuclear ribosomal DNA","volume":"9","author":"AM Aransay","year":"2000","journal-title":"Insect Mol Biol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1093\/glycob\/cwm003","article-title":"Recombinant human hyaluronidase Hyal-1: insect cells versus <italic>Escherichia coli<\/italic> as expression system and identification of low molecular weight inhibitors","volume":"17","author":"ESA Hofinger","year":"2007","journal-title":"Glycobiology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"15861","DOI":"10.1074\/jbc.275.21.15861","article-title":"Chrysoptin is a potent glycoprotein IIb\/IIIa fibrinogen receptor antagonist present in salivary gland extracts of the deerfly","volume":"275","author":"VB Reddy","year":"2000","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1590\/S0074-02762004000500012","article-title":"Antileishmanial IgG and IgE antibodies recognize predominantly carbohydrate epitopes of glycosylated antigens in visceral leishmaniasis","volume":"99","author":"A Atta","year":"2004","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1046\/j.1365-2915.2000.00240.x","article-title":"Salivary proteins and glycoproteins in phlebotomine sandflies of various species, sex and age","volume":"14","author":"P Volf","year":"2000","journal-title":"Med Vet Entomol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166191","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:45:12Z","timestamp":1588959912000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166191"}},"subtitle":[],"editor":[{"given":"Yara M.","family":"Traub-Csek\u00f6","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166191","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]}}}