{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T23:02:28Z","timestamp":1774047748215,"version":"3.50.1"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T00:00:00Z","timestamp":1479168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL088457"],"award-info":[{"award-number":["R01-HL088457"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01-DK079888"],"award-info":[{"award-number":["R01-DK079888"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30-DK063491"],"award-info":[{"award-number":["P30-DK063491"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","award":["M01-RR00425"],"award-info":[{"award-number":["M01-RR00425"]}],"id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000124"],"award-info":[{"award-number":["UL1TR000124"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0166263","type":"journal-article","created":{"date-parts":[[2016,11,15]],"date-time":"2016-11-15T19:07:16Z","timestamp":1479236836000},"page":"e0166263","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Insulin Clearance Is Associated with Hepatic Lipase Activity and Lipid and Adiposity Traits in Mexican Americans"],"prefix":"10.1371","volume":"11","author":[{"given":"Artak","family":"Labadzhyan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinrui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikl\u00f3s","family":"P\u00e9terfy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuqing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yii-Der I.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Willa A.","family":"Hsueh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome I.","family":"Rotter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark O.","family":"Goodarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2016,11,15]]},"reference":[{"issue":"7121","key":"ref1","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1038\/nature05482","article-title":"Mechanisms linking obesity to insulin resistance and type 2 diabetes","volume":"444","author":"SE Kahn","year":"2006","journal-title":"Nature"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.2337\/diabetes.49.12.2116","article-title":"Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response","volume":"49","author":"SD Mittelman","year":"2000","journal-title":"Diabetes"},{"issue":"5","key":"ref3","first-page":"608","article-title":"Insulin degradation: progress and potential","volume":"19","author":"WC Duckworth","year":"1998","journal-title":"Endocr Rev"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s00592-013-0511-9","article-title":"Differences in insulin clearance between metabolically healthy and unhealthy obese subjects","volume":"51","author":"MA Marini","year":"2014","journal-title":"Acta Diabetol"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1210\/jc.2014-3796","article-title":"Arterial norepinephrine concentration is inversely and independently associated with insulin clearance in obese individuals with metabolic syndrome","volume":"100","author":"NE Straznicky","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.2337\/diabetes.54.4.1222","article-title":"Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait","volume":"54","author":"MO Goodarzi","year":"2005","journal-title":"Diabetes"},{"issue":"7130","key":"ref7","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/nature05616","article-title":"A genome-wide association study identifies novel risk loci for type 2 diabetes","volume":"445","author":"R Sladek","year":"2007","journal-title":"Nature"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.2337\/db07-0856","article-title":"Studies of association of variants near the HHEX, CDKN2A\/B, and IGF2BP2 genes with type 2 diabetes and impaired insulin release in 10,705 Danish subjects: validation and extension of genome-wide association studies","volume":"56","author":"N Grarup","year":"2007","journal-title":"Diabetes"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.2337\/db07-0634","article-title":"Common variants of the novel type 2 diabetes genes CDKAL1 and HHEX\/IDE are associated with decreased pancreatic beta-cell function","volume":"56","author":"L Pascoe","year":"2007","journal-title":"Diabetes"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1007\/s00125-013-2880-6","article-title":"Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance","volume":"56","author":"MO Goodarzi","year":"2013","journal-title":"Diabetologia"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.2337\/db14-0732","article-title":"Genetic variants associated with quantitative glucose homeostasis traits translate to type 2 diabetes in Mexican Americans: the GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium","volume":"64","author":"ND Palmer","year":"2015","journal-title":"Diabetes"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2337\/dc12-1316","article-title":"Insulin clearance and the incidence of type 2 diabetes in Hispanics and African Americans: the IRAS Family Study","volume":"36","author":"CC Lee","year":"2013","journal-title":"Diabetes Care"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.2337\/diabetes.53.1.214","article-title":"Lipoprotein lipase is a gene for insulin resistance in Mexican Americans","volume":"53","author":"MO Goodarzi","year":"2004","journal-title":"Diabetes"},{"issue":"3","key":"ref14","first-page":"E214","article-title":"Glucose clamp technique: a method for quantifying insulin secretion and resistance","volume":"237","author":"RA DeFronzo","year":"1979","journal-title":"Am J Physiol"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.2337\/diabetes.54.4.1228","article-title":"Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study","volume":"54","author":"MO Goodarzi","year":"2005","journal-title":"Diabetes"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0021-9150(00)00461-5","article-title":"Improved common carotid elasticity and intima-media thickness measurements from computer analysis of sequential ultrasound frames","volume":"154","author":"RH Selzer","year":"2001","journal-title":"Atherosclerosis"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"4816","DOI":"10.1210\/jc.2005-0389","article-title":"The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity","volume":"90","author":"MO Goodarzi","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1038\/oby.2006.136","article-title":"Genetic effects on obesity assessed by bivariate genome scan: the Mexican-American coronary artery disease study","volume":"14","author":"X Li","year":"2006","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.2307\/2531248","article-title":"Longitudinal data analysis for discrete and continuous outcomes","volume":"42","author":"SL Zeger","year":"1986","journal-title":"Biometrics"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s11883-011-0175-2","article-title":"Role of hepatic lipase and endothelial lipase in high-density lipoprotein-mediated reverse cholesterol transport","volume":"13","author":"W Annema","year":"2011","journal-title":"Curr Atheroscler Rep"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1161\/01.ATV.0000140818.00570.2d","article-title":"Hepatic lipase, lipoprotein metabolism, and atherogenesis","volume":"24","author":"S Santamarina-Fojo","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"6","key":"ref22","first-page":"2831","article-title":"The contribution of intraabdominal fat to gender differences in hepatic lipase activity and low\/high density lipoprotein heterogeneity","volume":"86","author":"MC Carr","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.2337\/diabetes.53.11.2893","article-title":"Hepatic lipase mRNA, protein, and plasma enzyme activity is increased in the insulin-resistant, fructose-fed Syrian golden hamster and is partially normalized by the insulin sensitizer rosiglitazone","volume":"53","author":"GF Lewis","year":"2004","journal-title":"Diabetes"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/dmrr.2312","article-title":"Hepatic lipase activity is increased in non-alcoholic fatty liver disease beyond insulin resistance","volume":"28","author":"V Miksztowicz","year":"2012","journal-title":"Diabetes Metab Res Rev"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/hep.26988","article-title":"Relationship between disease severity, hyperinsulinemia, and impaired insulin clearance in patients with nonalcoholic steatohepatitis","volume":"59","author":"F Bril","year":"2014","journal-title":"Hepatology"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1053\/j.gastro.2008.03.021","article-title":"Increased liver fat, impaired insulin clearance, and hepatic and adipose tissue insulin resistance in type 2 diabetes","volume":"135","author":"A Kotronen","year":"2008","journal-title":"Gastroenterology"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1194\/jlr.R100020-JLR200","article-title":"Hepatic lipase: structure\/function relationship, synthesis, and regulation","volume":"43","author":"B Perret","year":"2002","journal-title":"J Lipid Res"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.2337\/diacare.28.12.2913","article-title":"Hepatic enzymes, the metabolic syndrome, and the risk of type 2 diabetes in older men","volume":"28","author":"SG Wannamethee","year":"2005","journal-title":"Diabetes Care"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.2337\/db10-1806","article-title":"Liver enzymes are associated with hepatic insulin resistance, insulin secretion, and glucagon concentration in healthy men and women","volume":"60","author":"F Bonnet","year":"2011","journal-title":"Diabetes"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000474989","article-title":"Insulin-degrading activity in experimental liver cirrhosis of the rat","volume":"48","author":"M Auletta","year":"1994","journal-title":"Enzyme Protein"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0009-8981(89)90369-0","article-title":"Insulin and glucagon degradation in liver are not affected by hepatic cirrhosis","volume":"183","author":"S Antoniello","year":"1989","journal-title":"Clin Chim Acta"},{"issue":"4A","key":"ref32","doi-asserted-by":"crossref","first-page":"42J","DOI":"10.1016\/S0002-9149(03)00615-5","article-title":"Regulation of reverse cholesterol transport and clinical implications","volume":"92","author":"DJ Rader","year":"2003","journal-title":"Am J Cardiol"},{"issue":"27","key":"ref33","doi-asserted-by":"crossref","first-page":"25287","DOI":"10.1074\/jbc.M101726200","article-title":"High density lipoprotein (HDL) particle uptake mediated by scavenger receptor class B type 1 results in selective sorting of HDL cholesterol from protein and polarized cholesterol secretion","volume":"276","author":"DL Silver","year":"2001","journal-title":"J Biol Chem"},{"issue":"8","key":"ref34","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1161\/ATVBAHA.110.207373","article-title":"Effects of high-density lipoproteins on pancreatic beta-cell insulin secretion","volume":"30","author":"MA Fryirs","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.2119\/molmed.2012.00113","article-title":"Apolipoprotein A-I modulates processes associated with diet-induced nonalcoholic fatty liver disease in mice","volume":"18","author":"EA Karavia","year":"2012","journal-title":"Mol Med"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/hep.21631","article-title":"Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?","volume":"45","author":"R Gambino","year":"2007","journal-title":"Hepatology"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/dom.12049","article-title":"Components of metabolic syndrome and 5-year change in insulin clearance\u2014the Insulin Resistance Atherosclerosis Study","volume":"15","author":"CC Lee","year":"2013","journal-title":"Diabetes Obes Metab"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/oby.21256","article-title":"Hyperinsulinemia in individuals with obesity: Role of insulin clearance","volume":"23","author":"MK Kim","year":"2015","journal-title":"Obesity (Silver Spring)"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2337\/dc12-0101","article-title":"Relationship of insulin sensitivity, insulin secretion, and adiposity with insulin clearance in a multiethnic population: the insulin Resistance Atherosclerosis study","volume":"36","author":"C Lorenzo","year":"2013","journal-title":"Diabetes Care"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"e65954","DOI":"10.1371\/journal.pone.0065954","article-title":"Body adiposity index versus body mass index and other anthropometric traits as correlates of cardiometabolic risk factors","volume":"8","author":"CT Lichtash","year":"2013","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0166263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T09:22:24Z","timestamp":1601198544000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0166263"}},"subtitle":[],"editor":[{"given":"Clemens","family":"F\u00fcrnsinn","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2016,11,15]]},"references-count":40,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2016,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0166263","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,15]]}}}